J.A. (Alberto) Nakauma Gonzalez, MSc

PhD student

Research

Research units:

Research interests

 

Evolution of the Bacterial Chemotaxis Network

Motile bacteria are able to direct their movement according to chemical gradients in the surrounding environment. The signal-transduction network responsible for this behaviour is well characterized, but few studies have examined its evolutionary dynamics using simple fitness functions. We examine this process and the emerging phenotypic properties. The analysis is built on a biochemical-mathematical model of the chemotaxis network in Escherichia coli that is embedded in a simulation of spatial movement. Based on the chemotaxis performance (accumulation rate of resources), we reconstruct the fitness landscape with thousands of potential genotypes. The project is initially concentrated on the analysis of adaptive walks through directed evolution. Then, we analyze the genotype-phenotype complex interaction and the topology of the fitness landscape.

Publications
  1. The evolution of the bacterial chemotaxis network

    Nakauma Gonzalez, J. A., 2019, [Groningen]: University of Groningen. 199 p.

    Research output: ThesisThesis fully internal (DIV)Academic

  2. Reconstructing the genotype-to-fitness map for the bacterial chemotaxis network and its emergent behavioural phenotypes

    Nakauma Gonzalez, A. & van Doorn, G. S., 7-May-2017, In : Journal of Theoretical Biology. 420, p. 200-212 13 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Biogas Production and Cleanup by Biofiltration for a Potential Use as an Alternative Energy Source

    Ines, E., Nakauma-Gonzalez, A. & Zarate-segur, P., 14-Mar-2012, Biogas. Kumar, S. (ed.). InTech, Chapter 6

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

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Activities
  1. 16th Society for Molecular Biology and Evolution Annual meeting

    Sander van Doorn (Speaker), Alberto Nakauma Gonzalez (Speaker)
    Jul-2015

    Activity: Talk or presentationProfessional

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