prof. dr. H. Meurs

Degrees
1974 BSc Chemistry, University of Groningen
1978: MSc Biochemistry, University of Groningen.
1984: PhD. Thesis: 'The beta-adrenergic system and airway reactivity: investigations in vivo and in vitro'.
1979-1987: Junior Research Scientist, UMCG, Department of Allergology
1987-1994: Assistant Professor, University of Groningen, Pharmacy, Department of Molecular Pharmacology
1994-2004: Associate Professor University of Groningen, Pharmacy, Department of Molecular Pharmacology
2004-present Professor of Immunopharmacology, University of Groningen, Pharmacy, Department of Molecular Pharmacology
2005-present Head of Department Molecular Pharmacology
Research interests
Immunological regulation of airway function, in particular with regard to the pathophysiology of chronic inflammatory obstructive airway diseases like asthma and COPD. Development of new pharmacological approaches for drug treatment.
Scientific activities
Scientific Board member Groningen Research Institute for Asthma and COPD
Board member Dutch Pharmacological Society
Member Scientific Advisory Board Netherlands Lung Foundation
Program Committee Dutch Medicines Days Netherlands Federation for Innovative Drug Research
Member Planning Committee of the Respiratory, Structure and Function Assembly of the American Thoracic Society
Editorial Board American Journal of Physiology
Editorial Board Respiratory Research
Editorial Board Pulmonary Pharmacology and Therapeutics
Member Faculty of 1000, Respiratory Physiology section
Reviewer for numerous scientific journals in Pharmacology and Respiratory Medicine
Reviewer for funding agencies, including Netherlands Lung Foundation, Dutch Scientific Organization (NWO), Wellcome Trust, UK, Biotechnology and Biological Sciences Research Council, UK
(Co-)organizer of more than 15 international meetings and congresses
More than 100 invited lectures and invited chairs at conferences and universities
More than 200 publications in refereed international journals and books, h-factor 41 (Web of Science), 47 (Google Scholar)
Awards
Honorary Fellow of the European Respiratory Society (FERS)
Recipient of the Joseph R. Rodarte Award 2015 of the American Thoracic Society
Selected key publications in international refereed journals
(see Google Scholar H. Meurs for full list: http://scholar.google.com/citations?hl=nl&user=MRksjOUAAAAJ&view_op=list_works&gmla=AJsN-F5O9eEhxSeDIbxpOhvOKfsoJ8IFiu7X-baOhFUQJa0kigRR2vfqVKG8JGUVmwYuw5hIfqQs-d9x6b35HKo5CAwL_-wlkHMplA_72dmg7Bq3GTViSxLGfB7M-QNK797bIJx0sMgx )
Meurs H., McKay S., Maarsingh, H., Hamer, M.A.M., Macic, L., Molendijk, N., Zaagsma, J. Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperreactivity. Br. J. Pharmacol. 136, 2002, 391-398.
Meurs, H., Maarsingh, H., Zaagsma, J. Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness. Trends Pharmacol. Sci. 24, 2003, 450-455.
Gosens, R., Nelemans, S.A., Grootte-Bromhaar, M.M., McKay, S., Zaagsma, J., Meurs, H. Muscarinic M3 receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am. J. Respir. Cell and Mol. Biol. 28, 2003, 257-262.
Gosens, R., Bos, I., Zaagsma, J., Meurs, H. Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling. Am. J. Respir. Crit. Care Med. 171, 2005, 1096-1102
Oostendorp, J., Postma, D.S., Volders, H., Jongepier, H., Kauffman, H.F., Boezen, M., Meyers, D.A., Bleecker, E.R., Nelemans, S.A., Zaagsma, J., Meurs, H. Differential desensitization of homozygous haplotypes of the b2-adrenergic receptor in lymphocytes. Am. J. Respir. Crit. Care Med. 172, 2005, 322-328.
Meurs, H., Santing, R.E., Remie, R., Van der Mark, T.W., Westerhof, F.J., Zuidhof, A.B., Bos, I.S.T., Zaagsma, J. A guinea pig model of acute and chronic asthma using permanently instrumented and unrestrained animals. Nat. Protoc. 1, 2006, 840-847.
Gosens, R., Zaagsma, J., Meurs, H., Halayko, A.J. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Repir. Res. 7, 2006, 73.
Schaafsma, D., McNeill, K.D., Stelmack, G.L., Gosens, R., Baarsma, H.A., Frohwerk, E., Dekkers, B.G.J., Penninks, J.M., Ens, K.M., Nelemans, S.A., Zaagsma, J., Halayko, A.J. , Meurs, H. Insulin increases the expression of contractile phenotypic markers in airway smooth muscle. Am. J. Physiol. Cell Physiol. 293, 2007, C429-439.
Maarsingh, H., Zuidhof, A.B., Bos, I.S., van Duin, M., Bouche,r J.L., Zaagsma, J., Meurs. H. Arginase inhibition protects against allergic airway obstruction, hyperresponsiveness & inflammation. Am. J. Respir. Crit. Care Med. 2008, 178, 565-573.
Meurs H, Gosens R, Zaagsma J. Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models. Eur Respir J. 32, 2008, 487-502.
Dekkers, B.G.J., Schaafsma D., Tran, T., Zaagsma, J., Meurs, H. Insulin-induced laminin expression promotes a hypercontractile airway smooth muscle phenotype. Am. J. Respir. Cell Mol. Biol. 41, 2009, 494-504.
Maarsingh, H., Zaagsma, J., Meurs, H. Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. Br. J. Pharmacol. 158, 2009, 652-664.
Dekkers, B.G.J., Bos, I.S.T., Gosens, R., Halayko, A.J., Zaagsma, J., Meurs, H. The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. Am. J. Respir. Crit. Care Med. 181, 2010, 556-565.
Vonk, J.M., Postma, D.S., Maarsingh, H., Bruinenberg, M., Koppelman, G.H., Meurs, H. Arginase 1 and 2 variations associate with asthma, asthma severity and beta-2 agonist and steroid response. Pharmacogenet. Genomics 20, 2010, 179-186.
Pera, T., Zuidhof, A.B., Valadas, J., Smit, M., Schoemaker, R.G., Gosens, R., Maarsingh, H., Zaagsma, J., Meurs, H. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD. Eur. Respir. J. 38, 2011, 789-796.
Dekkers, B.G., Bos, I.S., Zaagsma, J., Meurs, H. Functional consequences of human airway smooth muscle phenotype plasticity. Br. J. Pharmacol. 166, 2012, 359-367.
Meurs, H., Oenema, T.A., Kistemaker, L.E.M., Gosens R. A new perspective on muscarinic receptor antagonism in obstructive airways diseases. Curr. Opin. Pharmacol. 13, 2013, 316-323.
Smit, M., Zuidhof, A.B., Bos, I.S.T., Maarsingh, H., Gosens, R., Zaagsma, J., Meurs, H. Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma. J. Pharmacol. Exp. Ther. 348, 2014, 303-310.
Wright, D.B., Meurs, H., Dekkers, B.G. J. Integrins: therapeutic targets in airway hyperresponsiveness and remodelling? Trends Pharmacol. Sci. 35, 2014, 567-574.
Kistemaker, L.E.M, Van Os, R.P., Dethmers-Ausema, A., Bos, I.S.T., Hylkema, M.N., Van den Berge, M., Hiemstra, P.S., Wess, J., Meurs, H., Kerstjens, H.A.M., Gosens, R. Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 308, 2015, L96-L103.
Last modified: | 04 May 2016 09.01 a.m. |