Burgess, J. K., Jonker, M. R., Berg, M., Ten Hacken, N. T. H., Meyer, K. B., van den Berge, M., Nawijn, M. C., & Heijink, I. H. (2021). Periostin: contributor to abnormal airway epithelial function in asthma? European Respiratory Journal, 57(1). https://doi.org/10.1183/13993003.01286-2020

BIOS Consortium, Xu, C-J., Qi, C., van Rijkom, B., van der Vlies, P., Nawijn, M. C., & Wijmenga, C. (2020). Shared DNA methylation signatures in childhood allergy: the MeDALL study. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2020.11.044

Ketelaar, M. E., van Ginkel, C. W., Nawijn, M. C., Dubois, A., & Koppelman, G. H. (2020). IL-1RL1a serum levels and IL1RL1 SNPs in the prediction of food allergy. Clinical and Experimental Allergy. https://doi.org/10.1111/cea.13802

Hesse, L., van Ieperen, N., Petersen, A. H., Oude Elberink, H. N. G., van Oosterhout, A. J. M., & Nawijn, M. C. (2020). High dose vitamin D3 empowers effects of subcutaneous immunotherapy in a grass pollen-driven mouse model of asthma. Scientific Reports, 10(1), [20876]. https://doi.org/10.1038/s41598-020-77947-6

Jiang, J., Faiz, A., Berg, M., Carpaij, O. A., Vermeulen, C. J., Brouwer, S., Hesse, L., Teichmann, S. A., Ten Hacken, N., Timens, W., van den Berge, M., & Nawijn, M. C. (2020). Gene signatures from scRNA-seq accurately quantify mast cells in biopsies in asthma. Clinical and Experimental Allergy, (12), 1428-1431. https://doi.org/10.1111/cea.13732

Aliee, H., Massip, F., Qi, C., Stella de Biase, M., van Nijnatten, J. L., Kersten, E. T. G., Kermani, N. Z., Khuder, B., Vonk, J. M., Vermeulen, R. C. H., Neighbors, M., Tew, G. W., Grimbaldeston, M., Ten Hacken, N. H. T., Hu, S., Guo, Y., Zhang, X., Sun, K., Hiemstra, P. S., ... Faiz, A. (2020). Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways. medRxiv : the preprint server for health sciences. https://doi.org/10.1101/2020.08.31.20169946

Carpaij, O. A., Goorsenberg, A. W. M., d'Hooghe, J. N. S., de Bruin, D. M., van den Elzen, R. M., Nawijn, M. C., Annema, J. T., van den Berge, M., Bonta, P. I., & Burgess, J. K. (2020). Optical Coherence Tomography Intensity Correlates with Extracellular Matrix Components in the Airway Wall. American Journal of Respiratory and Critical Care Medicine, 202(5), 762-766. https://doi.org/10.1164/rccm.201908-1512LE

INDURAIN-investigators, Boudewijn, I. M., Roffel, M. P., Vermeulen, C. J., Nawijn, M. C., Kok, K., Terpstra, M. M., Koppelman, G. H., Guryev, V., & van den Berge, M. (2020). A Novel Role for Bronchial MicroRNAs and Long Noncoding RNAs in Asthma Remission. American Journal of Respiratory and Critical Care Medicine, 202(4), 614-618. https://doi.org/10.1164/rccm.201908-1610LE

Hesse, L., Feenstra, R., Kalay, H., Ambrosini, M., Petersen, A. H., Vietor, H., Van Kooyk, Y., & Nawijn, M. C. (2020). Glycan modification of rPhl p5a leads to superior suppression of allergic inflammation in SCIT mouse model of allergic asthma. Allergy, 75, 98-98.

Nawijn, M. C., & Timens, W. (2020). Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19? Molecular Systems Biology, 16(7), [e9841]. https://doi.org/10.15252/msb.20209841

Heijink, I. H., Kuchibhotla, V., Roffel, M. P., Maes, T., Knight, D. A., Sayers, I., & Nawijn, M. C. (2020). Epithelial cell dysfunction, a major driver of asthma development. Allergy, 75(8), 1898-1913. https://doi.org/10.1111/all.14421

Hesse, L., Petersen, A. H., Oude Elberink, H. N. G., van Oosterhout, A. J. M., & Nawijn, M. C. (2020). 1,25(OH)2VitD3 supplementation enhances suppression of grass pollen-induced allergic asthma by subcutaneous and sublingual immunotherapy in a mouse model. Scientific Reports, 10(1), [8960]. https://doi.org/10.1038/s41598-020-65946-6

Qi, C., Jiang, Y., Yang, I. V., Forno, E., Wang, T., Vonk, J. M., Gehring, U., Smit, H. A., Milanzi, E. B., Carpaij, O. A., Berg, M., Hesse, L., Brouwer, S., Cardwell, J., Vermeulen, C. J., Acosta-Pérez, E., Canino, G., Boutaoui, N., van den Berge, M., ... Koppelman, G. H. (2020). Nasal DNA methylation profiling of asthma and rhinitis. Journal of Allergy and Clinical Immunology, 145(6), 1655-1663. https://doi.org/10.1016/j.jaci.2019.12.911

HCA Lung Biological Network. Electronic address: lung-network@humancellatlas.org, Ziegler, C. G. K., Allon, S. J., Nyquist, S. K., Mbano, I. M., Miao, V. N., Tzouanas, C. N., Cao, Y., Yousif, A. S., Bals, J., Hauser, B. M., Feldman, J., Muus, C., Wadsworth, M. H., Kazer, S. W., Hughes, T. K., Doran, B., Gatter, G. J., Vukovic, M., ... Theis, F. J. (2020). SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell, 181(5), 1016-1035.e19. https://doi.org/10.1016/j.cell.2020.04.035

Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., Grotenboer, N. S., Obeidat, M., Henry, A. P., Billington, C. K., Shaw, D., Johnson, S. R., Pogson, Z. E., Fogarty, A., McKeever, T. M., Nickle, D. C., Bossé, Y., van den Berge, M., Faiz, A., ... Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI Insight, 5(8), [132446]. https://doi.org/10.1172/jci.insight.132446

Koopmans, T., Hesse, L., Nawijn, M. C., Kumawat, K., Menzen, M. H., Sophie T Bos, I., Smits, R., Bakker, E. R. M., van den Berge, M., Koppelman, G. H., Guryev, V., & Gosens, R. (2020). Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation. Scientific Reports, 10(1), [6754]. https://doi.org/10.1038/s41598-020-63741-x

Van Der Wijst, M. G. P., De Vries, D. H., Groot, H. E., Trynka, G., Hon, C. C., Bonder, M. J., Stegle, O., Nawijn, M. C., Idaghdour, Y., Van Der Harst, P., Ye, C. J., Powell, J., Theis, F. J., Mahfouz, A., Heing, M., & Franke, L. (2020). The single-cell eQTLGen consortium. eLife, 9, [52155]. https://doi.org/10.7554/eLife.52155

Kuchibhotla, V. N. S., Jonker, M. R., de Bruin, H. G., Noordhoek, J. A., Knight, D. A., Nawijn, M. C., & Heijink, I. H. (2020). Inhibition of beta-catenin/CBP signalling improves airway epithelial barrier function and suppresses CCL20 release. Allergy, 75(7), 1786-1789. https://doi.org/10.1111/all.14216

Vermeulen, C. J., Xu, C-J., Vonk, J. M., ten Hacken, N. H. T., Timens, W., Heijink, I. H., Nawijn, M. C., Boekhoudt, J., van Oosterhout, A. J., Affleck, K., Weckmann, M., Koppelman, G. H., & van den Berge, M. (2020). Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission. European Respiratory Journal, 55(2), [1901280]. https://doi.org/10.1183/13993003.01280-2019

Boudewijn, I. M., Lan, A., Faiz, A., Cox, C. A., Brouwer, S., Schokker, S., Vroegop, S. J., Nawijn, M. C., Woodruff, P. G., Christenson, S. A., Hagedoorn, P., Frijlink, H. W., Choy, D. F., Brouwer, U., Wisman, M., Postma, D. S., Fingleton, J., Beasley, R., van den Berge, M., & Guryev, V. (2020). Nasal gene expression changes with inhaled corticosteroid treatment in asthma. Allergy, 75(1), 191-194. https://doi.org/10.1111/all.13952

Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., Xu, C. J., Hankinson, J., Bhaker, S., Henry, A. P., Billington, C. K., Shaw, D. E., Johnson, S. R., Benest, A. V., Pang, V., Bates, D., Pogson, Z. E. K., Fogarty, A., McKeever, T. M., ... Nawijn, M. C. (2020). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology, (1), 144-157. https://doi.org/10.1016/j.jaci.2020.04.051

Dijk, F. N., Vijverberg, S. J., Hernandez-Pacheco, N., Repnik, K., Karimi, L., Mitratza, M., Farzan, N., Nawijn, M. C., Burchard, E. G., Engelkes, M., Verhamme, K. M., Potočnik, U., Pino-Yanes, M., Postma, D. S., Maitland-van der Zee, A., & Koppelman, G. H. (2019). IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids. Allergy, 75(4), 984-989. https://doi.org/10.1111/all.14125

Carpaij, O. A., Muiser, S., Bell, A. J., Kerstjens, H. A. M., Galban, C. J., Fortuna, A. B., Siddiqui, S., Olin, A-C., Nawijn, M. C., & van den Berge, M. (2019). Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air. ERJ Open Research, 5(4), [202]. https://doi.org/10.1183/23120541.00202-2019

Carpaij, O., Vonk, J., Nawijn, M., Kerstjens, H., Koppelman, G., & Van Den Berge, M. (2019). Externally validating the asthma remission prediction model to the Dutch asthma remission studies. European Respiratory Journal, 54. https://doi.org/10.1183/13993003.congress-2019.PA4512

Schenk, H. M., van Ockenburg, S. L., Nawijn, M. C., De Jonge, P., & Rosmalen, J. G. M. (2019). Identification of inflammatory markers suitable for non-invasive, repeated measurement studies in biobehavioral research: A feasibility study. PLoS ONE, 14(9), [e0221993]. https://doi.org/10.1371/journal.pone.0221993

Carpaij, O. A., Burgess, J. K., Kerstjens, H. A. M., Nawijn, M. C., & van den Berge, M. (2019). A review on the pathophysiology of asthma remission. Pharmacology & Therapeutics, 201, 8-24. https://doi.org/10.1016/j.pharmthera.2019.05.002

Hesse, L., Feenstra, R., Ambrosini, M., de Jager, W. A., Petersen, A., Vietor, H., Unger, W. W. J., van Kooyk, Y., & Nawijn, M. C. (2019). Subcutaneous immunotherapy using modified Phl p5a-derived peptides efficiently alleviates allergic asthma in mice. Allergy. https://doi.org/10.1111/all.13918

Braga, F. A. V., Kar, G., Berg, M., Carpaij, O. A., Polanski, K., Simon, L. M., Brouwer, S., Gomes, T., Hesse, L., Jiang, J., Fasouli, E. S., Efremova, M., Vento-Tormo, R., Talavera-Lopez, C., Jonker, M. R., Affleck, K., Palit, S., Strzelecka, P. M., Firth, H. V., ... Teichmann, S. A. (2019). A cellular census of human lungs identifies novel cell states in health and in asthma. Nature Medicine, 25(7), 1153-1163. https://doi.org/10.1038/s41591-019-0468-5

Schiller, H. B., Montoro, D. T., Simon, L. M., Rawlins, E. L., Meyer, K. B., Strunz, M., Vieira Braga, F., Timens, W., Koppelman, G. H., Budinger, G. R. S., Burgess, J. K., van den Berge, M., Theis, F. J., Regev, A., Kaminski, N., Rajagopal, J., Teichmann, S. A., Misharin, A. V., & Nawijn, M. C. (2019). The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease. American Journal of Respiratory Cell and Molecular Biology, 61(1), 31-41. https://doi.org/10.1165/rcmb.2018-0416TR

Carpaij, O. A., Vonk, J. M., Nawijn, M. C., Kerstjens, H. A. M., Koppelman, G. H., & van den Berge, M. (2019). Applying the CAMP trial asthma remission prediction model to the Dutch asthma remission studies. Journal of Allergy and Clinical Immunology, 143(5), 1973-1975. https://doi.org/10.1016/j.jaci.2019.01.040

Taylor, D. M., Aronow, B. J., Tan, K., Bernt, K., Salomonis, N., Greene, C. S., Frolova, A., Henrickson, S. E., Wells, A., Pei, L., Jaiswal, J. K., Whitsett, J., Hamilton, K. E., MacParland, S. A., Kelsen, J., Heuckeroth, R. O., Potter, S. S., Vella, L. A., Terry, N. A., ... White, P. S. (2019). The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell, 49(1), 10-29. https://doi.org/10.1016/j.devcel.2019.03.001

Braga, F. V., Kar, G., Berg, M., Carpaij, O., polanski, K., Simon, L., Brouwer, S., Gomes, T., Hesse, L., Jiang, J., Fasouli, E. S., Efremova, M., Vento-Tormo, R., Affleck, K., Palit, S., strzelecka, P., Firth, H. V., Mahbubani, K. T. A., Cvejic, A., ... Teichmann, S. A. (2019). A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease. Manuscript submitted for publication. https://doi.org/10.1101/527408

Ketelaar, M., Portelli, M. A., Dijk, F. N., Faiz, A., Shrine, N., Hankinson, J., Bhaker, S., Henry, A. P., Billington, C. K., Shaw, D., Johnson, S. R., Benest, A. V., Pogson, Z. E. K., Fogarty, A., McKeever, T. M., Singapuri, A., Heaney, L., Mansur, A., Gaudhuri, R., ... Nawijn, M. C. (2019). Functional Translation of IL33 Locus Polymorphisms Into Altered Epithelial Cell Function Underlying Asthma. American Journal of Respiratory and Critical Care Medicine, 199.

Pouwels, S. D., Hesse, L., van Oldeniel, D., Gosens, R., Nawijn, M. C., & Heijink, I. H. (2019). Rage Induces Acute Neutrophilic Airway Inflammation in Mice Susceptible to Develop Emphysema and Is Directly Involved in Elastase-Induced Lung Tissue Damage. American Journal of Respiratory and Critical Care Medicine, 199.

Carpaij, O., Brouwer, S., Kerstjens, H. A. M., Olin, A., Nawijn, M. C., & van den Berge, M. (2019). Small Airways Disease Parameters Defined by PExA Particle Mass in Asthma, Asthma Remission and Healthy Controls. American Journal of Respiratory and Critical Care Medicine, 199.

Pouwels, S. D., Faiz, A., Heijink, I. H., Vermeulen, C. J., Guryev, V., Van den Berge, M., & Nawijn, M. C. (2018). Cigarette smoke exposure decreases CFLAR expression in bronchial epithelium, augmenting susceptibility for cell death and DAMP release. European Respiratory Journal, 52. https://doi.org/10.1183/13993003.congress-2018.PA586

Nawijn, M., Carpaij, O., Braga, F. V., Berg, M., Brouwer, S., Kar, G., Teichmann, S., & Van den Berge, M. (2018). Novel cell types and altered cell states in asthma revealed by single-cell RNA sequencing of airway wall biopsies. European Respiratory Journal, 52. https://doi.org/10.1183/13993003.congress-2018.OA505

Carpaij, O., Muntinghe, F. O. W., Wagenaar, M. B., Habing, J. W., Timens, W., Kerstjens, H. A. M., Nawijn, M. C., Kunz, L. I. Z., Hiemstra, P. S., Holweg, C. T. J., Tew, W., & Van den Berge, M. (2018). Serum periostin is not a good biomarker to identify Th2-driven inflammation in COPD. European Respiratory Journal, 52. https://doi.org/10.1183/13993003.congress-2018.PA962

Koopmans, T., Hesse, L., Nawijn, M., Menzen, M., Smits, R., Bakker, E., Vonk, J., Van den Berge, M., Koppelman, G., Guryev, V., & Gosens, R. (2018). Smooth-muscle-derived WNT-5A drives allergen-induced remodelling and Th2 type inflammation. European Respiratory Journal, 52. https://doi.org/10.1183/13993003.congress-2018.PA5256

Post, S., Heijink, I. H., Hesse, L., Koo, H. K., Shaheen, F., Fouadi, M., Kuchibhotla, V. N. S., Lambrecht, B. N., Van Oosterhout, A. J. M., Hackett, T. L., & Nawijn, M. C. (2018). Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology. Scientific Reports, 8(1), [13275]. https://doi.org/10.1038/s41598-018-31500-8

Faiz, A., Heijink, I. H., Vermeulen, C. J., Guryev, V., van den Berge, M., Nawijn, M. C., & Pouwels, S. D. (2018). Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release. Scientific Reports, 8(1), [12426]. https://doi.org/10.1038/s41598-018-30602-7

Hesse, L., Brouwer, U., Petersen, A. H., Gras, R., Bosman, L., Brimnes, J., Oude Elberink, H. N. G., van Oosterhout, A. J. M., & Nawijn, M. C. (2018). Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma. Clinical and Experimental Allergy, 48(8), 1035-1049. https://doi.org/10.1111/cea.13169

Carpaij, O. A., Muntinghe, F. O. W., Wagenaar, M. B., Habing, J. W., Timens, W., Kerstjens, H. A. M., Nawijn, M. C., Kunz, L. I. Z., Hiemstra, P. S., Tew, G. W., Holweg, C. T. J., Brandsma, C. A., & van den Berge, M. (2018). Serum periostin does not reflect type 2-driven inflammation in COPD. Respiratory Research, 19(1), [112]. https://doi.org/10.1186/s12931-018-0818-8

Xu, C-J., Söderhäll, C., Bustamante, M., Baïz, N., Gruzieva, O., Gehring, U., Mason, D., Chatzi, L., Basterrechea, M., Llop, S., Torrent, M., Forastiere, F., Fantini, M. P., Carlsen, K. C. L., Haahtela, T., Morin, A., Kerkhof, M., Merid, S. K., van Rijkom, B., ... BIOS Consortium (2018). DNA methylation in childhood asthma: an epigenome-wide meta-analysis. The Lancet. Respiratory Medicine, 6(5), 379-388. https://doi.org/10.1016/S2213-2600(18)30052-3

Hesse, L., van Ieperen, N., Habraken, C., Petersen, A. H., Korn, S., Smilda, T., Goedewaagen, B., Ruiters, M. H., van der Graaf, A. C., & Nawijn, M. C. (2018). Subcutaneous immunotherapy with purified Der p1 and 2 suppresses type 2 immunity in a murine asthma model. Allergy, 73(4), 862-874. https://doi.org/10.1111/all.13382

Dijk, F. N., Xu, C., Melén, E., Carsin, A-E., Kumar, A., Nolte, I. M., Gruzieva, O., Pershagen, G., Grotenboer, N. S., Savenije, O. E. M., Antó, J. M., Lavi, I., Dobaño, C., Bousquet, J., van der Vlies, P., van der Valk, R. J. P., de Jongste, J. C., Nawijn, M. C., Guerra, S., ... Koppelman, G. H. (2018). Genetic regulation ofmethylation and IL1RL1-a protein levels in asthma. European Respiratory Journal, 51(3). https://doi.org/10.1183/13993003.01377-2017

Nawijn, M. C., Brouwer, U., den Boef, L., Hesse, L., & Koppelman, G. H. (2018). Pcdh1 Loss Leads to a SMAD3-Dependent Increase in HDM-Induced Airway Hyperresponsiveness in Mice. American Journal of Respiratory and Critical Care Medicine, 197.

Human Lung Cell Atlas Working Grp (2018). The Human Lung Cell Atlas: A Comprehensive Reference Map for All Cell Types in the Healthy Human Lung. American Journal of Respiratory and Critical Care Medicine, 197.