prof. dr. G.H. (Gerard) Koppelman

Pediatric Pulmonologist, Program leader Groningen Research Institute of Asthma and COPD, Head, section of Pediatric Pulmonology and Pediatric Allergology

prof. dr. G.H. (Gerard) Koppelman
Telephone:
G.A. (Georgette) Hoogendijk, secretary:
E-mail:
g.h.koppelman umcg.nl

Research

  1. 2016
  2. McGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., Wise, R. A., Szefler, S. J., Sharma, S., Kho, A. T., Cho, M. H., Croteau-Chonka, D. C., Castaldi, P. J., Jain, G., Sanyal, A., Zhan, Y., Lajoie, B. R., Dekker, J., Stamatoyannopoulos, J., ... CAMP Res Grp (2016). Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthmag. American Journal of Respiratory and Critical Care Medicine, 194(12), 1465-1474. https://doi.org/10.1164/rccm.201602-0250OC
  3. Nieuwenhuis, M. A., Siedlinski, M., van den Berge, M., Granell, R., Li, X., Niens, M., van der Vlies, P., Altmueller, J., Nuernberg, P., Kerkhof, M., van Schayck, O. C., Riemersma, R. A., van der Molen, T., de Monchy, J. G., Bosse, Y., Sandford, A., Bruijnzeel-Koomen, C. A., Gerth van Wijk, R., ten Hacken, N. H., ... Koppelman, G. H. (2016). Combining genomewide association study and lung eQTL analysis provides evidence for novel genes associated with asthma. Allergy, 71(12), 1712-1720. https://doi.org/10.1111/all.12990
  4. Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. L., Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., ... Xu, C. (2016). Paving the way of systems biology and precision medicine in allergic diseases: The MeDALL success story. Allergy, 71(11), 1513-1525. https://doi.org/10.1111/all.12880
  5. Tellez, G. F., Willemse, B. W. M., Brouwer, U., Nijboer-Brinksma, S., Vandepoele, K., Noordhoek, J. A., Heijink, I., de Vries, M., Smithers, N. P., Postma, D. S., Timens, W., Wiffen, L., van Roy, F., Holloway, J. W., Leckie, P. M., Nawijn, M. C., & Koppelman, G. H. (2016). Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma. PLoS ONE, 11(10), [e0163967]. https://doi.org/10.1371/journal.pone.0163967
  6. Dalmeijer, G. W., Wijga, A. H., Gehring, U., Renders, C. M., Koppelman, G. H., Smit, H. A., & van Rossem, L. (2016). Fatty acid composition in breastfeeding and school performance in children aged 12 years. European journal of nutrition, 55(7), 2199-2207. https://doi.org/10.1007/s00394-015-1030-y
  7. Fuertes, E., Markevych, I., Bowatte, G., Gruzieva, O., Gehring, U., Becker, A., Berdel, D., von Berg, A., Bergstrom, A., Brauer, M., Brunekreef, B., Brueske, I., Carlsten, C., Chan-Yeung, M., Dharmage, S. C., Hoffmann, B., Kluemper, C., Koppelman, G. H., Kozyrskyj, A., ... MACS (2016). Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts. Allergy, 71(10), 1461-1471. https://doi.org/10.1111/all.12915
  8. Lockett, G. A., Soto-Ramirez, N., Ray, M. A., Everson, T. M., Xu, C-J., Patil, V. K., Terry, W., Kaushal, A., Rezwan, F. I., Ewart, S. L., Gehring, U., Postma, D. S., Koppelman, G. H., Arshad, S. H., Zhang, H., Karmaus, W., & Holloway, J. W. (2016). Association of season of birth with DNA methylation and allergic disease. Allergy, 71(9), 1314-1324. https://doi.org/10.1111/all.12882
  9. Schieck, M., Schouten, J. P., Michel, S., Suttner, K., Toncheva, A. A., Gaertner, V. D., Illig, T., Lipinski, S., Franke, A., Klintschar, M., Kalayci, O., Sahiner, U. M., Birben, E., Melen, E., Pershagen, G., Freidin, M. B., Ogorodova, L. M., Granell, R., Henderson, J., ... Kabesch, M. (2016). Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages. Journal of Allergy and Clinical Immunology, 138(2), 421-431. https://doi.org/10.1016/j.jaci.2015.12.1305
  10. Berentzen, N. E., Wijga, A. H., van Rossem, L., Koppelman, G. H., van Nieuwenhuizen, B., Gehring, U., Spijkerman, A. M. W., & Smit, H. A. (2016). Family history of myocardial infarction, stroke and diabetes and cardiometabolic markers in children. Diabetologia, 59(8), 1666-1674. https://doi.org/10.1007/s00125-016-3988-2
  11. Marenholz, I., Esparza-Gordillo, J., Rueschendorf, F., Strachan, D. P., Spycher, B. D., Baurecht, H., Margaritte-Jeannin, P., Saeaef, A., Kerkhof, M., Ege, M., Baltic, S., Matheson, M. C., Li, J., Ang, W. Q., McArdle, W., Homuth, G., Bouzigon, E., Pershagen, G., Postma, D. S., ... Lee, Y-A. (2016). Genome-wide association study unravels genetic determinants of the atopic march. Allergy, 71, 431-431.
  12. Bousquet, J., Farrell, J., Crooks, G., Hellings, P., Bel, E. H., Bewick, M., Chavannes, N. H., de Sousa, J. C., Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., ... Mercier, J. (2016). Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5). Clinical and translational allergy, 6, [29]. https://doi.org/10.1186/s13601-016-0116-9
  13. McGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., Wise, R. A., Szefler, S. J., Sharma, S., Kho, A. T., Cho, M. H., Croteau-Chonka, D. C., Castaldi, P. J., Jain, G., Sanyal, A., Zhan, Y., Lajoie, B. R., Dekker, J., Stamatoyannopoulos, J., ... CAMP Res Grp (2016). Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. New England Journal of Medicine, 374(19), 1842-1852. https://doi.org/10.1056/NEJMoa1513737
  14. Joubert, B. R., Felix, J. F., Yousefi, P., Bakulski, K. M., Just, A. C., Breton, C., Reese, S. E., Markunas, C. A., Richmond, R. C., Xu, C., Kupers, L. K., Oh, S. S., Hoyo, C., Gruzieva, O., Soderhal, C., Salas, L. A., Baiz, N., Zhang, H., Lepeule, J., ... London, S. J. (2016). DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. American Journal of Human Genetics, 98(4), 680-696. https://doi.org/10.1016/j.ajhg.2016.02.019
  15. Leusink, M., Vijverberg, S. J. H., Koenderman, L., Raaijmakers, J. A. M., de Jongste, J. C., Sterk, P. J., Duiverman, E. J., Onland-Moret, N. C., Postma, D. S., de Boer, A., de Bakker, P. I. W., Koppelman, G. H., & Maitland-van der Zee, A. H. (2016). Genetic variation in uncontrolled childhood asthma despite ICS treatment. Pharmacogenomics journal, 16(2), 158-163. https://doi.org/10.1038/tpj.2015.36
  16. Timmerman, J. G., Heederik, D., Spee, T., van Rooy, F. G., Krop, E. J. M., Koppelman, G. H., Rustemeyer, T., & Smit, L. A. M. (2016). Contact dermatitis in the construction industry: the role of filaggrin loss-of-function mutations. BRITISH JOURNAL OF DERMATOLOGY, 174(2), 348-355. https://doi.org/10.1111/bjd.14215
  17. Felix, J. F., Bradfield, J. P., Monnereau, C., van der Valk, R. J. P., Stergiakouli, E., Chesi, A., Gaillard, R., Feenstra, B., Thiering, E., Kreiner-Moller, E., Mahajan, A., Pitkanen, N., Joro, R., Cavadino, A., Huikari, V., Franks, S., Groen-Blokhuis, M. M., Cousminer, D. L., Marsh, J. A., ... Early Growth Genetics EGG (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics, 25(2), 389-403. https://doi.org/10.1093/hmg/ddv472
  18. Berentzen, N. E., van Rossem, L., Gehring, U., Koppelman, G. H., Postma, D. S., de Jongste, J. C., Smit, H. A., & Wijga, A. H. (2016). Overweight patterns throughout childhood and cardiometabolic markers in early adolescence. International Journal of Obesity, 40(1), 58-64. https://doi.org/10.1038/ijo.2015.196
  19. Merid, S. K., Xu, C., Koppelman, G., Bustamante, M., Baiz, N., Annesi-Maesano, I., Antó, J. M., Bousquet, J., Gruzieva, O., Kere, J., Kumar, A., Pershagen, G., Postma, D. S., Sunyer, J., Soderhall, C., Tantisira, K. G., Weiss, S. T., & Melen, E. (2016). Differentially methylated genes related to gestational age are also expressed during fetal lung development. European Respiratory Journal, 48(suppl 60), OA5004. https://doi.org/10.1183/13993003.congress-2016.OA5004
  20. Kumar, A., Soderhall, C., Merid, S. K., Xu, C., Koppelman, G., Melen, E., Gruzieva, O., Kere, J., & Pershagen, G. (2016). meQTL analysis of asthma GWAS loci and DNA methylation. European Respiratory Journal, 48(Supplement 60), [PA1209]. https://doi.org/10.1183/13993003.congress-2016.PA1209
  21. 2015
  22. Kurakula, K., Vos, M., Logiantara, A., Roelofs, J. J. T. H., Nieuwenhuis, M. A., Koppelman, G. H., Postma, D. S., Brandsma, C. A., Sin, D. D., Bosse, Y., Nickle, D. C., van Rijt, L. S., & de Vries, C. J. M. (2015). Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper-responsiveness. Allergy, 70(12), 1531-1544. https://doi.org/10.1111/all.12709
  23. Gehring, U., Wijga, A. H., Hoek, G., Bellander, T., Berdel, D., Brueske, I., Fuertes, E., Gruzieva, O., Heinrich, J., Hoffmann, B., de Jongste, J. C., Kluemper, C., Koppelman, G. H., Korek, M., Kraemer, U., Maier, D., Melen, E., Pershagen, G., Postma, D. S., ... Brunekreef, B. (2015). Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: A population-based birth cohort study. The Lancet. Respiratory Medicine, 3(12), 933-942. https://doi.org/10.1016/S2213-2600(15)00426-9
  24. Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bonnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C., Thyssen, J. P., den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., ... EAGLE Consortium (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 47(12), 1449-1458. https://doi.org/10.1038/ng.3424
  25. Bilenko, N., Brunekreef, B., Beelen, R., Eeftens, M., de Hoogh, K., Hoek, G., Koppelman, G. H., Wang, M., van Rossem, L., & Gehring, U. (2015). Associations between particulate matter composition and childhood blood pressure - The PIAMA study. Environment international, 84, 1-6. https://doi.org/10.1016/j.envint.2015.07.010
  26. van Elten, T. M., van Rossem, L., Wijga, A. H., Brunekreef, B., de Jongste, J. C., Koppelman, G. H., & Smit, H. A. (2015). Breast milk fatty acid composition has a long-term effect on the risk of asthma, eczema, and sensitization. Allergy, 70(11), 1468-1476. https://doi.org/10.1111/all.12703
  27. Bousquet, J., Schunemann, H. J., Fonseca, J., Samolinski, B., Bachert, C., Canonica, G. W., Casale, T., Cruz, A. A., Demoly, P., Hellings, P., Valiulis, A., Wickman, M., Zuberbier, T., Bosnic-Anticevitch, S., Bedbrook, A., Bergmann, K. C., Caimmi, D., Dahl, R., Fokkens, W. J., ... Mercier, J. (2015). MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation. Allergy, 70(11), 1372-1392. https://doi.org/10.1111/all.12686
  28. van Rossem, L., Wijga, A. H., Gehring, U., Koppelman, G. H., & Smit, H. A. (2015). Maternal Gestational and Postdelivery Weight Gain and Child Weight. Pediatrics, 136(5), E1294-E1301. https://doi.org/10.1542/peds.2015-0874
  29. Marenholz, I., Esparza-Gordillo, J., Rueschendorf, F., Bauerfeind, A., Strachan, D. P., Spycher, B. D., Baurecht, H., Margaritte-Jeannin, P., Saaf, A., Kerkhof, M., Ege, M., Baltic, S., Matheson, M. C., Li, J., Michel, S., Ang, W. Q., McArdle, W., Arnold, A., Homuth, G., ... Lee, Y. A. (2015). Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nature Communications, 6, [8804]. https://doi.org/10.1038/ncomms9804
  30. van Ginkel, C. D., Dubois, A. E. J., & Koppelman, G. (2015). Genetics of Allergic Disorders. In D. L. Rosenstreich, M. P. Fried, G. S. De Vos, & A. H. Jackman (Eds.), Manual of Allergy and Clinical Immunology for Otolaryngologists (pp. 89). [Chapter 4] Plural Publishing, Inc..
  31. Bousquet, J., Anto, J. M., Wickman, M., Keil, T., Valenta, R., Haahtela, T., Carlsen, K. L., van Hage, M., Akdis, C., Bachert, C., Akdis, M., Auffray, C., Annesi-Maesano, I., Bindslev-Jensen, C., Cambon-Thomsen, A., Carlsen, K. H., Chatzi, L., Forastiere, F., Garcia-Aymerich, J., ... von Hertzen, L. (2015). Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis. Allergy, 70(9), 1062-1078. https://doi.org/10.1111/all.12637
  32. Boudewijn, I. M., Savenije, O. E. M., Koppelman, G. H., Wijga, A. H., Smit, H. A., de Jongste, J. C., Gehring, U., Postma, D. S., & Kerkhof, M. (2015). Nocturnal Dry Cough in the First 7 Years of Life is Associated With Asthma at School Age. Pediatric Pulmonology, 50(9), 848-855. https://doi.org/10.1002/ppul.23092
  33. Kurakula, K., Vos, M., Logiantara, A., Roelofs, J. J., Nieuwenhuis, M. A., Koppelman, G. H., Postma, D. S., van Rijt, L. S., & de Vries, C. J. M. (2015). Nuclear Receptor Nur77 Attenuates Airway Inflammation in Mice by Suppressing NF-kappa B Activity in Lung Epithelial Cells. Journal of Immunology, 195(4), 1388-1398. https://doi.org/10.4049/jimmunol.1401714
  34. Garcia-Aymerich, J., Benet, M., Saeys, Y., Pinart, M., Basagana, X., Smit, H. A., Siroux, V., Just, J., Momas, I., Ranciere, F., Keil, T., Hohmann, C., Lau, S., Wahn, U., Heinrich, J., Tischer, C. G., Fantini, M. P., Lenzi, J., Porta, D., ... Anto, J. M. (2015). Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster. Allergy, 70(8), 973-984. https://doi.org/10.1111/all.12640
  35. Bousquet, J., Anto, J. M., Berkouk, K., Gergen, P., Antunes, J. P., Auge, P., Camuzat, T., Bringer, J., Mercier, J., Best, N., Bourret, R., Akdis, M., Arshad, S. H., Bedbrook, A., Berr, C., Bush, A., Cavalli, G., Charles, M. A., Clavel-Chapelon, F., ... Zins, M. (2015). Developmental determinants in non-communicable chronic diseases and ageing. Thorax, 70(6), 595-597. https://doi.org/10.1136/thoraxjnl-2014-206304
  36. Vijverberg, S. J. H., Koster, E. S., Tavendale, R., Leusink, M., Koenderman, L., Raaijmakers, J. A. M., Postma, D. S., Koppelman, G. H., Turner, S. W., Mukhopadhyay, S., Tse, S. M., Tantisira, K. G., Hawcutt, D. B., Francis, B., Pirmohamed, M., Pino-Yanes, M., Eng, C., Burchard, E. G., Palmer, C. N. A., & Maitland-van der Zee, A. H. (2015). ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults. Clinical and Experimental Allergy, 45(6), 1051-1059. https://doi.org/10.1111/cea.12492
  37. Dijkstra, A. E., Smolonska, J., van den Berge, M., Wijmenga, C., Zanen, P., Luinge, M. A., Platteel, M., Lammers, J-W., Dahlback, M., Tosh, K., Hiemstra, P. S., Sterk, P. J., Spira, A., Vestbo, J., Nordestgaard, B. G., Benn, M., Nielsen, S. F., Dahl, M., Verschuren, W. M., ... Lifelines Cohort Study (2015). Correction: Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study. PLoS ONE, 10(5), [e0129524]. https://doi.org/10.1371/journal.pone.0129524
  38. Gehring, U., Beelen, R., Eeftens, M., Hoek, G., de Hoogh, K., de Jongste, J. C., Keuken, M., Koppelman, G. H., Meliefste, K., Oldenwening, M., Postma, D. S., van Rossem, L., Wang, M., Smit, H. A., & Brunekreef, B. (2015). Particulate Matter Composition and Respiratory Health The PIAMA Birth Cohort Study. Epidemiology, 26(3), 300-309. https://doi.org/10.1097/EDE.0000000000000264
  39. Bouzigon, E., Nadif, R., Thompson, E. E., Concas, M. P., Kuldanek, S., Du, G., Brossard, M., Lavielle, N., Sarnowski, C., Vaysse, A., Dessen, P., van der Valk, R. J. P., Duijts, L., Henderson, A. J., Jaddoe, V. W. V., de Jongste, J. C., Casula, S., Biino, G., Dizier, M. -H., ... EAGLE Consortium (2015). A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults. Clinical and Experimental Allergy, 45(4), 797-806. https://doi.org/10.1111/cea.12461
  40. Hettinga, K. A., Reina, F. M., Boeren, S., Zhang, L., Koppelman, G. H., Postma, D. S., Vervoort, J. J. M., & Wijga, A. H. (2015). Difference in the Breast Milk Proteome between Allergic and Non-Allergic Mothers. PLoS ONE, 10(3), [e0122234]. https://doi.org/10.1371/journal.pone.0122234

ID: 103081