H.J. Westra

E-mail:
h.j.westra umcg.nl

Research

  1. 2019
  2. 2018
  3. Westra, H-J., Martinez-Bonet, M., Onengut-Gumuscu, S., Lee, A., Luol, Y., Teslovich, N., ... Raychaudhuri, S. (2018). Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. Nature Genetics, 50(10), 1366-1374. https://doi.org/10.1038/s41588-018-0216-7
  4. 2017
  5. Pital-Zhernakova, D., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., ... Franke, L. (2017). Identification of context-dependent expression quantitative trait loci in whole blood. Nature Genetics, 49(1), 139-145. https://doi.org/10.1038/ng.3737
  6. 2016
  7. Okbay, A., Baselmans, B. M. L., De Neve, J-E., Turley, P., Nivard, M. G., Fontana, M. A., ... Lifelines Cohort Study (2016). Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48(12), 1591. https://doi.org/10.1038/ng1216-1587b
  8. Okbay, A., Baselmans, B. M. L., De Neve, J-E., Turley, P., Nivard, M. G., Fontana, M. A., ... Lifelines Cohort Study (2016). Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (vol 48, pg 624, 2016). Nature Genetics, 48(8), 1587-1587. https://doi.org/10.1038/ng1216-1587b
  9. Okbay, A., Baselmans, B. M. L., Neve, J-E. D., Turley, P., Nivard, M. G., Fontana, M. A., ... Lifelines Cohort Study (2016). Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48(8), 970. https://doi.org/10.1038/ng0816-970c
  10. Okbay, A., Baselmans, B. M. L., De Neve, J-E., Turley, P., Nivard, M. G., Fontana, M. A., ... Lifelines Cohort Study (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48(6), 624-636. https://doi.org/10.1038/ng.3552
  11. Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., ... Loos, R. J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7, [10495]. https://doi.org/10.1038/ncomms10495
  12. 2015
  13. Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., ... MAGIC Consortium (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS genetics, 11(10), [e1005378]. https://doi.org/10.1371/journal.pgen.1005378
  14. Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., ... NABEC UKBEC Consortium (2015). The transcriptional landscape of age in human peripheral blood. Nature Communications, 6, [8570]. https://doi.org/10.1038/ncomms9570
  15. Draisma, H. H. M., Pool, R., Kobl, M., Jansen, R., Petersen, A-K., Vaarhorst, A. A. M., ... Boomsma, D. I. (2015). Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Nature Communications, 6, [7208]. https://doi.org/10.1038/ncomms8208
  16. Surakka, I., Horikoshi, M., Magi, R., Sarin, A-P., Mahajan, A., Lagou, V., ... ENGAGE Consortium (2015). The impact of low-frequency and rare variants on lipid levels. Nature Genetics, 47(6), 589-597. https://doi.org/10.1038/ng.3300
  17. Westra, H-J., Arends, D., Esko, T., Peters, M. J., Schurmann, C., Schramm, K., ... Franke, L. (2015). Cell Specific eQTL Analysis without Sorting Cells. PLoS genetics, 11(5), [1005223]. https://doi.org/10.1371/journal.pgen.1005223
  18. Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., Paynter, N., ... UK Brain Expression Consortium (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20(5), 647-656. https://doi.org/10.1038/mp.2014.107
  19. Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., ... Lifelines Cohort Study (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206. https://doi.org/10.1038/nature14177
  20. Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Lockes, A. E., Maegi, R., ... ReproGen Consortium (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-96. https://doi.org/10.1038/nature14132
  21. Andiappan, A. K., Narayanan, S., Myers, R. A., Lee, B., Nieuwenhuis, M. A., Nardin, A., ... Chew, F. T. (2015). Genetic variants of inducible costimulator are associated with allergic asthma susceptibility. Journal of Allergy and Clinical Immunology, 135(2), 556-+. https://doi.org/10.1016/j.jaci.2014.06.028
  22. Pers, T. H., Karjalainen, J. M., Chan, Y., Westra, H-J., Wood, A. R., Yang, J., ... Genetic Invest ANthropometric Trai (2015). Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications, 6, [5890]. https://doi.org/10.1038/ncomms6890
  23. 2014
  24. Wood, A. R., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., ... Lifelines Cohort Study (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46(11), 1173-1186. https://doi.org/10.1038/ng.3097
  25. Hemani, G., Shakhbazov, K., Westra, H-J., Esko, T., Henders, A. K., McRae, A. F., ... Powell, J. E. (2014). Another explanation for apparent epistasis Reply. Nature, 514(7520), E5-E6. https://doi.org/10.1038/nature13692
  26. Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., ... InterAct Consortium (2014). Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nature Communications, 5, [4926]. https://doi.org/10.1038/ncomms5926
  27. Gockel, I., Becker, J., Wouters, M. M., Niebisch, S., Gockel, H. R., Hess, T., ... Schumacher, J. (2014). Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia. Nature Genetics, 46(8), 901-904. https://doi.org/10.1038/ng.3029
  28. Cozen, W., Timofeeva, M. N., Li, D., Diepstra, A., Hazelett, D., Delahaye-Sourdeix, M., ... Mckay, J. D. (2014). A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Nature Communications, 5, [3856]. https://doi.org/10.1038/ncomms4856
  29. de Zeeuw, E. L., van Beijsterveldt, C. E. M., Glasner, T. J., Bartels, M., Ehli, E. A., Davies, G. E., ... Social Science Genetic Assotiation Consortium (2014). Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 165(6), 510-520. https://doi.org/10.1002/ajmg.b.32254
  30. Hemani, G., Shakhbazov, K., Westra, H-J., Esko, T., Henders, A. K., McRae, A. F., ... Powell, J. E. (2014). Detection and replication of epistasis influencing transcription in humans. Nature, 508(7495), 249-253. https://doi.org/10.1038/nature13005
  31. Okada, Y., Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., ... GARNET Consortium (2014). Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506(7488), 376-+. https://doi.org/10.1038/nature12873
  32. 2013
  33. Westra, H-J., Peters, M. J., Esko, T., Yaghootkar, H., Schurmann, C., Kettunen, J., ... Hoen, P. A. C. . (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45(10), 1238-1243. https://doi.org/10.1038/ng.2756
  34. Trouw, L. A., Daha, N., Kurreeman, F. A. S., Boehringer, S., Goulielmos, G. N., Westra, H. J., ... Toes, R. E. M. (2013). Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis. Clinical and Experimental Immunology, 173(1), 76-83. https://doi.org/10.1111/cei.12097
  35. den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J. J. M., Peal, D. S., Evans, D. M., ... CHARGE-AF Consortium (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45(6), 621-31. https://doi.org/10.1038/ng.2610
  36. Gockel, I., Becker, J., Wouters, M. M., Brun, P., Vigo, A. G., Trynka, G., ... Schumacher, J. (2013). An Insertion of Eight Amino Acids in HLA-DQA1 and Three Amino Acid Substitutions in HLA-DQA1 and HLA-DQB1 Confer Risk to Idiopathic Achalasia. Gastroenterology, 144(5), S142-S142.
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