prof. dr. G.H. (Gerard) Koppelman

Pediatric Pulmonologist, Program leader Groningen Research Institute of Asthma and COPD, Head, section of Pediatric Pulmonology and Pediatric Allergology

prof. dr. G.H. (Gerard) Koppelman
Telephone:
G.A. (Georgette) Hoogendijk, secretary:
E-mail:
g.h.koppelman umcg.nl

Research

  1. 2018
  2. Asai, Y., Eslami, A., van Ginkel, C. D., Akhabir, L., Wan, M., Ben-Shoshan, M., Martino, D., Ferreira, M. A., Allen, K., Mazer, B., de Jong, N. W., Gerth van Wijk, R. N., Dubois, A. E. J., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J. S., Melles, R. B., ... Daley, D. (2018). Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy. Journal of Allergy and Clinical Immunology, 141(3), 991-1001. https://doi.org/10.1016/j.jaci.2017.09.015
  3. Paternoster, L., Savenije, O. E. M., Heron, J., Evans, D. M., Vonk, J. M., Brunekreef, B., Wijga, A. H., Henderson, A. J., Koppelman, G. H., & Brown, S. J. (2018). Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts. Journal of Allergy and Clinical Immunology, 141(3), 964-971. https://doi.org/10.1016/j.jaci.2017.09.044
  4. Felix, J. F., Joubert, B. R., Baccarelli, A. A., Sharp, G. C., Almqvist, C., Annesi-Maesano, I., Arshad, H., Baïz, N., Bakermans-Kranenburg, M. J., Bakulski, K. M., Binder, E. B., Bouchard, L., Breton, C. V., Brunekreef, B., Brunst, K. J., Burchard, E. G., Bustamante, M., Chatzi, L., Cheng Munthe-Kaas, M., ... London, S. J. (2018). Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. International Journal of Epidemiology, 47(1). https://doi.org/10.1093/ije/dyx190
  5. Demenais, F., Margaritte-Jeannin, P., Barnes, K. C., Cookson, W. O. C., Altmüller, J., Ang, W., Barr, R. G., Beaty, T. H., Becker, A. B., Beilby, J., Bisgaard, H., Bjornsdottir, U. S., Bleecker, E., Bønnelykke, K., Boomsma, D. I., Bouzigon, E., Brightling, C. E., Brossard, M., Brusselle, G. G., ... Australian Asthma Genetics Consortium (AAGC) collaborators (2018). Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nature Genetics, 50(1), 42-53. https://doi.org/10.1038/s41588-017-0014-7
  6. Dijk, F. N., Xu, C., Melén, E., Carsin, A-E., Kumar, A., Nolte, I. M., Gruzieva, O., Pershagen, G., Grotenboer, N. S., Savenije, O. E. M., Antó, J. M., Lavi, I., Dobaño, C., Bousquet, J., van der Vlies, P., van der Valk, R. J. P., de Jongste, J. C., Nawijn, M. C., Guerra, S., ... Koppelman, G. H. (2018). Genetic regulation ofmethylation and IL1RL1-a protein levels in asthma. European Respiratory Journal, 51(3). https://doi.org/10.1183/13993003.01377-2017
  7. 2017
  8. 23andMe Res Team, AAGC collaborators, BIOS Consortium, & Lifelines Cohort Study (2017). Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nature Genetics, 49(12), 1752-1757. https://doi.org/10.1038/ng.3985
  9. Eslami, A., Akhabir, L., Vonk, J. M., Becker, A. B., Kozyrskyj, A. L., Pare, P. D., Sandford, A. J., Koppelman, G. H., Laprise, C., & Daley, D. (2017). Genome-wide Meta-Analysis of Parent-of-Origin Effects of Asthma in Four Cohorts. Genetic epidemiology, 41(7), 686-687.
  10. Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., Bohlin, J., Xu, Z., Huang, R-C., Reese, S. E., Xu, C-J., Baïz, N., Hoyo, C., Agha, G., Roy, R., Holloway, J. W., Ghantous, A., Merid, S. K., Bakulski, K. M., ... Relton, C. L. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics, 26(20), 4067-4085. https://doi.org/10.1093/hmg/ddx290
  11. Berkers, G., Dekkers, J. F., Kruisselbrink, E., Vonk, A. M., Heida-Michel, S., Geerdink, M., Janse-Seip, van Panhuis, H., de Winter-de Groot, K. M., Arets, H. G., Heijerman, H. G., van de Graaf, E. A., Majoor, C. J., Koppelman, G. H., Roukema, J., Bakker, M., Clevers, J. C., & van der Ent, C. K. (2017). Correlation between individual clinical responses and forskolin-induced swelling of paired intestinal organoids upon CFTR modulator treatment. Pediatric Pulmonology, 52, S295.
  12. Kreiner, E., Waage, J., Standl, M., Brix, S., Pers, T. H., Couto Alves, A., Warrington, N. M., Tiesler, C. M., Fuertes, E., Franke, L., Hirschhorn, J. N., James, A., Simpson, A., Tung, J. Y., Koppelman, G. H., Postma, D. S., Pennell, C. E., Jarvelin, M-R., Custovic, A., ... Bønnelykke, K. (2017). Shared genetic variants suggest common pathways in allergy and autoimmune diseases. Journal of Allergy and Clinical Immunology, 140(3), 771-781. https://doi.org/10.1016/j.jaci.2016.10.055
  13. Pinto, L. A., Guerra, S., Anto, J. M., Postma, D., Koppelman, G. H., de Jongste, J. C., Gehring, U., Smit, H. A., & Wijga, A. H. (2017). Increased risk of asthma in overweight children born large for gestational age. Clinical and Experimental Allergy, 47(8), 1050-1056. https://doi.org/10.1111/cea.12961
  14. Van Ginkel, C. D., Dubois, A. E., De Jong, N. W., Van Wijk, G. R., De Groot, H., & Koppelman, G. H. (2017). Replication of the association of the STAT6 gene with food allergy, as diagnosed by DBPCFC. Allergy, 72, 129-130. [1422].
  15. Farzan, N., Vijverberg, S. J., Andiappan, A. K., Arianto, L., Berce, V., Blanca-Lopez, N., Bisgaard, H., Bonnelykke, K., Burchard, E. G., Campo, P., Canino, G., Carleton, B., Celedon, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Daley, D., Den Dekker, H. T., Dijk, N. F., ... Maitland-van der Zee, A. H. (2017). Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium. Pharmacogenomics, 18(10), 931-943. https://doi.org/10.2217/pgs-2017-0035
  16. Aguilar, D., Pinart, M., Koppelman, G. H., Saeys, Y., Nawijn, M. C., Postma, D. S., Akdis, M., Auffray, C., Ballereau, S., Benet, M., Garcia-Aymerich, J., Ramon Gonzalez, J., Guerra, S., Keil, T., Kogevinas, M., Lambrecht, B. N., Lemonnier, N., Melen, E., Sunyer, J., ... Anto, J. M. (2017). Computational analysis of multimorbidity between asthma, eczema and rhinitis. PLoS ONE, 12(6), [0179125]. https://doi.org/10.1371/journal.pone.0179125
  17. Gref, A., Kebede Merid, S., Gruzieva, O., Ballereau, S., Becker, A., Bellander, T., Bergström, A., Bossé, Y., Bottai, M., Chan-Yeung, M., Fuertes, E., Ierodiakonou, D., Jiang, R., Joly, S., Jones, M., Kobor, M. S., Korek, M., Kozyrskyj, A. L., Kumar, A., ... Melén, E. (2017). Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up. American Journal of Respiratory and Critical Care Medicine, 195(10), 1373-1383. https://doi.org/10.1164/rccm.201605-1026OC
  18. Nieuwenhuis, M. A. E., Vonk, J., Himes, B. E., Sarnowski, C., Minelli, C., Jarvis, D., Bouzigon, E., Nickle, D. C., Laviolette, M., Sin, D., Weiss, S. T., van den Berge, M., Koppelman, G. H., & Postma, D. S. (2017). PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma. Allergy, 72(5), 792-801. [13062]. https://doi.org/10.1111/all.13062
  19. Smith, D., Helgason, H., Sulem, P., Bjornsdottir, U. S., Lim, A. C., Sveinbjornsson, G., Hasegawa, H., Brown, M., Ketchem, R. R., Gavala, M., Garrett, L., Jonasdottir, A., Jonasdottir, A., Sigurdsson, A., Magnusson, O. T., Eyjolfsson, G. I., Olafsson, I., Onundarson, P. T., Sigurdardottir, O., ... Stefansson, K. (2017). A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma. PLoS genetics, 13(3), 1-24. https://doi.org/10.1371/journal.pgen.1006659
  20. Vonk, J. M., Scholtens, S., Postma, D. S., Moffatt, M. F., Jarvis, D., Ramasamy, A., Wjst, M., Omenaas, E. R., Bouzigon, E., Demenais, F., Nadif, R., Siroux, V., Polonikov, A. V., Solodilova, M., Ivanov, V. P., Curjuric, I., Imboden, M., Kumar, A., Probst-Hensch, N., ... Boezen, H. M. (2017). Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium. PLoS ONE, 12(3), [e0172716]. https://doi.org/10.1371/journal.pone.0172716
  21. Portelli, M. A., Moseley, C., Stewart, C. E., Postma, D. S., Howarth, P., Warner, J. A., Holloway, J. W., Koppelman, G. H., Brightling, C., & Sayers, I. (2017). Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients. Allergy, 72(3), 473-482. https://doi.org/10.1111/all.13046
  22. Gallo, V., Dijk, F. N., Holloway, J. W., Ring, S. M., Koppelman, G. H., Postma, D. S., Strachan, D. P., Granell, R., de Jongste, J. C., Jaddoe, V. W. V., den Dekker, H. T., Duijts, L., Henderson, A. J., & Shaheen, S. O. (2017). TRPA1 gene polymorphisms and childhood asthma. Pediatric Allergy and Immunology, 28(2), 191-198. https://doi.org/10.1111/pai.12673
  23. Bousquet, J., Farrell, J. J., Crooks, G., Hellings, P. W., Bel, E. H., Bewick, M., Chavannes, N. H., de Sousa, J. C., Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S. S., Robalo-Cordeiro, C., Samolinski, B., ... Mercier, J-C. (2017). Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing: (Action Plan B3 Area 5) (vol 6, 29, 2016). Clinical and translational allergy, 7(5). https://doi.org/10.1186/s13601-016-0135-6
  24. Anto, J. M., Bousquet, J., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. L., Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., ... Xu, C-J. (2017). Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes. Journal of Allergy and Clinical Immunology, 139(2), 388-399. https://doi.org/10.1016/j.jaci.2016.12.940
  25. Xu, C-J., Bonder, M. J., Soderhall, C., Bustamante, M., Baiz, N., Gehring, U., Jankipersadsing, S. A., van der Vlies, P., van Diemen, C. C., van Rijkom, B., Just, J., Kull, I., Kere, J., Anto, J. M., Bousquet, J., Zhernakova, A., Wijmenga, C., Annesi-Maesano, I., Sunyer, J., ... Koppelman, G. H. (2017). The emerging landscape of dynamic DNA methylation in early childhood. BMC Genomics, 18(25), 25. https://doi.org/10.1186/s12864-016-3452-1
  26. Bousquet, J., Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., ... De Oliveira-Alves, B. (2017). Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA. The Journal of Nutrition, Health & Aging, 21(1), 92-104. https://doi.org/10.1007/s12603-016-0803-1
  27. Gruzieva, O., Xu, C-J., Breton, C. V., Annesi-Maesano, I., Anto, J. M., Auffray, C., Ballereau, S., Bellander, T., Bousquet, J., Bustamante, M., Charles, M-A., de Kluizenaar, Y., den Dekker, H. T., Duijts, L., Felix, J. F., Gehring, U., Guxens, M., Jaddoe, V. V. W., Jankipersadsing, S. A., ... Melen, E. (2017). Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure. Environmental Health Perspectives, 125(1), 104-110. https://doi.org/10.1289/EHP36
  28. Janssen, N. A. H., Hoek, G., Fischer, P. H., Wijga, A. H., Koppelman, G., de Jongste, J. J., Brunekreef, B., & Gehring, U. (2017). Joint Association of Long-term Exposure to Both O-3 and NO2 with Children's Respiratory Health. Epidemiology, 28(1), E7-E9. https://doi.org/10.1097/EDE.0000000000000572
  29. 2016
  30. Bousquet, J., Hellings, P. W., Agache, I., Bedbrook, A., Bachert, C., Bergmann, K. C., Bewick, M., Bindslev-Jensen, C., Bosnic-Anticevitch, S., Bucca, C., Caimmi, D. P., Camargos, P. A. M., Canonica, G. W., Casale, T., Chavannes, N. H., Cruz, A. A., De Carlo, G., Dahl, R., Demoly, P., ... Zidarn, M. (2016). ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle. Clinical and translational allergy, 6(47). https://doi.org/10.1186/s13601-016-0137-4

ID: 103081