dr. M. (Marco) Demaria

dr. M. (Marco) Demaria
E-mail:
m.demaria umcg.nl

Research

  1. 2020
  2. 2019
  3. Wiley, C. D., Liu, S., Limbad, C., Zawadzka, A. M., Beck, J., Demaria, M., ... Kapahi, P. (2019). SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells. Cell reports, 28(13), 3329-3337.e5. https://doi.org/10.1016/j.celrep.2019.08.049
  4. Palacio, L., Goyer, M-L., Maggiorani, D., Espinosa, A., Villeneuve, N., Bourbonnais, S., ... Beauséjour, C. (2019). Restored immune cell functions upon clearance of senescence in the irradiated splenic environment. Aging Cell, 18(4), [12971]. https://doi.org/10.1111/acel.12971
  5. Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., ... Kirkland, J. L. (2019). Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell, 18(3), [12950]. https://doi.org/10.1111/acel.12950
  6. Calcinotto, A., Kohli, J., Zagato, E., Pellegrini, L., Demaria, M., & Alimonti, A. (2019). Cellular Senescence: Aging, Cancer, and Injury. Physiological reviews, 99(2), 1047-1078. https://doi.org/10.1152/physrev.00020.2018
  7. Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., ... Demaria, M. (2019). Cellular Senescence: Defining a Path Forward. Cell, 179(4), 813-827. https://doi.org/10.1016/j.cell.2019.10.005
  8. 2018
  9. Demaria, M. (2018). Biomarkers for cellular senescence. (Patent No. WO2018164580).
  10. Alimirah, F., Valdovinos, A., Chang, E., Alptekin, S., Pulido, T., Jones, E., ... Campisi, J. (2018). Cellular senescence drives skin carcinogenesis. Cancer Research, 78(13). https://doi.org/10.1158/1538-7445.AM2018-466
  11. 2017
  12. Campisi, J., van Deursen, J. M. A., Kirkland, J. L., Tchkonia, T., Baker, D. J., & Demaria, M. (2017). Animal models for cancer and uses thereof. (Patent No. US20170042129).
  13. van Deursen, J. M. A., Baker, D. J., Kirkland, J. L., Tchkonia, T., Campisi, J., Demaria, M., & Laberge, R-M. (2017). Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof. (Patent No. US2017027139).
  14. Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., ... Campisi, J. (2017). Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer discovery, 7(2), 165-176. https://doi.org/10.1158/2159-8290.CD-16-0241
  15. Laberge, R-M., Campisi, J., Davalos, A., Lopez-Dominguez , J. A., Demaria, M., David, N., ... Zhu, Y. (2017). Compositions and methods for treating senescence-associated diseases and disorders. (Patent No. WO2017008060).
  16. Demaria, M. (2017). Cellular Senescence and Tumor Promotion. In M. Extermann (Ed.), Geriatric Oncology (pp. 1-15). Springer. https://doi.org/10.1007/978-3-319-44870-1_79-1
  17. 2016
  18. Chinta, S. J., Woods, G., Demaria, M., Campisi, J., & Andersen, J. K. (2016). Cellular senescence induced by paraquat drives neuropathology associated with Parkinson's disease. Movement Disorders, 31, S252-S252. [776].
  19. 2015
  20. Kang, C., Xu, Q., Martin, T. D., Li, M. Z., Demaria, M., Aron, L., ... Elledge, S. J. (2015). The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science, 349(6255), aaa5612. https://doi.org/10.1126/science.aaa5612
  21. Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015). Cellular senescence and the aging brain. Experimental Gerontology, 68, 3-7. https://doi.org/10.1016/j.exger.2014.09.018
  22. Laberge, R-M., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., ... Campisi, J. (2015). MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nature Cell Biology, 17(8), 1049-61. https://doi.org/10.1038/ncb3195
  23. Christy, B., Demaria, M., Campisi, J., Huang, J., Jones, D., Dodds, S. G., ... Hasty, P. (2015). p53 and rapamycin are additive. Oncotarget, 6(18), 15802-13. https://doi.org/10.18632/oncotarget.4602
  24. 2014
  25. Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., ... Campisi, J. (2014). An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell, 31(6), 722-733. https://doi.org/10.1016/j.devcel.2014.11.012
  26. Chinta, S. J., Wood, G., Lieu, C., Rane, A., DeMaria, M., Campisi, J., & Andersen, J. K. (2014). CELLULAR SENESCENCE AND BRAIN AGING. Free Radical Biology and Medicine, 76(1), S3-S3. https://doi.org/10.1016/j.freeradbiomed.2014.10.013
  27. Camporeale, A., Demaria, M., Monteleone, E., Giorgi, C., Wieckowski, M. R., Pinton, P., & Poli, V. (2014). STAT3 Activities and Energy Metabolism: Dangerous Liaisons. Cancers, 6(3), 1579-96. https://doi.org/10.3390/cancers6031579
  28. 2013
  29. Laberge, R-M., Adler, D., DeMaria, M., Mechtouf, N., Teachenor, R., Cardin, G. B., ... Rodier, F. (2013). Mitochondrial DNA damage induces apoptosis in senescent cells. Cell death & disease, 4, [e727]. https://doi.org/10.1038/cddis.2013.199
  30. 2012
  31. Laberge, R-M., Zhou, L., Sarantos, M. R., Rodier, F., Freund, A., de Keizer, P. L. J., ... Campisi, J. (2012). Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell, 11(4), 569-78. https://doi.org/10.1111/j.1474-9726.2012.00818.x
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