dr. I.R. Holtman

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E-mail:
i.r.holtman umcg.nl

Research

  1. 2020
  2. Wlodarczyk, A., Khorooshi, R., Marczynska, J., Holtman, I. R., Burton, M., Jensen, K. N., Blaabjerg, M., Meyer, M., Thomassen, M., Eggen, B. J. L., Asgari, N., & Owens, T. (2020). Type I interferon-activated microglia are critical for neuromyelitis optica pathology. Glia, 1-11. https://doi.org/10.1002/glia.23938
  3. 2019
  4. Nott, A., Holtman, I. R., Coufal, N. G., Schlachetzki, J. C. M., Yu, M., Hu, R., Han, C. Z., Pena, M., Xiao, J., Wu, Y., Keulen, Z., Pasillas, M. P., O'Connor, C., Nickl, C. K., Schafer, S. T., Shen, Z., Rissman, R. A., Brewer, J. B., Gosselin, D., ... Glass, C. K. (2019). Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science, 366(6469), 1134-1139. https://doi.org/10.1126/science.aay0793
  5. 2018
  6. Link, V. M., Duttke, S. H., Chun, H. B., Holtman, I. R., Westin, E., Hoeksema, M. A., Abe, Y., Skola, D., Romanoski, C. E., Tao, J., Fonseca, G. J., Troutman, T. D., Spann, N. J., Strid, T., Sakai, M., Yu, M., Hu, R., Fang, R., Metzler, D., ... Glass, C. K. (2018). Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function. Cell, 173(7), 1796-1809.e17. https://doi.org/10.1016/j.cell.2018.04.018
  7. 2017
  8. Wlodarczyk, A., Holtman, I. R., Krueger, M., Yogev, N., Bruttger, J., Khorooshi, R., Benmamar-Badel, A., de Boer-Bergsma, J. J., Martin, N. A., Karram, K., Kramer, I., Boddeke, E. W. G. M., Waisman, A., Eggen, B. J. L., & Owens, T. (2017). A novel microglial subset plays a key role in myelinogenesis in developing brain. The EMBO Journal, 36(22), 3292-3308. https://doi.org/10.15252/embj.201696056
  9. Galatro, T. F., Holtman, I. R., Lerario, A. M., Vainchtein, I. D., Brouwer, N., Sola, P. R., Veras, M. M., Pereira, T. F., Leite, R. E. P., Möller, T., Wes, P. D., Sogayar, M. C., Laman, J. D., den Dunnen, W., Pasqualucci, C. A., Oba-Shinjo, S. M., Boddeke, E. W. G. M., Marie, S. K. N., & Eggen, B. J. L. (2017). Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. Nature neuroscience, 20(8), 1162-1171. https://doi.org/10.1038/nn.4597
  10. Gosselin, D., Skola, D., Coufal, N. G., Holtman, I. R., Schlachetzki, J. C. M., Sajti, E., Jaeger, B. N., O'Connor, C., Fitzpatrick, C., Pasillas, M. P., Pena, M., Adair, A., Gonda, D. D., Levy, M. L., Ransohoff, R. M., Gage, F. H., & Glass, C. K. (2017). An environment-dependent transcriptional network specifies human microglia identity. Science, 356(6344), 1248-+. https://doi.org/10.1126/science.aal3222
  11. 2016
  12. Janova, H., Boettcher, C., Holtman, I. R., Regen, T., van Rossum, D., Goetz, A., Ernst, A-S., Fritsche, C., Gertig, U., Saiepour, N., Gronke, K., Wrzos, C., Ribes, S., Rolfes, S., Weinstein, J., Ehrenreich, H., Pukrop, T., Kopatz, J., Stadelmann, C., ... Hanisch, U-K. (2016). CD14 is a key organizer of microglial responses to CNS infection and injury. Glia, 64(4), 635-649. https://doi.org/10.1002/glia.22955
  13. 2015
  14. Szulzewsky, F., Pelz, A., Feng, X., Synowitz, M., Markovic, D., Langmann, T., Holtman, I. R., Wang, X., Eggen, B. J. L., Boddeke, H. W. G. M., Hambardzumyan, D., Wolf, S. A., & Kettenmann, H. (2015). Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1. PLoS ONE, 10(2), [e0116644]. https://doi.org/10.1371/journal.pone.0116644
  15. 2014
  16. Raj, D. D. A., Jaarsma, D., Holtman, I. R., Olah, M., Ferreira, F. M., Schaafsma, W., Brouwer, N., Meijer, M. M., de Waard, M. C., van der Pluijm, I., Brandt, R., Kreft, K. L., Laman, J. D., de Haan, G., Biber, K. P. H., Hoeijmakers, J. H. J., Eggen, B. J. L., & Boddeke, H. W. G. M. (2014). Priming of microglia in a DNA-repair deficient model of accelerated aging. Neurobiology of Aging, 35(9), 2147-2160. https://doi.org/10.1016/j.neurobiolaging.2014.03.025
  17. Bsibsi, M., Peferoen, L. A. N., Holtman, I. R., Nacken, P. J., Gerritsen, W. H., Witte, M. E., van Horssen, J., Eggen, B. J. L., van der Valk, P., Amor, S., & van Noort, J. M. (2014). Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-gamma and alpha B-crystallin. Acta Neuropathologica, 128(2), 215-229. https://doi.org/10.1007/s00401-014-1317-8
  18. 2013

ID: 405376