M. (Michael) Chang

Associate Professor

M. (Michael) Chang
+31 6 5272 4893 (Office)
m.chang umcg.nl



Profile photoMichael Chang

Group leader
European Research Institute on the Biology of Ageing (ERIBA)
University Medical Centre Groningen (UMCG)
University of Groningen (RUG)
A. Deusinglaan 1
9713 AV Groningen
The Netherlands

Email: m.chang@umcg.nl
Phone: +31 652724856

Professional experience

2012 – present
Group leader, European Research Institute for the Biology of Ageing (ERIBA),University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

2008 – 2011
Postdoctoral fellow, Dept. of Genetics & Development, Columbia University, New York, USA
(Supervisor: Dr. Rodney J. Rothstein)

2006 – 2008
Postdoctoral fellow, Swiss Institute for Experimental Cancer Research (ISREC),Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
(Supervisor: Dr. Joachim Lingner)


2000 – 2005
Ph.D., Department of Biochemistry, University of Toronto, Canada (Supervisor: Dr. Grant W. Brown; Thesis: Identification of novel DNA damage response genes using functional genomics)

1996 – 2000
Hon. B.Sc., Faculty of Arts and Science, University of Toronto, Canada
Specialist program: Molecular Genetics & Molecular Biology
Major program: Human biology
Minor program: Zoology
4th year project supervisor: Dr. Brenda J. Andrews

Grants and awards

2019 IMB-ERIBA Collaborative Grant (co-applicant)
2014 ERIBA-UMCG Collaborative Grant (co-applicant; EUR 50,000)
2013 Netherlands Organisation for Scientific Research (NWO) Vidi Grant (EUR 860,000) 2010 Terry Fox Foundation Fellowship (CAD 96,416)
2007 Human Frontier Science Program Long-Term Fellowship (CHF 132,850 + USD,76,807) 2006 EMBO Long-Term Fellowship (CHF 56,382)
2005 Canadian Institutes of Health Research Short-Term Research Grant
2004 Ontario Graduate Scholarship (CAD 15,000)
2004 National Cancer Institute of Canada Student Travel Award
2004 Dorothy Sterling Dow Walsh Award
2003 Ontario Graduate Scholarship (CAD 15 000)
2002 University of Toronto Open Fellowship (CAD 12,000)
2001 University of Toronto Open Fellowship (CAD 12,000)
2000 Summer Undergraduate Research Fellowship

Research output

Rap1, Rif2, and the Ku complex work in concert to cap chromosome ends

Bringas, F. R. R., Stinus, S., Wanders, L., Zoeten, P. D., Cohn, M. & Chang, M., 30-Dec-2020

Quantum monitoring the metabolism of individual yeast mutant strain cells when aged, stressed or treated with antioxidant

Morita, A., Nusantara, C., Perona Martinez, F., Hamoh, T., Damle, V., Laan, van der, K., Sigaeva, A., Vedelaar, T., Chang, M., Chipaux, M. & Schirhagl, R., 31-Jul-2020

A Genome-Wide Screen for Genes Affecting Spontaneous Direct-Repeat Recombination in Saccharomyces cerevisiae

Novarina, D., Desai, R., Vaisica, J. A., Ou, J., Bellaoui, M., Brown, G. W. & Chang, M., Jun-2020, In : G3 : Genes, Genomes, Genetics. 10, 6, p. 1858-1867 50 p.

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells

Novarina, D., Janssens, G. E., Bokern, K., Schut, T., van Oerle, N. C., Kazemier, H. G., Veenhoff, L. M. & Chang, M., 1-Feb-2020, In : Aging Cell. 19, 2, 13 p., e13084.

Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in Saccharomyces cerevisiae

van Mourik, P. M., de Jong, J., Sharma, S., Kavšek, A., Chabes, A. & Chang, M., Aug-2018, In : G3 : Genes, Genomes, Genetics. 8, 8, p. 2551-2558 8 p.

Telomerase regulation by the Pif1 helicase: a length-dependent effect?

Stinus, S., Paeschke, K. & Chang, M., Apr-2018, In : Current Genetics. 64, 2, p. 509-513 5 p.

Guidelines and recommendations on yeast cell death nomenclature

Carmona-Gutierrez, D., Bauer, M. A., Zimmermann, A., Aguilera, A., Austriaco, N., Ayscough, K., Balzan, R., Bar-Nun, S., Barrientos, A., Belenky, P., Blondel, M., Braun, R. J., Breitenbach, M., Burhans, W. C., Büttner, S., Cavalieri, D., Chang, M., Cooper, K. F., Côrte-Real, M., Costa, V., Cullin, C., Dawes, I., Dengjel, J., Dickman, M. B., Eisenberg, T., Fahrenkrog, B., Fasel, N., Fröhlich, K-U., Gargouri, A., Giannattasio, S., Goffrini, P., Gourlay, C. W., Grant, C. M., Greenwood, M. T., Guaragnella, N., Heger, T., Heinisch, J., Herker, E., Herrmann, J. M., Hofer, S., Jiménez-Ruiz, A., Jungwirth, H., Kainz, K., Kontoyiannis, D. P., Ludovico, P., Manon, S., Martegani, E., Mazzoni, C., Megeney, L. A., Meisinger, C., Nielsen, J., Nyström, T., Osiewacz, H. D., Outeiro, T. F., Park, H-O., Pendl, T., Petranovic, D., Picot, S., Polčic, P., Powers, T., Ramsdale, M., Rinnerthaler, M., Rockenfeller, P., Ruckenstuhl, C., Schaffrath, R., Segovia, M., Severin, F. F., Sharon, A., Sigrist, S. J., Sommer-Ruck, C., Sousa, M. J., Thevelein, J. M., Thevissen, K., Titorenko, V., Toledano, M. B., Tuite, M., Vögtle, F-N., Westermann, B., Winderickx, J., Wissing, S., Wölfl, S., Zhang, Z. J., Zhao, R. Y., Zhou, B., Galluzzi, L., Kroemer, G. & Madeo, F., 1-Jan-2018, In : Microbial Cell. 5, 1, p. 4-31 28 p.

Genome-wide mapping of sister chromatid exchange events in single yeast cells using Strand-seq

Claussin, C., Porubsky, D., Spierings, D. C. J., Halsema, N., Rentas, S., Guryev, V., Lansdorp, P. M. & Chang, M., 12-Dec-2017, In : eLife. 6, 17 p., 30560.

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

Strecker, J., Stinus, S., Caballero, M. P., Szilard, R. K., Chang, M. & Durocher, D., 3-Aug-2017, In : eLife. 6, 59 p., e23783.

Generally Applicable Transformation Protocols for Fluorescent Nanodiamond Internalization into Cells

Hemelaar, S. R., van der Laan, K. J., Hinterding, S. R., Koot, M. V., Ellermann, E., Perona-Martinez, F. P., Roig, D., Hommelet, S., Novarina, D., Takahashi, H., Chang, M. & Schirhagl, R., 19-Jul-2017, In : Scientific Reports. 7, 7 p., 5862.

Double-strand breaks are not the main cause of spontaneous sister chromatid exchange in wild-type yeast cells

Claussin, C., Porubský, D., Spierings, D. C. J., Halsema, N., Rentas, S., Guryev, V., Lansdorp, P. M. & Chang, M., 17-Jul-2017, In : bioRxiv. 36 p.

Increased genome instability is not accompanied by sensitivity to DNA damaging agents in aged yeast cells

Novarina, D., Mavrova, S. N., Janssens, G. E., Rempel, I. L., Veenhoff, L. M. & Chang, M., Jun-2017, In : Dna repair. 54, p. 1-7 7 p.

A simple microfluidic platform to study age-dependent protein abundance and localization changes in Saccharomyces cerevisiae

Cabrera, M., Novarina, D., Rempel, I. L., Veenhoff, L. M. & Chang, M., 13-Apr-2017, In : Microbial Cell. 4, 5, p. 169-174 6 p.

Multiple Rad52-Mediated Homology-Directed Repair Mechanisms Are Required to Prevent Telomere Attrition-Induced Senescence in Saccharomyces cerevisiae

Claussin, C. & Chang, M., Jul-2016, In : PLoS genetics. 12, 7, 19 p., 1006176.

Recombination-Mediated Telomere Maintenance in Saccharomyces cerevisiae Is Not Dependent on the Shu Complex

Mourik, van, P. M., de Jong, J., Agpalo, D., Claussin, C., Rothstein, R. & Chang, M., 14-Mar-2016, In : PLoS ONE. 11, 3, 9 p., e0151314.

The many facets of homologous recombination at telomeres

Claussin, C. & Chang, M., 1-Sep-2015, In : Microbial Cell. 2, 9, p. 308-321 14 p.

Telomere length homeostasis responds to changes in intracellular dNTP pools

Gupta, A., Sharma, S., Reichenbach, P., Marjavaara, L., Nilsson, A. K., Lingner, J., Chabes, A., Rothstein, R. & Chang, M., Apr-2013, In : Genetics. 193, 4, p. 1095-1105 11 p.

Rif2 Promotes a Telomere Fold-Back Structure through Rpd3L Recruitment in Budding Yeast

Poschke, H., Dees, M., Chang, M., Amberkar, S., Kaderali, L., Rothstein, R. & Luke, B., Sep-2012, In : PLoS genetics. 8, 9, 13 p., e1002960.

Long telomeres: Too much of a good thing

Chang, M., 2012, In : BioMolecular Concepts. 3, p. 387-393 7 p.

Rif1/2 and Tel1 function in separate pathways during replicative senescence

Chang, M. & Rothstein, R., 1-Nov-2011, In : Cell Cycle. 10, 21, p. 3798-9 2 p.

Long telomeres are preferentially extended during recombination-mediated telomere maintenance

Chang, M., Dittmar, J. C. & Rothstein, R., Apr-2011, In : Nature Structural & Molecular Biology. 18, 4, p. 451-456 6 p.

Telomerase Is Essential to Alleviate Pif1-Induced Replication Stress at Telomeres

Chang, M., Luke, B., Kraft, C., Li, Z., Peter, M., Lingner, J. & Rothstein, R., Nov-2009, In : Genetics. 183, 3, p. 779-791 13 p.

Cell signaling - Tel2 finally tells one story

Chang, M. & Lingner, J., 4-Apr-2008, In : Science. 320, 5872, p. 60-61 2 p.

Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae

Chang, M., Arneric, M. & Lingner, J., 1-Oct-2007, In : Genes & Development. 21, 19, p. 2485-2494 10 p.

BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates

Wu, L., Bachrati, C. Z., Ou, J., Xu, C., Yin, JH., Chang, M., Wang, W., Li, L., Brown, GW. & Hickson, ID., 14-Mar-2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 11, p. 4068-4073 6 p.

Genomic approaches for identifying DNA damage response pathways in S-cerevisiae

Chang, M., Parsons, A. B., Sheikh, B. H., Boone, C. & Brown, G. W., 2006, Methods in Enzymology. Campbell, JL. & Modrich, P. (eds.). Academic Press, Vol. 409. p. 213-235 23 p. (Methods in Enzymology; vol. 409).

RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex

Chang, M., Bellaoui, M., Zhang, CY., Desai, R., Morozov, P., Delgado-Cruzata, L., Rothstein, R., Freyer, GA., Boone, C. & Brown, GW., 1-Jun-2005, In : EMBO Journal. 24, 11, p. 2024-2033 10 p.

The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae

Suter, B., Tong, A., Chang, M., Yu, L., Brown, G. W., Boone, C. & Rine, J., Jun-2004, In : Genetics. 167, 2, p. 579-591 13 p.

Identification of protein complexes required for efficient sister chromatid cohesion

Mayer, ML., Pot, A., Chang, M., Xu, H., Aneliunas, V., Kwok, T., Newitt, R., Aebersold, R., Boone, C., Brown, GW. & Hieter, P., Apr-2004, In : Molecular Biology of the Cell. 15, 4, p. 1736-1745 10 p.

Global mapping of the yeast genetic interaction network

Tong, AHY., Lesage, G., Bader, GD., Ding, HM., Xu, H., Xin, XF., Young, J., Berriz, GF., Brost, RL., Chang, M., Chen, YQ., Cheng, Y., Chua, G., Friesen, H., Goldberg, DS., Haynes, J., Humphries, C., He, G., Hussein, S., Ke, LZ., Krogan, N., Li, ZJ., Levinson, JN., Lu, H., Menard, P., Munyana, C., Parsons, AB., Ryan, O., Tonikian, R., Roberts, T., Sdicu, AM., Shapiro, J., Sheikh, B., Suter, B., Wong, SL., Zhang, LV., Zhu, HW., Burd, CG., Munro, S., Sander, C., Rine, J., Greenblatt, J., Peter, M., Bretscher, A., Bell, G., Roth, FP., Brown, GW., Andrews, B., Bussey, H. & Boone, C., 6-Feb-2004, In : Science. 303, 5659, p. 808-813 6 p.

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity

Bellaoui, M., Chang, M., Ou, J., Xu, H., Boone, C. & Brown, G. W., 15-Aug-2003, In : EMBO Journal. 22, 16, p. 4304-4313 10 p.

A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage

Chang, M., Bellaoui, M., Boone, C. & Brown, GW., 24-Dec-2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 26, p. 16934-16939 6 p.

Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4

Baetz, K., Moffat, J., Haynes, J., Chang, M. & Andrews, B., Oct-2001, In : Molecular and Cellular Biology. 21, 19, p. 6515-28 14 p.

ID: 429251