prof. dr. E. (Eelko) Hak
Full professor of Clinical Pharmacoepidemiology/Educational director Pharmacy-MPS

Telephone:
E-mail:
e.hak rug.nl
Research
Postal address:
A Deusinglaan1
Gebouw 3214, ruimte 0457
9713 AV
Groningen
Netherlands
Phone: +31 50 363 8707
1 - 50 out of 361Page size: 50
- 2020
- Groothof, D., Post, A., Sotomayor, C. G., Keyzer, C. A., Flores-Guerero, J. L., Hak, E., Bos, J. H. J., Schurgers, L. J., Navis, G., Gans, R. O. B., Eelderink, C., de Borst, M. H., Bakker, S. J. L., & Riphagen, I. J. (2020). Functional vitamin K status and risk of incident chronic kidney disease and microalbuminuria: a prospective general population-based cohort study. Nephrology, Dialysis, Transplantation. https://doi.org/10.1093/ndt/gfaa304
- Oktora, M. P., Alfian, S. D., Bos, H. J., Schuiling-Veninga, C. C. M., Taxis, K., Hak, E., & Denig, P. (2020). Trends in polypharmacy and potentially inappropriate medication (PIM) in older and middle-aged people treated for diabetes. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.14685
- Bahar, M. A., Lanting, P., Bos, J. H. J., Sijmons, R. H., Hak, E., & Wilffert, B. (2020). Impact of Drug-Gene-Interaction, Drug-Drug-Interaction, and Drug-Drug-Gene-Interaction on (es)Citalopram Therapy: The PharmLines Initiative. Journal of personalized medicine, (4), 1-20. https://doi.org/10.3390/jpm10040256
- Alfian, S. D., van Boven, J. F. M., Abdulah, R., Sukandar, H., Denig, P., & Hak, E. (2020). Effectiveness of a targeted and tailored pharmacist-led intervention to improve adherence to antihypertensive drugs among patients with type 2 diabetes in Indonesia: a cluster randomised controlled trial. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.14610
- Minović, I., Kieneker, L. M., Gansevoort, R. T., Eggersdorfer, M., Touw, D. J., Voerman, A-J., Connelly, M. A., Boer, R. A. D., Hak, E., Bos, J., Dullaart, R. P. F., Kema, I. P., & Bakker, S. J. L. (2020). Vitamin B6, Inflammation, and Cardiovascular Outcome in a Population-Based Cohort: The Prevention of Renal and Vascular End-Stage Disease (PREVEND) Study. Nutrients, 12(9), 1-17. [2711]. https://doi.org/10.3390/nu12092711
- van der Schans, J., Hak, E., Postma, M., Breuning, L., Brouwers, J. R. B. J., Ditters, K., Jansen, P. A. F., Kok, R. M., Maring, J. G., van Marum, R., Mulder, H., Nanninga, J., Voshaar, R. C. O., Risselada, A. J., Vleugel, L., Stek, M., van Schaik, R. H. N., Berm, E. J. J., & Wilffert, B. (2020). Article Selected to Receive the Mitchell B. Balter Award for 2020. Journal of Clinical Psychopharmacology, 40(5), 443-443. https://doi.org/10.1097/JCP.0000000000001273
- Chimeh, R. A., Gafar, F., Pradipta, I. S., Akkerman, O. W., Hak, E., Alffenaar, J-W. C., & van Boven, J. F. M. (2020). Clinical and economic impact of medication non-adherence in drug-susceptible tuberculosis: a systematic review. International Journal of Tuberculosis and Lung Disease, 24(8), 811-819. https://doi.org/10.5588/ijtld.19.0754
- Groothof, D., Flores-Guerrero, J. L., Nolte, I. M., Bouma, H. R., Gruppen, E. G., Bano, A., Post, A., Kootstra-Ros, J. E., Hak, E., Bos, J. H. J., de Borst, M. H., Gans, R. O. B., Links, T. P., Dullaart, R. P. F., & Bakker, S. J. L. (2020). Thyroid function and risk of all-cause and cardiovascular mortality: a prospective population-based cohort study. Endocrine. https://doi.org/10.1007/s12020-020-02397-z
- Irawati, S., Prayudeni, S., Rachmawati, R., Wita, I. W., Willfert, B., Hak, E., & Taxis, K. (2020). Key factors influencing the prescribing of statins: A qualitative study among physicians working in primary healthcare facilities in Indonesia. BMJ Open, 10(6), [e035098]. https://doi.org/10.1136/bmjopen-2019-035098
- Pradipta, I. S., Houtsma, D., van Boven, J. F. M., Alffenaar, J-W. C., & Hak, E. (2020). Interventions to improve medication adherence in tuberculosis patients: A systematic review of randomized controlled studies. npj Primary Care Respiratory Medicine, 30(1), [21]. https://doi.org/10.1038/s41533-020-0179-x
- Bahar, M. A., Bos, J. H. J., Borgsteede, S. D., Dotinga, A., Alingh, R. A., Wilffert, B., & Hak, E. (2020). Prevalence and Accuracy of Information on CYP2D6, CYP2C19, and CYP2C9 Related Substrate and Inhibitor Co-Prescriptions in the General Population: A Cross-Sectional Descriptive Study as Part of the PharmLines Initiative. Frontiers in Pharmacology, 11, [624]. https://doi.org/10.3389/fphar.2020.00624
- Alfian, S. D., Annisa, N., Fajriansyah, F., Perwitasari, D. A., Abdulah, R., Hak, E., & Denig, P. (2020). Modifiable Factors Associated with Non-adherence to Antihypertensive or Antihyperlipidemic Drugs Are Dissimilar: a Multicenter Study Among Patients with Diabetes in Indonesia. Journal of General Internal Medicine, 35(10), 2897-2906. https://doi.org/10.1007/s11606-020-05809-y
- Pleguezuelos, O., Dille, J., de Groen, S., Oftung, F., Niesters, H. G. M., Islam, M. A., Naess, L. M., Hungnes, O., Aldarij, N., Idema, D. L., Perez, A. F., James, E., Frijlink, H. W., Stoloff, G., Groeneveld, P., & Hak, E. (2020). Immunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults. Annals of Internal Medicine, 172(7), 453-462. https://doi.org/10.7326/M19-0735
- Sluiter, M. N., de Vries, Y. A., Koning, L. G., Hak, E., Bos, J. H. J., Schuiling-Veninga, C. C. M., Batstra, L., Doornenbal, J. M., & de Jonge, P. (2020). A Prescription Trend Analysis of Methylphenidate: Relation to Study Reports on Efficacy. Administration and Policy in Mental Health and Mental Health Services Research , 47(2), 291–299. https://doi.org/10.1007/s10488-019-00983-6
- Gruppen, E. G., Kootstra-Ros, J., Kobold, A. M., Connelly, M. A., Touw, D., Bos, J. H. J., Hak, E., Links, T. P., Bakker, S. J. L., & Dullaart, R. P. F. (2020). Cigarette smoking is associated with higher thyroid hormone and lower TSH levels: The PREVEND study. Endocrine, 67(3), 613–622. https://doi.org/10.1007/s12020-019-02125-2
- Wang, Y., Bos, J., Boezen, H. M., Alffenaar, J-W., Boven, van, J., Schuiling-Veninga, C., Wilffert, B., & Hak, E. (2020). Influence of age on real-life effects of doxycycline for acute exacerbations among COPD outpatients: A population-based cohort study. BMJ Open Respir Res, 7(1), [e000535]. https://doi.org/10.1136/bmjresp-2019-000535
- Losenkov, I. S., Mulder, N. J. V., Levchuk, L. A., Vyalova, N. M., Loonen, A. J. M., Bosker, F. J., Simutkin, G. G., Boiko, A. S., Bokhan, N. A., Wilffert, B., Hak, E., Schmidt, A. F., & Ivanova, S. A. (2020). Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients. Frontiers in Psychiatry, 11, [38]. https://doi.org/10.3389/fpsyt.2020.00038
- Irawati, S., Dharma, S., Taxis, K., Nguyen, T., Nursyarofah, N., Wilffert, B., & Hak, E. (2020). Association between Adherence to Guideline-Recommended Preventive Medications and In-Hospital Mortality among Non-Reperfused ST-Elevation Myocardial Infarction Patients Admitted to a Tertiary Care Academic Center in a Developing Country. Global heart, 15(1), 8. https://doi.org/10.5334/gh.394
- van der Schans, J., Cao, Q., Bos, E. H., Rours, G. I. J. G., Hoekstra, P. J., Hak, E., & de Vries, T. W. (2020). The temporal order of fluctuations in atopic disease symptoms and attention-deficit/hyperactivity disorder symptoms: A time-series study in ADHD patients. European Child & Adolescent Psychiatry, 29(2), 137-144. https://doi.org/10.1007/s00787-019-01336-2
- Flores-Guerrero, J. L., Minovic, I., Groothof, D., Gruppen, E. G., Riphagen, I. J., Kootstra-Ros, J., Kobold, A. M., Hak, E., Navis, G., Gansevoort, R. T., de Borst, M. H., Dullaart, R. P. F., & Bakker, S. J. L. (2020). Association of Plasma Concentration of Vitamin B-12 With All-Cause Mortality in the General Population in the Netherlands. Jama network open, 3(1), e1919274. https://doi.org/10.1001/jamanetworkopen.2019.19274
- Alfian, S. D., Abdulah, R., Denig, P., van Boven, J. F. M., & Hak, E. (2020). Targeted and tailored pharmacist-led intervention to improve adherence to antihypertensive drugs among patients with type 2 diabetes in Indonesia: Study protocol of a cluster randomised controlled trial. BMJ Open, 10(1), [e034507]. https://doi.org/10.1136/bmjopen-2019-034507
- 2019
- Edelman, M., Jellema, P., Hak, E., Denig, P., & Blanker, M. H. (2019). Patients' Attitudes Towards Deprescribing Alpha-Blockers and Their Willingness to Participate in a Discontinuation Trial. Drugs & Aging, 36(12), 1133-1139. https://doi.org/10.1007/s40266-019-00712-6
- Douwes, R. M., Gomes-Neto, A. W., Schutten, J. C., van den Berg, E., de Borst, M. H., Berger, S. P., Touw, D. J., Hak, E., Blokzijl, H., Navis, G., & Bakker, S. J. L. (2019). Proton-Pump Inhibitors and Hypomagnesaemia in Kidney Transplant Recipients. Journal of Clinical Medicine, 8(12), [2162]. https://doi.org/10.3390/jcm8122162
- van der Schans, J., Hak, E., Postma, M., Breuning, L., Brouwers, J. R. B. J., Ditters, K., Jansen, P. A. F., Kok, R. M., Maring, J. G., van Marum, R., Mulder, H., Nanninga, J., Oude Voshaar, R. C., Risselada, A. J., Vleugel, L., Stek, M., van Schaik, R. H. N., Berm, E. J. J., & Wilffert, B. (2019). Effects of Pharmacogenetic Screening for CYP2D6 Among Elderly Starting Therapy With Nortriptyline or Venlafaxine: A Pragmatic Randomized Controlled Trial (CYSCE Trial). Journal of Clinical Psychopharmacology, 39(6), 583-590. https://doi.org/10.1097/JCP.0000000000001129
- Herawati, F., Yulia, R., Hak, E., Hartono, A. H., Michiels, T., Woerdenbag, H. J., & Avanti, C. (2019). A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia. Hospital Pharmacy Europe, 54(5), 323-329. https://doi.org/10.1177/0018578718792804
- Wang, Y., Bahar, M. A., Jansen, A. M. E., Kocks, J. W. H., Alffenaar, J-W. C., Hak, E., Wilffert, B., & Borgsteede, S. D. (2019). Improving antibacterial prescribing safety in the management of COPD exacerbations: systematic review of observational and clinical studies on potential drug interactions associated with frequently prescribed antibacterials among COPD patients. Journal of Antimicrobial Chemotherapy, 74(10), 2848-2864. https://doi.org/10.1093/jac/dkz221
- Martono, D. P., Heerspink, H. J. L., Hak, E., Denig, P., & Wilffert, B. (2019). No significant association of type 2 diabetes-related genetic risk scores with glycated haemoglobin levels after initiating metformin or sulphonylurea derivatives. Diabetes obesity & metabolism, 21(10), 2267-2273. https://doi.org/10.1111/dom.13803
- Douwes, R. M., Gomes-Neto, A. W., Eisenga, M. F., Vinke, J. S. J., de Borst, M. H., van den Berg, E., Berger, S. P., Touw, D. J., Hak, E., Blokzijl, H., Navis, G., & Bakker, S. J. L. (2019). Chronic Use of Proton-Pump Inhibitors and Iron Status in Renal Transplant Recipients. Journal of Clinical Medicine, 8(9), [1382]. https://doi.org/10.3390/jcm8091382
- Irawati, S., Dharma, S., Taxis, K., Nguyen Thang, Nursyarofah, N., Wilffert, B., & Hak, E. (2019). Association between adherence to guideline-recommended preventive medications and in-hospital mortality among non-reperfused ST-elevation myocardial infarction patients admitted to a tertiary care academic center in a developing country. Pharmacoepidemiology and Drug Safety, 28, 525-525.
- Hordijk, I. M. J., Steffens, M. G., Hak, E., & Blanker, M. H. (2019). Continuation rates of alpha-blockers mono-therapy in adult men, prescribed by urologists or general practitioners: A pharmacy-based study. World journal of urology, 37(8), 1659-1664. https://doi.org/10.1007/s00345-018-2557-3
- Pradipta, I. S., van’t Boveneind-Vrubleuskaya, N., Akkerman, O. W., Alffenaar, J-W. C., & Hak, E. (2019). Predictors for treatment outcomes among patients with drug-susceptible tuberculosis in the Netherlands: a retrospective cohort study. Clinical Microbiology and Infection, 25(6), 761.e1-761.e7. https://doi.org/10.1016/j.cmi.2018.10.009
- Fortanier, A. C., Venekamp, R. P., Boonacker, C. W. B., Hak, E., Schilder, A. G. M., Sanders, E. A. M., & Damoiseaux, R. A. M. J. (2019). Pneumococcal conjugate vaccines for preventing acute otitis media in children. Cochrane database of systematic reviews (Online), 5, [CD001480]. https://doi.org/10.1002/14651858.CD001480.pub5
- Irawati, S., Wasir, R., Floriaan Schmidt, A., Islam, A., Feenstra, T., Buskens, E., Wilffert, B., & Hak, E. (2019). Long-term incidence and risk factors of cardiovascular events in Asian populations: systematic review and meta-analysis of population-based cohort studies. Current Medical Research and Opinion, 35(2), 291-299. https://doi.org/10.1080/03007995.2018.1491149
- Blaauwhof , AMA., Hak, E., Bos, J., & Schuiling-Veninga, C. (2019). Psychotropic co‐medication in Dutch children and adolescents using psycho‐stimulants: A prescription sequence symmetry analysis. Pharmcoepidemiology and Drug Safety, 28(52), 166-166. [335].
- Wang, Y., Bos, J., Schuiling-Veninga, C., Wilffert, B., & Hak, E. (2019). The effects of amoxicillin on acute COPD exacerbations in the outpatient setting: A retrospective cohort study based on real‐world data. Pharmcoepidemiology and Drug Safety, 28(52), 581-582. [1208]. https://doi.org/10.1002/pds.4864
- 2018
- Wang, Y., Zijp, T. R., Bahar, M. A., Kocks, J. W. H., Wilffert, B., & Hak, E. (2018). Effects of prophylactic antibiotics on patients with stable COPD: a systematic review and meta-analysis of randomized controlled trials. Journal of Antimicrobial Chemotherapy, 73(12), 3231–3243. https://doi.org/10.1093/jac/dky326
- Pradipta, I. S., Forsman, L. D., Bruchfeld, J., Hak, E., & Alffenaar, J-W. (2018). Risk factors of multidrug-resistant tuberculosis: A global systematic review and meta-analysis. Journal of infection, 77(6), 469-478. https://doi.org/10.1016/j.jinf.2018.10.004
- Bahar, M. A., Kamp, J., Borgsteede, S. D., Hak, E., & Wilffert, B. (2018). The impact of CYP2D6 mediated drug-drug interaction: A systematic review on a combination of metoprolol and paroxetine/fluoxetine. British Journal of Clinical Pharmacology, 84(12), 2704-2715. https://doi.org/10.1111/bcp.13741
- Sediq , R., van der Schans, J., Dotinga, A., Alingh, R., Wilffert, B., Schuiling-Veninga, CCM., Hak, E., & Bos, HJ. (2018). Concordance assessment of self-reported medication use in the Netherlands three-generation Lifelines Cohort Study with the pharmacy database IADB.nl: The PharmLines Initiative. Clinical Epidemiology 2018:2010;1-9. Journal of Clinical Epidemiology, 10, 981-989. https://doi.org/10.2147/CLEP.S163037
ID: 347541