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prof. dr. J.P. (John) LaCava

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  1. 2020
  2. Carter, V., LaCava, J., Taylor, M. S., Liang, S. Y., Mustelin, C., Ukadike, K. C., Bengtsson, A., Lood, C., & Mustelin, T. (2020). High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus. Arthritis & Rheumatology, 72(1), 89-99. https://doi.org/10.1002/art.41054
  3. LaCava, J., & Vaňáčová, Š. (Eds.) (2020). The Eukaryotic RNA Exosome: Methods and Protocols. (Methods in Molecular Biology ; Vol. 2062). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9822-7
  4. 2019
  5. Ardeljan, D., Wang, X., Oghbaie, M., Taylor, M. S., Husband, D., Deshpande, V., Steranka, J. P., Gorbounov, M., Yang, W. R., Sie, B., Larman, H. B., Jiang, H., Molloy, K. R., Altukhov, I., Li, Z., McKerrow, W., Fenyo, D., Burns, K. H., & LaCava, J. (2019). LINE-1 ORF2p expression is nearly imperceptible in human cancers. Mobile dna, 11(1), [1]. https://doi.org/10.1186/s13100-019-0191-2
  6. Winczura, K., Domanski, M., & LaCava, J. (2019). Affinity Proteomic Analysis of the Human Exosome and Its Cofactor Complexes. (Methods in Molecular Biology). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9822-7_15
  7. Oghbaie, M., v Sulc, P., Fenyö, D., Pennock, M., & LaCava, J. (2019). Complex+: Aided Decision-Making for the Study of Protein Complexes. bioRxiv. https://doi.org/10.1101/744656
  8. Jiang, H., Taylor, M. S., Molloy, K. R., Altukhov, I., & LaCava, J. (2019). Identification of RNase-sensitive LINE-1 Ribonucleoprotein Interactions by Differential Affinity Immobilization. Bio-Protocol, 9(7), [3200]. https://doi.org/10.21769/BioProtoc.3200
  9. LaCava, J. (2019). RNA Binding Proteins as Regulators of Retrotransposon-Induced Exonization. BioEssays, 41(2), [1800263]. https://doi.org/10.1002/bies.201800263
  10. Mustelin, T., Ukadike, K., LaCava, J., & Taylor, M. (2019). To the editor in reply to Dr. Crow's letter. Arthritis & Rheumatology, 72(2), 376-377. https://doi.org/10.1002/art.41104
  11. Ma, Y., Silveri, L., Lacava, J., Vassetzky, Y., & Dokudovskaya, S. (2019). Mtorc1 pathway in DNA damage response. Biopolymers and Cell, 35(3), 184. https://doi.org/10.7124/bc.0009BC
  12. 2018
  13. Pronier, E., Cifani, P., Merlinsky, T. R., Berman, K. B., Somasundara, A. V. H., Rampal, U. K., LaCava, J., Wei, K. E., Pastore, F., Maag, J. L., Park, J., Koche, R., Kentsis, A., & Levine, R. L. (2018). Targeting the CALR interactome in myeloproliferative neoplasms. JCI Insight, 3(22), [122703]. https://doi.org/10.1172/jci.insight.122703
  14. Zinoviev, A., Goyal, A., Jindal, S., LaCava, J., Komar, A. A., Rodnina, M. V., Hellen, C. U. T., & Pestova, T. V. (2018). Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2. Genes & Development, 32(17-18), 1226-1241. https://doi.org/10.1101/gad.314724.118
  15. Chan, H. L., Beckedorff, F., Zhang, Y., Garcia-Huidobro, J., Jiang, H., Colaprico, A., Bilbao, D., Figueroa, M. E., LaCava, J., Shiekhattar, R., & Morey, L. (2018). Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms. Nature Communications, 9, [3377]. https://doi.org/10.1038/s41467-018-05728-x
  16. Altukhov, I., Taylor, M. S., Molloy, K. R., Mita, P., Jiang, H., Adney, E. M., Wudzinska, A., Badri, S., Ischenko, D. S., Eng, G., Burns, K. H., Fenyo, D., Chait, B. T., Alexeev, D., Rout, M. P., Boeke, J. D., & LaCava, J. (2018). Proteomic analysis of affinity captured LINE-1 macromolecular complexes. 25. https://doi.org/10.18699/BGRSSB-2018-003
  17. Taylor, M. S., Altukhov, I., Molloy, K. R., Mita, P., Jiang, H., Andey, E. M., Wudzinska, A., Badri, S., Ishenko, D., Eng, G., Burns, K. H., Fenyo, D., Chait, B. T., Alexeev, D., Rout, M. P., Boeke, J. D., & LaCava, J. (2018). Dissection of affinity captured LINE-1 macromolecular complexes. eLife, 7, [30094]. https://doi.org/10.7554/eLife.30094
  18. Mita, P., Wudzinska, A., Sun, X., Andrade, J., Nayak, S., Kahler, D. J., Badri, S., LaCava, J., Ueberheide, B., Yun, C. Y., Fenyo, D., & Boeke, J. D. (2018). LINE-1 protein localization and functional dynamics during the cell cycle. eLife, 7, [30058]. https://doi.org/10.7554/eLife.30058
  19. Winczura, K., Schmid, M., Iasillo, C., Molloy, K. R., Harder, L. M., Andersen, J. S., LaCava, J., & Jensen, T. H. (2018). Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions. Cell reports, 22(1), 44-58. https://doi.org/10.1016/j.celrep.2017.12.037
  20. 2017
  21. Ma, Y., Silveri, L., LaCava, J., & Dokudovskaya, S. (2017). Tumor suppressor NPRL2 induces ROS production and DNA damage response. Scientific Reports, 7, [15311]. https://doi.org/10.1038/s41598-017-15497-0
  22. Santanach, A., Blanco, E., Jiang, H., Molloy, K. R., Sanso, M., LaCava, J., Morey, L., & Di Croce, L. (2017). The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity. Nature Communications, 8, [1235]. https://doi.org/10.1038/s41467-017-01464-w
  23. Domanski, M., & LaCava, J. (2017). Affinity Purification of the RNA Degradation Complex, the Exosome, from HEK-293 Cells. Bio-Protocol, 7(8). https://doi.org/10.21769/BioProtoc.2238
  24. Domanski, M., & LaCava, J. (2017). RNA Degradation Assay Using RNA Exosome Complexes, Affinity-purified from HEK-293 Cells. Bio-Protocol, 7(8), [2239]. https://doi.org/10.21769/BioProtoc.2239
  25. Molloy, K. R., Taylor, M. S., Altukhov, I., Mita, P., Jiang, H., Adney, E. M., Wudzinska, A., Ischenko, D., Burns, K. H., Fenyö, D., Chait, B. T., Alexeev, D., Rout, M. P., Boeke, J. D., & LaCava, J. (2017). Dissection of purified LINE-1 reveals distinct nuclear and cytoplasmic intermediates. bioRxiv. https://doi.org/10.1101/157818
  26. 2016
  27. LaCava, J., Jiang, H., & Rout, M. P. (2016). Protein Complex Affinity Capture from Cryomilled Mammalian Cells. Journal of Visualized Experiments, (118), [54518]. https://doi.org/10.3791/54518(2016)
  28. Domanski, M., Upla, P., Rice, W. J., Molloy, K. R., Ketaren, N. E., Stokes, D. L., Jensen, T. H., Rout, M. P., & Lacava, J. (2016). Purification and analysis of endogenous human RNA exosome complexes. RNA, 22(9), 1467-1475. https://doi.org/10.1261/rna.057760.116
  29. Fernandez-Martinez, J., LaCava, J., & Rout, M. P. (2016). Density Gradient Ultracentrifugation to Isolate Endogenous Protein Complexes after Affinity Capture. (7 ed.) (Cold Spring Harbor Protocols). https://doi.org/10.1101/pdb.prot087957
  30. LaCava, J., Fernandez-Martinez, J., & Rout, M. P. (2016). Native Elution of Yeast Protein Complexes Obtained by Affinity Capture. (7 ed.) (Cold Spring Harbor Protocols). https://doi.org/10.1101/pdb.prot087940
  31. LaCava, J., Fernandez-Martinez, J., Hakhverdyan, Z., & Rout, M. P. (2016). Optimized Affinity Capture of Yeast Protein Complexes. (7 ed.) (Cold Spring Harbor Protocols). https://doi.org/10.1101/pdb.prot087932
  32. LaCava, J., Fernandez-Martinez, J., Hakhverdyan, Z., & Rout, M. P. (2016). Protein complex purification by affinity capture. In Cold Spring Harbor Protocols: July (7 ed., Vol. 2016, pp. 601-605). (Cold Spring Harbor Protocols). https://doi.org/10.1101/pdb.top077545
  33. LaCava, J., Molloy, K. R., Fenyo, D., Taylor, M. S., Chait, B. T., Boeke, J. D., & Rout, M. P. (2016). Interactomic and Enzymatic Analyses of Distinct Affinity Isolated Human Retrotransposon Intermediates. FASEB Journal, 30(Supp. 1).
  34. Taylor, M. S., LaCava, J., Dai, L., Mita, P., Burns, K. H., Rout, M. P., & Boeke, J. D. (2016). Characterization of L1-Ribonucleoprotein Particles. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-3372-3_20
  35. 2015
  36. Oroskar, A. A., Oroskar, A. R., LaCava, J., & Rout, M. P. (2015). Apparatus and method for parallel collection and analysis of the proteome and complex compositions. (Patent No. USPTO 9084994 ). https://patents.google.com/patent/US20130065771?oq=lacava+apparatus+oroskar
  37. Hakhverdyan, Z., Domanski, M., Hough, L. E., Oroskar, A. A., Oroskar, A. R., Keegan, S., Dilworth, D. J., Molloy, K. R., Sherman, V., Aitchison, J. D., Fenyoe, D., Chait, B. T., Jensen, T. H., Rout, M. P., & LaCava, J. (2015). Rapid, optimized interactomic screening. Nature Methods, 12(6), 553-560. https://doi.org/10.1038/nmeth.3395
  38. LaCava, J., Molloy, K. R., Taylor, M. S., Domanski, M., Chait, B. T., & Rout, M. P. (2015). Affinity proteomics to study endogenous protein complexes: Pointers, pitfalls, preferences and perspectives. Biotechniques, 58(3), 103-119. https://doi.org/10.2144/000114262
  39. 2014
  40. Dai, L., LaCava, J., Taylor, M. S., & Boeke, J. D. (2014). Expression and detection of LINE-1 ORF-encoded proteins. Mobile genetic elements, 4(3), [e29319]. https://doi.org/10.4161/mge.29319
  41. 2013
  42. Andersen, P. R., Domanski, M., Kristiansen, M. S., Storvall, H., Ntini, E., Verheggen, C., Schein, A., Bunkenborg, J., Poser, I., Hallais, M., Sandberg, R., Hyman, A., LaCava, J., Rout, M. P., Andersen, J. S., Bertrand, E., & Jensen, T. H. (2013). The human cap-binding complex is functionally connected to the nuclear RNA exosome. Nature Structural & Molecular Biology, 20(12), 1367-1376. https://doi.org/10.1038/nsmb.2703
  43. Taylor, M. S., LaCava, J., Mita, P., Molloy, K. R., Huang, C. R. L., Li, D., Adney, E. M., Jiang, H., Burns, K. H., Chait, B. T., Rout, M. P., Boeke, J. D., & Dai, L. (2013). Affinity Proteomics Reveals Human Host Factors Implicated in Discrete Stages of LINE-1 Retrotransposition. Cell, 155(5), 1034-1048. https://doi.org/10.1016/j.cell.2013.10.021
  44. LaCava, J., Hakhverdyan, Z., Domanski, M., Akgol, B., Saleem, R., Aitchison, J. D., Chait, B. T., Jensen, T. H., Fenyo, D., & Rout, M. P. (2013). Complementary tools supporting comprehensive mapping of protein complexes via affinity capture/mass spectrometry. Febs Journal, 280, 484. https://doi.org/10.1111/febs.12340
  45. LaCava, J., Chandramouli, N., Jiang, H., & Rout, M. P. (Accepted/In press). Improved Native Isolation of Endogenous Protein A-Tagged Protein Complexes. Biotechniques, 54(4), 213-216. https://doi.org/10.2144/000114012
  46. 2012
  47. Domanski, M., Molloy, K., Jiang, H., Chait, B. T., Rout, M. P., Jensen, T. H., & LaCava, J. (2012). Improved methodology for the affinity isolation of human protein complexes expressed at near endogenous levels. Biotechniques, 0(0), 1-6. https://doi.org/10.2144/000113864
  48. LaCava, J., Hakhverdyan, Z., Fenyo, D., Domanski, M., Oroskar, A., Oroskar, A., Hough, L., Jensen, T. H., Chait, B. T., & Rout, M. P. (2012). High-Throughput, Single-Step Purification of Affinity-Tagged Protein Complexes. FASEB Journal, 26.
  49. 2006
  50. Houseley, J., LaCava, J., & Tollervey, D. (2006). RNA-quality control by the exosome. Nature Reviews Molecular Cell Biology, 7(7), 529-539. https://doi.org/10.1038/nrm1964
  51. 2005
  52. LaCava, J., Houseley, J., Saveanu, C., Petfalski, E., Thompson, E., Jacquier, A., & Tollervey, D. (2005). RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell, 121(5), 713-724. https://doi.org/10.1016/j.cell.2005.04.029
  53. 2004
  54. LaCava, J., Milligan, L., Torchet, C., Houseley, J., & Tollervey, D. (2004). Nuclear RNA turnover. European Journal of Biochemistry Supplement, 271. https://insights.ovid.com/european-biochemistry-supplement/ejbios/2004/02/711/nuclear-rna-turnover/146/01038983
  55. LaCava, J. (2004). Activation of the Yeast Exosome Complex. [S.n.].

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