prof. dr. M.D. (Martin) Witte

Associate Professor

Research

Research units:

Postal address:
Nijenborgh
7
Gebouw 5172, ruimte 0840
Groningen
Netherlands
Phone: +31 50 363 5643Fax: +31 50 363 4296
  1. 2019
  2. 2018
  3. Kuo, C-L., van Meel, E., Kytidou, K., Kallemeijn, W. W., Witte, M., Overkleeft, H. S., ... Aerts, J. M. (2018). Activity-Based Probes for Glycosidases: Profiling and Other Applications. In B. Imperiali (Ed.), CHEMICAL GLYCOBIOLOGY, PT B: MONITORING GLYCANS AND THEIR INTERACTIONS (pp. 217-235). (Methods in Enzymology; Vol. 598). Academic Press. https://doi.org/10.1016/bs.mie.2017.06.039
  4. 2017
  5. Bdira, F. B., Kallemeijn, W. W., Oussoren, S. V., Scheij, S., Bleijlevens, B., Florea, B. I., ... Aerts, J. M. F. G. (2017). Stabilization of Glucocerebrosidase by Active Site Occupancy. ACS chemical biology, 12(7), 1830-1841. https://doi.org/10.1021/acschembio.7b00276
  6. Kallemeijn, W. W., Scheij, S., Hoogendoorn, S., Witte, M. D., Herrera Moro Chao, D., van Roomen, C. P. A. A., ... Aerts, J. M. F. G. (2017). Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes. PLoS ONE, 12(2), [e0170268]. https://doi.org/10.1371/journal.pone.0170268
  7. Dockerty, P., Edens, J. G., Tol, M. B., Morales Angeles, D., Domenech Pena, A., Liu, Y., ... Witte, M. D. (2017). Bicyclic enol cyclocarbamates inhibit penicillin-binding proteins. Organic & Biomolecular Chemistry, 15(4), 894-910. https://doi.org/10.1039/c6ob01664b
  8. Claessen, J. H. L., & Witte, M. D. (2017). A Protocol for Protein Profiling Using Chemoselective Cleavable Linker Probes in Semi-permeabilized Cells. In H. S. Overkleeft, & B. I. Florea (Eds.), Activity-Based Proteomics: Methods and Protocols (Vol. 1491, pp. 173-184). (Methods in Molecular Biology; Vol. 1491). New York: Springer. https://doi.org/10.1007/978-1-4939-6439-0_13
  9. 2016
  10. Kallemeijn, W. W., Scheij, S., Voorn-Brouwer, T. M., Witte, M. D., Verhoek, M., Overkleeft, H. S., ... Aerts, J. M. F. G. (2016). Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement. ChemBioChem, 17(18), 1698-1704. https://doi.org/10.1002/cbic.201600312
  11. 2015
  12. Witte, M. D., Wu, T., Guimaraes, C. P., Theile, C. S., Blom, A. E. M., Ingram, J. R., ... Ploegh, H. L. (2015). Site-specific protein modification using immobilized sortase in batch and continuous-flow systems. Nature protocols, 10(3), 508-516. https://doi.org/10.1038/nprot.2015.026
  13. 2014
  14. Li, K-Y., Jiang, J., Witte, M. D., Kallemeijn, W. W., Donker-Koopman, W. E., Boot, R. G., ... Overkleeft, H. S. (2014). Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors. Organic & Biomolecular Chemistry, 12(39), 7786-7791. https://doi.org/10.1039/c4ob01611d
  15. Li, K-Y., Jiang, J., Witte, M. D., Kallemeijn, W. W., van den Elst, H., Wong, C-S., ... Overkleeft, H. S. (2014). Synthesis of Cyclophellitol, Cyclophellitol Aziridine, and Their Tagged Derivatives. European Journal of Organic Chemistry, 2014(27), 6030-6043. https://doi.org/10.1002/ejoc.201402588
  16. Willems, L. I., Jiang, J., Li, K-Y., Witte, M. D., Kallemeijn, W. W., Beenakker, T. J. N., ... Overkleeft, H. S. (2014). From covalent glycosidase inhibitors to activity-based glycosidase probes. Chemistry, 20(35), 10864-10872. https://doi.org/10.1002/chem.201404014
  17. Witte, M. (2014). Rational Design of Activity-Based Retaining B-Exoglucosidase Probes. In H. Waldmann, & P. Janning (Eds.), Concepts and Case Studies in Chemical Biology (pp. 19-206). Wiley.
  18. Avalos, A. M., Bilate, A. M., Witte, M. D., Tai, A. K., He, J., Frushicheva, M. P., ... Ploegh, H. L. (2014). Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. Journal of Experimental Medicine, 211(2), 365-379. https://doi.org/10.1084/jem.20131603
  19. Kallemeijn, W. W., Witte, M. D., Wennekes, T., & Aerts, J. M. F. G. (2014). Mechanism-based inhibitors of glycosidases: design and applications. In D. Horton (Ed.), Advances in Carbohydrate Chemistry and Biochemistry (Vol. 71, pp. 297-338). (Advances in Carbohydrate Chemistry and Biochemistry; Vol. 71). SAN DIEGO: Academic Press. https://doi.org/10.1016/B978-0-12-800128-8.00004-2
  20. 2013
  21. Guimaraes, C. P., Witte, M. D., Theile, C. S., Bozkurt, G., Kundrat, L., Blom, A. E. M., & Ploegh, H. L. (2013). Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions. Nature protocols, 8(9), 1787-1799. https://doi.org/10.1038/nprot.2013.101
  22. Theile, C. S., Witte, M. D., Blom, A. E. M., Kundrat, L., Ploegh, H. L., & Guimaraes, C. P. (2013). Site-specific N-terminal labeling of proteins using sortase-mediated reactions. Nature protocols, 8(9), 1800-1807. https://doi.org/10.1038/nprot.2013.102
  23. 2012
  24. Nieuwendijk, A. M. C. H. V. D., Berg, R. J. B. H. N. V. D., Ruben, M., Witte, M. D., Brussee, J., Boot, R. G., ... Overkleeft, H. S. (2012). Synthesis of Eight 1-Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin. European Journal of Organic Chemistry, 2012(18), 3437-3446. https://doi.org/10.1002/ejoc.201200377
  25. Walvoort, M. T. C., Kallemeijn, W. W., Willems, L. I., Witte, M. D., Aerts, J. M. F. G., Marel, G. A. V. D., ... Overkleeft, H. S. (2012). Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining β-glucosidase probes. Chemical Communications, 48(84), 10386-10388.
  26. 2011
  27. Aerts, J. M. F. G., Kallemeijn, W. W., Wegdam, W., Ferraz, M. J., Breemen, M. J. V., Dekker, N., ... Boot, R. G. (2011). Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies. Journal of Inherited Metabolic Disease, 34(3), 605-619. https://doi.org/10.1007/s10545-011-9308-6
  28. Witte, M. D., Walvoort, M. T. C., Li, K-Y., Kallemeijn, W. W., Donker-Koopman, W. E., Boot, R. G., ... Overkleeft, H. S. (2011). Activity-Based Profiling of Retaining beta-Glucosidases: A Comparative Study. ChemBioChem, 12(8), 1263-1269. https://doi.org/10.1002/cbic.201000773
  29. Witte, M. D., Walvoort, M. T. C., Li, K-Y., Kallemeijn, W. W., Donker-Koopman, W. E., Boot, R. G., ... Overkleeft, H. S. (2011). Activity-Based Profiling of Retaining β-Glucosidases: A Comparative Study. ChemBioChem, 12(8), 1263-1269.
  30. 2010
  31. Geurink, P. P., Florea, B. I., Li, N., Witte, M. D., Verasdonck, J., Kuo, C-L., ... Overkleeft, H. S. (2010). A Cleavable Linker Based on the Levulinoyl Ester for Activity-Based Protein Profiling. Angewandte Chemie International Edition, 49(38), 6802-6805. https://doi.org/10.1002/anie.201001767
  32. Witte, M. D., Kallemeijn, W. W., Aten, J., Li, K-Y., Strijland, A., Donker-Koopman, W. E., ... Aerts, J. M. F. G. (2010). Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nature Chemical Biology, 6(12), 907-913. https://doi.org/10.1038/nchembio.466
  33. 2009
  34. Witte, M. D., Florea, B. I., Verdoes, M., Adeyanju, O., Marel, G. A. V. D., & Overkleeft, H. S. (2009). O-GlcNAc Peptide Epoxyketones Are Recognized by Mammalian Proteasomes. Journal of the American Chemical Society, 131(34), 12064-12065. https://doi.org/10.1021/ja901231w
  35. 2007
  36. Witte, M. D., Descals, C. V., Lavoir, S. V. P. D., Florea, B. I., Marel, G. A. V. D., & Overkleeft, H. S. (2007). Bodipy-VAD-Fmk, a useful tool to study yeast peptide N-glycanase activity. Organic & Biomolecular Chemistry, 5(22), 3690-3697. https://doi.org/10.1039/b711531h
  37. 2006
  38. Verdoes, M., Florea, B. I., Menendez-Benito, V., Maynard, C. J., Witte, M. D., Linden, W. A. V. D., ... Overkleeft, H. S. (2006). A Fluorescent Broad-Spectrum Proteasome Inhibitor. Chemistry & Biology, 13(11), 1217-1226. https://doi.org/10.1016/j.chembiol.2006.09.013
  39. Berger, A. B., Witte, M. D., Denault, J-B., Sadaghiani, A. M., Sexton, K. M. B., Salvesen, G. S., & Bogyo, M. (2006). Identification of Early Intermediates of Caspase Activation Using Selective Inhibitors and Activity-Based Probes. Molecular Cell, 23(4), 509-521. https://doi.org/10.1016/j.molcel.2006.06.021
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