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prof. dr. K. (Klaas) Poelstra

Professor

Research

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Postal address:
A Deusinglaan1
Gebouw 5161, ruimte 0509
9713 AV
Groningen
Netherlands
Phone: +31 50 363 7721Fax: +31 50 363 3247
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  1. 2019
  2. van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y. O., Zuidema, J., ... Olinga, P. (2019). The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor. Journal of Controlled Release, 296, 250-257. https://doi.org/10.1016/j.jconrel.2018.12.039
  3. Klein, S., Frohn, F., Magdaleno, F., Reker-Smit, C., Schierwagen, R., Schierwagen, I., ... Trebicka, J. (2019). Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats. Scientific Reports, 9(1), 2256. https://doi.org/10.1038/s41598-019-38678-5
  4. 2018
  5. Deshmukh, M., Nakagawa, S., Higashi, T., Vincek, A., Venkatesh, A., Ruiz de Galarreta, M., ... Hoshida, Y. (2018). Cell type-specific pharmacological kinase inhibition for cancer chemoprevention. Nanomedicine-Nanotechnology biology and medicine, 14(2), 317-325. https://doi.org/10.1016/j.nano.2017.11.004
  6. van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., ... Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. https://doi.org/10.1016/j.jconrel.2017.11.029
  7. 2017
  8. Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., ... Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. https://doi.org/10.1016/j.ijpharm.2017.09.072
  9. Schippers, M., Beljaars, L., Post, E., Lotersztajn, S., Reker-Smit, C., Han, B., ... Poelstra, K. (2017). Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E-2 in Liver Fibrosis Is Associated with Reduced Fibrogenesiss. Journal of Pharmacology and Experimental Therapeutics, 363(2), 126-135. https://doi.org/10.1124/jpet.117.241646
  10. Magdaleno, F., Klein, S., Frohn, F., Reker-Smit, C., Uschner, F. E., Schierwagen, R., ... Trebicka, J. (2017). Rho-kinase inhibitor coupled with peptide-modified albumin carrier reduces fibrogenesis and portal pressure in cirrhotic rats without systemic effects. Hepatology, 66(1 (Suppl.)), 142A-142A.
  11. van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Kim, Y. O., Frijlink, E., ... Olinga, P. (2017). Therapeutic proteins in the treatment of liver fibrosis: The antifibrotic potential of a sustained release formulation for a PDGF beta-receptor targeted rho-kinase inhibitor. Hepatology, 66, 217A.
  12. Beljaars, L., Daliri, S., Dijkhuizen, C., Poelstra, K., & Gosens, R. (2017). WNT-5A regulates TGFβ-related activities in liver fibrosis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 312(3), G219-G227. https://doi.org/10.1152/ajpgi.00160.2016
  13. Van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Schuppan, D., Kim, Y. O., ... Olinga, P. (2017). Towards clinical use of targeted therapies for liver fibrosis: development of a sustained release formulation for therapeutic proteins. Journal of Hepatology, 66(1), S44-S44.
  14. 2016
  15. Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Beljaars, L., van den Born, J., ... Poelstra, K. (2016). Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice. Oncotarget, 7(34), 54240-54252. https://doi.org/10.18632/oncotarget.11095
  16. Draijer, C., Boorsma, C. E., Reker-Smit, C., Post, E., Poelstra, K., & Melgert, B. N. (2016). PGE(2)-treated macrophages inhibit development of allergic lung inflammation in mice. Journal of Leukocyte Biology, 100(1), 95-102. https://doi.org/10.1189/jlb.3MAB1115-505R
  17. Poelstra, K. (2016). Liver fibrosis in 2015: Crucial steps towards an effective treatment. Nature Reviews Gastroenterology & Hepatology, 13(2), 67-68. https://doi.org/10.1038/nrgastro.2015.224
  18. Draijer, C., Boorsma, C. E., Reker-Smit, C., Post, E., Poelstra, K., & Melgert, B. N. (2016). PGE2-treated macrophages inhibit development of allergic lung inflammation in mice. Journal of Leukocyte Biology, 100(1), 95-102. https://doi.org/10.1189/jlb.3MAB1115-505R
  19. Draijer, C., Boorsma, C. E., Reker-Smit, C., Post, E., Poelstra, K., & Melgert, B. N. (2016). PGE2-treated macrophages inhibit development of allergic lung inflammation in mice. American Journal of Respiratory and Critical Care Medicine, 193.
  20. 2015
  21. Poosti, F., Pham, B., Oosterhuis, D., Poelstra, K., van Goor, H., Olinga, P., & Hillebrands, J-L. (2015). Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo. Disease models & mechanisms, 8(10), 1227-1236. https://doi.org/10.1242/dmm.020172
  22. Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Post, E., Klok, P., ... Hillebrands, J-L. (2015). Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis. The FASEB Journal, 29(3), 1029-1042. https://doi.org/10.1096/fj.14-258459
  23. van Dijk, F., Olinga, P., Poelstra, K., & Beljaars, L. (2015). Targeted Therapies in Liver Fibrosis: Combining the Best Parts of Platelet-Derived Growth Factor BB and Interferon Gamma. Frontiers in Medicine, 2, [72]. https://doi.org/10.3389/fmed.2015.00072
  24. 2014
  25. Beljaars, L., Schippers, M., Reker-Smit, C., Martinez, F. O., Helming, L., Poelstra, K., & Melgert, B. N. (2014). Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans. Frontiers in Immunology, 5, [430]. https://doi.org/10.3389/fimmu.2014.00430
  26. Mahajan, V., Hartimath, S., Comley, R., Poelstra, K., Reker-Smit, C., Kamps, J., ... de Vries, E. (2014). Non-invasive imaging of Kupffer cell status using radiolabelled mannosylated albumin. Journal of Nuclear Medicine, 55(Supplement 1).
  27. Arabpour, M., Poelstra, K., Helfrich, W., Bremer, E., & Haisma, H. J. (2014). Targeted Elimination of Activated Hepatic Stellate Cells by Anti-EGF-Receptor scFv-sTRAIL Fusion Protein. Molecular Therapy, 22(suppl. 1), S121-S121.
  28. Bansal, R., Prakash, J., De Ruiter, M., & Poelstra, K. (2014). Interferon gamma peptidomimetic targeted to hepatic stellate cells ameliorates acute and chronic liver fibrosis in vivo. Journal of Controlled Release, 179, 18-24. https://doi.org/10.1016/j.jconrel.2014.01.022
  29. Mahajan, V., Hartimath, S., Comley, R., Stefan-Gueldner, M., Roth, A., Poelstra, K., ... de Vries, E. (2014). Non-invasive imaging of kupffer cell status using radiolabelled mannosylated albumin. Journal of Hepatology, 60(1, Suppl.), S180-S181. https://doi.org/10.1016/S0168-8278(14)60503-1
  30. Poelstra, K. (2014). New Highlights for Relaxin. Hepatology, 59(4), 1223-1224. https://doi.org/10.1002/hep.26713
  31. Bansal, R., Prakash, J., De Ruiter, M., & Poelstra, K. (2014). Targeted Recombinant Fusion Proteins of IFN gamma and Mimetic IFN gamma with PDGF beta R Bicyclic Peptide Inhibits Liver Fibrogenesis In Vivo. PLoS ONE, 9(2), [e89878]. https://doi.org/10.1371/journal.pone.0089878
  32. Beljaars, L., Boorsma, C. E., Guney, B., Poelstra, K., & Melgert, B. N. (2014). A new communication system regulating extracellular matrix in liver fibrosis: RANK/RANKL/OPG. Hepatology, 60(Supplement 1), 584A-584A. https://doi.org/10.1002/hep.27412
  33. Arabpour, M., Poelstra, K., Helfrich, W., Bremer, E., & Haisma, H. J. (2014). Targeted elimination of activated hepatic stellate cells by an anti-epidermal growth factor-receptor single chain fragment variable antibody-tumor necrosis factor-related apoptosis-inducing ligand (scFv425-sTRAIL). Journal of gene medicine, 16(9-10), 281-290. https://doi.org/10.1002/jgm.2776
  34. 2013
  35. Poelstra, K., Beljaars, L., & Melgert, B. N. (2013). Cell-specific delivery of biologicals: Problems, pitfalls and possibilities of antifibrotic compounds in the liver. Drug Discovery Today, 18(23-24), 1237-1242. https://doi.org/10.1016/j.drudis.2013.05.013
  36. Beljaars, L., Daliri, S., Dijkhuizen, C., Poelstra, K., & Gosens, R. (2013). Exploring the role of WNT-5A in liver fibrogenesis. Hepatology, 58(SI), 589A. [805].
  37. Schippers, M., Post, E., Cetintas, A., Reker-Smit, C., Malo, M. S., Hodin, R. A., ... Poelstra, K. (2013). Intrahepatic alkaline phosphatase attenuates LPS-mediated effects during liver fibrosis. Hepatology, 58(SI), 579A.
  38. van Beuge, M. M., Prakash, J., Lacombe, M., Post, E., Reker-Smit, C., Beljaars, L., & Poelstra, K. (2013). Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury. PLoS ONE, 8(2), [e56442]. https://doi.org/10.1371/journal.pone.0056442
  39. 2012
  40. Klein, S., Van Beuge, M. M., Granzow, M., Beljaars, L., Schierwagen, R., Kilic, S., ... Trebicka, J. (2012). HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects. Journal of Hepatology, 57(6), 1220-1227. https://doi.org/10.1016/j.jhep.2012.07.033
  41. Bansal, R., Tomar, T., Ostman, A., Poelstra, K., & Prakash, J. (2012). Selective Targeting of Interferon gamma to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth. Molecular cancer therapeutics, 11(11), 2419-2428. https://doi.org/10.1158/1535-7163.MCT-11-0758
  42. Mattos Pinto, A., de Jager-Krikken, A., de Haan, M., Beljaars, L., & Poelstra, K. (2012). PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl4-induced fibrogenesis in mice. Journal of Controlled Release, 162(1), 84-91. https://doi.org/10.1016/j.jconrel.2012.05.041
  43. Poelstra, K., Prakash, J., & Beljaars, L. (2012). Drug targeting to the diseased liver. Journal of Controlled Release, 161(2), 188-197. https://doi.org/10.1016/j.jconrel.2012.02.011
  44. van Beuge, M. M., Poelstra, K., & Prakash, J. (2012). Specific delivery of kinase inhibitors in nonmalignant and malignant diseases. Expert Opinion on Drug Delivery, 9(1), 59-70. https://doi.org/10.1517/17425247.2012.638625
  45. Klein, S., Granzow, M., Schierwagen, R., Kilic, S., Heidari, I., Huss, S., ... Trebicka, J. (2012). Gezielte Rho-Kinase-Hemmung in Hepatischen Sternzellen als Therapie der portalen Hypertension bei der Leberzirrhose. Zeitschrift für Gastroenterologie, 50(08). https://doi.org/10.1055/s-0032-1323962
  46. Klein, S., Granzow, M., Schierwagen, R., Huss, S., van Beuge, M., Poelstra, K., ... Trebicka, J. (2012). HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen. Zeitschrift für Gastroenterologie, 50(01). https://doi.org/10.1055/s-0031-1295752
  47. 2011
  48. Bansal, R., Post, E., Proost, J. H., de Jager-Krikken, A., Poelstra, K., & Prakash, J. (2011). PEGylation improves pharmacokinetic profile, liver uptake and efficacy of Interferon gamma in liver fibrosis. Journal of Controlled Release, 154(3), 233-240. https://doi.org/10.1016/j.jconrel.2011.05.027
  49. de Jong, E., Winkel, P., Poelstra, K., & Prakash, J. (2011). Anticancer Effects of 15d-Prostaglandin-J(2) in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC. PLoS ONE, 6(9), [25192]. https://doi.org/10.1371/journal.pone.0025192
  50. Wisastra, R., Poelstra, K., Bischoff, R., Maarsingh, H., Haisma, H. J., & Dekker, F. J. (2011). Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections. ChemBioChem, 12(13), 2016-2020. https://doi.org/10.1002/cbic.201100148
  51. Poelstra, K., & Schuppan, D. (2011). Targeted therapy of liver fibrosis/cirrhosis and its complications. Journal of Hepatology, 55(3), 726-728.
  52. Klein, S., Granzow, M., Gautsch, S., van Beuge, M., Poelstra, K., Sauerbruch, T., & Trebicka, J. (2011). HSC-gezielte Hemmung der Rho-kinase senkt den Portaldruck mit nur geringen systemischen Nebenwirkungen. Zeitschrift für Gastroenterologie, 49(08). https://doi.org/10.1055/s-0031-1285665
  53. van Beuge, M. M., Prakash, J., Lacombe, M., Post, E., Reker-Smit, C., Beljaars, L., & Poelstra, K. (2011). Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632. Pharmaceutical Research, 28(8), 2045-2054. https://doi.org/10.1007/s11095-011-0430-9
  54. Bansal, R., Prakash, J., Post, E., Beljaars, L., Schuppan, D., & Poelstra, K. (2011). Novel Engineered Targeted Interferon-gamma Blocks Hepatic Fibrogenesis in Mice. Hepatology, 54(2), 586-596. https://doi.org/10.1002/hep.24395
  55. van Beuge, M. M., Prakash, J., Lacombe, M., Gosens, R., Post, E., Reker-Smit, C., ... Poelstra, K. (2011). Reduction of Fibrogenesis by Selective Delivery of a Rho Kinase Inhibitor to Hepatic Stellate Cells in Mice. Journal of Pharmacology and Experimental Therapeutics, 337(3), 628-635. https://doi.org/10.1124/jpet.111.179143
  56. Rachmawati, H., Beljaars, L., Reker-Smit, C., Bakker, H., van Loenen - Weemaes, A., Lub-de Hooge, M., & Poelstra, K. (2011). Intravenous administration of recombinant human IL-10 suppresses the development of anti-thy 1-induced glomerulosclerosis in rats. Pda journal of pharmaceutical science and technology, 65(2), 116-130.
  57. Barisal, R., Prakash, J., de Ruijter, M., Beljaars, L., & Poelstra, K. (2011). Peptide-Modified Albumin Carrier Explored as a Novel Strategy for a Cell-Specific Delivery of Interferon Gamma To Treat Liver Fibrosis. Molecular pharmaceutics, 8(5), 1899-1909. https://doi.org/10.1021/mp200263q
  58. 2010
  59. Prakash, J., de Jong, E., Post, E., Gouw, A. S. H., Beljaars, L., & Poelstra, K. (2010). A novel approach to deliver anticancer drugs to key cell types in tumors using a PDGF receptor-binding cyclic peptide containing carrier. Journal of Controlled Release, 145(2), 91-101. https://doi.org/10.1016/j.jconrel.2010.03.018
  60. Prakash, J., Beljaars, L., Harapanahalli, A. K., Zeinstra-Smith, M., de Jager-Krikken, A., Hessing, M., ... Poelstra, K. (2010). Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor. International Journal of Cancer, 126(8), 1966-1981. https://doi.org/10.1002/ijc.24914
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