prof. dr. G.H. (Gerard) Koppelman

Pediatric Pulmonologist, Program leader Groningen Research Institute of Asthma and COPD, Head, section of Pediatric Pulmonology and Pediatric Allergology

prof. dr. G.H. (Gerard) Koppelman
Telephone:
G.A. (Georgette) Hoogendijk, secretary:
E-mail:
g.h.koppelman umcg.nl

Research

  1. 2019
  2. Braga, F. A. V., Kar, G., Berg, M., Carpaij, O. A., Polanski, K., Simon, L. M., Brouwer, S., Gomes, T., Hesse, L., Jiang, J., Fasouli, E. S., Efremova, M., Vento-Tormo, R., Talavera-Lopez, C., Jonker, M. R., Affleck, K., Palit, S., Strzelecka, P. M., Firth, H. V., ... Teichmann, S. A. (2019). A cellular census of human lungs identifies novel cell states in health and in asthma. Nature Medicine, 25(7), 1153-1163. https://doi.org/10.1038/s41591-019-0468-5
  3. Schiller, H. B., Montoro, D. T., Simon, L. M., Rawlins, E. L., Meyer, K. B., Strunz, M., Vieira Braga, F., Timens, W., Koppelman, G. H., Budinger, G. R. S., Burgess, J. K., van den Berge, M., Theis, F. J., Regev, A., Kaminski, N., Rajagopal, J., Teichmann, S. A., Misharin, A. V., & Nawijn, M. C. (2019). The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease. American Journal of Respiratory Cell and Molecular Biology, 61(1), 31-41. https://doi.org/10.1165/rcmb.2018-0416TR
  4. Reese, S. E., Xu, C-J., den Dekker, H. T., Lee, M. K., Sikdar, S., Ruiz-Arenas, C., Merid, S. K., Rezwan, F. I., Page, C. M., Ullemar, V., Melton, P. E., Oh, S. S., Yang, I. V., Burrows, K., Söderhäll, C., Jima, D. D., Gao, L., Arathimos, R., Wielscher, M., ... Koppelman, G. H. (2019). Epigenome-wide Meta-analysis of DNA Methylation and Childhood Asthma. Journal of Allergy and Clinical Immunology, 143(6), 2062-2074. https://doi.org/10.1016/j.jaci.2018.11.043
  5. Ierodiakonou, D., Coull, B. A., Zanobetti, A., Postma, D. S., Boezen, H. M., Vonk, J. M., McKone, E. F., Schildcrout, J. S., Koppelman, G. H., Croteau-Chonka, D. C., Lumley, T., Koutrakis, P., Schwartz, J., Gold, D. R., & Weiss, S. T. (2019). Pathway analysis of a genome-wide gene by air pollution interaction study in asthmatic children. Journal of exposure science & environmental epidemiology, 29(4), 539-547. https://doi.org/10.1038/s41370-019-0136-3
  6. van Rossem, L., Smit, H. A., Lentjes, E. G., Maitimu-Smeele, I., Brunekreef, B., Koppelman, G. H., & Wijga, A. H. (2019). Does breast milk adiponectin affect BMI and cardio-metabolic markers in childhood? British Journal of Nutrition, 121(8), 905-913. https://doi.org/10.1017/S0007114519000266
  7. Kupers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., Page, C. M., Reese, S. E., Wilcox, A. J., Czamara, D., Starling, A. P., Novoloaca, A., Lent, S., Roy, R., Hoyo, C., Breton, C., Allard, C., Just, A. C., Bakulski, K. M., ... Felix, J. F. (2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nature Communications, 10(1), [1893]. https://doi.org/10.1038/s41467-019-09671-3
  8. Taylor, D. M., Aronow, B. J., Tan, K., Bernt, K., Salomonis, N., Greene, C. S., Frolova, A., Henrickson, S. E., Wells, A., Pei, L., Jaiswal, J. K., Whitsett, J., Hamilton, K. E., MacParland, S. A., Kelsen, J., Heuckeroth, R. O., Potter, S. S., Vella, L. A., Terry, N. A., ... White, P. S. (2019). The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell, 49(1), 10-29. https://doi.org/10.1016/j.devcel.2019.03.001
  9. 23andMe Research Team, Ferreira, M. A. R., Mathur, R., Vonk, J. M., Szwajda, A., Brumpton, B., Granell, R., Brew, B. K., Ullemar, V., Lu, Y., Jiang, Y., Magnusson, P. K. E., Karlsson, R., Hinds, D. A., Paternoster, L., Koppelman, G. H., & Almqvist, C. (2019). Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. American Journal of Human Genetics, 104(4), 665-684. https://doi.org/10.1016/j.ajhg.2019.02.022
  10. Forno, E., Wang, T., Qi, C., Yan, Q., Xu, C-J., Boutaoui, N., Han, Y-Y., Weeks, D. E., Jiang, Y., Rosser, F., Vonk, J. M., Brouwer, S., Acosta-Perez, E., Colón-Semidey, A., Alvarez, M., Canino, G., Koppelman, G. H., Chen, W., & Celedón, J. C. (2019). A genome-wide study of DNA methylation in nasal epithelium, atopy, and atopic asthma in children. The Lancet. Respiratory Medicine, 7(4), 336-346. https://doi.org/10.1016/S2213-2600(18)30466-1
  11. Berkers, G., van Mourik, P., Vonk, A. M., Kruisselbrink, E., Dekkers, J. F., de Winter-de Groot, K. M., Arets, H. G. M., Marck-van der Wilt, R. E. P., Vanderschuren, M. M., Houwen, R. H. J., Heijerman, H. G. M., van de Graaf, E. A., Elias, S. G., Majoor, C. J., Koppelman, G. H., Roukema, J., Bakker, M., Janssens, H. M., van der Meer, R., ... van der Ent, C. K. (2019). Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis. Cell reports, 26(7), 1701-1708.e3. https://doi.org/10.1016/j.celrep.2019.01.068
  12. 23 Me Res Team, Collaborators SHARE Study, Ferreira, M. A. R., Vonk, J. M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J. D., Helmer, Q., Tillander, A., Ullemar, V., Lu, Y., Ruschendorf, F., Hinds, D. A., Hubner, N., Weidinger, S., Magnusson, P. K. E., Jorgenson, E., Lee, Y-A., ... Paternoster, L. (2019). Eleven loci with new reproducible genetic associations with allergic disease risk. Journal of Allergy and Clinical Immunology, 143(2), 691-699. https://doi.org/10.1016/j.jaci.2018.03.012
  13. Braga, F. V., Kar, G., Berg, M., Carpaij, O., polanski, K., Simon, L., Brouwer, S., Gomes, T., Hesse, L., Jiang, J., Fasouli, E. S., Efremova, M., Vento-Tormo, R., Affleck, K., Palit, S., strzelecka, P., Firth, H. V., Mahbubani, K. T. A., Cvejic, A., ... Teichmann, S. A. (2019). A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease. Manuscript submitted for publication. https://doi.org/10.1101/527408
  14. Hersh, C. P., Adcock, I. M., Celedón, J. C., Cho, M. H., Christiani, D. C., Himes, B. E., Kaminski, N., Mathias, R. A., Meyers, D. A., Quackenbush, J., Redline, S., Steiling, K. A., Tabor, H. K., Tobin, M. D., Wurfel, M. M., Yang, I. V., & Koppelman, G. H. (2019). High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report. Annals of the American Thoracic Society, 16(1), 1-16. https://doi.org/10.1513/AnnalsATS.201810-716WS
  15. Prins-van Ginkel, A. C., Bruijning-Verhagen, P. C. J., Wijga, A. H., Bots, M. L., Gehring, U., van der Hoek, W., Koppelman, G. H., van Rossem, L., Uiterwaal, C. S. P. M., Smit, H. A., & van der Sande, M. A. B. (2019). Childhood infections and common carotid intima media thickness in adolescence. Epidemiology And Infection, 147, 1-7. [37]. https://doi.org/10.1017/S095026881800287X
  16. Slob, E., Kats, C. J. A. R., Vijverberg, S. J. H., Pijnenburg, M. W. H., van Beijsterveldt, T. C. E. M., Koppelman, G. H., Boomsma, D. I., & Maitland-van der Zee, A. H. (2019). Early-Life Antibiotics Use Increases the Risk of Asthma and Eczema: A Discordant Twin Study. American Journal of Respiratory and Critical Care Medicine, 199.
  17. Qi, C., Jiang, Y., Yang, I. V., Forno, E., Wang, T., Vonk, J. M., Gehring, U., Cardwell, J., Acosta-Perez, E., Canino, G., Boutaoui, N., Chen, W., Celedon, J. C., Xu, C., & Koppelman, G. H. (2019). Epigenome-Wide Association Study Identifies Epigenetic Markers for Asthma and Rhinitis in Nasal Epithelial Cells. American Journal of Respiratory and Critical Care Medicine, 199.
  18. Ketelaar, M., Portelli, M. A., Dijk, F. N., Faiz, A., Shrine, N., Hankinson, J., Bhaker, S., Henry, A. P., Billington, C. K., Shaw, D., Johnson, S. R., Benest, A. V., Pogson, Z. E. K., Fogarty, A., McKeever, T. M., Singapuri, A., Heaney, L., Mansur, A., Gaudhuri, R., ... Nawijn, M. C. (2019). Functional Translation of IL33 Locus Polymorphisms Into Altered Epithelial Cell Function Underlying Asthma. American Journal of Respiratory and Critical Care Medicine, 199.
  19. Forno, E., Wang, T., Qi, C., Yan, Q., Xu, C., Boutaoui, N., Han, Y., Weeks, D., Jiang, Y., Rosser, F., Vonk, J., Brouwer, S., Acosta-Perez, E., Colon-Semidey, A., Alvarez, M., Canino, G., Koppelman, G. H., Chen, W., & Celedon, J. C. (2019). Nasal Methylation Panel Accurately Classifies Children by Atopy or Atopic Asthma. American Journal of Respiratory and Critical Care Medicine, 199.
  20. 2018
  21. Slob, E. M. A., Vijverberg, S. J. H., Palmer, C. N. A., Zazuli, Z., Farzan, N., Oliveri, N. M. B., Pijnenburg, M. W., Koppelman, G. H., & Maitland-van der Zee, A. H. (2018). Pharmacogenetics of inhaled long-acting beta2-agonists in asthma: A systematic review. Pediatric Allergy and Immunology, 29(7), 705-714. https://doi.org/10.1111/pai.12956
  22. Eslami, A., Akhabir, L., Vonk, J. M., Becker, A. B., Kozyrskyj, A. L., Sandford, A. J., Koppelman, G. H., Laprise, C., & Daley, D. (2018). Genome- wide meta-analysis of parent-of-origin effects of asthma, atopy and airway hyperresponsiveness in four cohorts. Genetic epidemiology, 42(7), 697-698.
  23. Vonk, J. M., Nieuwenhuis, M. A. E., Dijk, F. N., Boudier, A., Siroux, V., Bouzigon, E., Probst-Hensch, N., Imboden, M., Keidel, D., Sin, D., Bosse, Y., Hao, K., van den Berge, M., Faiz, A., Koppelman, G. H., & Postma, D. S. (2018). Novel genes and insights in complete asthma remission: A genome-wide association study on clinical and complete asthma remission. Clinical and Experimental Allergy, 48(10), 1286-1296. https://doi.org/10.1111/cea.13181
  24. Hüls, A., Klümper, C., MacIntyre, E. A., Brauer, M., Melén, E., Bauer, M., Berdel, D., Brunekreef, B., Chan-Yeung, M., Fuertes, E., Gehring, U., Gref, A., Heinrich, J., Standl, M., Lehmann, I., Kerkhof, M., Koppelman, G. H., Kozyrskyj, A. L., Pershagen, G., ... TAG Study Group (2018). Atopic dermatitis: Interaction between genetic variants of GSTP1, TNF, TLR2 & TLR4 and air pollution in early life. Pediatric Allergy and Immunology, 29(6), 596-605. https://doi.org/10.1111/pai.12903
  25. Xu, C-J., Söderhäll, C., Bustamante, M., Baïz, N., Gruzieva, O., Gehring, U., Mason, D., Chatzi, L., Basterrechea, M., Llop, S., Torrent, M., Forastiere, F., Fantini, M. P., Carlsen, K. C. L., Haahtela, T., Morin, A., Kerkhof, M., Merid, S. K., van Rijkom, B., ... BIOS Consortium (2018). DNA methylation in childhood asthma: an epigenome-wide meta-analysis. The Lancet. Respiratory Medicine, 6(5), 379-388. https://doi.org/10.1016/S2213-2600(18)30052-3
  26. Slob, E. M., Vijverberg, S. J., Pijnenburg, M. W., Koppelman, G. H., & der Zee, A-H. M. (2018). What do we need to transfer pharmacogenetics findings into the clinic? Pharmacogenomics, 19(7), 589-592. https://doi.org/10.2217/pgs-2018-0026
  27. Thacher, J. D., Gehring, U., Gruzieva, O., Standl, M., Pershagen, G., Bauer, C-P., Berdel, D., Keller, T., Koletzko, S., Koppelman, G. H., Kull, I., Lau, S., Lehmann, I., Maier, D., Schikowski, T., Wahn, U., Wijga, A. H., Heinrich, J., Bousquet, J., ... Bergström, A. (2018). Maternal Smoking during Pregnancy and Early Childhood and Development of Asthma and Rhinoconjunctivitis - a MeDALL Project. Environmental Health Perspectives, 126(4), [047005]. https://doi.org/10.1289/EHP2738
  28. Asai, Y., Eslami, A., van Ginkel, C. D., Akhabir, L., Wan, M., Yin, D., Ellis, G., Ben-Shoshan, M., Marenholz, I., Martino, D., Ferreira, M. A., Allen, K., Mazer, B., de Groot, H., de Jong, N. W., Gerth van Wijk, R., Dubois, A. E. J., Grosche, S., Ashley, S., ... Daley, D. (2018). Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma. Journal of Allergy and Clinical Immunology, 141(4), 1513-1516. https://doi.org/10.1016/j.jaci.2017.10.047
  29. Guerra, S., Melén, E., Sunyer, J., Xu, C-J., Lavi, I., Benet, M., Bustamante, M., Carsin, A-E., Dobaño, C., Guxens, M., Tischer, C., Vrijheid, M., Kull, I., Bergström, A., Kumar, A., Söderhäll, C., Gehring, U., Dijkstra, D. J., van der Vlies, P., ... Koppelman, G. H. (2018). Genetic and epigenetic regulation of YKL-40 in childhood. Journal of Allergy and Clinical Immunology, 141(3), 1105-1114. https://doi.org/10.1016/j.jaci.2017.06.030

ID: 103081