M. Baranov, MSc
In 2014 Maksim Baranov graduated from Master's program in Molecular Mechanisms of Disease (MMD) at the Radboud University of Nijmegen, the Netherlands. During his Master's student internship at the department of Tumor Immunology, in 2013, Maksim identified a new mechanism in dendritic cells, andhow they utilize their actin cytoskeleton to probe for antigens across epithelial barriers. This led to two first-author publicatons (Baranov, et al. (2014) J. Cell Sci. 127, 1052; Baranov, et al. (2014) Commun. Integr. Biol. 7: e29084).
In 2014-2018 Maksim worked on his PhD training in the group of Geert van den Bogaart researching how dendritc cells and other phagocytes of the immune system process ingested microbial pathogens in phagosomes. The key research objective was to understand how a specific class of lipids – phosphoinositides – drive formation and maturation of phagosomes over time. Maksim discovered the key adapter protein – SWAP70 – responsible for the specific tethering, stabilization and organization of the F-actin cytoskeleton on newly formed phagosomes containing microbial pathogens. These new data revealed that SWAP70 can anchor F-actin to phagosomes which is used for creation of pulling forces required for pathogen engulfment. These findings were published in (Baranov, et al. (2016) Cell Reports 17, 1518; Baranov, et al. (2017) Small GTPases 10, 1). In 2018 Maksim concluded his PhD research by publishing a study revealing an important role of PIKfyve kinase in producing PI(3,5)P2 driving phagosomal maturation leading to presentation in MHC-class II (Baranov, et al. (2019) iScience 11, 160).
Currently, in the course of his PostDoctoral research Maksim is trying understand how a geometrical shape of a particle may affect phagosomal maturation.
|Last modified:||11 November 2019 3.15 p.m.|