dr. ir. N.M. (Marianna) Sijtsema

Medical Physicist

dr. ir. N.M. (Marianna) Sijtsema
Telephone:
Secretary:
E-mail:
n.m.sijtsema umcg.nl

Research

CV

Nanna Maria (Marianna) Sijtsema, Ph.D.

Profile photoRadiation Oncology
University Medical Center Groningen
Hanzeplein 1
9713 GZ Groningen
Netherlands
Email: n.m.sijtsema@umcg.nl

Current position

2005-Present
Medical Physicist Radiotherapy

Clinical expertise:
Adaptive radiotherapy and image guided radiotherapy for both photon and proton therapy

Research subjects:
- Radiomics / Image biomarkers for improved prediction of treatment outcome after
radiotherapy (both tumor related outcomes and complications).
- Development and implementation of deep learning methods in radiaton oncology.

Education

2001-2005
Training for Medical Physicist Radiation Oncology, Department of Radiation Oncology, University Medical Center Groningen, the Netherlands.

1993-1997
PhD. Biophysics, Faculty of Applied Physics, University of Twente, Enschede, the Netherlands.
Thesis: Towards Chemical Imaging of Living Cells: Design and Application of a Confocal Raman Microscope.
Promotor: Prof. J. Greve.

1987-1993
M. Sc. Applied Physics, University of Twente, Enschede, the Netherlands.

Employment

1997-2001
Postdoc, Applied Physics, Radboud University Nijmegen, Nijmegen, the Netherlands.
Development of laser-based techniques for characterization of supersonic nozzel flows.

Memberships

Full member of the European Society for Therapeutic Radiology and Oncology (ESTRO)
Full member of the Dutch Society of Medical Physicist (NVKF)
Full member of the Dutch Society of Radiatiotherapy and Oncology (NVRO)

Peer-reviewed journal articles

  1. External validation of nodal failure prediction models including radiomics in head and neck cancer

    Zhai, T-T., Wesseling, F., Langendijk, J. A., Shi, Z., Kalendralis, P., van Dijk, L. V., Hoebers, F., Steenbakkers, R. J. H. M., Dekker, A., Wee, L. & Sijtsema, N. M., 11-Nov-2020, In : Oral Oncology. 112, p. 105083
  2. A comprehensive motion analysis - consequences for high precision image-guided radiotherapy of esophageal cancer patients

    Roos, C. T. G., Faiz, Z., Visser, S., Dieters, M., van der Laan, H. P., den Otter, L. A., Plukker, J. T. M., Langendijk, J. A., Knopf, A-C., Muijs, C. T. & Sijtsema, N. M., 5-Nov-2020, In : ACTA ONCOLOGICA. p. 1-8 8 p.
  3. Development and Internal Validation of an NTCP-model for Acute Coronary Events after Breast Cancer Radiotherapy: First Results of the MEDIRAD BRACE Study (H2020-Euratom-1.4 / 755523)

    Spoor, D., Leeuwen, F. E. V., Russell, N., Boekel, N. B., Jacob, S., Combs, S. E., Borm, K., Vliegenthart, R., Sikkema, G., van den Bogaard, V. A. B., Sijtsema, M., Maduro, J. H., Shuit, E., Langendijk, H. & Crijns, A. P. G., Nov-2020, In : International Journal of Radiation Oncology Biology Physics. 108, 3, p. S11-S12
  4. Weekly robustness evaluation of intensity-modulated proton therapy for oesophageal cancer

    Anakotta, R. M., van der Laan, H. P., Visser, S., Ribeiro, C. O., Dieters, M., Langendijk, J. A., Both, S., Korevaar, E. W., Sijtsema, N. M., Knopf, A. & Muijs, C. T., Oct-2020, In : Radiotherapy and Oncology. 151, p. 66-72 7 p.
  5. Inter-fraction motion robustness and organ sparing potential of proton therapy for cervical cancer

    Gort, E. M., Beukema, J. C., Matysiak, W., Sijtsema, N. M., Aluwini, S., Langendijk, J. A., Both, S. & Brouwe, C. L., 18-Sep-2020, In : Radiotherapy and Oncology. 154, p. 194-200 7 p.
  6. Head and Neck IMPT probabilistic dose accumulation: feasibility of a 2 mm setup uncertainty setting

    Wagenaar, D., Kierkels, R. G. J., van der Schaaf, A., Meijers, A., Scandurra, D., Sijtsema, N. M., Korevaar, E. W., Steenbakkers, R. J. H. M., Knopf, A. C., Langendijk, J. A. & Both, S., 5-Sep-2020, In : Radiotherapy and Oncology. 154, p. 45-52 8 p.
  7. Can we safely reduce the radiation dose to the heart while compromising the dose to the lungs in oesophageal cancer patients?

    Beukema, J. C., Kawaguchi, Y., Sijtsema, N. M., Zhai, T-T., Langendijk, J. A., van Dijk, L. V., van Luijk, P., Teshima, T. & Muijs, C. T., Aug-2020, In : Radiotherapy and Oncology. 149, p. 222-227 6 p.
  8. Investigation of inter-fraction target motion variations in the context of pencil beam scanned proton therapy in non-small cell lung cancer patients

    den Otter, L. A., Anakotta, R. M., Weessies, M., Roos, C. T. G., Sijtsema, N. M., Muijs, C. T., Dieters, M., Wijsman, R., Troost, E. G. C., Richter, C., Meijers, A., Langendijk, J. A., Both, S. & Knopf, A-C., 9-Jul-2020, In : Medical Physics. 47, 9, p. 3835-3844 10 p.
  9. Pre-treatment radiomic features predict individual lymph node failure for head and neck cancer patients

    Zhai, T-T., Langendijk, J. A., van Dijk, L. V., van der Schaaf, A., Sommers, L., Vemer-van den Hoek, J. G. M., Bijl, H. P., Halmos, G. B., Witjes, M. J. H., Oosting, S. F., Noordzij, W., Sijtsema, N. M. & Steenbakkers, R. J. H. M., May-2020, In : Radiotherapy and Oncology. 146, p. 58-65 8 p.
  10. The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping

    image standardization intitiative, Zwanenburg, A., Vallières, M., Abdalah, M. A., Aerts, H. J. W. L., Andrearczyk, V., Apte, A., Ashrafinia, S., Bakas, S., Beukinga, R. J., Boellaard, R., Bogowicz, M., Boldrini, L., Buvat, I., Cook, G. J. R., Davatzikos, C., Depeursinge, A., Desseroit, M-C., Dinapoli, N., Dinh, C. V. & Echegaray, S., May-2020, In : RADIOLOGY. 295, 2, p. 328-338 11 p.
  11. Organ sparing potential and inter-fraction robustness of adaptive intensity modulated proton therapy for lung cancer

    van der Laan, H. P., Anakotta, R. M., Korevaar, E. W., Dieters, M., Ubbels, J. F., Wijsman, R., Sijtsema, N. M., Both, S., Langendijk, J. A., Muijs, C. T. & Knopf, A. C., 25-Sep-2019, In : ACTA ONCOLOGICA. 8 p.
  12. Delta-radiomics features during radiotherapy improve the prediction of late xerostomia

    van Dijk, L. V., Langendijk, J. A., Zhai, T-T., Vedelaar, T. A., Noordzij, W., Steenbakkers, R. J. H. M. & Sijtsema, N. M., 28-Aug-2019, In : Scientific Reports. 9, 1, 8 p., 12483.
  13. The prognostic value of CT-based image-biomarkers for head and neck cancer patients treated with definitive (chemo-)radiation

    Zhai, T. T., Langendijk, J. A., van Dijk, L. V., Halmos, G. B., Witjes, M. J. H., Oosting, S. F., Noordzij, W., Sijtsema, N. M. & Steenbakkers, R. J. H. M., 1-Aug-2019, In : Oral Oncology. 95, p. 178-186 9 p.
  14. Evaluation of a 3D surface imaging system for deep inspiration breath-hold patient positioning and intra-fraction monitoring

    Hamming, V. C., Visser, C., Batin, E., McDermott, L. N., Busz, D. M., Both, S., Langendijk, J. A. & Sijtsema, N. M., 11-Jul-2019, In : Radiation oncology. 14, 1, 8 p., 125.
  15. Development and evaluation of an auto-segmentation tool for the left anterior descending coronary artery of breast cancer patients based on anatomical landmarks

    van den Bogaard, V. A. B., van Dijk, L. V., Vliegenthart, R., Sijtsema, N. M., Langendijk, J. A., Maduro, J. H. & Crijns, A. P. G., Jul-2019, In : Radiotherapy and Oncology. 136, p. 15-20 6 p.
  16. Cardiac Function After Radiation Therapy for Breast Cancer

    van den Bogaard, V. A. B., van Luijk, P., Hummel, Y. M., van der Meer, P., Schuit, E., Boerman, L. M., Maas, S. W. M. C., Nauta, J. F., Steggink, L. C., Gietema, J. A., de Bock, G. H., Berendsen, A. J., Smit, W. G. J. M., Sijtsema, N. M., Kierkels, R. G. J., Langendijk, J. A., Crijns, A. P. G. & Maduro, J. H., 1-Jun-2019, In : International Journal of Radiation Oncology, Biology, Physics. 104, 2, p. 392-400 9 p.
  17. Parotid gland fat related Magnetic Resonance image biomarkers improve prediction of late radiation-induced xerostomia

    van Dijk, L. V., Thor, M., Steenbakkers, R. J. H. M., Apte, A., Zhai, T-T., Borra, R., Noordzij, W., Estilo, C., Lee, N., Langendijk, J. A., Deasy, J. O. & Sijtsema, N. M., Sep-2018, In : Radiotherapy and Oncology. 128, 3, p. 459-466 8 p.
  18. An automated, quantitative, and case-specific evaluation of deformable image registration in computed tomography images

    Kierkels, R. G. J., den Otter, L. A., Korevaar, E. W., Langendijk, J. A., van der Schaaf, A., Knopf, A-C. & Sijtsema, N. M., 21-Feb-2018, In : Physics in Medicine and Biology. 63, 24 p., 045026.
  19. (18)F-FDG PET image biomarkers improve prediction of late radiation-induced xerostomia

    van Dijk, L. V., Noordzij, W., Brouwer, C. L., Boellaard, R., Burgerhof, J. G. M., Langendijk, J. A., Sijtsema, N. M. & Steenbakkers, R. J. H. M., Jan-2018, In : Radiotherapy and Oncology. 126, 1, p. 89-95 7 p.
  20. Geometric Image Biomarker Changes of the Parotid Gland Are Associated With Late Xerostomia

    van Dijk, L. V., Brouwer, C. L., van der Laan, H. P., Burgerhof, J. G. M., Langendijk, J. A., Steenbakkers, R. J. H. M. & Sijtsema, N. M., 1-Dec-2017, In : International Journal of Radiation Oncology Biology Physics. 99, 5, p. 1101-1110 10 p.
  21. Improving the prediction of overall survival for head and neck cancer patients using image biomarkers in combination with clinical parameters

    Zhai, T-T., van Dijk, L. V., Huang, B-T., Lin, Z-X., Ribeiro, C. O., Brouwer, C. L., Oosting, S. F., Halmos, G. B., Witjes, M. J. H., Langendijk, J. A., Steenbakkers, R. J. H. M. & Sijtsema, N. M., Aug-2017, In : Radiotherapy and Oncology. 124, 2, p. 256-262 7 p.
  22. CT image biomarkers to improve patient-specific prediction of radiation-induced xerostomia and sticky saliva

    van Dijk, L. V., Brouwer, C. L., van der Schaaf, A., Burgerhof, J. G. M., Beukinga, R. J., Langendijk, J. A., Sijtsema, N. M. & Steenbakkers, R. J. H. M., Feb-2017, In : Radiotherapy and Oncology. 122, 2, p. 185-191 7 p.
  23. Reply letter to "Texture analysis of parotid gland as a predictive factor of radiation induced xerostomia: A subset analysis"

    van Dijk, L. V., Langendijk, J. A., Sijtsema, N. M. & Steenbakkers, R. J. H. M., Feb-2017, In : Radiotherapy and Oncology. 122, 2, p. 322-322 1 p.
  24. Selection of head and neck cancer patients for adaptive radiotherapy to decrease xerostomia

    Brouwer, C. L., Steenbakkers, R. J. H. M., van der Schaaf, A., Sopacua, C. T. C., van Dijk, L. V., Kierkels, R. G. J., Bijl, H. P., Burgerhof, J. G. M., Langendijk, J. A. & Sijtsema, N. M., Jul-2016, In : Radiotherapy and Oncology. 120, 1, p. 36-40 5 p.
  25. An exploratory study of volumetric analysis for assessing tumor response with 18F-FAZA PET/CT in patients with advanced non-small-cell lung cancer (NSCLC)

    Kerner, G. S. M. A., Bollineni, V. R., Hiltermann, T. J. N., Sijtsema, N. M., Fischer, A., Bongaerts, A. H. H., Pruim, J. & Groen, H. J. M., 18-Apr-2016, In : EJNMMI Research. 6, 8 p., 33.
  26. CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines

    Brouwer, C. L., Steenbakkers, R. J. H. M., Bourhis, J., Budach, W., Grau, C., Gregoire, V., van Herk, M., Lee, A., Maingon, P., Nutting, C., O'Sullivan, B., Porceddu, S. V., Rosenthal, D. I., Sijtsema, N. M. & Langendijk, J. A., Oct-2015, In : Radiotherapy and Oncology. 117, 1, p. 83-90 8 p.
  27. Identifying patients who may benefit from adaptive radiotherapy: Does the literature on anatomic and dosimetric changes in head and neck organs at risk during radiotherapy provide information to help?

    Brouwer, C. L., Steenbakkers, R. J. H. M., Langendijk, J. A. & Sijtsema, N. M., Jun-2015, In : Radiotherapy and Oncology. 115, 3, p. 285-294 10 p.
  28. The effects of computed tomography image characteristics and knot spacing on the spatial accuracy of B-spline deformable image registration in the head and neck geometry

    Brouwer, C. L., Kierkels, R. G. J., van t Veld, A. A., Sijtsema, N. M. & Meertens, H., 29-Jul-2014, In : Radiation oncology. 9, 169, 10 p.
  29. Differences in delineation guidelines for head and neck cancer result in inconsistent reported dose and corresponding NTCP

    Brouwer, C. L., Steenbakkers, R. J. H. M., Gort, E., Kamphuis, M. E., van der Laan, H. P., van t Veld, A. A., Sijtsema, N. M. & Langendijk, J. A., Apr-2014, In : Radiotherapy and Oncology. 111, 1, p. 148-152 5 p.
  30. Systematic review of the role of a belly board device in radiotherapy delivery in patients with pelvic malignancies

    Wiesendanger-Wittmer, E. M., Sijtsema, N. M., Muijs, C. T. & Beukema, J. C., Mar-2012, In : Radiotherapy and Oncology. 102, 3, p. 325-334 10 p.
  31. External beam radiotherapy combined with intraluminal brachytherapy in esophageal carcinoma

    Muijs, C. T., Beukema, J. C., Mul, V. E., Plukker, J. T., Sijtsema, N. M. & Langendijk, J. A., Feb-2012, In : Radiotherapy and Oncology. 102, 2, p. 303-308 6 p.
  32. Electronic portal images (EPIs) based position verification for the breast simultaneous integrated boost (SIB) technique

    Sijtsema, N. M., van Dijk-Peters, F. B. J., Langendijk, J. A., Maduro, J. H. & van 't Veld, A. A., Jan-2012, In : Radiotherapy and Oncology. 102, 1, p. 108-114 7 p.
  33. Patient position verification with oblique radiation beams

    Sijtsema, N. M., van den Bergh, A. C. M., Burlage, F. R., Bijl, H. P., Langendijk, J. A. & Meertens, H., Oct-2007, In : Radiotherapy and Oncology. 85, 1, p. 126-131 6 p.
  34. Quantitative spectrally resolved imaging through a spectrograph

    Tolboom, RAL., Sijtsema, NM., ter Meulen, JJ. & Dam, N. J., 1-Nov-2003, In : Optics Letters. 28, 21, p. 2046-2048 3 p.
  35. Air photolysis and recombination tracking: A new molecular tagging velocimetry scheme

    Sijtsema, NM., Dam, NJ., Klein-Douwel, RJH. & ter Meulen, JJ., Jun-2002, In : AIAA Journal. 40, 6, p. 1061-1064 4 p.
  36. Nitric oxide flow tagging in unseeded air

    Dam, N., Klein-Douwel, RJH., Sijtsema, NM. & ter Meulen, JJ., 1-Jan-2001, In : Optics Letters. 26, 1, p. 36-38 3 p.
  37. Intracellular reactions in single human granulocytes upon phorbol myristate acetate activation using confocal Raman microspectroscopy

    Sijtsema, N. M., Tibbe, A. G. J., Segers-Nolten, I. G. M. J., Verhoeven, A. J., Weening, R. S., Greve, J. & Otto, C., 2000, In : Biophysical Journal. 78, 5, p. 2606-2613 8 p.
  38. Characterization of the Asp94 and Glu242 mutants in myeloperoxidase, the residues linking the heme group via ester bonds

    Kooter, I. M., Moguilevsky, N., Bollen, A., Sijtsema, N. M., Otto, C., Dekker, H. L. & Wever, R., 1-Aug-1999, In : European Journal of Biochemistry. 264, 1, p. 211-217 7 p.
  39. Localization study of Co-phthalocyanines in cells by Raman micro(spectro)scopy

    Arzhantsev, S. Y., Chikishev, A. Y., Koroteev, N. I., Greve, J., Otto, C. & Sijtsema, N. M., Mar-1999, In : Journal of Raman Spectroscopy. 30, 3, p. 205-208 4 p.
  40. Two-dimensional multispecies imaging of a supersonic nozzle flow

    Sijtsema, N. M., Tolboom, R. A. L., Dam, N. J. & ter Meulen, J. J., 1999, In : Optics Letters. 24, 10, p. 664-666 3 p.
  41. Resonance Raman Microspectroscopy of Myeloperoxidase and Cytochrome b(558) in Human Neutrophilic Granulocytes

    Sijtsema, N. M., Otto, C., Segers-Nolten, G. M. J., Verhoeven, A. J. & Greve, J., Jun-1998, In : Biophysical Journal. 74, 6, p. 3250-3255 6 p.
  42. Confocal direct imaging Raman microscope: Design and applications in biology

    Sijtsema, N. M., Wouters, S. D., Grauw, C. J. D., Otto, C. & Greve, J., 1998, In : Applied Spectroscopy. 52, 3, p. 348-355 8 p.
  43. Confocal Raman microspectroscopy of the activation of single neutrophilic granulocytes

    Otto, C., Sijtsema, N. M. & Greve, J., 1998, In : European Biophysics Journal. 27, 6, p. 582-589 8 p.
  44. Axial resolution of confocal Raman microscopes: Gaussian beam theory and practice

    Grauw, C. J. D., Sijtsema, N. M., Otto, C. & Greve, J., Dec-1997, In : Journal of Microscopy. 188, p. 273-279 7 p.
  45. Site-directed mutagenesis of Met243, a residue of myeloperoxidase involved in binding of the prosthetic group

    Kooter, I. M., Moguilevsky, N., Bollen, A., Sijtsema, N. M., Otto, C. & Wever, R., 1-Apr-1997, In : Journal of biological inorganic chemistry. 2, 2, p. 191-197 7 p.
  46. Applications of micro-Raman imaging in biomedical research

    Otto, C., DeGrauw, C. J., Duindam, J. J., Sijtsema, N. M. & Greve, J., Feb-1997, In : Journal of Raman Spectroscopy. 28, 2-3, p. 143-150 8 p.
  47. Carotenoid levels in human lymphocytes, measured by Raman microspectroscopy

    Ramanauskaite, R. B., SegersNolten, IGMJ., DeGrauw, K. J., Sijtsema, N. M., VanderMaas, L., Greve, J., Otto, C. & Figdor, C. G., 1997, In : Pure and Applied Chemistry. 69, 10, p. 2131-2134 4 p.
  48. Evidence for Hoogsteen GC base pairs in the proton-induced transition from right-handed to left-handed poly(dG-dC)center dot poly(dG-dC)

    SegersNolten, G. M. J., Sijtsema, N. M. & Otto, C., 1997, In : Biochemistry. 36, 43, p. 13241-13247 7 p.
  49. Imaging with extrinsic Raman labels

    Sijtsema, N. M., Duindam, J. J., Puppels, G. J., Otto, C. & Greve, J., 1-May-1996, In : Applied Spectroscopy. 50, 5, p. 545-551 7 p.
  50. Confocal Raman microscopy on eye lenses and single living cells

    Sijtsema, N. M., Duindam, J. J., Tibbe, A. G. J., Ramanauskaite, R., Otto, C., Figdor, C. & Greve, J., 1996, In : Progress in Biophysics & Molecular Biology. 65, p. 192 1 p.
  51. Evidence for the presence of protonated Hoogsteen GC base pairs in poly(DG-DC)center dot poly(DG-DC) at reduced pH values.

    SegersNolten, G. M. J., Otto, C., DeGrauw, C. J., Sijtsema, N. M. & Greve, J., 1996, In : Progress in Biophysics & Molecular Biology. 65, p. PB110-PB110
  52. Development and Application of Raman Microspectroscopic and Raman Imaging Techniques for Cell Biological Studies

    PUPPELS, G. J., SCHUT, T. C. B., SIJTSEMA, N. M., GROND, M., MARABOEUF, F., DEGRAUW, C. G., FIGDOR, C. G. & GREVE, J., 1-Mar-1995, In : Journal of Molecular Structure. 347, p. 477-483 7 p.

Meeting Abstracts

  1. Robustness Evaluation Using Dose Accumulation in Head and Neck IMPT

    Wagenaar, D., Kierkels, R. G. J., van der Schaaf, A., Meijers, A., Scandurra, D., Sijtsema, M., Korevaar, E. W., Steenbakkers, R., Knopf, A., Langendijk, J. A. & Both, S., 1-Sep-2019, In : International Journal of Radiation Oncology Biology Physics. 105, 1, p. E744-E745 2 p.
  2. The REACT-Study - a Comprehensive Data Set of REpeated 4D CTs and Cbcts to Prepare for Pencil Beam Scanned Proton Therapy (PBS-PT) in Lung and Esophagus Patients

    Knopf, A., Muijs, C., Wijsman, R., Meijers, A., Ribeiro, C. O., Visser, S., den Otter, L., van der Laan, H. P., Anakotta, M., Roos, C. T. G., Korevaar, E. W., Sijtsema, M., Both, S. & Langendijk, J. A., 1-Sep-2019, In : International Journal of Radiation Oncology Biology Physics. 105, 1, p. E752 1 p.
  3. Evaluation of AlignRT for deep inspiration breath hold positioning and intrafraction monitoring

    Hamming, V., Visser, C., Busz, D., Batin, E., Langendijk, J. A., Both, S. & Sijtsema, N. M., Apr-2019, In : Radiotherapy and Oncology. 133, p. S277-S278 2 p.
  4. MR-Delta image biomarkers to identify partial HNC responders that advance to complete responders

    Van Dijk, L. V., Zhai, T., Van Dijk, M., Bijl, H. P., Vemer-van der Hoek, J. G. M., Dieters, M., Sijtsema, N. M., Steenbakkers, R. J. H. M. & Langendijk, J. A., Apr-2019, In : Radiotherapy and Oncology. 133, p. S521-S522 2 p.
  5. PO-0764 The effect of automatic heart contouring on model performance in predicting acute coronary events

    SPOOR, D., Peters, F., Van den Bogaard, V., Van der Schaaf, A., Ta, B., Vliegenthart, R., Kierkels, R., Langendijk, H., Maduro, J., Sijtsema, M. & Crijns, A., Apr-2019, p. S393. 1 p.
  6. Pre-treatment radiomic features predict individual nodal failure in head and neck cancer

    Zhai, T., Steenbakkers, R. J. H. M., Van Dijk, L. V., Vemer-van den Hoek, J. G. M., Bijl, H. P., Dieters, M., Noordzij, W., Van der Schaaf, A., Sijtsema, N. M. & Langendijk, J. A., Apr-2019, In : Radiotherapy and Oncology. 133, p. S204 1 p.
  7. Probabilistic Dose Accumulation Based Evaluation of Head and Neck Intensity Modulated Proton Therapy

    Wagenaar, D., Kierkels, R. G. J., Van der Schaaf, A., Reis, M. R., Meijers, A., Scandurra, D., Sijtsema, M., Korevaar, E., Knopf, A., Van den Hoek, A., Langendijk, J. A. & Both, S., Apr-2019, In : Radiotherapy and Oncology. 133, p. S42-S43 2 p.
  8. Can we safely reduce the radiation dose to the heart in esophageal cancer patients?

    Beukema, J. C., Kawaguchi, Y., Langendijk, J. A., Luijk, P. V., Sijtsema, N. M., Schaaf, A. V. D., Teshima, T. & Muijs, C. T., Apr-2018, In : Radiotherapy and Oncology. 127, p. S55-S56 2 p.
  9. Evaluation of a 3D surface imaging system for patient positioning and intra-fraction monitoring

    Hamming, V. C., Visser, C., Both, S. & Sijtsema, N. M., Apr-2018, In : Radiotherapy and Oncology. 127, Suppl. 1, p. S509 1 p.
  10. Geometric image biomarker changes at the third treatment week predict late xerostomia

    Vedelaar, T. A., Van Dijk, L. V., Zhai, T., Brouwer, C. L., Langendijk, J. A., Steenbakkers, R. J. H. M. & Sijtsema, N. M., Apr-2018, In : Radiotherapy and Oncology. 127, p. S536 1 p.
  11. Parotid gland fat related Magnetic Resonance Image biomarkers improve prediction of late xerostomia

    Van Dijk, L. V., Thor, M., Steenbakkers, R. J. H. M., Apte, A., Zhai, T., Borra, R., Lee, N., Langendijk, J. A., Deasy, J. O. & Sijtsema, N. M., Apr-2018, In : Radiotherapy and Oncology. 127, p. S95-S96 2 p.
  12. Prognostic value of CT based image biomarkers for treatment outcome in head and neck cancer patients

    Zhai, T. T., Van Dijk, L. V., Langendijk, J. A., Sijtsema, N. M. & Steenbakkers, R. J. H. M., Apr-2018, In : Radiotherapy and Oncology. 127, p. S223-S224 2 p.
  13. OC-0070: 18F-FDG PET image biomarkers improve prediction of late radiation-induced xerostomia

    Dijk, L. V. V., Noordzij, W., Brouwer, C. L., Burgerhof, J. G. M., Langendijk, J. A., Sijtsema, N. M. & Steenbakkers, R. J. H. M., May-2017, p. S35 - S36. 2 p.
  14. Prognostic Image Biomarkers for Nasopharyngeal Cancer Patients Treated With (Chemo)Radiation

    Zhai, T. T., van Dijk, L. V., Lin, Z., Huang, B., Ribeiro, C. O., Langendijk, J. A., Steenbakkers, R. J. & Sijtsema, N. M., 1-Oct-2016, In : International Journal of Radiation Oncology Biology Physics. 96, Supplement 2, p. E372 2918.
  15. OC-0067: An automated patient-specific and quantitative approachfor deformable image registration evaluation

    Kierkels, R. G., Brouwer, C. L., Steenbakkers, R. J., Bijl, H. P., Langendijk, J. A. & Sijtsema, N. M., Apr-2016, p. S29 - S30. 2 p.
  16. OC-0261: CT Image biomarkers improve the prediction of xerostomia and sticky saliva

    Sijtsema, N. M., Dijk, L. V. V., Brouwer, C. L., Beukinga, R. J., Schaaf, A. V. D., Burgerhof, H. G. M., Langendijk, J. A. & Steenbakkers, R. J. H. M., Apr-2016, p. S121. 1 p.
  17. EP-1890: Accurate organs at risk contour propagation in head and neck adaptive radiotherapy

    Zhai, T. T., Bijl, H. P., Langendijk, J. A., Steenbakkers, R. J., Brouwer, C. L., Laan-Boomsma, H. J. V. D., Sijtsema, N. M. & Kierkels, R. G., 2016, p. S893 - S894. 2 p.
  18. PV-0477: Early CT image biomarkers change and xerostomia score are strong predictors for late xerostomia

    Dijk, L. V. V., Brouwer, C. L., Beukinga, R. J., Schaaf, A. V. D., Laan, H. P. V. D., Burgerhof, H. G. M., Langendijk, J. A., Steenbakkers, R. J. H. M. & Sijtsema, N. M., 2016, p. S227 - S228. 2 p.
  19. PD-0529: CT image features associated with patient-rated xerostomia after radiotherapy for head and neck cancer

    Wagenaar, D., Schaaf, A. V. D., Sijtsema, N. M., Dijk, L. V. V., Langendijk, J. A., Steenbakkers, R. J. H. M. & Brouwer, C. L., Apr-2015, p. S256 - S257. 2 p.
  20. Rigid Dose Transformation as a Surrogate for Dose Recalculation When Assessing the Need for Adaptive Re-Planning in Head and Neck Cancer Patients

    Kierkels, R. G. J., Pickup, L. C., Gooding, M. J., Free, J., Langendijk, J. A., Brouwer, C. L., Bijl, H. P. & Sijtsema, N. M., 1-Sep-2014, In : International Journal of Radiation Oncology Biology Physics. 90, p. S107-S107 1 p.
  21. OC-0579: Decision support for re-planning in head and neck cancer patients treated with adaptive radiotherapy

    Kierkels, R. G. J., Pickup, L. C., Gooding, M. J., Free, J., Langendijk, J. A., Brouwer, C. L. & Sijtsema, N. M., 2014, p. S227. 1 p.
  22. EP-1259: Influence of the type of headrest (individual or standard) on the actual given dose in target volumes and organs at risk

    Free, J., Wittendorp, P. W. H., Brouwer, C. L., Schaaf, A. V. D., Langendijk, J. A., Veld, A. A. V. ., Steenbakkers, R. J. H. M. & Sijtsema, N. M., 2013, p. S475 - S476. 2 p.
  23. OC-0341: Robustness of swallowing-sparing proton therapy for head and neck cancer

    Laan, H. P. V. D., Brouwer, C. L., Korevaar, E. W., Veld, A. A. V. ., Sijtsema, N. M. & Langendijk, J. A., 2013, p. S133. 1 p.

Awarded grands

Deep learning Algorithms for Medical image Evaluation (DAME), P.M.A. van Ooijen and N.M. Sijtsema. EU INTERREG Deutschland Nederland. Project period: October 2017 - October 2021.

Proton Therapy Research Infrastructure: ProTRAIT. Prof.dr. J.A. Langendijk, Prof.dr.ir. A. Dekker, dr.ir. N.M. Sijtsema, KWF Pilot infrastructure Initiative proposal. Project period: February 2018 - Februari 2021.

Invited lectures

NTCP-model enrichment using radiomics. Sijtsema, N.M., Opening Symposium Proton Therapy @ Groningen (Groningen 6 June 2018). Invited lecture. 

Image biomarkers to improve prediction of treatment outcome in radiotherapy. Sijtsema, N.M., Noordelijke Refereeravond Radiotherapie. Advance imaging for radiotherapy. (Groningen, 9 oktober 2018). Invited lecture.

Protonentherapie in Groningen en het ProTRAIT project. Sijtsema, N.M.,  KWF bijeenkomst Hoogezand. (Hoogezand, 1 november 2018), invited lecture.

Image biomarkers add to clinical feature in predicting the overall survival in head and neck cancer patients. Sijtsema, N.M., Radiomics 2017. (Clearwater Beach, VS, 23 Oktober 2017). Invited lecture.

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