Wlodarczyk, A., Khorooshi, R., Marczynska, J., Holtman, I. R., Burton, M., Jensen, K. N., Blaabjerg, M., Meyer, M., Thomassen, M., Eggen, B. J. L., Asgari, N., & Owens, T. (2020). Type I interferon-activated microglia are critical for neuromyelitis optica pathology. Glia, 1-11. https://doi.org/10.1002/glia.23938

Nott, A., Holtman, I. R., Coufal, N. G., Schlachetzki, J. C. M., Yu, M., Hu, R., Han, C. Z., Pena, M., Xiao, J., Wu, Y., Keulen, Z., Pasillas, M. P., O'Connor, C., Nickl, C. K., Schafer, S. T., Shen, Z., Rissman, R. A., Brewer, J. B., Gosselin, D., ... Glass, C. K. (2019). Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science, 366(6469), 1134-1139. https://doi.org/10.1126/science.aay0793

Link, V. M., Duttke, S. H., Chun, H. B., Holtman, I. R., Westin, E., Hoeksema, M. A., Abe, Y., Skola, D., Romanoski, C. E., Tao, J., Fonseca, G. J., Troutman, T. D., Spann, N. J., Strid, T., Sakai, M., Yu, M., Hu, R., Fang, R., Metzler, D., ... Glass, C. K. (2018). Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function. Cell, 173(7), 1796-1809.e17. https://doi.org/10.1016/j.cell.2018.04.018

Wlodarczyk, A., Holtman, I. R., Krueger, M., Yogev, N., Bruttger, J., Khorooshi, R., Benmamar-Badel, A., de Boer-Bergsma, J. J., Martin, N. A., Karram, K., Kramer, I., Boddeke, E. W. G. M., Waisman, A., Eggen, B. J. L., & Owens, T. (2017). A novel microglial subset plays a key role in myelinogenesis in developing brain. The EMBO Journal, 36(22), 3292-3308. https://doi.org/10.15252/embj.201696056

Holtman, I. R., Skola, D., & Glass, C. K. (2017). Transcriptional control of microglia phenotypes in health and disease. CLIN Journal, 127(9), 3220-3229. https://doi.org/10.1172/JCI90604

Galatro, T. F., Holtman, I. R., Lerario, A. M., Vainchtein, I. D., Brouwer, N., Sola, P. R., Veras, M. M., Pereira, T. F., Leite, R. E. P., Möller, T., Wes, P. D., Sogayar, M. C., Laman, J. D., den Dunnen, W., Pasqualucci, C. A., Oba-Shinjo, S. M., Boddeke, E. W. G. M., Marie, S. K. N., & Eggen, B. J. L. (2017). Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. Nature neuroscience, 20(8), 1162-1171. https://doi.org/10.1038/nn.4597

Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., Hol, E. M., Kamphuis, W., Bayer, T. A., De Deyn, P. P., & Boddeke, E. (2017). Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease. Neurobiology of Aging, 55, 115-122. https://doi.org/10.1016/j.neurobiolaging.2017.03.021

Raj, D., Yin, Z., Breur, M., Doorduin, J., Holtman, I. R., Olah, M., Mantingh-Otter, I. J., Van Dam, D., De Deyn, P. P., den Dunnen, W., Eggen, B. J. L., Amor, S., & Boddeke, E. (2017). Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain. Frontiers in Molecular Neuroscience, 10, [206]. https://doi.org/10.3389/fnmol.2017.00206

Gosselin, D., Skola, D., Coufal, N. G., Holtman, I. R., Schlachetzki, J. C. M., Sajti, E., Jaeger, B. N., O'Connor, C., Fitzpatrick, C., Pasillas, M. P., Pena, M., Adair, A., Gonda, D. D., Levy, M. L., Ransohoff, R. M., Gage, F. H., & Glass, C. K. (2017). An environment-dependent transcriptional network specifies human microglia identity. Science, 356(6344), 1248-+. https://doi.org/10.1126/science.aal3222

Raj, D., Yin, Z., Breur, M., Doorduin, J., Holtman, I., Olah, M., Otter, I. M., van Dam, D., de Deyn, P., Den Dunnen, W., Eggen, B., Amor, S., & Boddeke, E. (2017). Increased white matter inflammation in aging- and Alzheimer's disease brain. Frontiers in Molecular Neuroscience, 10, [206]. https://doi.org/10.3389/fnmol.2017.00206

Holtman, I. R., Bsibsi, M., Gerritsen, W. H., Boddeke, H. W. G. M., Eggen, B. J. L., van der Valk, P., Kipp, M., van Noort, J. M., & Amor, S. (2017). Identification of Highly Connected Hub Genes in the Protective Response Program of Human Macrophages and Microglia Activated by Alpha B-Crystallin. Glia, 65(3), 460-473. https://doi.org/10.1002/glia.23104

Janssen, L., Dubbelaar, M. L., Holtman, I. R., de Boer-Bergsma, J., Eggen, B. J. L., Boddeke, H. W. G. M., De Deyn, P. P., & Dam, van, D. (2017). Aging, microglia and cytoskeletal regulation are key factors in the pathological evolution of the APP23 mouse model for Alzheimer's disease. Biochimica et biophysica acta-Molecular basis of disease, 1863(2), 395-405. https://doi.org/10.1016/j.bbadis.2016.11.014

Oosterhof, N., Holtman, I. R., Kuil, L. E., van der Linde, H. C., Boddeke, E. W. G. M., Eggen, B. J. L., & van Ham, T. J. (2017). Identification of a Conserved and Acute Neurodegeneration-Specific Microglial Transcriptome in the Zebrafish. Glia, 65(1), 138-149. https://doi.org/10.1002/glia.23083

Scheffold, A., Holtman, I. R., Dieni, S., Brouwer, N., Katz, S-F., Jebaraj, B. M. C., Kahle, P. J., Hengerer, B., Lechel, A., Stilgenbauer, S., Boddeke, E. W. G. M., Eggen, B. J. L., Rudolph, K-L., & Biber, K. (2016). Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model. Acta neuropathologica communications, 4(87), [87]. https://doi.org/10.1186/s40478-016-0364-x

Jagessar, S. A., Holtman, I. R., Hofman, S., Morandi, E., Heijmans, N., Laman, J. D., Gran, B., Faber, B. W., van Kasteren, S. I., Eggen, B. J. L., & 't Hart, B. A. (2016). Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein. Journal of Immunology, 197(4), 1074-1088. https://doi.org/10.4049/jimmunol.1600124

Janova, H., Boettcher, C., Holtman, I. R., Regen, T., van Rossum, D., Goetz, A., Ernst, A-S., Fritsche, C., Gertig, U., Saiepour, N., Gronke, K., Wrzos, C., Ribes, S., Rolfes, S., Weinstein, J., Ehrenreich, H., Pukrop, T., Kopatz, J., Stadelmann, C., ... Hanisch, U-K. (2016). CD14 is a key organizer of microglial responses to CNS infection and injury. Glia, 64(4), 635-649. https://doi.org/10.1002/glia.22955

Raj, D. D. A., Moser, J., van der Pol, S. M. A., van Os, R. P., Holtman, I. R., Brouwer, N., Oeseburg, H., Schaafsma, W., Wesseling, E. M., Dunnen, den, W., Biber, K. P. H., de Vries, H. E., Eggen, B. J. L., & Boddeke, H. W. G. M. (2015). Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening. Aging Cell, 14(6), 1003-1013. https://doi.org/10.1111/acel.12370

Holtman, I. R., Noback, M., Bijlsma, M., Duong, K. N., van der Geest, M. A., Ketelaars, P. T., Brouwer, N., Vainchtein, I. D., Eggen, B. J. L., & Boddeke, H. W. G. M. (2015). Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease. Glia, 63(9), 1495-1506. https://doi.org/10.1002/glia.22810

Wes, P. D., Holtman, I. R., Boddeke, E. W. G. M., Möller, T., & Eggen, B. J. L. (2015). Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease. Glia, 64(2), 197-213. https://doi.org/10.1002/glia.22866

Szulzewsky, F., Pelz, A., Feng, X., Synowitz, M., Markovic, D., Langmann, T., Holtman, I. R., Wang, X., Eggen, B. J. L., Boddeke, H. W. G. M., Hambardzumyan, D., Wolf, S. A., & Kettenmann, H. (2015). Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1. PLoS ONE, 10(2), [e0116644]. https://doi.org/10.1371/journal.pone.0116644

Holtman, I. R., Raj, D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., Hol, E. M., Boddeke, E. W. G. M., & Eggen, B. J. L. (2015). Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta neuropathologica communications, 3, [31]. https://doi.org/10.1186/s40478-015-0203-5

Raj, D. D. A., Jaarsma, D., Holtman, I. R., Olah, M., Ferreira, F. M., Schaafsma, W., Brouwer, N., Meijer, M. M., de Waard, M. C., van der Pluijm, I., Brandt, R., Kreft, K. L., Laman, J. D., de Haan, G., Biber, K. P. H., Hoeijmakers, J. H. J., Eggen, B. J. L., & Boddeke, H. W. G. M. (2014). Priming of microglia in a DNA-repair deficient model of accelerated aging. Neurobiology of Aging, 35(9), 2147-2160. https://doi.org/10.1016/j.neurobiolaging.2014.03.025

Bsibsi, M., Peferoen, L. A. N., Holtman, I. R., Nacken, P. J., Gerritsen, W. H., Witte, M. E., van Horssen, J., Eggen, B. J. L., van der Valk, P., Amor, S., & van Noort, J. M. (2014). Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-gamma and alpha B-crystallin. Acta Neuropathologica, 128(2), 215-229. https://doi.org/10.1007/s00401-014-1317-8

Bsibsi, M., Holtman, I. R., Gerritsen, W. H., Eggen, B. J. L., Boddeke, E., van der Valk, P., van Noort, J. M., & Amor, S. (2013). Alpha-B-Crystallin Induces an Immune-Regulatory and Antiviral Microglial Response in Preactive Multiple Sclerosis Lesions. Journal of neuropathology and experimental neurology, 72(10), 970-979.

van Noort, J. M., Bsibsi, M., Nacken, P. J., Gerritsen, W. H., Amor, S., Holtman, I. R., Boddeke, E., van Ark, I., Leusink-Muis, T., Folkerts, G., Hennink, W. E., & Amidi, M. (2013). Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles. Biomaterials, 34(3), 831-839. https://doi.org/10.1016/j.biomaterials.2012.10.028