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prof. dr. J.L. (Hans) Hillege

Cardiology

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  1. 2020
  2. Hagdorn, Q. A. J., Beurskens, N. E. G., Gorter, T. M., Eshuis, G., Hillege, H. L., Lui, G. K., Ceresnak, S. R., Chan, F. P., van Melle, J. P., Berger, R. M. F., & Willems, T. P. (2020). Sex differences in patients with repaired tetralogy of Fallot support a tailored approach for males and females: a cardiac magnetic resonance study. International Journal Of Cardiovascular Imaging, 36(10), 1997-2005. https://doi.org/10.1007/s10554-020-01900-x
  3. Haarman, M. G., Kerstjens-Frederikse, W. S., Vissia-Kazemier, T. R., Breeman, K. T. N., Timens, W., Vos, Y. J., Roofthooft, M. T. R., Hillege, H. L., & Berger, R. M. F. (2020). The Genetic Epidemiology of Pediatric Pulmonary Arterial Hypertension. The Journal of Pediatrics, 225, 65-+. https://doi.org/10.1016/j.jpeds.2020.05.051
  4. Bomer, N., Grote Beverborg, N., Hoes, M. F., Streng, K. W., Vermeer, M., Dokter, M. M., IJmker, J., Anker, S. D., Cleland, J. G. F., Hillege, H. L., Lang, C. C., Ng, L. L., Samani, N. J., Tromp, J., van Veldhuisen, D. J., Touw, D. J., Voors, A. A., & van der Meer, P. (2020). Selenium and outcome in heart failure. European Journal of Heart Failure, 22(8), 1415-1423. https://doi.org/10.1002/ejhf.1644
  5. Wolff, D., van Melle, J. P., Willems, T. P., Bartelds, B., Ploegstra, M-J., Hillege, H., Ebels, T., & Berger, R. M. F. (2020). N-terminal pro-brain natriuretic peptide serum levels reflect attrition of the Fontan circulation. Cardiology in the young, 30(6), 753-760. https://doi.org/10.1017/S1047951120000657
  6. Brankovic, M., Akkerhuis, K. M., Hoorn, E. J., van Boven, N., van den Berge, J. C., Constantinescu, A., Brugts, J., van Ramshorst, J., Germans, T., Hillege, H., Boersma, E., Umans, V., & Kardys, I. (2020). Renal tubular damage and worsening renal function in chronic heart failure: Clinical determinants and relation to prognosis (Bio-SHiFT study). Clinical Cardiology, 43(6), 630-638. https://doi.org/10.1002/clc.23359
  7. Meyer, S. L., Wolff, D., Ridderbos, F-J. S., Eshuis, G., Hillege, H., Willems, T. P., Ebels, T., van Melle, J. P., & Berger, R. M. F. (2020). GDF-15 (Growth Differentiation Factor 15) Is Associated With Hospitalization and Mortality in Patients With a Fontan Circulation. Journal of the American Heart Association, 9(10), e015521. [e015521]. https://doi.org/10.1161/JAHA.119.015521
  8. Sama, I. E., Woolley, R. J., Nauta, J. F., Romaine, S. P. R., Tromp, J., ter Maaten, J. M., van der Meer, P., Lam, C. S. P., Samani, N. J., Ng, L. L., Metra, M., Dickstein, K., Anker, S. D., Zannad, F., Lang, C. C., Cleland, J. G. F., van Veldhuisen, D. J., Hillege, H. L., & Voors, A. A. (2020). A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure. European Journal of Heart Failure, 22(5), 821-833. https://doi.org/10.1002/ejhf.1811
  9. Said, F., Haarman, M. G., Roofthooft, M. T. R., Hillege, H. L., Ploegstra, M-J., & Berger, R. M. F. (2020). Serial Measurements of N-Terminal Pro-B-Type Natriuretic Peptide Serum Level for Monitoring Pulmonary Arterial Hypertension in Children. The Journal of Pediatrics, 220, 139-145. https://doi.org/10.1016/j.jpeds.2020.01.001
  10. Tromp, J., Voors, A. A., Sharma, A., Ferreira, J. P., Ouwerkerk, W., Hillege, H. L., Gomez, K. A., Dickstein, K., Anker, S. D., Metra, M., Lang, C. C., Ng, L. L., van der Harst, P., van Veldhuisen, D. J., van Der Meer, P., Lam, C. S. P., Zannad, F., & Sama, I. E. (2020). Distinct Pathological Pathways in Patients With Heart Failure and Diabetes. JACC. Heart failure, 8(3), 234-242. https://doi.org/10.1016/j.jchf.2019.11.005
  11. ter Maaten, J. M., Martens, P., Damman, K., Dickstein, K., Ponikowski, P., Lang, C. C., Ng, L. L., Anker, S. D., Samani, N. J., Filippatos, G., Cleland, J. G., Zannad, F., Hillege, H. L., van Veldhuisen, D. J., Metra, M., Voors, A. A., & Mullens, W. (2020). Higher doses of loop diuretics limit uptitration of angiotensin-converting enzyme inhibitors in patients with heart failure and reduced ejection fraction. Clinical Research in Cardiology, (8), 1048-1059. https://doi.org/10.1007/s00392-020-01598-w
  12. van der Plas, R. M., Hoefnagel, M. H. N., Hillege, H. L., & Roes, K. C. B. (2020). Pragmatic rules for comparability of biological medicinal products. Biologicals, 63, 97-100. https://doi.org/10.1016/j.biologicals.2019.11.002
  13. 2019
  14. Hoes, M. F., Tromp, J., Ouwerkerk, W., Bomer, N., Oberdorf-Maass, S. U., Samani, N. J., Ng, L. L., Lang, C. C., van der Harst, P., Hillege, H., Anker, S. D., Metra, M., van Veldhuisen, D. J., Voors, A. A., & van der Meer, P. (2019). The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.1674
  15. Whitty, J. A., de Bekker-Grob, E. W., Cook, N. S., Terris-Prestholt, F., Drummond, M., Falchetto, R., & Hillege, H. L. (2019). Patient Preferences in the Medical Product Lifecycle. Patient-Patient: centered outcomes research. https://doi.org/10.1007/s40271-019-00400-y
  16. Haarman, M. G., Douwes, J. M., Ploegstra, M-J., Roofthooft, M. T. R., Vissia-Kazemier, T. R., Hillege, H. L., & Berger, R. M. F. (2019). The Clinical Value of Proposed Risk Stratification Tools in Pediatric Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 200(10), 1312-1315. https://doi.org/10.1164/rccm.201902-0266LE
  17. van den Berg, M. E., Rijnbeek, P. R., Niemeijer, M. N., Hofman, A., van Herpen, G., Bots, M. L., Hillege, H., Swenne, C. A., Eijgelsheim, M., Stricker, B. H., & Kors, J. A. (2019). Corrigendum: Normal Values of Corrected Heart-Rate Variability in 10-Second Electrocardiograms for All Ages. Frontiers in Physiology, 10, [1373]. https://doi.org/10.3389/fphys.2019.01373
  18. ASIAN-HF Investigators, Santema, B. T., Ouwerkerk, W., Tromp, J., Sama, I. E., Ravera, A., Regitz-Zagrosek, V., Hillege, H., Samani, N. J., Zannad, F., Dickstein, K., Lang, C. C., Cleland, J. G., Ter Maaten, J. M., Metra, M., Anker, S. D., van der Harst, P., Ng, L. L., van der Meer, P., ... Voors, A. A. (2019). Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study. The Lancet, 394(10205), 1254-1263. https://doi.org/10.1016/S0140-6736(19)31792-1
  19. van den Berg, M. E., Kors, J. A., van Herpen, G., Bots, M. L., Hillege, H., Swenne, C. A., Stricker, B. H., & Rijnbeek, P. R. (2019). Normal Values of QT Variability in 10-s Electrocardiograms for all Ages. Frontiers in Physiology, 10, [1272]. https://doi.org/10.3389/fphys.2019.01272
  20. Roldan, S., Postmus, D., De Vries, S., Mol, P., & Hillege, H. (2019). Patient-, disease- and treatment related factors that impact values attached to drug effects: A preferences study among patients with type 2 diabetes. Pharmacoepidemiology and Drug Safety, 28, 220.
  21. Abbasi, A., Corpeleijn, E., Meijer, E., Postmus, D., Gansevoort, R. T., Gans, R. O. B., Struck, J., Hillege, H. L., Stolk, R. P., Navis, G., & Bakker, S. J. L. (2019). Sex differences in the association between plasma copeptin and incident type 2 diabetes: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study (vol 59, pg 1963, 2012). Diabetologia, 62(8), 1518-1519. https://doi.org/10.1007/s00125-019-4917-y
  22. Markousis-Mavrogenis, G., Tromp, J., Ouwerkerk, W., Devalaraja, M., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., van der Harst, P., Lang, C. C., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., Zannad, F., Zwinderman, A. H., Hillege, H. L., van Veldhuisen, D. J., Kakkar, R., ... van der Meer, P. (2019). The clinical significance of interleukin-6 in heart failure: results from the BIOSTAT-CHF study. European Journal of Heart Failure, 21(8), 965-973. https://doi.org/10.1002/ejhf.1482
  23. Suzuki, T., Yazaki, Y., Voors, A. A., Jones, D. J. L., Chan, D. C. S., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Hillege, H. L., Lang, C. C., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Zwinderman, A. H., Metra, M., & Ng, L. L. (2019). Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure: results from BIOSTAT-CHF. European Journal of Heart Failure, 21(7), 877-886. https://doi.org/10.1002/ejhf.1338
  24. Mordi, I. R., Santema, B. T., Kloosterman, M., Choy, A-M., Rienstra, M., van Gelder, I., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., van der Harst, P., Hillege, H. L., Metra, M., Ng, L. L., Ouwerkerk, W., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., ... Lang, C. C. (2019). Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation. Clinical Research in Cardiology, 108(7), 797-805. https://doi.org/10.1007/s00392-018-1409-x
  25. Tromp, J. J., Voors, A. A., Sharma, A., Ferreira, J. P., Ouwerkerk, W., Hillege, H. L., Van der Harst, P., Van Veldhuisen, D. J., Van der Meer, P., & Sama, I. (2019). Diabetes is associated with unique pathological mechanisms in heart failure. European Journal of Heart Failure, 21, 432.
  26. Markousis-Mavrogenis, G., Tromp, J., Ouwerkerk, W., Devalaraja, M., Filippatos, G., Van Der Harst, P., Hillege, H. L., Van Veldhuisen, D. J., Kakkar, R., Voors, A. A., & Van Der Meer, P. (2019). The clinical significance of interleukin-6 in heart failure: results from the BIOSTAT-CHF study. European Journal of Heart Failure, 21, 111.
  27. Makady, A., van Acker, S., Nijmeijer, H., de Boer, A., Hillege, H., Klungel, O., & Goettsch, W. (2019). Conditional Financing of Drugs in the Netherlands: Past, Present, and Future-Results From Stakeholder Interviews. Value in Health, 22(4), 399-407. https://doi.org/10.1016/j.jval.2018.11.016
  28. Gruppen, E., Kunutsor, S., Kieneker, L., van der Vegt, B., Connelly, M., Hillege, H., Bakker, S., & Dullaart, R. (2019). GlycA, a novel pro-inflammatory glycoprotein biomarker predicts mortality: Results from The PREVEND study and meta-analysis. European Journal of Clinical Investigation, 49, 74-75.
  29. Cao, Q., Buskens, E., Hillege, H. L., Jaarsma, T., Postma, M., & Postmus, D. (2019). Stratified treatment recommendation or one-size-fits-all? A health economic insight based on graphical exploration. European Journal of Health Economics, 20(3), 475-482. https://doi.org/10.1007/s10198-018-1013-z
  30. RACE 3 Investigators (2019). Targeted therapy of underlying conditions improves quality of life in patients with persistent atrial fibrillation: results of the RACE 3 study. Europace, 21(4), 563-571. https://doi.org/10.1093/europace/euy311
  31. Makady, A., van Veelen, A., de Boer, A., Hillege, H., Klungel, O. H., & Goettsch, W. (2019). Implementing managed entry agreements in practice: The Dutch reality check. Health Policy, 123(3), 267-274. https://doi.org/10.1016/j.healthpol.2018.09.016
  32. Emerging Risk Factors Collaboratio (2019). Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. European Heart Journal, 40(7), 621-631. https://doi.org/10.1093/eurheartj/ehy653
  33. Ferreira, J. P., Metra, M., Mordi, I., Gregson, J., ter Maaten, J. M., Tromp, J., Anker, S. D., Dickstein, K., Hillege, H. L., Ng, L. L., van Veldhuisen, D. J., Lang, C. C., Voors, A. A., & Zannad, F. (2019). Heart failure in the outpatient versus inpatient setting: Findings from the BIOSTAT-CHF study. European Journal of Heart Failure, 21(1), 112-120. https://doi.org/10.1002/ejhf.1323
  34. 2018
  35. Tromp, J., Ouwerkerk, W., Demissei, B. G., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., van der Harst, P., Hillege, H. L., Lang, C. C., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Zwinderman, A. H., Voors, A. A., & van der Meer, P. (2018). Novel endotypes in heart failure: effects on guideline-directed medical therapy. European Heart Journal, 39(48), 4269-4276. https://doi.org/10.1093/eurheartj/ehy712
  36. Kraai, I. H., Vermeulen, K. M., Hillege, H. L., Jaarsma, T., & Hoekstra, T. (2018). Optimism and quality of life in patients with heart failure. Palliative & supportive care, 16(6), 725-731. https://doi.org/10.1017/S1478951517001055
  37. GetReal Workpackage 1 (2018). Social media as a tool for assessing patient perspectives on quality of life in metastatic melanoma: A feasibility study. HEALTH AND QUALITY OF LIFE OUTCOMES, 16, [222]. https://doi.org/10.1186/s12955-018-1047-z
  38. Streng, K. W., Nauta, J. F., Hillege, H. L., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Lang, C. C., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Zannad, F., Damman, K., van der Meer, P., & Voors, A. A. (2018). Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction. International Journal of Cardiology, 271, 132-139. https://doi.org/10.1016/j.ijcard.2018.04.001
  39. Santema, B. T., Kloosterman, M., Van Gelder, I. C., Mordi, I., Lang, C. C., Lam, C. S. P., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Van der Harst, P., Hillege, H. L., Ter Maaten, J. M., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., Van Veldhuisen, D. J., Zwinderman, A. H., ... Voors, A. A. (2018). Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction. European Heart Journal, 39(43), 3867-3875. https://doi.org/10.1093/eurheartj/ehy421
  40. Thong Huy Cao, Jones, D. J. L., Quinn, P. A., Chan, D. C. S., Hafid, N., Parry, H. M., Mohan, M., Sandhu, J. K., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Hillege, H. L., Metra, M., Ponikowski, P., Samani, N. J., Van Veldhuisen, D. J., Zannad, F., Zwinderman, A. H., ... Ng, L. L. (2018). Using matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling in order to predict clinical outcomes of patients with heart failure. Clinical proteomics, 15, [35]. https://doi.org/10.1186/s12014-018-9213-1
  41. Linssen, G. C. M., Jaarsma, T., Hillege, H. L., Voors, A. A., & van Veldhuisen, D. J. (2018). A comparison of the prognostic value of BNP versus NT-proBNP after hospitalisation for heart failure. Netherlands Heart Hournal, 26(10), 486-492. https://doi.org/10.1007/s12471-018-1145-x
  42. Tromp, J., Westenbrink, B. D., Ouwerkerk, W., van Veldhuisen, D. J., Samani, N. J., Ponikowski, P., Metra, M., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., van der Harst, P., Lang, C. C., Ng, L. L., Zannad, F., Zwinderman, A. H., Hillege, H. L., van der Meer, P., & Voors, A. A. (2018). Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction. Journal of the American College of Cardiology, 72(10), 1081-1090. https://doi.org/10.1016/j.jacc.2018.06.050
  43. Streng, K. W., Voors, A. A., Hillege, H. L., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Zannad, F., Damman, K., van der Meer, P., & Lang, C. C. (2018). Waist-to-hip ratio and mortality in heart failure. European Journal of Heart Failure, 20(9), 1269-1277. https://doi.org/10.1002/ejhf.1244
  44. Rienstra, M., Hobbelt, A. H., Alings, M., Tijssen, J. G. P., Smit, M. D., Brügemann, J., Geelhoed, B., Tieleman, R. G., Hillege, H. L., Tukkie, R., Van Veldhuisen, D. J., Crijns, H. J. G. M., Van Gelder, I. C., & RACE 3 Investigators (2018). Targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent atrial fibrillation: Results of the RACE 3 trial. European Heart Journal, 39(32), 2987-2996. https://doi.org/10.1093/eurheartj/ehx739
  45. Ataher, Q. S., Postmus, D., Hillege, H. L., & Tervonen, T. (2018). Quantitative benefit-risk assessment: Hands-on workshop. Pharmacoepidemiology and Drug Safety, 27, 360.
  46. Savji, N., Meijers, W. C., Bartz, T. M., Bhambhani, V., Cushman, M., Nayor, M., Kizer, J. R., Sarma, A., Blaha, M. J., Gansevoort, R. T., Gardin, J. M., Hillege, H. L., Ji, F., Kop, W. J., Lau, E. S., Lee, D. S., Sadreyev, R., van Gilst, W. H., Wang, T. J., ... Ho, J. E. (2018). The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF. JACC. Heart failure, 6(8), 701-709. https://doi.org/10.1016/j.jchf.2018.05.018
  47. Lycholip, E., Aamodt, I. T., Lie, I., Simbelyte, T., Puronaite, R., Hillege, H., de Vries, A., Kraai, I., Stromberg, A., Jaarsma, T., & Celutkiene, J. (2018). The dynamics of self-care in the course of heart failure management: Data from the IN TOUCH study. Patient Preference and Adherence, 12, 1113-1122. https://doi.org/10.2147/PPA.S162219
  48. Juárez-Orozco, L. E., Alexanderson, E., Dierckx, R. A., Boersma, H. H., Hillege, J. L., Zeebregts, C. J., Martínez-Aguilar, M. M., Jordán-Ríos, A., Ayala-German, A. G., Prakken, N., Tio, R. A., & Slart, R. H. (2018). Stress myocardial blood flow correlates with ventricular function and synchrony better than myocardial perfusion reserve: A Nitrogen-13 ammonia PET study. Journal of Nuclear Cardiology, 25(3), 797-806. https://doi.org/10.1007/s12350-016-0669-y
  49. Arjaans, S., Zwart, E. A. H., Ploegstra, M-J., Bos, A. F., Kooi, E. M. W., Hillege, H. L., & Berger, R. M. F. (2018). Identification of gaps in the current knowledge on pulmonary hypertension in extremely preterm infants: A systematic review and meta-analysis. Paediatric and Perinatal Epidemiology, 32(3), 258-267. https://doi.org/10.1111/ppe.12444
  50. Beusekamp, J. C., Tromp, J., van der Wal, H. H., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., van der Harst, P., Hillege, H. L., Lang, C. C., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Rossignol, P., Zannad, F., Voors, A. A., & van der Meer, P. (2018). Potassium and the use of renin-angiotensin-aldosterone system inhibitors in heart failure with reduced ejection fraction: data from BIOSTAT-CHF. European Journal of Heart Failure, 20(5), 923-930. https://doi.org/10.1002/ejhf.1079
  51. van den Berg, M. E., Rijnbeek, P. R., Niemeijer, M. N., Hofman, A., van Herpen, G., Bots, M. L., Hillege, H., Swenne, C. A., Eijgelsheim, M., Stricker, B. H., & Kors, J. A. (2018). Normal Values of Corrected Heart-Rate Variability in 10-Second Electrocardiograms for All Ages. Frontiers in Physiology, 9, [424]. https://doi.org/10.3389/fphys.2018.00424
  52. Ferreira, J. P., Rossignol, P., Demissei, B., Sharma, A., Girerd, N., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Hillege, H. L., Lang, C. C., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Voors, A., & Zannad, F. (2018). Coronary angiography in worsening heart failure: Determinants, findings and prognostic implications. Heart, 104(7), 606-613. https://doi.org/10.1136/heartjnl-2017-311750
  53. Brankovic, M., Akkerhuis, K. M., van Boven, N., Anroedh, S., Constantinescu, A., Caliskan, K., Manintveld, O., Cornel, J. H., Baart, S., Rizopoulos, D., Hillege, H., Boersma, E., Umans, V., & Kardys, I. (2018). Patient-specific evolution of renal function in chronic heart failure patients dynamically predicts clinical outcome in the Bio-SHiFT study. Kidney International, 93(4), 952-960. https://doi.org/10.1016/j.kint.2017.09.013
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