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About usHow to find usprof. dr. K.N. (Klaas Nico) Faber

prof. dr. K.N. (Klaas Nico) Faber

Associate professor / adjunct professor

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+31 50 361 2620 (Secretariat)
E-mail:
k.n.faber umcg.nl

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  1. 2019
  2. Geng, Y., Villanueva, A. H., Oun, A., Buist-Homan, M., Blokzijl, H., Faber, K. N., ... Moshage, H. (2019). Protective effect of metformin against palmitate-induced hepatic cell death. Biochimica et biophysica acta-Molecular basis of disease, 165621. https://doi.org/10.1016/j.bbadis.2019.165621
  3. Bourgonje, A. R., von Martels, J. Z. H., Gabriëls, R. Y., Blokzijl, T., Buist-Homan, M., Heegsma, J., ... Dijkstra, G. (2019). A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease. Frontiers in Medicine, 6, [251].
  4. Damba, T., Zhang, M., Buist-Homan, M., van Goor, H., Faber, K. N., & Moshage, H. (2019). Hydrogen sulfide stimulates activation of hepatic stellate cells through increased cellular bio-energetics. Nitric oxide-Biology and chemistry, 92(1), 26-33. https://doi.org/10.1016/j.niox.2019.08.004
  5. Vich Vila, A., Boddeke, A., Kurilshikov, A., Collij, V., Sureda Horrach, P., Martels ,von, J. Z. H., ... Weersma, R. K. (2019). Combining absolute quantification of fecal bacteria with metagenomic sequencing data improves the characterization of the gut microbiome of patients with Crohn’s disease. United European Gastroenterology Journal.
  6. Gabriëls, R. Y., Bourgonje, A. R., von Martels, J. Z. H., Trentadue, G., Blokzijl, T., Dullemen, van, H. M., ... Dijkstra, G. (2019). Eotaxin-1 and mucosal eosinophil abundance predict treatment response to vedolizumab in Inflammatory Bowel Disease. United European Gastroenterology Journal.
  7. Saeed, A., Yang, J., Heegsma, J., Groen, A. K., Van Mil, S. W. C., Paulusma, C. C., ... Faber, K. N. (2019). Farnesoid x receptor and bile acids regulate vitamin a storage. Hepatology, 70, 1222A-1222A.
  8. Sydor, S., Manka, P., Van Buren, L., Heegsma, J., Best, J., Baba, H., ... Bechmann, L. P. (2019). KLF6 INTERACTS WITH FXR TARGET GENES AND EFFECTS THE OUTCOME OF PRIMARY SCLEROSING CHOLANGITIS. Hepatology, 70, 805A-805A.
  9. Bourgonje, A. R., Gabriëls, R. Y., Borst, de, M. H., Bulthuis, M. L. C., Faber, K. N., van Goor, H., & Dijkstra, G. (2019). Levels of serum free thiols are superior to fecal calprotectin in predicting endoscopic disease activity in Inflammatory Bowel Disease. United European Gastroenterology Journal, 7(8(Suppl)), 137-138. [P0352].
  10. von Martels, J. Z. H., Bourgonje, A. R., Klaassen, M. A. Y., Alkhalifah, H. A. A., Sadaghian Sadabad, M., Vich Vila, A., ... Dijkstra, G. (2019). Riboflavin suppresses inflammation and attenuates Crohn’s disease symptoms (RISE-UP Study). United European Gastroenterology Journal, 7(8(Suppl)), 460-461. [P0683].
  11. Fagundes Rosa, R. R., Bourgonje, A. R., Barbieri, R., Jansen, D., Taylor, C. T., Faber, K. N., & Dijkstra, G. (2019). Systemic iron deficiency is associated with activation of the HIF-1α pathway in the intestinal mucosa of patients with Inflammatory Bowel Disease. United European Gastroenterology Journal.
  12. Bourgonje, A. R., Gabriëls, R. Y., Borst, de, M. H., Bulthuis, M. L. C., Faber, K. N., van Goor, H., & Dijkstra, G. (2019). Serum Free Thiols Are Superior to Fecal Calprotectin in Reflecting Endoscopic Disease Activity in Inflammatory Bowel Disease. Antioxidants (Basel, Switzerland), 8(9), [351]. https://doi.org/10.3390/antiox8090351
  13. Gabriëls, R. Y., Bourgonje, A. R., Trentadue, G., Faber, K. N., Dijkstra, G., & Kats-Ugurlu, G. (2019). Eosinophil counts in colon biopsies can predict treatment response to vedolizumab in Inflammatory Bowel Disease. Virchows Archiv, 475(Suppl 1), S199-S200.
  14. Shajari, S., Saeed, A., Smith-Cortinez, N. F., Heegsma, J., Sydor, S., & Faber, K. N. (2019). Hormone-sensitive lipase is a retinyl ester hydrolase in human and rat quiescent hepatic stellate cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(9), 1258-1267. https://doi.org/10.1016/j.bbalip.2019.05.012
  15. Parada Venegas, D., De la Fuente, M. K., Landskron, G., Julieta Gonzalez, M., Quera, R., Dijkstra, G., ... Hermoso, M. A. (2019). Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases (vol 10, 277, 2019). Frontiers in Immunology, 10, [1486]. https://doi.org/10.3389/fimmu.2019.01486
  16. Bourgonje, A. R., Gabriëls, R. Y., de Borst, M. H., Bulthuis, M. L. C., Faber, K. N., Dijkstra, G., & van Goor, H. (2019). Levels of serum free thiols are superior to fecal calprotectin in predicting endoscopic disease activity in Inflammatory Bowel Disease. ISANH - Archives, 6(3), 51.
  17. Bourgonje, A. R., Gabriëls, R. Y., von Martels, J. Z. H., Blokzijl, T., Buist-Homan, M., Heegsma, J., ... Dijkstra, G. (2019). A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease. Gastroenterology, 156(6), S848. [Mo1814]. https://doi.org/10.1016/S0016-5085(19)39081-X
  18. Fagundes Rosa, R. R., Bourgonje, A. R., Sadaghian Sadabad, M., van Leeuwen, S. S., Harmsen, H. J. M., Dijkstra, G., & Faber, K. N. (2019). Reconstitution of Prebiotic-Driven Host-Microbe Syntrophy in the Colon; Inulin-Grown Faecalibacterium prausnitzii Cross-Feeds the Human Intestinal Epithelium. Gastroenterology, 156(6), S895. [Mo1946]. https://doi.org/10.1016/S0016-5085(19)39209-1
  19. Fagundes Rosa, R. R., Bourgonje, A. R., Cui, Y., Blokzijl, T., Harmsen, H. J. M., Dijkstra, G., ... Faber, K. N. (2019). The Intestinal Microenvironment Induces a Transcription Reprogramming of Epithelial Oxygen Sensing. Gastroenterology, 156(6), S37. [157]. https://doi.org/10.1016/S0016-5085(19)36870-2
  20. Bourgonje, A. R., von Martels, J. Z. H., Bulthuis, M. L. C., van Londen, M., Faber, K. N., Dijkstra, G., & van Goor, H. (2019). Crohn's Disease in Clinical Remission Is Marked by Systemic Oxidative Stress. Frontiers in Physiology, 10, [499]. https://doi.org/10.3389/fphys.2019.00499
  21. Ríos-Ocampo, W. A., Navas, M-C., Faber, K. N., Daemen, T., & Moshage, H. (2019). The cellular stress response in hepatitis C virus infection: A balancing act to promote viral persistence and host cell survival. Virus research, 263, 1-8. https://doi.org/10.1016/j.virusres.2018.12.013
  22. Parada Venegas, D., De la Fuente, M. K., Landskron, G., Julieta Gonzalez, M., Quera, R., Dijkstra, G., ... Hermoso, M. A. (2019). Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. Frontiers in Immunology, 10, [277]. https://doi.org/10.3389/fimmu.2019.00277
  23. von Martels, J. Z. H., Bourgonje, A. R., Harmsen, H. J. M., Faber, K. N., & Dijkstra, G. (2019). Assessing intestinal permeability in Crohn's disease patients using orally administered 52Cr-EDTA. PLoS ONE, 14(2), [e0211973]. https://doi.org/10.1371/journal.pone.0211973
  24. Uniken Venema, W. T., Voskuil, M. D., Vich Vila, A., van der Vries, G., Jansen, B. H., Jabri, B., ... Festen, E. A. (2019). Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. Gastroenterology, 156(3), 812-+. https://doi.org/10.1053/j.gastro.2018.10.046
  25. Bourgonje, A. R., von Martels, J. Z. H., Gabriëls, R. Y., Blokzijl, T., Buist-Homan, M., Heegsma, J., ... Dijkstra, G. (2019). A combined set of four serum inflammatory biomarkers reliably predicts endoscopic disease activity in inflammatory bowel disease. Journal of Crohn's and Colitis, 13(1).
  26. Ríos-Ocampo, W. A., Daemen, T., Buist-Homan, M., Faber, K. N., Navas, M-C., & Moshage, H. (2019). Hepatitis C virus core or NS3/4A protein expression preconditions hepatocytes against oxidative stress and endoplasmic reticulum stress. Redox Report, 24(1), 17-26. https://doi.org/10.1080/13510002.2019.1596431
  27. Wessel, H., Saeed, A., Heegsma, J., Connelly, M. A., Faber, K. N., & Dullaart, R. P. F. (2019). Plasma Levels of Retinol Binding Protein 4 Relate to Large VLDL and Small LDL Particles in Subjects with and without Type 2 Diabetes. Journal of Clinical Medicine, 8(11). https://doi.org/10.3390/jcm8111792
  28. 2018
  29. Buurman, D. J., Blokzijl, T., Festen, E. A. M., Pham, B. T., Faber, K. N., Brouwer, E., & Dijkstra, G. (2018). Quantitative comparison of the neutralizing capacity, immunogenicity and cross-reactivity of anti-TNF-alpha biologicals and an Infliximab-biosimilar. PLoS ONE, 13(12), [0208922]. https://doi.org/10.1371/journal.pone.0208922
  30. Sydor, S., Wenning, C., Assmuth, S., Messerschmidt, I., Best, J., Moshage, H., ... Bechmann, L. P. (2018). Effects of a Single Fast Food Binge on Hepatic Steatosis, Bile Acid Metabolism, and Cytokine Profiles. Hepatology, 68, 1023A.
  31. Rios-Ocampo, W. A., Buist-Homan, M., Navas, M. C., Faber, K. N., Daemen, T., & Moshage, H. (2018). Hepatitis C Virus Proteins Core and NS5A Are Highly Sensitive to Oxidative Stress-Induced Degradation through Selective Autophagy. Hepatology, 68, 604A.
  32. Saeed, A., Bartuzi, P., Heegsma, J., Dekker, D., Kloosterhuis, N., De Bruin, A., ... Faber, K. N. (2018). Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in Hepatocytes. Hepatology, 68, 738A-739A.
  33. Geng, Y., Hernandez, A., Buist-Homan, M., Blokzijl, H., Faber, K. N., & Moshage, H. (2018). Protective Effect of Metformin Against Palmitic Acid-Induced Hepatic Cell Death. Hepatology, 68, 1026A.
  34. Smith-Cortinez, N., Van Eunen, K., Sydor, S., Bechmann, L. P., Moshage, H., Thediek, K., ... Faber, K. N. (2018). Simultaneous Induction of Glycolysis and Oxidative Phosphorylation during Activation of Hepatic Stellate Cells Reveals Novel Targets to Treat Liver Fibrosis. Hepatology, 68, 642A.
  35. Visschedijk, M. C., Spekhorst, L. M., Cheng, S-C., van Loo, E. S., Jansen, B. H. D., Blokzijl, T., ... Festen, E. A. M. (2018). Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn's Disease. Journal of Crohn's and Colitis, 12(5), 582-588. https://doi.org/10.1093/ecco-jcc/jjy001
  36. Sydor, S., Manka, P. P., Schaenzer, J., Messerschmidt, I., Kinner, S., Link, A., ... Bechmann, L. P. (2018). Gut-liver interactions in celiac disease: FGF-19 and GLP-1 link disease activity to hepatic steatosis and liver injury. S561-S561. Poster session presented at International Liver Congress (ILC), Paris, France. https://doi.org/10.1016/S0168-8278(18)31378-3
  37. Bourgonje, A. R., von Martels, J. Z. H., de Vos, P., Faber, K. N., & Dijkstra, G. (2018). Increased fecal calprotectin levels in Crohn's disease correlate with elevated serum Th1- and Th17-associated cytokines. PLoS ONE, 13(2), [e0193202]. https://doi.org/10.1371/journal.pone.0193202
  38. Saeed, A., Dullaart, R. P. F., Schreuder, T. C. M. A., Blokzijl, H., & Faber, K. N. (2018). Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients, 10(1), [29]. https://doi.org/10.3390/nu10010029
  39. Mposhi, A., van der Wijst, M., Faber, K. N., & Rots, M. G. (2018). Selected Abstracts from the 3rd European Summer School on Nutrigenomics Jesi, June 25-29, 2018. Lifestyle genomics, 11(1), 19-38. https://doi.org/10.1159/000490753
  40. 2017
  41. Atanasovska, B., Rensen, S. S., van der Sijde, M. R., Marsman, G., Kumar, V., Jonkers, I., ... Fu, J. (2017). A Liver-Specific Long Noncoding RNA With a Role in Cell Viability Is Elevated in Human Nonalcoholic Steatohepatitis. Hepatology, 66(3), 794-808. https://doi.org/10.1002/hep.29034
  42. Sydor, S., Manka, P., Best, J., Jafoui, S., Sowa, J-P., Zoubek, M. E., ... Bechmann, L. P. (2017). Kruppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury. Scientific Reports, 7(1), [8119]. https://doi.org/10.1038/s41598-017-08680-w
  43. Nass, K. J., van den Berg, E. H., Faber, K. N., Schreuder, T. C. M. A., Blokzijl, H., & Dullaart, R. P. F. (2017). High prevalence of apolipoprotein B dyslipoproteinemias in non-alcoholic fatty liver disease: The lifelines cohort study. Metabolism, 72, 37-46. https://doi.org/10.1016/j.metabol.2017.04.004
  44. Klunder, L. J., Faber, K. N., Dijkstra, G., & van IJzendoorn, S. C. D. (2017). Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine. Cold Spring Harbor Perspectives in Biology, 9(7), [027888]. https://doi.org/10.1101/cshperspect.a027888
  45. Saeed, A., Hoekstra, M., Hoeke, M. O., Heegsma, J., & Faber, K. N. (2017). The interrelationship between bile acid and vitamin A homeostasis. Biochimica et biophysica acta-Molecular and cell biology of lipids, 1862(5), 496-512. https://doi.org/10.1016/j.bbalip.2017.01.007
  46. von Martels, J. Z. H., Sadabad, M. S., Bourgonje, A. R., Blokzijl, T., Dijkstra, G., Faber, K. N., & Harmsen, H. J. M. (2017). The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut. Anaerobe, 44, 3-12. https://doi.org/10.1016/j.anaerobe.2017.01.001
  47. Mposhi, A., van der Wijst, M. G. P., Faber, K. N., & Rots, M. G. (2017). Regulation of mitochondrial gene expression, the epigenetic enigma. Frontiers in bioscience-Landmark, 22, 1099-1113. https://doi.org/10.2741/4535
  48. van den Berg, E. H., Amini, M., Dullaart, R. P. F., Faber, K. N., Alizadeh, B. Z., & Blokzijl, H. (2017). Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort. PLoS ONE, 12(2), [e0171502]. https://doi.org/10.1371/journal.pone.0171502
  49. van den Berg, E. H., van Tienhoven-Wind, L. J. N., Amini, M., Schreuder, T. C. M. A., Faber, K. N., Blokzijl, H., & Dullaart, R. P. F. (2017). Higher free triiodothyronine is associated with non-alcoholic fatty liver disease in euthyroid subjects: The Lifelines Cohort Study. Metabolism, 67, 62-71. https://doi.org/10.1016/j.metabol.2016.11.002
  50. Haanstra, J. R., Gerding, A., Dolga, A. M., Sorgdrager, F. J. H., Buist-Homan, M., du Toit, F., ... Bakker, B. M. (2017). Targeting pathogen metabolism without collateral damage to the host. Scientific Reports, 7, [40406]. https://doi.org/10.1038/srep40406
  51. Bai, X., Yang, P., Zhou, Q., Cai, B., Buist-Homan, M., Cheng, H., ... Shi, G. (2017). The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro. British Journal of Pharmacology, 174(1), 41-56. https://doi.org/10.1111/bph.13645
  52. Arabpour, M., Cool, R., Faber, K. N., Quax, W. J., & Haisma, H. J. (2017). Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells. Journal of Drug Targeting, 25(4), 360-369. https://doi.org/10.1080/1061186X.2016.1262867
  53. 2016
  54. Van Den Berg, E., van Tienhoven-Wind, L., Amini, M., Schreuder, T. C. M. A., Faber, K. N., Blokzijl, H., & Dullaart, R. P. F. (2016). Free triiodothyronine as determinant of non-alcoholic fatty liver disease in euthyroid subjects: The lifelines cohort study. Metabolism Clinical and Experimental.
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