prof. dr. G.H. (Gerard) Koppelman

Pediatric Pulmonologist, Program leader Groningen Research Institute of Asthma and COPD, Head, section of Pediatric Pulmonology and Pediatric Allergology

prof. dr. G.H. (Gerard) Koppelman
Telephone:
G.A. (Georgette) Hoogendijk, secretary:
E-mail:
g.h.koppelman umcg.nl

Research

  1. 2011
  2. Tischer, C., Gehring, U., Chen, C-M., Kerkhof, M., Koppelman, G., Sausenthaler, S., Herbarth, O., Schaaf, B., Lehmann, I., Kraemer, U., Berdel, D., von Berg, A., Bauer, C. P., Koletzko, S., Wichmann, H-E., Brunekreef, B., & Heinrich, J. (2011). Respiratory health in children, and indoor exposure to (1,3)-beta-D-glucan, EPS mould components and endotoxin. European Respiratory Journal, 37(5), 1050-1059. https://doi.org/10.1183/09031936.00091210
  3. Savenije, O. E. M., Kerkhof, M., Reijmerink, N. E., Brunekreef, B., de Jongste, J. C., Smit, H. A., Wijga, A. H., Postma, D. S., & Koppelman, G. H. (2011). Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. Journal of Allergy and Clinical Immunology, 127(3), 750-U394. https://doi.org/10.1016/j.jaci.2010.12.014
  4. Gehring, U., Wijga, A. H., Fischer, P., de Jongste, J. C., Kerkhof, M., Koppelman, G. H., Smit, H. A., & Brunekreef, B. (2011). Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study. Environmental Research, 111(1), 125-135. https://doi.org/10.1016/j.envres.2010.10.004
  5. 2010
  6. Koster, E. S., Wijga, A. H., Raaijmakers, J. A. M., Koppelman, G. H., Postma, D. S., Kerkhof, M., Hoekstra, M. O., de Jongste, J. C., Smit, H. A., Brunekreef, B., & Maitland-van der Zee, A-H. (2010). High agreement between parental reported inhaled corticosteroid use and pharmacy prescription data. Pharmacoepidemiology and Drug Safety, 19(11), 1199-1203. https://doi.org/10.1002/pds.2015
  7. Penders, J., Thijs, C., Mommers, M., Stobberingh, E. E., Dompeling, E., Reijmerink, N. E., van den Brandt, P. A., Kerkhof, M., Koppelman, G. H., & Postma, D. S. (2010). Intestinal lactobacilli and the DC-SIGN gene for their recognition by dendritic cells play a role in the aetiology of allergic manifestations. Microbiology-Sgm, 156, 3298-3305. https://doi.org/10.1099/mic.0.042069-0
  8. Rzehak, P., Thijs, C., Standl, M., Mommers, M., Glaser, C., Jansen, E., Klopp, N., Koppelman, G. H., Singmann, P., Postma, D. S., Sausenthaler, S., Dagnelie, P. C., van den Brandt, P. A., Koletzko, B., Heinrich, J., & KOALA & LISA Study Grp (2010). Variants of the FADS1 FADS2 Gene Cluster, Blood Levels of Polyunsaturated Fatty Acids and Eczema in Children within the First 2 Years of Life. PLoS ONE, 5(10), [13261]. https://doi.org/10.1371/journal.pone.0013261
  9. Koster, E. S., Wijga, A. H., Zuidgeest, M. G. P., Belitser, S. V., Raaijmakers, J. A. M., Koppelman, G. H., Postma, D. S., Brunekreef, B., de Jongste, J. C., & Maitland-van der Zee, A-H. (2010). Patterns of asthma medication use: early asthma therapy initiation and asthma outcomes at age 8. Pharmacoepidemiology and Drug Safety, 19(10), 991-999. https://doi.org/10.1002/pds.1961
  10. Moffatt, M. F., Gut, I. G., Demenais, F., Strachan, D. P., Bouzigon, E., Heath, S., von Mutius, E., Farrall, M., Lathrop, M., Cookson, W. O. C. M., & GABRIEL Consortium (2010). A Large-Scale, Consortium-Based Genomewide Association Study of Asthma. New England Journal of Medicine, 363(13), 1211-1221.
  11. Caudri, D., Wijga, A. H., Hoekstra, M. O., Kerkhof, M., Koppelman, G. H., Brunekreef, B., Smit, H. A., & de Jongste, J. C. (2010). Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE. Thorax, 65(9), 801-807. https://doi.org/10.1136/thx.2009.126912
  12. Halapi, E., Gudbjartsson, D. F., Jonsdottir, G. M., Bjornsdottir, U. S., Thorleifsson, G., Helgadottir, H., Williams, C., Koppelman, G. H., Heinzmann, A., Boezen, H., Jonasdottir, A., Blondal, T., Gudjonsson, S. A., Jonasdottir, A., Thorlacius, T., Henry, A. P., Altmueller, J., Krueger, M., Shin, H. D., ... Stefansson, K. (2010). A sequence variant on 17q21 is associated with age at onset and severity of asthma. European Journal of Human Genetics, 18(8), 902-908. https://doi.org/10.1038/ejhg.2010.38
  13. Bergboer, J. G. M., Zeeuwen, P. L. J. M., Irvine, A. D., Weidinger, S., Giardina, E., Novelli, G., Den Heijer, M., Rodriguez, E., Illig, T., Riveira-Munoz, E., Campbell, L. E., Tyson, J., Dannhauser, E. N., O'Regan, G. M., Galli, E., Klopp, N., Koppelman, G. H., Novak, N., Estivill, X., ... Schalkwijk, J. (2010). Deletion of Late Cornified Envelope 3B and 3C Genes Is Not Associated with Atopic Dermatitis. Journal of Investigative Dermatology, 130(8), 2057-2061. https://doi.org/10.1038/jid.2010.88
  14. Bottema, R. W. B., Kerkhof, M., Reijmerink, N. E., Thijs, C., Smit, H. A., van Schayck, C. P., Brunekreef, B., van Oosterhout, A. J., Postma, D. S., & Koppelman, G. H. (2010). Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood. Journal of Allergy and Clinical Immunology, 126(2), 338-U62. https://doi.org/10.1016/j.jaci.2010.04.024
  15. Kerkhof, M., Postma, D. S., Brunekreef, B., Reijmerink, N. E., Wijga, A. H., de Jongste, J. C., Gehring, U., & Koppelman, G. H. (2010). Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Thorax, 65(8), 690-697. https://doi.org/10.1136/thx.2009.119636
  16. Bottema, R. W. B., Kerkhof, M., Reijmerink, N. E., Koppelman, G. H., Thijs, C., Stelma, F. F., Smit, H. A., Brunekreef, B., van Schayck, C. P., & Postma, D. S. (2010). X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts. Allergy, 65(7), 865-874. https://doi.org/10.1111/j.1398-9995.2009.02291.x
  17. Bouzigon, E., Forabosco, P., Koppelman, G. H., Cookson, W. O. C. M., Dizier, M-H., Duffy, D. L., Evans, D. M., Ferreira, M. A. R., Kere, J., Laitinen, T., Malerba, G., Meyers, D. A., Moffatt, M., Martin, N. G., Ng, M. Y., Pignatti, P. F., Wjst, M., Kauffmann, F., Demenais, F., & Lewis, C. M. (2010). Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy. European Journal of Human Genetics, 18(6), 700-706. https://doi.org/10.1038/ejhg.2009.224
  18. Snijders, B. E. P., Stelma, F. F., Reijmerink, N. E., Thijs, C., van der Steege, G., Damoiseaux, J. G. M. C., van den Brandt, P. A., van Ree, R., Postma, D. S., & Koppelman, G. H. (2010). CD14 polymorphisms in mother and infant, soluble CD14 in breast milk and atopy development in the infant (KOALA Study). Pediatric Allergy and Immunology, 21(3), 541-549. https://doi.org/10.1111/j.1399-3038.2009.00939.x
  19. Freathy, R. M., Mook-Kanamori, D. O., Sovio, U., Prokopenko, I., Timpson, N. J., Berry, D. J., Warrington, N. M., Widen, E., Hottenga, J. J., Kaakinen, M., Lange, L. A., Bradfield, J. P., Kerkhof, M., Marsh, J. A., Maegi, R., Chen, C-M., Lyon, H. N., Kirin, M., Adair, L. S., ... EGG Consortium (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42(5), 430-U73. https://doi.org/10.1038/ng.567
  20. Zuidgeest, M. G. P., Koster, E. S., Maitland-van der Zee, A-H., Smit, H. A., Brunekreef, B., Leufkens, H. G. M., Koppelman, G. H., Postma, D. S., de Jongste, J. C., Hoekstra, M. O., & PIAMA Study Grp (2010). Asthma Therapy During the First 8 Years of Life: A PIAMA Cohort Study. Journal of Asthma, 47(2), 209-213. https://doi.org/10.3109/02770900903483790
  21. Reijmerink, N. E., Bottema, R. W. B., Kerkhof, M., Gerritsen, J., Stelma, F. F., Thijs, C., van Schayck, C. P., Smit, H. A., Brunekreef, B., Koppelman, G. H., & Postma, D. S. (2010). TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy. Allergy, 65(2), 199-207. https://doi.org/10.1111/j.1398-9995.2009.02111.x
  22. Penders, J., Thijs, C., Mommers, M., Stobberingh, E. E., Dompeling, E., Reijmerink, N. E., van den Brandt, P. A., Kerkhof, M., Koppelman, G. H., & Postma, D. S. (2010). Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli. Journal of Allergy and Clinical Immunology, 125(1), 231-236. https://doi.org/10.1016/j.jaci.2009.10.011
  23. Bottema, R. W. B., Postma, D. S., Reijmerink, N. E., Thijs, C., Stelma, F. F., Simit, H. A., van Schayck, C. P., Brunekreef, B., Koppelman, G. H., & Kerkhof, M. (2010). Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE. European Respiratory Journal, 35(1), 54-63. https://doi.org/10.1183/09031936.00018909
  24. Bottema, R. W. B., Nolte, I. M., Howard, T. D., Koppelman, G. H., Dubois, A. E. J., de Meer, G., Kerkhof, M., Bleecker, E. R., Meyers, D. A., & Postma, D. S. (2010). Interleukin 13 and Interleukin 4 Receptor-alpha Polymorphisms in Rhinitis and Asthma. International Archives of Allergy and Immunology, 153(3), 259-267. https://doi.org/10.1159/000314366
  25. 2009
  26. Schuttelaar, M. L. A., Kerkhof, M., Jonkman, M. F., Koppelman, G. H., Brunekreef, B., de Jongste, J. C., Wijga, A., McLean, W. H. I., & Postma, D. S. (2009). Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure. Allergy, 64(12), 1758-1765. https://doi.org/10.1111/j.1398-9995.2009.02080.x
  27. Koppelman, G. H., Meyers, D. A., Howard, T. D., Zheng, S. L., Hawkins, G. A., Ampleford, E. J., Xu, J., Koning, H., Bruinenberg, M., Nolte, I. M., van Diemen, C. C., Boezen, H. M., Timens, W., Whittaker, P. A., Stine, O. C., Bartons, S. J., Holloway, J. W., Holgate, S. T., Graves, P. E., ... Postma, D. S. (2009). Identification of PCDH1 as a Novel Susceptibility Gene for Bronchial Hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine, 180(10), 929-935. https://doi.org/10.1164/rccm.200810-1621OC
  28. Koster, E. S., Raaijmakers, J. A. M., Koppelman, G. H., Postma, D. S., van der Ent, C. K., Koenderman, L., Bracke, M., & Maitland-van der Zee, A. H. (2009). Pharmacogenetics of anti-inflammatory treatment in children with asthma: rationale and design of the PACMAN cohort. Pharmacogenomics, 10(8), 1351-1361. https://doi.org/10.2217/PGS.09.79
  29. Barton, S. J., Koppelman, G. H., Vonk, J. M., Browning, C. A., Nolte, I. M., Stewart, C. E., Bainbridge, S., Mutch, S., Rose-Zerilli, M. J., Postma, D. S., Maniatis, N., Henry, A. P., Hall, I. P., Holgate, S. T., Tighe, P., Holloway, J. W., & Sayers, I. (2009). PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. Journal of Allergy and Clinical Immunology, 123(6), 1391-1400. https://doi.org/10.1016/j.jaci.2009.03.014
  30. Ruskamp, J. M., Hoekstra, M. O., Postma, D. S., Kerkhof, M., Bottema, R. W., Koppelman, G. H., Rovers, M. M., Wijga, A. H., de Jongste, J. C., Brunekreef, B., & Sanders, E. A. M. (2009). Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. Clinical and Experimental Immunology, 155(3), 433-440. https://doi.org/10.1111/j.1365-2249.2008.03844.x
  31. Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., Thorleifsson, G., Helgadottir, H., Steinthorsdottir, V., Stefansson, H., Williams, C., Hui, J., Beilby, J., Warrington, N. M., James, A., Palmer, L. J., Koppelman, G. H., Heinzmann, A., Krueger, M., ... Stefansson, K. (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41(3), 342-347. https://doi.org/10.1038/ng.323
  32. 2008
  33. Ruskamp, J. M., Hoekstra, M. O., Postma, D. S., Kerkhof, M., Bottema, R. W., Koppelman, G. H., Rovers, M. M., Wijga, A. H., de Jongste, J. C., Brunekreef, B., & Sanders, E. A. (2008). Polymorphisms in the Mannan-Binding Lectin Gene Are Not Associated with Questionnaire-Reported Respiratory Tract Infections in Children. Journal of infectious diseases, 198(11), 1707-1713. https://doi.org/10.1086/592989
  34. Kimman, T. G., Banus, S., Reijmerink, N., Reimerink, J., Stelma, F. F., Koppelman, G. H., Thijs, C., Postma, D. S., & Kerkhof, M. (2008). Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination. PLoS ONE, 3(11), [3665]. https://doi.org/10.1371/journal.pone.0003665
  35. Schuttelaar, M-LA., Kerkhof, M., Jonkman, M. F., Koppelman, G. H., Brunekreef, B., De Jongste, J. C., Wijga, A., McLean, W. H. I., & Postma, D. S. (2008). Filaggrine genmutaties in de Nederlandse populatie. Nederlands Tijdschrift voor Dermatologie en Venereologie, 18(9), 352-353.
  36. Bottema, R. W. B., Reijmerink, N. E., Kerkhof, M., Koppelman, G. H., Stelma, F. F., Gerritsen, J., Thijs, C., Brunekreef, B., van Schayck, C. P., & Postma, D. S. (2008). Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study. European Respiratory Journal, 32(3), 593-602. https://doi.org/10.1183/09031936.00162407
  37. 2007
  38. Banus, S., Bottema, R. W. B., Siezen, C. L. E., Vandebriel, R. J., Reimerink, J., Mommers, M., Koppelman, G. H., Hoebee, B., Thijs, C., Postma, D. S., Kimman, T. G., & Stelma, F. F. (2007). Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study. Clinical and vaccine immunology, 14(10), 1377-1380. https://doi.org/10.1128/CVI.00175-07
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