prof. dr. J.A. (Jan Albert) Kuivenhoven

Associate Professor and Principal Investigator

No picture available
E-mail:
j.a.kuivenhoven umcg.nl

Research

  1. 2020
  2. Norum, K. R., Remaley, A. T., Miettinen, H. E., Strom, E. H., Balbo, B. E. P., Sampaio, C. A. T. L., Wiig, I., Kuivenhoven, J. A., Calabresi, L., Tesmer, J. J., Zhou, M., Ng, D. S., Skeie, B., Karathanasis, S. K., Manthei, K. A., & Retterstol, K. (2020). Lecithin:cholesterol acyltransferase: symposium on 50 years of biomedical research from its discovery to latest findings. Journal of Lipid Research, 61(8), 1142-1149. https://doi.org/10.1194/jlr.S120000720
  3. van den Boogert, M. A. W., Crunelle, C. L., Ali, L., Larsen, L. E., Kuil, S. D., Levels, J. H. M., Schimmel, A. W. M., Konstantopoulou, V., Guerin, M., Kuivenhoven, J. A., Dallinga-Thie, G. M., Stroes, E. S. G., Lefeber, D. J., & Holleboom, A. G. (2020). Reduced CETP glycosylation and activity in patients with homozygous B4GALT1 mutations. Journal of Inherited Metabolic Disease, 43(3), 611-617. https://doi.org/10.1002/jimd.12200
  4. 2019
  5. van den Boogert, M. A. W., Larsen, L. E., Ali, L., Kuil, S. D., Chong, P. L. W., Loregger, A., Kroon, J., Schnitzler, J. G., Schimmel, A. W. M., Peter, J., Levels, J. H. M., Steenbergen, G., Morava, E., Dallinga-Thie, G. M., Wevers, R. A., Kuivenhoven, J. A., Hand, N. J., Zelcer, N., Rader, D. J., ... Holleboom, A. G. (2019). N-Glycosylation Defects in Humans Lower Low-Density Lipoprotein Cholesterol Through Increased Low-Density Lipoprotein Receptor Expression. Circulation, 140(4), 280-292. https://doi.org/10.1161/CIRCULATIONAHA.118.036484
  6. Seijkens, T. T. P., Poels, K., Meiler, S., van Tiel, C. M., Kusters, P. J. H., Reiche, M., Atzler, D., Winkels, H., Tjwa, M., Poelman, H., Slutter, B., Kuiper, J., Gijbels, M., Kuivenhoven, J. A., Matic, L. P., Paulsson-Berne, G., Hedin, U., Hansson, G. K., Nicolaes, G. A. F., ... Lutgens, E. (2019). Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8(+) T cell-mediated macrophage death. European Heart Journal, 40(4), 372-382. https://doi.org/10.1093/eurheartj/ehy714
  7. 2018
  8. Oldoni, F., Baldassarre, D., Castelnuovo, S., Ossoli, A., Amato, M., van Capelleveen, J., Hovingh, G. K., De Groot, E., Bochem, A., Simonelli, S., Barbieri, S., Veglia, F., Franceschini, G., Kuivenhoven, J. A., Holleboom, A. G., & Calabresi, L. (2018). Complete and Partial Lecithin: Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis. Circulation, 138(10), 1000-1007. https://doi.org/10.1161/CIRCULATIONAHA.118.034706
  9. Rozendaal, Y. J. W., Wang, Y., Paalvast, Y., Tambyrajah, L. L., Li, Z., Willems van Dijk, K., Rensen, P. C. N., Kuivenhoven, J. A., Groen, A. K., Hilbers, P. A. J., & van Riel, N. A. W. (2018). In vivo and in silico dynamics of the development of Metabolic Syndrome. PLoS Computational Biology, 14(6), [e1006145]. https://doi.org/10.1371/journal.pcbi.1006145
  10. 2017
  11. 2016
  12. Oldoni, F., van Capelleveen, J., Motazacker, M. M., Heeren, J., Sinke, R., Dallinga-Thie, G., Hui, D., Hovingh, K., & Kuivenhoven, J. A. (2016). Regulation of HDL-C levels via ABCA1: A role for LRP1. ATHEROSCLEROSIS, 252, E264-E264. https://doi.org/10.1016/j.atherosclerosis.2016.07.101
  13. Motazacker, M. M., Pirhonen, J., van Capelleveen, J. C., Weber-Boyvat, M., Kuivenhoven, J. A., Shah, S., Hovingh, G. K., Metso, J., Li, S., Ikonen, E., Jauhiainen, M., Dallinga-Thie, G. M., & Olkkonen, V. M. (2016). A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity. ATHEROSCLEROSIS, 249, 140-147. https://doi.org/10.1016/j.atherosclerosis.2016.04.005
  14. Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., van der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J., ... van de Sluis , B. (2016). CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nature Communications, 7, [10961]. https://doi.org/10.1038/ncomms10961
  15. 2015
  16. Ljunggren, S. A., Levels, J. H. M., Hovingh, K., Holleboom, A. G., Vergeer, M., Argyri, L., Gkolfinopoulou, C., Chroni, A., Sierts, J. A., Kastelein, J. J., Kuivenhoven, J. A., Lindahl, M., & Karlsson, H. (2015). Lipoprotein profiles in human heterozygote carriers of a functional mutation P297S in scavenger receptor class B1. Biochimica et biophysica acta-Molecular and cell biology of lipids, 1851(12), 1587-1595. https://doi.org/10.1016/j.bbalip.2015.09.006
  17. Wiegman, A., Gidding, S. S., Watts, G. F., Chapman, M. J., Ginsberg, H. N., Cuchel, M., Ose, L., Averna, M., Boileau, C., Boren, J., Bruckert, E., Catapano, A. L., Defesche, J. C., Descamps, O. S., Hegele, R. A., Hovingh, G. K., Humphries, S. E., Kovanen, P. T., Kuivenhoven, J. A., ... European Atherosclerosis Soc Conse (2015). Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. European Heart Journal, 36(36), 2425-2437. https://doi.org/10.1093/eurheartj/ehv157
  18. 2014
  19. Bartuzi, P., Wijshake, T., Dekker, D. C., Fedoseienko, A., Kloosterhuis, N. J., Youssef, S. A., Li, H., Shiri-Sverdlov, R., Kuivenhoven, J-A., de Bruin, A., Burstein, E., Hofker, M. H., & van de Sluis, B. (2014). A cell-type-specific role for murine Commd1 in liver inflammation. Biochimica et biophysica acta-Molecular basis of disease, 1842(11), 2257-2265. https://doi.org/10.1016/j.bbadis.2014.06.035
  20. Cuchel, M., Bruckert, E., Ginsberg, H. N., Raal, F. J., Santos, R. D., Hegele, R. A., Kuivenhoven, J. A., Nordestgaard, B. G., Descamps, O. S., Steinhagen-Thiessen, E., Tybjærg-Hansen, A., Watts, G. F., Averna, M., Boileau, C., Borén, J., Catapano, A. L., Defesche, J. C., Hovingh, G. K., Humphries, S. E., ... European Atherosclerosis Society Consensus Panel on Familial Hypercholesterolaemia (2014). Homozygous familial hypercholesterolaemia: New insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. European Heart Journal, 35(32), 2146-2157b. https://doi.org/10.1093/eurheartj/ehu274
  21. Hegele, R. A., Ginsberg, H. N., Chapman, M. J., Nordestgaard, B. G., Kuivenhoven, J. A., Averna, M., Boren, J., Bruckert, E., Catapano, A. L., Descamps, O. S., Hovingh, G. K., Humphries, S. E., Kovanen, P. T., Masana, L., Pajukanta, P., Parhofer, K. G., Raal, F. J., Ray, K. K., Santos, R. D., ... European Atherosclerosis Soc Conse (2014). The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes & Endocrinology, 2(8), 655-666. https://doi.org/10.1016/S2213-8587(13)70191-8
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