prof. dr. K. (Klaas) Poelstra
Professor

Telephone:
E-mail:
k.poelstra rug.nl
Research
Research units:
Postal address:
A Deusinglaan1
Gebouw 5161, ruimte 0509
9713 AV
Groningen
Netherlands
Phone: +31 50 363 7721Fax: +31 50 363 3247
1 - 50 out of 148Page size: 50
- 2020
- Schippers, M., Post, E., Eichhorn, I., Langeland, J., Beljaars, L., Malo, M. S., Hodin, R. A., Popov, Y., Schuppan, D., & Poelstra, K. (2020). Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis. Cells, 9(12), [2708]. https://doi.org/10.3390/cells9122708
- Adhyatmika, A., Beljaars, L., Putri, K. S. S., Habibie, H., Boorsma, C. E., Reker-Smit, C., Luangmonkong, T., Guney, B., Haak, A., Mangnus, K. A., Post, E., Poelstra, K., Ravnskjaer, K., Olinga, P., & Melgert, B. N. (2020). Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver. Pharmaceutics, 12(5), [471]. https://doi.org/10.3390/pharmaceutics12050471
- 2019
- van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y. O., Zuidema, J., Steendam, R., Klose, M. H. M., Meier-Menches, S. M., Casini, A., Horvatovich, P. L., Sijbrandi, N. J., Frijlink, H. W., Hinrichs, W. L. J., Poelstra, K., Beljaars, L., & Olinga, P. (2019). The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor. Journal of Controlled Release, 296, 250-257. https://doi.org/10.1016/j.jconrel.2018.12.039
- Klein, S., Frohn, F., Magdaleno, F., Reker-Smit, C., Schierwagen, R., Schierwagen, I., Uschner, F. E., van Dijk, F., Fürst, D. O., Djudjaj, S., Boor, P., Poelstra, K., Beljaars, L., & Trebicka, J. (2019). Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats. Scientific Reports, 9(1), 2256. https://doi.org/10.1038/s41598-019-38678-5
- 2018
- Deshmukh, M., Nakagawa, S., Higashi, T., Vincek, A., Venkatesh, A., Ruiz de Galarreta, M., Koh, A. P., Goossens, N., Hirschfield, H., Bian, C. B., Fujiwara, N., Ono, A., Hoshida, H., El-Abtah, M., Ahmad, N. B., Lujambio, A., Sanchez, R., Fuchs, B. C., Poelstra, K., ... Hoshida, Y. (2018). Cell type-specific pharmacological kinase inhibition for cancer chemoprevention. Nanomedicine-Nanotechnology biology and medicine, 14(2), 317-325. https://doi.org/10.1016/j.nano.2017.11.004
- van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., Kim, Y. O., Frijlink, H. W., Schuppand, D., Poelstra, K., Hinrichs, W. L. J., & Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. https://doi.org/10.1016/j.jconrel.2017.11.029
- 2017
- Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., Post, E., Hillebrands, J. L., Frijlink, H. W., Poelstra, K., Beljaars, L., Olinga, P., & Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. https://doi.org/10.1016/j.ijpharm.2017.09.072
- Schippers, M., Beljaars, L., Post, E., Lotersztajn, S., Reker-Smit, C., Han, B., Llancao, P. A., Schmidt, M., & Poelstra, K. (2017). Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E-2 in Liver Fibrosis Is Associated with Reduced Fibrogenesiss. Journal of Pharmacology and Experimental Therapeutics, 363(2), 126-135. https://doi.org/10.1124/jpet.117.241646
- Magdaleno, F., Klein, S., Frohn, F., Reker-Smit, C., Uschner, F. E., Schierwagen, R., Poelstra, K., Beljaars, L., & Trebicka, J. (2017). Rho-kinase inhibitor coupled with peptide-modified albumin carrier reduces fibrogenesis and portal pressure in cirrhotic rats without systemic effects. Hepatology, 66(1 (Suppl.)), 142A-142A.
- van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Kim, Y. O., Frijlink, E., Hinrichs, W., Schuppan, D., Poelstra, K., & Olinga, P. (2017). Therapeutic proteins in the treatment of liver fibrosis: The antifibrotic potential of a sustained release formulation for a PDGF beta-receptor targeted rho-kinase inhibitor. Hepatology, 66, 217A.
- Beljaars, L., Daliri, S., Dijkhuizen, C., Poelstra, K., & Gosens, R. (2017). WNT-5A regulates TGFβ-related activities in liver fibrosis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 312(3), G219-G227. https://doi.org/10.1152/ajpgi.00160.2016
- Van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Schuppan, D., Kim, Y. O., Poelstra, K., Frijlink, E., Hinrichs, W., & Olinga, P. (2017). Towards clinical use of targeted therapies for liver fibrosis: development of a sustained release formulation for therapeutic proteins. Journal of Hepatology, 66(1), S44-S44.
- 2016
- Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Beljaars, L., van den Born, J., de Borst, M. H., van Goor, H., Hillebrands, J-L., & Poelstra, K. (2016). Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice. Oncotarget, 7(34), 54240-54252. https://doi.org/10.18632/oncotarget.11095
- Draijer, C., Boorsma, C. E., Reker-Smit, C., Post, E., Poelstra, K., & Melgert, B. N. (2016). PGE(2)-treated macrophages inhibit development of allergic lung inflammation in mice. Journal of Leukocyte Biology, 100(1), 95-102. https://doi.org/10.1189/jlb.3MAB1115-505R
- Draijer, C., Boorsma, C. E., Reker-Smit, C., Post, E., Poelstra, K., & Melgert, B. N. (2016). PGE2-treated macrophages inhibit development of allergic lung inflammation in mice. Journal of Leukocyte Biology, 100(1), 95-102. https://doi.org/10.1189/jlb.3MAB1115-505R
- 2015
- Poosti, F., Pham, B., Oosterhuis, D., Poelstra, K., van Goor, H., Olinga, P., & Hillebrands, J-L. (2015). Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo. Disease models & mechanisms, 8(10), 1227-1236. https://doi.org/10.1242/dmm.020172
- Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Post, E., Klok, P., van den Born, J., de Borst, M. H., van Goor, H., Poelstra, K., & Hillebrands, J-L. (2015). Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis. The FASEB Journal, 29(3), 1029-1042. https://doi.org/10.1096/fj.14-258459
- 2014
- Beljaars, L., Schippers, M., Reker-Smit, C., Martinez, F. O., Helming, L., Poelstra, K., & Melgert, B. N. (2014). Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans. Frontiers in Immunology, 5, [430]. https://doi.org/10.3389/fimmu.2014.00430
- Mahajan, V., Hartimath, S., Comley, R., Poelstra, K., Reker-Smit, C., Kamps, J., Sijbesma, J., Stephan-Gueldner, M., Dierckx, R., & de Vries, E. (2014). Non-invasive imaging of Kupffer cell status using radiolabelled mannosylated albumin. Journal of Nuclear Medicine, 55(Supplement 1).
- Arabpour, M., Poelstra, K., Helfrich, W., Bremer, E., & Haisma, H. J. (2014). Targeted Elimination of Activated Hepatic Stellate Cells by Anti-EGF-Receptor scFv-sTRAIL Fusion Protein. Molecular Therapy, 22(suppl. 1), S121-S121.
- Bansal, R., Prakash, J., De Ruiter, M., & Poelstra, K. (2014). Interferon gamma peptidomimetic targeted to hepatic stellate cells ameliorates acute and chronic liver fibrosis in vivo. Journal of Controlled Release, 179, 18-24. https://doi.org/10.1016/j.jconrel.2014.01.022
- Mahajan, V., Hartimath, S., Comley, R., Stefan-Gueldner, M., Roth, A., Poelstra, K., Reker-Smit, C., Kamps, J., Dierckx, R., & de Vries, E. (2014). Non-invasive imaging of kupffer cell status using radiolabelled mannosylated albumin. Journal of Hepatology, 60(1, Suppl.), S180-S181. https://doi.org/10.1016/S0168-8278(14)60503-1
- Poelstra, K. (2014). New Highlights for Relaxin. Hepatology, 59(4), 1223-1224. https://doi.org/10.1002/hep.26713
- Bansal, R., Prakash, J., De Ruiter, M., & Poelstra, K. (2014). Targeted Recombinant Fusion Proteins of IFN gamma and Mimetic IFN gamma with PDGF beta R Bicyclic Peptide Inhibits Liver Fibrogenesis In Vivo. PLoS ONE, 9(2), [e89878]. https://doi.org/10.1371/journal.pone.0089878
- Beljaars, L., Boorsma, C. E., Guney, B., Poelstra, K., & Melgert, B. N. (2014). A new communication system regulating extracellular matrix in liver fibrosis: RANK/RANKL/OPG. Hepatology, 60(Supplement 1), 584A-584A. https://doi.org/10.1002/hep.27412
- Arabpour, M., Poelstra, K., Helfrich, W., Bremer, E., & Haisma, H. J. (2014). Targeted elimination of activated hepatic stellate cells by an anti-epidermal growth factor-receptor single chain fragment variable antibody-tumor necrosis factor-related apoptosis-inducing ligand (scFv425-sTRAIL). Journal of gene medicine, 16(9-10), 281-290. https://doi.org/10.1002/jgm.2776
- 2013
- Beljaars, L., Daliri, S., Dijkhuizen, C., Poelstra, K., & Gosens, R. (2013). Exploring the role of WNT-5A in liver fibrogenesis. Hepatology, 58(SI), 589A. [805].
- Schippers, M., Post, E., Cetintas, A., Reker-Smit, C., Malo, M. S., Hodin, R. A., Millan, J. L., Beljaars, L., & Poelstra, K. (2013). Intrahepatic alkaline phosphatase attenuates LPS-mediated effects during liver fibrosis. Hepatology, 58(SI), 579A.
- van Beuge, M. M., Prakash, J., Lacombe, M., Post, E., Reker-Smit, C., Beljaars, L., & Poelstra, K. (2013). Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury. PLoS ONE, 8(2), [e56442]. https://doi.org/10.1371/journal.pone.0056442
- 2012
- Klein, S., Van Beuge, M. M., Granzow, M., Beljaars, L., Schierwagen, R., Kilic, S., Heidari, I., Huss, S., Sauerbruch, T., Poelstra, K., & Trebicka, J. (2012). HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects. Journal of Hepatology, 57(6), 1220-1227. https://doi.org/10.1016/j.jhep.2012.07.033
- Bansal, R., Tomar, T., Ostman, A., Poelstra, K., & Prakash, J. (2012). Selective Targeting of Interferon gamma to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth. Molecular cancer therapeutics, 11(11), 2419-2428. https://doi.org/10.1158/1535-7163.MCT-11-0758
- Mattos Pinto, A., de Jager-Krikken, A., de Haan, M., Beljaars, L., & Poelstra, K. (2012). PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl4-induced fibrogenesis in mice. Journal of Controlled Release, 162(1), 84-91. https://doi.org/10.1016/j.jconrel.2012.05.041
- Poelstra, K., Prakash, J., & Beljaars, L. (2012). Drug targeting to the diseased liver. Journal of Controlled Release, 161(2), 188-197. https://doi.org/10.1016/j.jconrel.2012.02.011
- van Beuge, M. M., Poelstra, K., & Prakash, J. (2012). Specific delivery of kinase inhibitors in nonmalignant and malignant diseases. Expert Opinion on Drug Delivery, 9(1), 59-70. https://doi.org/10.1517/17425247.2012.638625
- Klein, S., Granzow, M., Schierwagen, R., Kilic, S., Heidari, I., Huss, S., van Beuge, M., Sauerbruch, T., Poelstra, K., & Trebicka, J. (2012). Gezielte Rho-Kinase-Hemmung in Hepatischen Sternzellen als Therapie der portalen Hypertension bei der Leberzirrhose. Zeitschrift für Gastroenterologie, 50(08). https://doi.org/10.1055/s-0032-1323962
- Klein, S., Granzow, M., Schierwagen, R., Huss, S., van Beuge, M., Poelstra, K., Sauerbruch, T., & Trebicka, J. (2012). HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen. Zeitschrift für Gastroenterologie, 50(01). https://doi.org/10.1055/s-0031-1295752
- 2011
- Bansal, R., Post, E., Proost, J. H., de Jager-Krikken, A., Poelstra, K., & Prakash, J. (2011). PEGylation improves pharmacokinetic profile, liver uptake and efficacy of Interferon gamma in liver fibrosis. Journal of Controlled Release, 154(3), 233-240. https://doi.org/10.1016/j.jconrel.2011.05.027
- de Jong, E., Winkel, P., Poelstra, K., & Prakash, J. (2011). Anticancer Effects of 15d-Prostaglandin-J(2) in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC. PLoS ONE, 6(9), [25192]. https://doi.org/10.1371/journal.pone.0025192
- Wisastra, R., Poelstra, K., Bischoff, R., Maarsingh, H., Haisma, H. J., & Dekker, F. J. (2011). Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections. ChemBioChem, 12(13), 2016-2020. https://doi.org/10.1002/cbic.201100148
- Poelstra, K., & Schuppan, D. (2011). Targeted therapy of liver fibrosis/cirrhosis and its complications. Journal of Hepatology, 55(3), 726-728.
- Klein, S., Granzow, M., Gautsch, S., van Beuge, M., Poelstra, K., Sauerbruch, T., & Trebicka, J. (2011). HSC-gezielte Hemmung der Rho-kinase senkt den Portaldruck mit nur geringen systemischen Nebenwirkungen. Zeitschrift für Gastroenterologie, 49(08). https://doi.org/10.1055/s-0031-1285665
- van Beuge, M. M., Prakash, J., Lacombe, M., Post, E., Reker-Smit, C., Beljaars, L., & Poelstra, K. (2011). Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632. Pharmaceutical Research, 28(8), 2045-2054. https://doi.org/10.1007/s11095-011-0430-9
- Bansal, R., Prakash, J., Post, E., Beljaars, L., Schuppan, D., & Poelstra, K. (2011). Novel Engineered Targeted Interferon-gamma Blocks Hepatic Fibrogenesis in Mice. Hepatology, 54(2), 586-596. https://doi.org/10.1002/hep.24395
- van Beuge, M. M., Prakash, J., Lacombe, M., Gosens, R., Post, E., Reker-Smit, C., Beljaars, L., & Poelstra, K. (2011). Reduction of Fibrogenesis by Selective Delivery of a Rho Kinase Inhibitor to Hepatic Stellate Cells in Mice. Journal of Pharmacology and Experimental Therapeutics, 337(3), 628-635. https://doi.org/10.1124/jpet.111.179143
ID: 128486