prof. dr. G.H. (Gerard) Koppelman

Pediatric Pulmonologist, Program leader Groningen Research Institute of Asthma and COPD, Head, section of Pediatric Pulmonology and Pediatric Allergology

prof. dr. G.H. (Gerard) Koppelman
Telephone:
G.A. (Georgette) Hoogendijk, secretary:
E-mail:
g.h.koppelman umcg.nl

Research

  1. 2015
  2. Klaassen, E. M. M., Penders, J., Jobsis, Q., van de Kant, K. D. G., Thijs, C., Mommers, M., van Schayck, C. P., van Eys, G., Koppelman, G. H., & Dompeling, E. (2015). An ADAM33 Polymorphism Associates with Progression of Preschool Wheeze into Childhood Asthma: A Prospective Case-Control Study with Replication in a Birth Cohort Study. PLoS ONE, 10(3), [e0119349]. https://doi.org/10.1371/journal.pone.0119349
  3. van der Valk, R. J. P., Kreiner-Moller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Saaf, A., Bradfield, J. P., Geller, F., Hayes, M. G., Cousminer, D. L., Koerner, A., Thiering, E., Curtin, J. A., Myhre, R., Huikari, V., Joro, R., Kerkhof, M., Warrington, N. M., Pitkanen, N., ... Early Growth Genetics EGG (2015). A novel common variant in DCST2 is associated with length in early life and height in adulthood. Human Molecular Genetics, 24(4), 1155-1168. https://doi.org/10.1093/hmg/ddu510
  4. Fuertes, E., Soderhall, C., Acevedo, N., Becker, A., Brauer, M., Chan-Yeung, M., Dijk, F. N., Heinrich, J., de Jongste, J., Koppelman, G. H., Postma, D. S., Kere, J., Kozyrskyj, A. L., Pershagen, G., Sandford, A., Standl, M., Tiesler, C. M. T., Waldenberger, M., Westman, M., ... Melen, E. (2015). Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts. Journal of Allergy and Clinical Immunology, 135(2), 573-+. https://doi.org/10.1016/j.jaci.2014.08.016
  5. Andiappan, A. K., Narayanan, S., Myers, R. A., Lee, B., Nieuwenhuis, M. A., Nardin, A., Park, C-S., Shin, H. D., Kim, J-H., Westra, H-J., Franke, L., Esko, T., Metspalu, A., Teo, Y-Y., Saw, S. M., Khor, C. C., Liu, J., Koppelman, G. H., Postma, D. S., ... Chew, F. T. (2015). Genetic variants of inducible costimulator are associated with allergic asthma susceptibility. Journal of Allergy and Clinical Immunology, 135(2), 556-+. https://doi.org/10.1016/j.jaci.2014.06.028
  6. Bilenko, N., van Rossem, L., Brunekreef, B., Beelen, R., Eeftens, M., Hoek, G., Houthuijs, D., de Jongste, J. C., van Kempen, E., Koppelman, G. H., Meliefste, K., Oldenwening, M., Smit, H. A., Wijga, A. H., & Gehring, U. (2015). Traffic-related air pollution and noise and children's blood pressure: Results from the PIAMA birth cohort study. European Journal of Preventive Cardiology, 22(1), 4-12. https://doi.org/10.1177/2047487313505821
  7. Dijk, F., Grotenboer, N. S., Xu, C., Kumar, A., Soderhall, C., Melen, E., Lavi, I., Dobano, C., Guerra, S., Savenije, O., Nolte, I., Van der Vlies, P., Smit, H., Brunekreef, B., Van der Valk, R., De Jongste, J., Kerkhof, M., Nawijn, M. C., Postma, D. S., & Koppelman, G. H. (2015). (epi)genetic Regulation Of Expression Of Il1rl1 Mrna And Il1rl1-A Protein Levels In Asthma. American Journal of Respiratory and Critical Care Medicine, 191. http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=Y1jSSm1LApMDrkjYbiq&page=1&doc=1
  8. 2014
  9. Smolonska, J., Koppelman, G. H., Wijmenga, C., Vonk, J. M., Zanen, P., Bruinenberg, M., Curjuric, I., Imboden, M., Thun, G-A., Franke, L., Probst-Hensch, N. M., Nuernberg, P., Riemersma, R. A., van Schayck, C. P., Loth, D. W., Brusselle, G. G., Stricker, B. H., Hofman, A., Uitterlinden, A. G., ... Postma, D. S. (2014). Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis. European Respiratory Journal, 44(4), 860-872. https://doi.org/10.1183/09031936.00001914
  10. Eeftens, M., Hoek, G., Gruzieva, O., Moelter, A., Agius, R., Beelen, R., Brunekreef, B., Custovic, A., Cyrys, J., Fuertes, E., Heinrich, J., Hoffmann, B., de Hoogh, K., Jedynska, A., Keuken, M., Kluemper, C., Kooter, I., Kraemer, U., Korek, M., ... Gehring, U. (2014). Elemental Composition of Particulate Matter and the Association with Lung Function. Epidemiology, 25(5), 648-657. https://doi.org/10.1097/EDE.0000000000000136
  11. Savenije, O. E., John, J. M. M., Granell, R., Kerkhof, M., Dijk, F. N., de Jongste, J. C., Smit, H. A., Brunekreef, B., Postma, D. S., Van Steen, K., Henderson, J., & Koppelman, G. H. (2014). Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. Journal of Allergy and Clinical Immunology, 134(1), 170-177. https://doi.org/10.1016/j.jaci.2013.12.1080
  12. van der Valk, R. J. P., Duijts, L., Timpson, N. J., Salam, M. T., Standl, M., Curtin, J. A., Genuneit, J., Kerkhof, M., Kreiner-Moller, E., Caceres, A., Gref, A., Liang, L. L., Taal, H. R., Bouzigon, E., Demenais, F., Nadif, R., Ober, C., Thompson, E. E., Estrada, K., ... EAGLE Consortium (2014). Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. Journal of Allergy and Clinical Immunology, 134(1), 46-55. https://doi.org/10.1016/j.jaci.2013.08.053
  13. Dijkstra, A. E., Smolonska, J., van den Berge, M., Wijmenga, C., Zanen, P., Luinge, M. A., Platteel, M., Lammers, J-W., Dahlback, M., Tosh, K., Hiemstra, P. S., Sterk, P. J., Spira, A., Vestbo, J., Nordestgaard, B. G., Benn, M., Nielsen, S. F., Dahl, M., Verschuren, W. M., ... Lifelines Cohort Study (2014). Susceptibility to chronic mucus hypersecretion, a genome wide association study. PLoS ONE, 9(4), [e91621]. https://doi.org/10.1371/journal.pone.0091621
  14. Wijga, A. H., Kerkhof, M., Gehring, U., de Jongste, J. C., Postma, D. S., Aalberse, R. C., Wolse, A. P. H., Koppelman, G. H., van Rossem, L., Oldenwening, M., Brunekreef, B., & Smit, H. A. (2014). Cohort profile: The Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort. International Journal of Epidemiology, 43(2), 527-535. https://doi.org/10.1093/ije/dys231
  15. MacIntyre, E. A., Brauer, M., Melen, E., Bauer, C. P., Bauer, M., Berdel, D., Bergstroem, A., Brunekreef, B., Chan-Yeung, M., Kluemper, C., Fuertes, E., Gehring, U., Gref, A., Heinrich, J., Herbarth, O., Kerkhof, M., Koppelman, G. H., Kozyrskyj, A. L., Pershagen, G., ... TAG Study Grp (2014). GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study. Environmental Health Perspectives, 122(4), 418-424. https://doi.org/10.1289/ehp.1307459
  16. Vijverberg, S. J. H., Tavendale, R., Leusink, M., Koenderman, L., Raaijmakers, J. A. M., Postma, D. S., Koppelman, G. H., Turner, S. W., Mukhopadhyay, S., Palmer, C. N. A., & Maitland-van der Zee, A. H. (2014). Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids. Pharmacogenomics, 15(6), 799-806. https://doi.org/10.2217/PGS.14.37
  17. Klaassen, E. M. M., van de Kant, K. D. G., Jobsis, Q., Penders, J., van Schooten, F. J., Quaak, M., den Hartog, G. J. M., Koppelman, G. H., van Schayck, C. P., van Eys, G., & Dompeling, E. (2014). Integrative genomic analysis identifies a role for intercellular adhesion molecule 1 in childhood asthma. Pediatric Allergy and Immunology, 25(2), 166-172. https://doi.org/10.1111/pai.12160
  18. Gruzieva, O., Gehring, U., Aalberse, R., Agius, R., Beelen, R., Behrendt, H., Bellander, T., Birk, M., de Jongste, J. C., Fuertes, E., Heinrich, J., Hoek, G., Kluemper, C., Koppelman, G., Korek, M., Kraemer, U., Lindley, S., Moelter, A., Simpson, A., ... Pershagen, G. (2014). Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts. Journal of Allergy and Clinical Immunology, 133(3), 767-776.e7. https://doi.org/10.1016/j.jaci.2013.07.048
  19. Scholtens, S., Postma, D. S., Moffatt, M. F., Panasevich, S., Granell, R., Henderson, A. J., Melen, E., Nyberg, F., Pershagen, G., Jarvis, D., Ramasamy, A., Wjst, M., Svanes, C., Bouzigon, E., Demenais, F., Kauffmann, F., Siroux, V., von Mutius, E., Ege, M. J., ... GABRIELA Study Grp (2014). Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure. Journal of Allergy and Clinical Immunology, 133(3), 885-888. https://doi.org/10.1016/j.jaci.2013.08.049
  20. Pinart, M., Benet, M., Annesi-Maesano, I., von Berg, A., Berdel, D., Carlsen, K. C. L., Carlsen, K-H., Bindslev-Jensen, C., Eller, E., Fantini, M. P., Lenzi, J., Gehring, U., Heinrich, J., Hohmann, C., Just, J., Keil, T., Kerkhof, M., Kogevinas, M., Koletzko, S., ... Anto, J. M. (2014). Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study. The Lancet. Respiratory Medicine, 2(2), 131-140. https://doi.org/10.1016/S2213-2600(13)70277-7
  21. Portelli, M. A., Siedlinski, M., Stewart, C. E., Postma, D. S., Nieuwenhuis, M. A., Vonk, J. M., Nurnberg, P., Altmuller, J., Moffatt, M. F., Wardlaw, A. J., Parker, S. G., Connolly, M. J., Koppelman, G. H., & Sayers, I. (2014). Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels. The FASEB Journal, 28(2), 923-934. https://doi.org/10.1096/fj.13-240879
  22. MacIntyre, E. A., Gehring, U., Moelter, A., Fuertes, E., Kluemper, C., Kraemer, U., Quass, U., Hoffmann, B., Gascon, M., Brunekreef, B., Koppelman, G. H., Beelen, R., Hoek, G., Birk, M., de Jongste, J. C., Smit, H. A., Cyrys, J., Gruzieva, O., Korek, M., ... Heinrich, J. (2014). Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project. Environmental Health Perspectives, 122(1), 107-113. https://doi.org/10.1289/ehp.1306755
  23. Kerkhof, M., Boezen, H., Granell, R., Wijga, A. H., Brunekreef, B., Smit, H. A., de Jongste, J. C., Thijs, C., Mommers, M., Penders, J., Henderson, J., Koppelman, G. H., & Postma, D. S. (2014). Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes. Journal of Allergy and Clinical Immunology, 133(1), 68-76.e4. https://doi.org/10.1016/j.jaci.2013.06.004
  24. 2013
  25. Scheffers, F. R., Bekkers, M. B. M., Kerkhof, M., Gehring, U., Koppelman, G. H., Schipper, M., Haveman-Nies, A., & Wijga, A. H. (2013). The association between indoor temperature and body mass index in children: the PIAMA birth cohort study. BMC Public Health, 13, [1119]. https://doi.org/10.1186/1471-2458-13-1119
  26. Zuurhout, M. J. L., Vijverberg, S. J. H., Raaijmakers, J. A. M., Koenderman, L., Postma, D. S., Koppelman, G. H., & Maitland-van der Zee, A. H. (2013). Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting beta(2)-agonists: results of the PACMAN cohort. Pharmacogenomics, 14(16), 1965-1971. https://doi.org/10.2217/PGS.13.200
  27. Bekkers, M. B., Aalberse, R. C., Gehring, U., Kerkhof, M., Koppelman, G. H., de Jongste, J. C., Smit, H. A., Brunekreef, B., & Wijga, A. H. (2013). Hen's egg, not cow's milk, sensitization in infancy is associated with asthma: 10-year follow-up of the PIAMA birth cohort. Journal of Allergy and Clinical Immunology, 132(6), 1427-1428. https://doi.org/10.1016/j.jaci.2013.07.053
  28. Caudri, D., Savenije, O. E. M., Smit, H. A., Postma, D. S., Koppelman, G. H., Wijga, A. H., Kerkhof, M., Gehring, U., Hoekstra, M. O., Brunekreef, B., & de Jongste, J. C. (2013). Perinatal risk factors for wheezing phenotypes in the first 8 years of life. Clinical and Experimental Allergy, 43(12), 1395-1405. https://doi.org/10.1111/cea.12173
  29. Hafkamp-de Groen, E., Lingsma, H. F., Caudri, D., Levie, D., Wijga, A., Koppelman, G. H., Duijts, L., Jaddoe, V. W. V., Smit, H. A., Kerkhof, M., Moll, H. A., Hofman, A., Steyerberg, E. W., de Jongste, J. C., & Raat, H. (2013). Predicting asthma in preschool children with asthma-like symptoms: Validating and updating the PIAMA risk score. Journal of Allergy and Clinical Immunology, 132(6), 1303-1310.e6. https://doi.org/10.1016/j.jaci.2013.07.007
  30. Kreiner-Moller, E., Chawes, B. L. K., Vissing, N. H., Koppelman, G. H., Postma, D. S., Madsen, J. S., Olsen, D. A., Baty, F., Vonk, J. M., Kerkhof, M., Sleiman, P., Hakonarsson, H., Mortensen, L. J., Poorisrisak, P., Bisgaard, H., & Bonnelykke, K. (2013). VEGFA variants are associated with pre-school lung function, but not neonatal lung function. Clinical and Experimental Allergy, 43(11), 1236-1245. https://doi.org/10.1111/cea.12188
  31. Vijverberg, S. J. H., Koster, E. S., Tavendale, R., Leusink, M., Koenderman, L., Raaijmakers, J. A. M., Postma, D. S., Koppelman, G. H., Turner, S. W., Mukhopadhyay, S., Tse, S. M., Tantisira, K. G., Palmer, C. N. A., & Maitland-van der Zee, A-H. (2013). ST13 Polymorphisms Increase the Risk of Exacerbations in Steroid-Treated Asthmatic Children and Young Adults. Pharmcoepidemiology and Drug Safety, 22, 25-25.
  32. Himes, B. E., Qiu, W., Klanderman, B., Ziniti, J., Senter-Sylvia, J., Szefler, S. J., Lemanske, R. F., Zeiger, R. S., Strunk, R. C., Martinez, F. D., Boushey, H., Chinchilli, V. M., Israel, E., Mauger, D., Koppelman, G. H., Nieuwenhuis, M. A. E., Postma, D. S., Vonk, J. M., Rafaels, N., ... Weiss, S. (2013). ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. BMC MEDICAL GENETICS, 14, [86]. https://doi.org/10.1186/1471-2350-14-86
  33. Bonnelykke, K., Matheson, M. C., Pers, T. H., Granell, R., Strachan, D. P., Alves, A. C., Linneberg, A., Curtin, J. A., Warrington, N. M., Standl, M., Kerkhof, M., Jonsdottir, I., Bukvic, B. K., Kaakinen, M., Sleimann, P., Thorleifsson, G., Thorsteinsdottir, U., Schramm, K., Baltic, S., ... EAGLE Consortium (2013). Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nature Genetics, 45(8), 902-906. https://doi.org/10.1038/ng.2694
  34. Cousminer, D. L., Berry, D. J., Timpson, N. J., Ang, W., Thiering, E., Byrne, E. M., Taal, H. R., Huikari, V., Bradfield, J. P., Kerkhof, M., Groen-Blokhuis, M. M., Kreiner-Moller, E., Marinelli, M., Holst, C., Leinonen, J. T., Perry, J. R. B., Surakka, I., Pietilainen, O., Kettunen, J., ... Early Growth Genetics EGG (2013). Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Human Molecular Genetics, 22(13), 2735-2747. https://doi.org/10.1093/hmg/ddt104
  35. Taal, H. R., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, D. O., Warrington, N. M., Kaakinen, M., Kreiner-Moller, E., Bradfield, J. P., Freathy, R. M., Geller, F., Guxens, M., Cousminer, D. L., Kerkhof, M., Timpson, N. J., Ikram, M. A., Beilin, L. J., Bonnelykke, K., Buxton, J. L., ... EGG Consortium (2013). Common variants at 12q15 and 12q24 are associated with infant head circumference (vol 44, pg 532, 2012). Nature Genetics, 45(6), 713-713. https://doi.org/10.1038/ng0613-713a
  36. Eenhuizen, E., Gehring, U., Wijga, A. H., Smit, H. A., Fischer, P. H., Brauer, M., Koppelman, G. H., Kerkhof, M., de Jongste, J. C., Brunekreef, B., & Hoek, G. (2013). Traffic-related air pollution is related to interrupter resistance in 4-year-old children. European Respiratory Journal, 41(6), 1257-1263. https://doi.org/10.1183/09031936.00020812
  37. Molto-Puigmarti, C., Jansen, E., Heinrich, J., Standl, M., Mensink, R. P., Plat, J., Penders, J., Mommers, M., Koppelman, G. H., Postma, D. S., & Thijs, C. (2013). Genetic Variation in FADS Genes and Plasma Cholesterol Levels in 2-Year-Old Infants: KOALA Birth Cohort Study. PLoS ONE, 8(5), [e61671]. https://doi.org/10.1371/journal.pone.0061671
  38. Melén, E., Granell, R., Kogevinas, M., Strachan, D., Gonzalez, J. R., Wjst, M., Jarvis, D., Ege, M., Braun-Fahrländer, C., Genuneit, J., Horak, E., Bouzigon, E., Demenais, F., Kauffmann, F., Siroux, V., Michel, S., von Berg, A., Heinzmann, A., Kabesch, M., ... Lasky-Su, J. (2013). Genome-wide association study of body mass index in 23 000 individuals with and without asthma. Clinical and Experimental Allergy, 43(4), 463-474. https://doi.org/10.1111/cea.12054
  39. van Rossem, L., Wijga, A. H., de Jongste, J. C., Koppelman, G. H., Oldenwening, M., Postma, D. S., Abrahamse-Berkeveld, M., van de Heijning, B., Brunekreef, B., & Smit, H. A. (2013). Response to Children's Home Blood Pressure and Growth Environment. Hypertension, 61(4), E34-E35. https://doi.org/10.1161/HYPERTENSIONAHA.111.00851
  40. Himes, B. E., Sheppard, K., Berndt, A., Leme, A. S., Myers, R. A., Gignoux, C. R., Levin, A. M., Gauderman, W. J., Yang, J. J., Mathias, R. A., Romieu, I., Torgerson, D. G., Roth, L. A., Huntsman, S., Eng, C., Klanderman, B., Ziniti, J., Senter-Sylvia, J., Szefler, S. J., ... Weiss, S. (2013). Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS ONE, 8(2), [e56179]. https://doi.org/10.1371/journal.pone.0056179

ID: 103081