prof. dr. G.H. (Gerard) Koppelman

Pediatric Pulmonologist, Program leader Groningen Research Institute of Asthma and COPD, Head, section of Pediatric Pulmonology and Pediatric Allergology

prof. dr. G.H. (Gerard) Koppelman
Telephone:
G.A. (Georgette) Hoogendijk, secretary:
E-mail:
g.h.koppelman umcg.nl

Research

  1. 2020
  2. Vehmeijer, F. O. L., Küpers, L. K., Sharp, G. C., Salas, L. A., Lent, S., Jima, D. D., Tindula, G., Reese, S., Qi, C., Gruzieva, O., Page, C., Rezwan, F. I., Melton, P. E., Nohr, E., Escaramís, G., Rzehak, P., Heiskala, A., Gong, T., Tuominen, S. T., ... Felix, J. F. (2020). DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. Genome medicine, 12(1), 105. https://doi.org/10.1186/s13073-020-00810-w
  3. Merid, S. K., Bustamante, M., Standl, M., Sunyer, J., Heinrich, J., Lemonnier, N., Aguilar, D., Antó, J. M., Bousquet, J., Santa-Marina, L., Lertxundi, A., Bergström, A., Kull, I., Wheelock, Å. M., Koppelman, G. H., Melén, E., & Gruzieva, O. (2020). Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure. Environment international, 146, 106248. https://doi.org/10.1016/j.envint.2020.106248
  4. Slob, E. M. A., Brew, B. K., Vijverberg, S. J. H., Dijs, T., van Beijsterveldt, C. E. M., Koppelman, G. H., Bartels, M., Dolan, C. V., Larsson, H., Lundström, S., Lichtenstein, P., Gong, T., Maitland-van der Zee, A. H., Kraneveld, A. D., Almqvist, C., & Boomsma, D. I. (2020). Early-life antibiotic use and risk of attention-deficit hyperactivity disorder and autism spectrum disorder: results of a discordant twin study. International Journal of Epidemiology. https://doi.org/10.1093/ije/dyaa168
  5. Yan, Q., Forno, E., Cardenas, A., Qi, C., Han, Y-Y., Acosta-Pérez, E., Kim, S., Zhang, R., Boutaoui, N., Canino, G., Vonk, J. M., Xu, C-J., Chen, W., Oken, E., Gold, D. R., Koppelman, G. H., & Celedón, J. C. (2020). Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children. medRxiv : the preprint server for health sciences. https://doi.org/10.1101/2020.11.03.20225250
  6. Faiz, A., Imkamp, K., van der Wiel, E., Boudewijn, I. M., Koppelman, G. H., Brandsma, C-A., Kerstjens, H. A. M., Timens, W., Vroegop, S., Pasma, H. R., Boersma, W. G., Wielders, P., van den Elshout, F., Mansour, K., Steiling, K., Spira, A., Lenburg, M. E., Heijink, I. H., Postma, D. S., & van den Berge, M. (2020). Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD. Scientific Reports, 10(1), 1-12. [17415]. https://doi.org/10.1038/s41598-020-72551-0
  7. Early Growth Genetics Consortium, Vogelezang, S., Bradfield, J. P., Ahluwalia, T. S., Curtin, J. A., Lakka, T. A., Grarup, N., Scholz, M., van der Most, P. J., Monnereau, C., Stergiakouli, E., Heiskala, A., Horikoshi, M., Fedko, I. O., Vilor-Tejedor, N., Cousminer, D. L., Standl, M., Wang, C. A., Viikari, J., ... Snieder, H. (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS genetics, 16(10), [e1008718]. https://doi.org/10.1371/journal.pgen.1008718
  8. Melén, E., Standl, M., Gehring, U., Altug, H., Antó, J. M., Berdel, D., Bergström, A., Bousquet, J., Heinrich, J., Koppelman, G. H., Kull, I., Lupinek, C., Markevych, I., Schikowski, T., Thiering, E., Valenta, R., van Hage, M., von Berg, A., Vonk, J. M., ... Gruzieva, O. (2020). Air pollution and IgE sensitization in four European birth cohorts - the MeDALL project. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2020.08.030
  9. Aliee, H., Massip, F., Qi, C., Stella de Biase, M., van Nijnatten, J. L., Kersten, E. T. G., Kermani, N. Z., Khuder, B., Vonk, J. M., Vermeulen, R. C. H., Neighbors, M., Tew, G. W., Grimbaldeston, M., Ten Hacken, N. H. T., Hu, S., Guo, Y., Zhang, X., Sun, K., Hiemstra, P. S., ... Faiz, A. (2020). Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways. medRxiv : the preprint server for health sciences. https://doi.org/10.1101/2020.08.31.20169946
  10. Faiz, A., Vijverberg, S. J., Longo, C., Soares, P., Chew, F. T., Pino-Yanes, M., Herrera-Luis, E., Ortiz, E. A., Burchard, E. G., Potocnik, U., Palmer, C., Maroteau, C., Turner, S., Verhamme, K., Karimi, L., Mukhopadhyay, S., Timens, W., Hiemstra, P., Pijnenburg, M., ... Koppelman, G. H. (2020). Bronchial airway inducible expression and methylation QTL mapping identifies a single nucleotide polymorphism predicting inhaled corticosteroids response heterogeneity in childhood asthma. Allergy, 75, 352-352.
  11. Asai, Y., Martino, D., Eiwegger, T., Nadeau, K., Koppelman, G. H., Clarke, A. E., Lee, Y-A., Chan, E. S., Simons, E., Laprise, C., Mazer, B., Marenholz, I., Royce, D., Elliott, S. J., Hampson, C., Gerdts, J., Eslami, A., Soller, L., Hui, J., ... Daley, D. (2020). Phenotype consensus is required to enable large-scale genetic consortium studies of food allergy. Allergy, 75(9), 2383-2387. https://doi.org/10.1111/all.14333
  12. Berkers, G., van der Meer, R., van Mourik, P., Vonk, A. M., Kruisselbrink, E., Suen, S. W., Heijerman, H. G., Majoor, C. J., Koppelman, G. H., Roukema, J., Janssens, H. M., de Rijke, Y. B., Kemper, E. M., Beekman, J. M., van der Ent, C. K., & de Jonge, H. R. (2020). Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1251N gating mutation. Journal of Cystic Fibrosis. https://doi.org/10.1016/j.jcf.2020.04.014
  13. 23andMe Res Team, Collaborators SHARE Study, Ferreira, M. A. R., Vonk, J. M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J. D., Helmer, Q., Tillander, A., Ullemar, V., Lu, Y., Grosche, S., Rueschendorf, F., Granell, R., Brumpton, B. M., Fritsche, L. G., Bhatta, L., Gabrielsen, M. E., ... Koppelman, G. H. (2020). Age-of-onset information helps identify 76 genetic variants associated with allergic disease. PLoS genetics, 16(6), [e1008725]. https://doi.org/10.1371/journal.pgen.1008725
  14. Qi, C., Jiang, Y., Yang, I. V., Forno, E., Wang, T., Vonk, J. M., Gehring, U., Smit, H. A., Milanzi, E. B., Carpaij, O. A., Berg, M., Hesse, L., Brouwer, S., Cardwell, J., Vermeulen, C. J., Acosta-Pérez, E., Canino, G., Boutaoui, N., van den Berge, M., ... Koppelman, G. H. (2020). Nasal DNA methylation profiling of asthma and rhinitis. Journal of Allergy and Clinical Immunology, 145(6), 1655-1663. https://doi.org/10.1016/j.jaci.2019.12.911
  15. MeDALL Study Group, Lemonnier, N., Melén, E., Jiang, Y., Joly, S., Ménard, C., Aguilar, D., Acosta-Perez, E., Bergström, A., Boutaoui, N., Bustamante, M., Canino, G., Forno, E., González, J. R., Garcia-Aymerich, J., Gruzieva, O., Guerra, S., Heinrich, J., Kull, I., ... Bousquet, J. (2020). A novel whole blood gene expression signature for asthma, dermatitis and rhinitis multimorbidity in children and adolescents. Allergy, 1-13. https://doi.org/10.1111/all.14314
  16. Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., Grotenboer, N. S., Obeidat, M., Henry, A. P., Billington, C. K., Shaw, D., Johnson, S. R., Pogson, Z. E., Fogarty, A., McKeever, T. M., Nickle, D. C., Bossé, Y., van den Berge, M., Faiz, A., ... Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI Insight, 5(8), [132446]. https://doi.org/10.1172/jci.insight.132446
  17. Dekker, P. M., Boeren, S., Wijga, A. H., Koppelman, G. H., Vervoort, J. J. M., & Hettinga, K. A. (2020). Maternal Allergy and the Presence of Nonhuman Proteinaceous Molecules in Human Milk. Nutrients, 12(4), [1169]. https://doi.org/10.3390/nu12041169
  18. Slob, E. M. A., Brew, B. K., Vijverberg, S. J. H., Kats, C. J. A. R., Longo, C., Pijnenburg, M. W., van Beijsterveldt, T. C. E. M., Dolan, C. V., Bartels, M., Magnusson, P., Lichtenstein, P., Gong, T., Koppelman, G. H., Almqvist, C., Boomsma, D. I., & Maitland-van der Zee, A. H. (2020). Early-life antibiotic use and risk of asthma and eczema: results of a discordant twin study. European Respiratory Journal, 55(4), [1902021]. https://doi.org/10.1183/13993003.02021-2019
  19. Merid, S. K., Novoloaca, A., Sharp, G. C., Kupers, L. K., Kho, A. T., Roy, R., Gao, L., Annesi-Maesano, I., Jain, P., Plusquin, M., Kogevinas, M., Allard, C., Vehmeijer, F. O., Kazmi, N., Salas, L. A., Rezwan, F. I., Zhang, H., Sebert, S., Czamara, D., ... Melen, E. (2020). Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age. Genome medicine, 12(1), 25. [25]. https://doi.org/10.1186/s13073-020-0716-9
  20. King, C., McKenna, A., Farzan, N., Vijverberg, S. J., van der Schee, M. P., Maitland-van der Zee, A. H., Arianto, L., Bisgaard, H., Bonnelykke, K., Berce, V., Potocnik, U., Repnik, K., Carleton, B., Daley, D., Chew, F. T., Chiang, W. C., Sio, Y. Y., Cloutier, M. M., Den Dekker, H. T., ... Hawcutt, D. B. (2020). Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation. Pharmacogenomics journal, 20(5), 621-628. https://doi.org/10.1038/s41397-019-0140-y
  21. Yan, Q., Forno, E., Herrera-Luis, E., Pino-Yanes, M., Qi, C., Rios, R., Han, Y-Y., Kim, S., Oh, S., Acosta-Pérez, E., Zhang, R., Hu, D., Eng, C., Huntsman, S., Avila, L., Boutaoui, N., Cloutier, M. M., Soto-Quiros, M. E., Xu, C-J., ... Celedón, J. C. (2020). A genome-wide association study of severe asthma exacerbations in Latino children and adolescents. European Respiratory Journal. https://doi.org/10.1183/13993003.02693-2020
  22. Hoang, T. T., Sikdar, S., Xu, C-J., Lee, M. K., Cardwell, J., Forno, E., Imboden, M., Jeong, A., Madore, A-M., Qi, C., Wang, T., Bennett, B. D., Ward, J. M., Parks, C. G., Beane-Freeman, L. E., King, D., Motsinger-Reif, A., Umbach, D. M., Wyss, A. B., ... London, S. J. (2020). Epigenome-Wide Association Study of DNA Methylation and Adult Asthma in the Agricultural Lung Health Study. European Respiratory Journal, 56(3), [2000217]. https://doi.org/10.1183/13993003.00217-2020
  23. Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., Xu, C. J., Hankinson, J., Bhaker, S., Henry, A. P., Billington, C. K., Shaw, D. E., Johnson, S. R., Benest, A. V., Pang, V., Bates, D., Pogson, Z. E. K., Fogarty, A., McKeever, T. M., ... Nawijn, M. C. (2020). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2020.04.051
  24. Yan, Q., Cardenas, A., Forno, E., Qi, C., Han, Y., Acosta-Perez, E., Zhang, R., Boutaoui, N., Canino, G., Chen, W., Oken, E., Xu, C., Gold, D. R., Koppelman, G. H., & Celedon, J. C. (2020). Psychosocial Stressors, DNA Methylation in Airway Epithelium, and Asthma in Children. American Journal of Respiratory and Critical Care Medicine, 201.
  25. 2019
  26. Dijk, F. N., Vijverberg, S. J., Hernandez-Pacheco, N., Repnik, K., Karimi, L., Mitratza, M., Farzan, N., Nawijn, M. C., Burchard, E. G., Engelkes, M., Verhamme, K. M., Potočnik, U., Pino-Yanes, M., Postma, D. S., Maitland-van der Zee, A., & Koppelman, G. H. (2019). IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids. Allergy, 75(4), 984-989. https://doi.org/10.1111/all.14125
  27. Aguilar, D., Lemonnier, N., Koppelman, G. H., Melén, E., Oliva, B., Pinart, M., Guerra, S., Bousquet, J., & Anto, J. M. (2019). Understanding allergic multimorbidity within the non-eosinophilic interactome. PLoS ONE, 14(11), [e0224448]. https://doi.org/10.1371/journal.pone.0224448
  28. Sikdar, S., Joehanes, R., Joubert, B. R., Xu, C-J., Vives-Usano, M., Rezwan, F. I., Felix, J. F., Ward, J. M., Guan, W., Richmond, R. C., Brody, J. A., Küpers, L. K., Baïz, N., Håberg, S. E., Smith, J. A., Reese, S. E., Aslibekyan, S., Hoyo, C., Dhingra, R., ... London, S. J. (2019). Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics, 11(13), 1487-1500. https://doi.org/10.2217/epi-2019-0066
  29. Dijk, F. N., Folkersma, C., Gruzieva, O., Kumar, A., Wijga, A. H., Gehring, U., Kull, I., Postma, D. S., Vonk, J. M., Melén, E., & Koppelman, G. H. (2019). Genetic risk scores do not improve asthma prediction in childhood. Journal of Allergy and Clinical Immunology, 144(3), 857-+. https://doi.org/10.1016/j.jaci.2019.05.017
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