prof. dr. G.H. (Gerard) Koppelman

Pediatric Pulmonologist, Program leader Groningen Research Institute of Asthma and COPD, Head, section of Pediatric Pulmonology and Pediatric Allergology

prof. dr. G.H. (Gerard) Koppelman
Telephone:
G.A. (Georgette) Hoogendijk, secretary:
E-mail:
g.h.koppelman umcg.nl

Research

  1. 2013
  2. Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D. O., Sovio, U., Taal, H. R., Hennig, B. J., Bradfield, J. P., St Pourcain, B., Evans, D. M., Charoen, P., Kaakinen, M., Cousminer, D. L., Lehtimaki, T., Kreiner-Moller, E., Warrington, N. M., Bustamante, M., Feenstra, B., Berry, D. J., Thiering, E., ... Early Growth Genetics EGG (2013). New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics, 45(1), 76-82. https://doi.org/10.1038/ng.2477
  3. 2012
  4. Hao, K., Bosse, Y., Nickle, D. C., Pare, P. D., Postma, D. S., Laviolette, M., Sandford, A., Hackett, T. L., Daley, D., Hogg, J. C., Elliott, W. M., Couture, C., Lamontagne, M., Brandsma, C-A., van den Berge, M., Koppelman, G., Reicin, A. S., Nicholson, D. W., Malkov, V., ... Sin, D. D. (2012). Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma. PLoS genetics, 8(11), [e1003029]. https://doi.org/10.1371/journal.pgen.1003029
  5. Bousquet, J., Schuenemann, H. J., Samolinski, B., Demoly, P., Baena-Cagnani, C. E., Bachert, C., Bonini, S., Boulet, L. P., Bousquet, P. J., Brozek, J. L., Canonica, G. W., Casale, T. B., Cruz, A. A., Fokkens, W. J., Fonseca, J. A., van Wijk, R. G., Grouse, L., Haahtela, T., Khaltaev, N., ... World Hlth Org Collaborating Ctr (2012). Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs. Journal of Allergy and Clinical Immunology, 130(5), 1049-1062. https://doi.org/10.1016/j.jaci.2012.07.053
  6. van Rossem, L., Wijga, A. H., de Jongste, J. C., Koppelman, G. H., Oldenwening, M., Postma, D. S., Abrahamse-Berkeveld, M., van de Heijning, B., Brunekreef, B., & Smit, H. A. (2012). Blood Pressure in 12-Year-Old Children Is Associated With Fatty Acid Composition of Human Milk: The Prevention and Incidence of Asthma and Mite Allergy Birth Cohort. Hypertension, 60(4), 1055-1060. https://doi.org/10.1161/HYPERTENSIONAHA.112.197830
  7. van der Valk, R. J. P., Caudri, D., Savenije, O., Koppelman, G. H., Smit, H. A., Wijga, A. H., Postma, D. S., Kerkhof, M., Brunekreef, B., & de Jongste, J. C. (2012). Childhood wheezing phenotypes and FeNO in atopic children at age 8. Clinical and Experimental Allergy, 42(9), 1329-1336. https://doi.org/10.1111/j.1365-2222.2012.04010.x
  8. Vijverberg, S. J. H., Koster, E. S., Koenderman, L., Arets, H. G. M., van der Ent, C. K., Postma, D. S., Koppelman, G. H., Raaijmakers, J. A. M., & Maitland-van der Zee, A-H. (2012). Exhaled NO is a poor marker of asthma control in children with a reported use of asthma medication: a pharmacy-based study. Pediatric Allergy and Immunology, 23(6), 529-+. https://doi.org/10.1111/j.1399-3038.2012.01279.x
  9. Wang, C., Rose-Zerilli, M. J., Koppelman, G. H., Sandling, J. K., Holloway, J. W., Postma, D. S., Holgate, S. T., Bours, V., Syvanen, A-C., & Dideberg, V. (2012). Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma. Gene, 504(2), 220-225. https://doi.org/10.1016/j.gene.2012.05.021
  10. Koster, E. S., Raaijmakers, J. A., Vijverberg, S. J., Koenderman, L., Postma, D. S., Koppelman, G. H., van der Ent, C. K., & Maitland-van der Zee, A-H. (2012). Limited agreement between current and long-term asthma control in children: the PACMAN cohort study (vol 22, pg 776, 2011). Pediatric Allergy and Immunology, 23(5), 503-503. https://doi.org/10.1111/j.1399-3038.2012.01344.x
  11. Himes, B. E., Jiang, X., Hu, R., Wu, A. C., Lasky-Su, J. A., Klanderman, B. J., Ziniti, J., Senter-Sylvia, J., Lima, J. J., Irvin, C. G., Peters, S. P., Meyers, D. A., Bleecker, E. R., Kubo, M., Tamari, M., Nakamura, Y., Szefler, S. J., Lemanske, R. F., Zeiger, R. S., ... Weiss, S. T. (2012). Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene. PLoS genetics, 8(7), [e1002824]. https://doi.org/10.1371/journal.pgen.1002824
  12. Willers, S. M., Brunekreef, B., Smit, H. A., van der Beek, E. M., Gehring, U., de Jongste, J. C., Kerkhof, M., Koppelman, G. H., & Wijga, A. H. (2012). BMI Development of Normal Weight and Overweight Children in the PIAMA Study. PLoS ONE, 7(6), [e39517]. https://doi.org/10.1371/journal.pone.0039517
  13. van der Valk, R. J. P., Duijts, L., Kerkhof, M., Willemsen, S. P., Hofman, A., Moll, HA., Smit, H. A., Brunekreef, B., Postma, D. S., Jaddoe, V. W. V., Koppelman, G. H., & de Jongste, J. C. (2012). Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma-like symptoms. Allergy, 67(6), 767-774. https://doi.org/10.1111/j.1398-9995.2012.02819.x
  14. Bekkers, M. B. M., Elstgeest, L. E. M., Soholtens, S., Haveman-Nies, A., de Jongste, J. C., Kerkhof, M., Koppelman, G. H., Gehring, U., Smit, H. A., & Wijga, A. H. (2012). Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy. European Respiratory Journal, 39(6), 1468-1474. https://doi.org/10.1183/09031936.00094511
  15. Miedema, K. G. E., Tissing, W. J. E., Poele , te, E., Kamps, W. A., Alizadeh, B. Z., Kerkhof, M., de Jongste, J. C., Smit, H. A., de Pagter, A. P., Bierings, M., Boezen, H. M., Postma, D. S., de Bont, E. S. J. M., & Koppelman, G. H. (2012). Polymorphisms in the TLR6 gene associated with the inverse association between childhood acute lymphoblastic leukemia and atopic disease. Leukemia, 26(6), 1203-1210. https://doi.org/10.1038/leu.2011.341
  16. Taal, H. R., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, D. O., Warrington, N. M., Kaakinen, M., Kreiner-Moller, E., Bradfield, J. P., Freathy, R. M., Geller, F., Guxens, M., Cousminer, D. L., Kerkhof, M., Timpson, N. J., Ikram, M. A., Beilin, L. J., Bonnelykke, K., Buxton, J. L., ... Early Growth Genetics EGG Consorti (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44(5), 532–538 . https://doi.org/10.1038/ng.2238
  17. Imboden, M., Bouzigon, E., Curjuric, I., Ramasamy, A., Kumar, A., Hancock, D. B., Wilk, J. B., Vonk, J. M., Thun, G. A., Siroux, V., Nadif, R., Monier, F., Gonzalez, J. R., Wjst, M., Heinrich, J., Loehr, L. R., Franceschini, N., North, K. E., Altmueller, J., ... Probst-Hensch, N. M. (2012). Genome-wide association study of lung function decline in adults with and without asthma. Journal of Allergy and Clinical Immunology, 129(5), 1218-1228. https://doi.org/10.1016/j.jaci.2012.01.074
  18. Koning, H., Postma, D. S., Brunekreef, B., Duiverman, E. J., Smit, H. A., Thijs, C., Penders, J., Kerkhof, M., & Koppelman, G. H. (2012). Protocadherin-1 polymorphisms are associated with eczema in two Dutch birth cohorts. Pediatric Allergy and Immunology, 23(3), 270-277. https://doi.org/10.1111/j.1399-3038.2011.01201.x
  19. te Poele , E. M., Siedlinski, M., de Pagter, P. J. A., Bierings, M. B., Scherpen, F. J. G., Meeuwsen-de Boer, T. G. J., Koppelman, G. H., Postma, D. S., Kamps, W. A., Boezen, H. M., & De Bont, E. S. J. M. (2012). MBL2 and fever during neutropenia in children with acute lymphoblastic leukaemia. British Journal of Haematology, 157(1), 132-135. https://doi.org/10.1111/j.1365-2141.2011.08912.x
  20. Anto, J. M., Pinart, M., Akdis, M., Auffray, C., Bachert, C., Basagana, X., Carlsen, K-H., Guerra, S., von Hertzen, L., Illi, S., Kauffmann, F., Keil, T., Kiley, J. P., Koppelman, G. H., Lupinek, C., Martinez, F. D., Nawijn, M. C., Postma, D. S., Siroux, V., ... WHO Collaborating Ctr Asthma (2012). Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar. Journal of Allergy and Clinical Immunology, 129(4), 943-954.e4. https://doi.org/10.1016/j.jaci.2012.01.047
  21. Veldwijk, J., Fries, M. C. E., Bemelmans, W. J. E., Haveman-Nies, A., Smit, H. A., Koppelman, G. H., & Wijga, A. H. (2012). Overweight and School Performance Among Primary School Children: The PIAMA Birth Cohort Study. Obesity, 20(3), 590-596. https://doi.org/10.1038/oby.2011.327
  22. Paternoster, L., Standl, M., Chen, C-M., Ramasamy, A., Bonnelykke, K., Duijts, L., Ferreira, M. A., Alves, A. C., Thyssen, J. P., Albrecht, E., Baurecht, H., Feenstra, B., Sleiman, P. M. A., Hysi, P., Warrington, N. M., Curjuric, I., Myhre, R., Curtin, J. A., Groen-Blokhuis, M. M., ... EAGLE Consortium (2012). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature Genetics, 44(2), 187-192. https://doi.org/10.1038/ng.1017
  23. Penders, J., Mommers, M., van Nimwegen, F. A., Stobberingh, E. E., Postma, D. S., Koppelman, G. H., Kerkhof, M., Reijmerink, N. E., Dompeling, E., van den Brandt, P. A., Ferreira, I., & Thijs, C. (2012). The mediating effect of microbial colonization on the effect of cesarean section delivery Reply. Journal of Allergy and Clinical Immunology, 129(2), 585-586. https://doi.org/10.1016/j.jaci.2011.11.041
  24. Kerkhof, M., Daley, D., Postma, D. S., Park, J. E., Yeung, M. C., Wijga, A. H., Gehring, U., de Jongste, J. C., Smit, H. A., Brunekreef, B., van Schayck, O. C. P., Becker, A., & Koppelman, G. H. (2012). Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies. Journal of Allergy and Clinical Immunology, 129(1), 256-259. https://doi.org/10.1016/j.jaci.2011.08.040
  25. Bousquet, J., Anto, J. M., Demoly, P., Schuenemann, H. J., Togias, A., Akdis, M., Auffray, C., Bachert, C., Bieber, T., Bousquet, P. J., Carlsen, K. H., Casale, T. B., Cruz, A. A., Keil, T., Carlsen, K. C. L., Maurer, M., Ohta, K., Papadopoulos, N. G., Rodriguez, M. R., ... WHO Collaborating Ctr Asthma (2012). Severe Chronic Allergic (and Related) Diseases: A Uniform Approach - A MeDALL - GA(2)LEN - ARIA Position Paper. International Archives of Allergy and Immunology, 158(3), 216-231. https://doi.org/10.1159/000332924
  26. 2011
  27. Koster, E. S., Raaijmakers, J. A. M., Vijverberg, S. J. H., Koenderman, L., Postma, D. S., Koppelman, G. H., van der Ent, C. K., & Maitland-van der Zee, A-H. (2011). Limited agreement between current and long-term asthma control in children: the PACMAN cohort study. Pediatric Allergy and Immunology, 22(8), 776-783. https://doi.org/10.1111/j.1399-3038.2011.01188.x
  28. van Oeffelen, A. A. M., Bekkers, M. B. M., Smit, H. A., Kerkhof, M., Koppelman, G. H., Haveman-Nies, A., van der A, D. L., Jansen, E. H. J. M., & Wijga, A. H. (2011). Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatric Allergy and Immunology, 22(8), 784-793. https://doi.org/10.1111/j.1399-3038.2011.01190.x
  29. Caudri, D., Wijga, A. H., Smit, H. A., Koppelman, G. H., Kerkhof, M., Hoekstra, M. O., Brunekreef, B., & de Jongste, J. C. (2011). Asthma symptoms and medication in the PIAMA birth cohort: Evidence for under and overtreatment. Pediatric Allergy and Immunology, 22(7), 652-659. https://doi.org/10.1111/j.1399-3038.2011.01193.x
  30. Smit, L. A. M., Heederik, D., Doekes, G., Koppelman, G. H., Bottema, R. W. B., Postma, D. S., & Wouters, I. M. (2011). Endotoxin exposure, CD14 and wheeze among farmers: a gene-environment interaction. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 68(11), 826-831. https://doi.org/10.1136/oem.2010.060038
  31. van Nimwegen, F. A., Penders, J., Stobberingh, E. E., Postma, D. S., Koppelman, G. H., Kerkhof, M., Reijmerink, N. E., Dompeling, E., van den Brandt, P. A., Ferreira, I., Mommers, M., & Thijs, C. (2011). Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. Journal of Allergy and Clinical Immunology, 128(5), 948-U371. https://doi.org/10.1016/j.jaci.2011.07.027
  32. Reijmerink, N. E., Kerkhof, M., Bottema, R. W. B., Gerritsen, J., Stelma, F. F., Thijs, C., van Schayck, C. P., Smit, H. A., Brunekreef, B., Postma, D. S., & Koppelman, G. H. (2011). Toll-like receptors and microbial exposure: gene-gene and gene-environment interaction in the development of atopy. European Respiratory Journal, 38(4), 833-840. https://doi.org/10.1183/09031936.00099210
  33. Koster, E. S., Wijga, A. H., Koppelman, G. H., Postma, D. S., Brunekreef, B., De Jongste, J. C., Smit, H. A., Hoekstra, M. O., Raaijmakers, J. A. M., & Maitland-van der Zee, A-H. (2011). Uncontrolled asthma at age 8: The importance of parental perception towards medication. Pediatric Allergy and Immunology, 22(5), 462-468. https://doi.org/10.1111/j.1399-3038.2011.01150.x
  34. Savenije, O. E., Granell, R., Caudri, D., Koppelman, G. H., Smit, H. A., Wijga, A., de Jongste, J. C., Brunekreef, B., Sterne, J. A., Postma, D. S., Henderson, J., & Kerkhof, M. (2011). Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA. Journal of Allergy and Clinical Immunology, 127(6), 1505-U285. https://doi.org/10.1016/j.jaci.2011.02.002
  35. Bousquet, J., Anto, J., Auffray, C., Akdis, M., Cambon-Thomsen, A., Keil, T., Haahtela, T., Lambrecht, B. N., Postma, D. S., Sunyer, J., Valenta, R., Akdis, C. A., Annesi-Maesano, I., Arno, A., Bachert, C., Ballester, F., Basagana, X., Baumgartner, U., Bindslev-Jensen, C., ... Zuberbier, T. (2011). MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy, 66(5), 596-604. https://doi.org/10.1111/j.1398-9995.2010.02534.x

ID: 103081