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prof. dr. K.N. (Klaas Nico) Faber

Associate professor / adjunct professor

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  1. 2019
  2. Bourgonje, A. R., Gabriels, R. Y., Borst, de, M. H., Bulthuis, M. L. C., Faber, K. N., van Goor, H., & Dijkstra, G. (2019). Serum Free Thiols Are Superior to Fecal Calprotectin in Reflecting Endoscopic Disease Activity in Inflammatory Bowel Disease. Antioxidants (Basel, Switzerland), 8(9), [351]. https://doi.org/10.3390/antiox8090351
  3. Shajari, S., Saeed, A., Smith-Cortinez, N. F., Heegsma, J., Sydor, S., & Faber, K. N. (2019). Hormone-sensitive lipase is a retinyl ester hydrolase in human and rat quiescent hepatic stellate cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(9), 1258-1267. https://doi.org/10.1016/j.bbalip.2019.05.012
  4. Damba, T., Zhang, M., Buist-Homan, M., van Goor, H., Faber, K. N., & Moshage, H. (2019). Hydrogen sulfide stimulates activation of hepatic stellate cells through increased cellular bio-energetics. Nitric oxide-Biology and chemistry, 92(1), 26-33. https://doi.org/10.1016/j.niox.2019.08.004
  5. Parada Venegas, D., De la Fuente, M. K., Landskron, G., Julieta Gonzalez, M., Quera, R., Dijkstra, G., ... Hermoso, M. A. (2019). Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases (vol 10, 277, 2019). Frontiers in Immunology, 10, [1486]. https://doi.org/10.3389/fimmu.2019.01486
  6. Bourgonje, A. R., Gabriëls, R. Y., de Borst, M. H., Bulthuis, M. L. C., Faber, K. N., Dijkstra, G., & van Goor, H. (2019). Levels of serum free thiols are superior to fecal calprotectin in predicting endoscopic disease activity in Inflammatory Bowel Disease. ISANH - Archives, 6(3), 51.
  7. Bourgonje, A. R., Gabriëls, R. Y., von Martels, J. Z. H., Blokzijl, T., Buist-Homan, M., Heegsma, J., ... Dijkstra, G. (2019). A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease. Gastroenterology, 156(6), S848. [Mo1814]. https://doi.org/10.1016/S0016-5085(19)39081-X
  8. Fagundes Rosa, R. R., Bourgonje, A. R., Sadaghian Sadabad, M., van Leeuwen, S. S., Harmsen, H. J. M., Dijkstra, G., & Faber, K. N. (2019). Reconstitution of Prebiotic-Driven Host-Microbe Syntrophy in the Colon; Inulin-Grown Faecalibacterium prausnitzii Cross-Feeds the Human Intestinal Epithelium. Gastroenterology, 156(6), S895. [Mo1946]. https://doi.org/10.1016/S0016-5085(19)39209-1
  9. Fagundes Rosa, R. R., Bourgonje, A. R., Cui, Y., Blokzijl, T., Harmsen, H. J. M., Dijkstra, G., ... Faber, K. N. (2019). The Intestinal Microenvironment Induces a Transcription Reprogramming of Epithelial Oxygen Sensing. Gastroenterology, 156(6), S37. [157]. https://doi.org/10.1016/S0016-5085(19)36870-2
  10. Bourgonje, A. R., von Martels, J. Z. H., Bulthuis, M. L. C., van Londen, M., Faber, K. N., Dijkstra, G., & van Goor, H. (2019). Crohn's Disease in Clinical Remission Is Marked by Systemic Oxidative Stress. Frontiers in Physiology, 10, [499]. https://doi.org/10.3389/fphys.2019.00499
  11. Ríos-Ocampo, W. A., Navas, M-C., Faber, K. N., Daemen, T., & Moshage, H. (2019). The cellular stress response in hepatitis C virus infection: A balancing act to promote viral persistence and host cell survival. Virus research, 263, 1-8. https://doi.org/10.1016/j.virusres.2018.12.013
  12. Parada Venegas, D., De la Fuente, M. K., Landskron, G., Julieta Gonzalez, M., Quera, R., Dijkstra, G., ... Hermoso, M. A. (2019). Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. Frontiers in Immunology, 10, [277]. https://doi.org/10.3389/fimmu.2019.00277
  13. von Martels, J. Z. H., Bourgonje, A. R., Harmsen, H. J. M., Faber, K. N., & Dijkstra, G. (2019). Assessing intestinal permeability in Crohn's disease patients using orally administered 52Cr-EDTA. PLoS ONE, 14(2), [e0211973]. https://doi.org/10.1371/journal.pone.0211973
  14. Uniken Venema, W. T., Voskuil, M. D., Vich Vila, A., van der Vries, G., Jansen, B. H., Jabri, B., ... Festen, E. A. (2019). Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. Gastroenterology, 156(3), 812-+. https://doi.org/10.1053/j.gastro.2018.10.046
  15. Bourgonje, A. R., von Martels, J. Z. H., Gabriëls, R. Y., Blokzijl, T., Buist-Homan, M., Heegsma, J., ... Dijkstra, G. (2019). A combined set of four serum inflammatory biomarkers reliably predicts endoscopic disease activity in inflammatory bowel disease. Journal of Crohn's and Colitis, 13(1).
  16. Ríos-Ocampo, W. A., Daemen, T., Buist-Homan, M., Faber, K. N., Navas, M-C., & Moshage, H. (2019). Hepatitis C virus core or NS3/4A protein expression preconditions hepatocytes against oxidative stress and endoplasmic reticulum stress. Redox Report, 24(1), 17-26. https://doi.org/10.1080/13510002.2019.1596431
  17. 2018
  18. Buurman, D. J., Blokzijl, T., Festen, E. A. M., Pham, B. T., Faber, K. N., Brouwer, E., & Dijkstra, G. (2018). Quantitative comparison of the neutralizing capacity, immunogenicity and cross-reactivity of anti-TNF-alpha biologicals and an Infliximab-biosimilar. PLoS ONE, 13(12), [0208922]. https://doi.org/10.1371/journal.pone.0208922
  19. Sydor, S., Wenning, C., Assmuth, S., Messerschmidt, I., Best, J., Moshage, H., ... Bechmann, L. P. (2018). Effects of a Single Fast Food Binge on Hepatic Steatosis, Bile Acid Metabolism, and Cytokine Profiles. Hepatology, 68, 1023A.
  20. Rios-Ocampo, W. A., Buist-Homan, M., Navas, M. C., Faber, K. N., Daemen, T., & Moshage, H. (2018). Hepatitis C Virus Proteins Core and NS5A Are Highly Sensitive to Oxidative Stress-Induced Degradation through Selective Autophagy. Hepatology, 68, 604A.
  21. Saeed, A., Bartuzi, P., Heegsma, J., Dekker, D., Kloosterhuis, N., De Bruin, A., ... Faber, K. N. (2018). Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in Hepatocytes. Hepatology, 68, 738A-739A.
  22. Geng, Y., Hernandez, A., Buist-Homan, M., Blokzijl, H., Faber, K. N., & Moshage, H. (2018). Protective Effect of Metformin Against Palmitic Acid-Induced Hepatic Cell Death. Hepatology, 68, 1026A.
  23. Smith-Cortinez, N., Van Eunen, K., Sydor, S., Bechmann, L. P., Moshage, H., Thediek, K., ... Faber, K. N. (2018). Simultaneous Induction of Glycolysis and Oxidative Phosphorylation during Activation of Hepatic Stellate Cells Reveals Novel Targets to Treat Liver Fibrosis. Hepatology, 68, 642A.
  24. Visschedijk, M. C., Spekhorst, L. M., Cheng, S-C., van Loo, E. S., Jansen, B. H. D., Blokzijl, T., ... Festen, E. A. M. (2018). Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn's Disease. Journal of Crohn's and Colitis, 12(5), 582-588. https://doi.org/10.1093/ecco-jcc/jjy001
  25. Sydor, S., Manka, P. P., Schaenzer, J., Messerschmidt, I., Kinner, S., Link, A., ... Bechmann, L. P. (2018). Gut-liver interactions in celiac disease: FGF-19 and GLP-1 link disease activity to hepatic steatosis and liver injury. S561-S561. Poster session presented at International Liver Congress (ILC), Paris, France. https://doi.org/10.1016/S0168-8278(18)31378-3
  26. Bourgonje, A. R., von Martels, J. Z. H., de Vos, P., Faber, K. N., & Dijkstra, G. (2018). Increased fecal calprotectin levels in Crohn's disease correlate with elevated serum Th1- and Th17-associated cytokines. PLoS ONE, 13(2), [e0193202]. https://doi.org/10.1371/journal.pone.0193202
  27. Saeed, A., Dullaart, R. P. F., Schreuder, T. C. M. A., Blokzijl, H., & Faber, K. N. (2018). Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients, 10(1), [29]. https://doi.org/10.3390/nu10010029
  28. Mposhi, A., van der Wijst, M., Faber, K. N., & Rots, M. G. (2018). Selected Abstracts from the 3rd European Summer School on Nutrigenomics Jesi, June 25-29, 2018. Lifestyle genomics, 11(1), 19-38. https://doi.org/10.1159/000490753
  29. 2017
  30. Atanasovska, B., Rensen, S. S., van der Sijde, M. R., Marsman, G., Kumar, V., Jonkers, I., ... Fu, J. (2017). A Liver-Specific Long Noncoding RNA With a Role in Cell Viability Is Elevated in Human Nonalcoholic Steatohepatitis. Hepatology, 66(3), 794-808. https://doi.org/10.1002/hep.29034
  31. Sydor, S., Manka, P., Best, J., Jafoui, S., Sowa, J-P., Zoubek, M. E., ... Bechmann, L. P. (2017). Kruppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury. Scientific Reports, 7(1), [8119]. https://doi.org/10.1038/s41598-017-08680-w
  32. Nass, K. J., van den Berg, E. H., Faber, K. N., Schreuder, T. C. M. A., Blokzijl, H., & Dullaart, R. P. F. (2017). High prevalence of apolipoprotein B dyslipoproteinemias in non-alcoholic fatty liver disease: The lifelines cohort study. Metabolism, 72, 37-46. https://doi.org/10.1016/j.metabol.2017.04.004
  33. Klunder, L. J., Faber, K. N., Dijkstra, G., & van IJzendoorn, S. C. D. (2017). Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine. Cold Spring Harbor Perspectives in Biology, 9(7), [027888]. https://doi.org/10.1101/cshperspect.a027888
  34. Saeed, A., Hoekstra, M., Hoeke, M. O., Heegsma, J., & Faber, K. N. (2017). The interrelationship between bile acid and vitamin A homeostasis. Biochimica et biophysica acta-Molecular and cell biology of lipids, 1862(5), 496-512. https://doi.org/10.1016/j.bbalip.2017.01.007
  35. von Martels, J. Z. H., Sadabad, M. S., Bourgonje, A. R., Blokzijl, T., Dijkstra, G., Faber, K. N., & Harmsen, H. J. M. (2017). The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut. Anaerobe, 44, 3-12. https://doi.org/10.1016/j.anaerobe.2017.01.001
  36. Mposhi, A., van der Wijst, M. G. P., Faber, K. N., & Rots, M. G. (2017). Regulation of mitochondrial gene expression, the epigenetic enigma. Frontiers in bioscience-Landmark, 22, 1099-1113. https://doi.org/10.2741/4535
  37. van den Berg, E. H., Amini, M., Dullaart, R. P. F., Faber, K. N., Alizadeh, B. Z., & Blokzijl, H. (2017). Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort. PLoS ONE, 12(2), [e0171502]. https://doi.org/10.1371/journal.pone.0171502
  38. van den Berg, E. H., van Tienhoven-Wind, L. J. N., Amini, M., Schreuder, T. C. M. A., Faber, K. N., Blokzijl, H., & Dullaart, R. P. F. (2017). Higher free triiodothyronine is associated with non-alcoholic fatty liver disease in euthyroid subjects: The Lifelines Cohort Study. Metabolism, 67, 62-71. https://doi.org/10.1016/j.metabol.2016.11.002
  39. Haanstra, J. R., Gerding, A., Dolga, A. M., Sorgdrager, F. J. H., Buist-Homan, M., du Toit, F., ... Bakker, B. M. (2017). Targeting pathogen metabolism without collateral damage to the host. Scientific Reports, 7, [40406]. https://doi.org/10.1038/srep40406
  40. Bai, X., Yang, P., Zhou, Q., Cai, B., Buist-Homan, M., Cheng, H., ... Shi, G. (2017). The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro. British Journal of Pharmacology, 174(1), 41-56. https://doi.org/10.1111/bph.13645
  41. Arabpour, M., Cool, R., Faber, K. N., Quax, W. J., & Haisma, H. J. (2017). Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells. Journal of Drug Targeting, 25(4), 360-369. https://doi.org/10.1080/1061186X.2016.1262867
  42. 2016
  43. Van Den Berg, E., van Tienhoven-Wind, L., Amini, M., Schreuder, T. C. M. A., Faber, K. N., Blokzijl, H., & Dullaart, R. P. F. (2016). Free triiodothyronine as determinant of non-alcoholic fatty liver disease in euthyroid subjects: The lifelines cohort study. Metabolism Clinical and Experimental.
  44. Gonzalez Ponce, H. A., Consolacion Martinez-Saldana, M., Rosa Rincon-Sanchez, A., Teresa Sumaya-Martinez, M., Buist-Homan, M., Faber, K. N., ... Jaramillo-Juarez, F. (2016). Hepatoprotective Effect of Opuntia robusta and Opuntia streptacantha Fruits against Acetaminophen-Induced Acute Liver Damage. Nutrients, 8(10), [607]. https://doi.org/10.3390/nu8100607
  45. Bai, X., Yang, P., Zhou, Q., Cai, B., Buist-Homan, M., Zheng, H., ... Moshage, H. (2016). The natural compound hesperetin protects against fulminant hepatitis in vivo and in vitro in mice. Hepatology, 63(1 SUPP), 318A-318A. [639].
  46. Gonzalez , H. A., Buist-Homan, M., Faber, K. N., & Moshage, H. (2016). Therapeutic effect of purple Cactus fruits against Acetaminophen-induced acute liver damage. Hepatology, 63(Supplement 1), 316A-317A.
  47. Van Den Berg, E. H., Amini, M., Schreuder, T. C. M. A., Dullaart, R. P. F., Faber, K. N., Alizadeh, B. Z., & Blokzijl, H. (2016). Prevalence of non-alcoholic fatty liver disease and fibrosis in a large population cohort in the north of the Netherlands: A lifelines cohort study. S481. https://doi.org/10.1016/S0168-8278(16)00818-7
  48. Regeling, A., Imhann, F., Volders, H. H., Blokzijl, T., Bloks, V. W., Weersma, R. K., ... Faber, K. N. (2016). HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL. Biochimica et biophysica acta-Molecular basis of disease, 1862(4), 788-796. https://doi.org/10.1016/j.bbadis.2016.01.020
  49. Visschedijk, M. C., Spekhorst, L. M., Dijkstra, G., van Loo, E. S., de Jong, D. J., Van Der Meulen, A., ... Festen, E. A. (2016). Identification of a Genetic Risk Variant in the WWOX Gene Associated With Recurrent Fibrostenotic Crohn's Disease. Gastroenterology, 150(4), S570-S570. https://doi.org/10.1093/ecco-jcc/jjw019.838
  50. Verhaag, E. M., Buist-Homan, M., Koehorst, M., Groen, A. K., Moshage, H., & Faber, K. N. (2016). Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity. PLoS ONE, 11(3), [e0149782]. https://doi.org/10.1371/journal.pone.0149782
  51. von Martels, J. Z. H., Sadaghian Sadabad, M., Van der Meer, R., Overbeeke, A. N. J., Blokzijl, T., Harmsen, H. J. M., ... Faber, K. N. (2016). Anti-inflammatory properties of Faecalibacterium prausnitzii in the absence and presence of cigarette smoke using a novel epithelium-gut microbe coculture system. Journal of Crohn's and Colitis, 10(Supplement 1), S488. [P746]. https://doi.org/10.1093/ecco-jcc/jjw019.865
  52. Klunder, L. J., Blokzijl, T., Ferreira, R., Faber, K. -N., Dijkstra, G., & van IJzendoorn, S. C. D. (2016). Cigarette smoke impairs intestinal epithelial cell polarity development and morphogenesis. Journal of Crohn's and Colitis, 10(Supplement 1), S113-S113. [P048]. https://doi.org/10.1093/ecco-jcc/jjw019.167
  53. 2015
  54. Sadaghian, M., von Martels, J. Z. H., Khan, M., Blokzijl, T., Paglia, G., Dijkstra, G., ... Faber, K. N. (2015). A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells. Scientific Reports, 5, [17906]. https://doi.org/10.1038/srep17906
  55. Shajari, S., Laliena, A., Heegsma, J., Jesus Tunon, M., Moshage, H., & Faber, K. N. (2015). Melatonin suppresses activation of hepatic stellate cells through ROR alpha-mediated inhibition of 5-lipoxygenase. Journal of Pineal Research, 59(3), 391-401. https://doi.org/10.1111/jpi.12271
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