prof. dr. M.D. (Martin) Witte

Associate Professor

Research

Research units:

Postal address:
Nijenborgh7
Gebouw 5172, ruimte 0840
9747 AG
Groningen
Netherlands
Phone: +31 50 363 5643Fax: +31 50 363 4296
  1. 2020
  2. 2019
  3. 2018
  4. Kuo, C-L., van Meel, E., Kytidou, K., Kallemeijn, W. W., Witte, M., Overkleeft, H. S., ... Aerts, J. M. (2018). Activity-Based Probes for Glycosidases: Profiling and Other Applications. In B. Imperiali (Ed.), CHEMICAL GLYCOBIOLOGY, PT B: MONITORING GLYCANS AND THEIR INTERACTIONS (pp. 217-235). (Methods in Enzymology; Vol. 598). Academic Press. https://doi.org/10.1016/bs.mie.2017.06.039
  5. 2017
  6. Lohse, J., Schindl, A., Danda, N., Williams, C. P., Kramer, K., Kuster, B., ... Médard, G. (2017). Target and identify: triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy. Chem. Commun., 53(87), 11929-11932. https://doi.org/10.1039/C7CC07001B
  7. Bdira, F. B., Kallemeijn, W. W., Oussoren, S. V., Scheij, S., Bleijlevens, B., Florea, B. I., ... Aerts, J. M. F. G. (2017). Stabilization of Glucocerebrosidase by Active Site Occupancy. ACS chemical biology, 12(7), 1830-1841. https://doi.org/10.1021/acschembio.7b00276
  8. Kallemeijn, W. W., Scheij, S., Hoogendoorn, S., Witte, M. D., Herrera Moro Chao, D., van Roomen, C. P. A. A., ... Aerts, J. M. F. G. (2017). Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes. PLoS ONE, 12(2), [e0170268]. https://doi.org/10.1371/journal.pone.0170268
  9. Dockerty, P., Edens, J. G., Tol, M. B., Morales Angeles, D., Domenech Pena, A., Liu, Y., ... Witte, M. D. (2017). Bicyclic enol cyclocarbamates inhibit penicillin-binding proteins. Organic & Biomolecular Chemistry, 15(4), 894-910. https://doi.org/10.1039/c6ob01664b
  10. Claessen, J. H. L., & Witte, M. D. (2017). A Protocol for Protein Profiling Using Chemoselective Cleavable Linker Probes in Semi-permeabilized Cells. In H. S. Overkleeft, & B. I. Florea (Eds.), Activity-Based Proteomics: Methods and Protocols (Vol. 1491, pp. 173-184). (Methods in Molecular Biology; Vol. 1491). New York: Springer. https://doi.org/10.1007/978-1-4939-6439-0_13
  11. 2016
  12. Kallemeijn, W. W., Scheij, S., Voorn-Brouwer, T. M., Witte, M. D., Verhoek, M., Overkleeft, H. S., ... Aerts, J. M. F. G. (2016). Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement. ChemBioChem, 17(18), 1698-1704. https://doi.org/10.1002/cbic.201600312
  13. 2015
  14. Witte, M. D., Wu, T., Guimaraes, C. P., Theile, C. S., Blom, A. E. M., Ingram, J. R., ... Ploegh, H. L. (2015). Site-specific protein modification using immobilized sortase in batch and continuous-flow systems. Nature protocols, 10(3), 508-516. https://doi.org/10.1038/nprot.2015.026
  15. 2014
  16. Li, K-Y., Jiang, J., Witte, M. D., Kallemeijn, W. W., Donker-Koopman, W. E., Boot, R. G., ... Overkleeft, H. S. (2014). Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors. Organic & Biomolecular Chemistry, 12(39), 7786-7791. https://doi.org/10.1039/c4ob01611d
  17. Li, K-Y., Jiang, J., Witte, M. D., Kallemeijn, W. W., van den Elst, H., Wong, C-S., ... Overkleeft, H. S. (2014). Synthesis of Cyclophellitol, Cyclophellitol Aziridine, and Their Tagged Derivatives. European Journal of Organic Chemistry, 2014(27), 6030-6043. https://doi.org/10.1002/ejoc.201402588
  18. Willems, L. I., Jiang, J., Li, K-Y., Witte, M. D., Kallemeijn, W. W., Beenakker, T. J. N., ... Overkleeft, H. S. (2014). From covalent glycosidase inhibitors to activity-based glycosidase probes. Chemistry, 20(35), 10864-10872. https://doi.org/10.1002/chem.201404014
  19. Witte, M. (2014). Rational Design of Activity-Based Retaining B-Exoglucosidase Probes. In H. Waldmann, & P. Janning (Eds.), Concepts and Case Studies in Chemical Biology (pp. 19-206). Wiley.
  20. Avalos, A. M., Bilate, A. M., Witte, M. D., Tai, A. K., He, J., Frushicheva, M. P., ... Ploegh, H. L. (2014). Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. Journal of Experimental Medicine, 211(2), 365-379. https://doi.org/10.1084/jem.20131603
  21. Kallemeijn, W. W., Witte, M. D., Wennekes, T., & Aerts, J. M. F. G. (2014). Mechanism-based inhibitors of glycosidases: design and applications. In D. Horton (Ed.), Advances in Carbohydrate Chemistry and Biochemistry (Vol. 71, pp. 297-338). (Advances in Carbohydrate Chemistry and Biochemistry; Vol. 71). SAN DIEGO: Academic Press. https://doi.org/10.1016/B978-0-12-800128-8.00004-2
  22. 2013
  23. Guimaraes, C. P., Witte, M. D., Theile, C. S., Bozkurt, G., Kundrat, L., Blom, A. E. M., & Ploegh, H. L. (2013). Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions. Nature protocols, 8(9), 1787-1799. https://doi.org/10.1038/nprot.2013.101
  24. Theile, C. S., Witte, M. D., Blom, A. E. M., Kundrat, L., Ploegh, H. L., & Guimaraes, C. P. (2013). Site-specific N-terminal labeling of proteins using sortase-mediated reactions. Nature protocols, 8(9), 1800-1807. https://doi.org/10.1038/nprot.2013.102
  25. 2012
  26. Nieuwendijk, A. M. C. H. V. D., Berg, R. J. B. H. N. V. D., Ruben, M., Witte, M. D., Brussee, J., Boot, R. G., ... Overkleeft, H. S. (2012). Synthesis of Eight 1-Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin. European Journal of Organic Chemistry, 2012(18), 3437-3446. https://doi.org/10.1002/ejoc.201200377
  27. Walvoort, M. T. C., Kallemeijn, W. W., Willems, L. I., Witte, M. D., Aerts, J. M. F. G., Marel, G. A. V. D., ... Overkleeft, H. S. (2012). Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining β-glucosidase probes. Chemical Communications, 48(84), 10386-10388.
  28. 2011
  29. Aerts, J. M. F. G., Kallemeijn, W. W., Wegdam, W., Ferraz, M. J., Breemen, M. J. V., Dekker, N., ... Boot, R. G. (2011). Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies. Journal of Inherited Metabolic Disease, 34(3), 605-619. https://doi.org/10.1007/s10545-011-9308-6
  30. Witte, M. D., Walvoort, M. T. C., Li, K-Y., Kallemeijn, W. W., Donker-Koopman, W. E., Boot, R. G., ... Overkleeft, H. S. (2011). Activity-Based Profiling of Retaining beta-Glucosidases: A Comparative Study. ChemBioChem, 12(8), 1263-1269. https://doi.org/10.1002/cbic.201000773
  31. Witte, M. D., Walvoort, M. T. C., Li, K-Y., Kallemeijn, W. W., Donker-Koopman, W. E., Boot, R. G., ... Overkleeft, H. S. (2011). Activity-Based Profiling of Retaining β-Glucosidases: A Comparative Study. ChemBioChem, 12(8), 1263-1269.
  32. 2010
  33. Geurink, P. P., Florea, B. I., Li, N., Witte, M. D., Verasdonck, J., Kuo, C-L., ... Overkleeft, H. S. (2010). A Cleavable Linker Based on the Levulinoyl Ester for Activity-Based Protein Profiling. Angewandte Chemie International Edition, 49(38), 6802-6805. https://doi.org/10.1002/anie.201001767
  34. Witte, M. D., Kallemeijn, W. W., Aten, J., Li, K-Y., Strijland, A., Donker-Koopman, W. E., ... Aerts, J. M. F. G. (2010). Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nature Chemical Biology, 6(12), 907-913. https://doi.org/10.1038/nchembio.466
  35. 2009
  36. Witte, M. D., Florea, B. I., Verdoes, M., Adeyanju, O., Marel, G. A. V. D., & Overkleeft, H. S. (2009). O-GlcNAc Peptide Epoxyketones Are Recognized by Mammalian Proteasomes. Journal of the American Chemical Society, 131(34), 12064-12065. https://doi.org/10.1021/ja901231w
  37. 2007
  38. Witte, M. D., Descals, C. V., Lavoir, S. V. P. D., Florea, B. I., Marel, G. A. V. D., & Overkleeft, H. S. (2007). Bodipy-VAD-Fmk, a useful tool to study yeast peptide N-glycanase activity. Organic & Biomolecular Chemistry, 5(22), 3690-3697. https://doi.org/10.1039/b711531h
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