prof. dr. ir. E.A.A. (Ellen) Nollen

Professor

prof. dr. ir. E.A.A. (Ellen) Nollen
E-mail:
e.a.a.nollen umcg.nl

Research

Postal address:
Netherlands
  1. 2019
  2. Janssens, G. E., Lin, X-X., Millan-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., ... Riedel, C. G. (2019). Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell reports, 27(2), 467-480.e6. https://doi.org/10.1016/j.celrep.2019.03.044
  3. 2018
  4. Javer, A., Currie, M., Lee, C. W., Hokanson, J., Li, K., Martineau, C. N., ... Brown, A. E. X. (2018). An open-source platform for analyzing and sharing worm-behavior data. Nature Methods, 15(9), 645-646. https://doi.org/10.1038/s41592-018-0112-1
  5. Perni, M., Flagmeier, P., Limbocker, R., Cascella, R., Aprile, F. A., Galvagnion, C., ... Dobson, C. M. (2018). Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology, 13(8), 2308-2319. https://doi.org/10.1021/acschembio.8b00466
  6. Sinnige, T., Laine, R. F., Ma, K. Y., Haack, A. J., Gaida, P., Curry, N., ... Kaminski, C. F. (2018). Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans. Biophysical Journal, 114(3), 350A.
  7. 2017
  8. Yoshimura, Y., Holmberg, M. A., Kukic, P., Andersen, C. B., Mata-Cabana, A., Falsone, S. F., ... Mulder, F. A. A. (2017). MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions. The Journal of Biological Chemistry, 292(20), 8269-8278. https://doi.org/10.1074/jbc.M116.764886
  9. Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., ... International Parkinson’s Disease Genetics Consortium (IPGDC) (2017). Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology, 18(22). https://doi.org/10.1186/s13059-017-1147-9
  10. 2016
  11. Koopman, M., Michels, H., Dancy, B. M., Kamble, R., Mouchiroud, L., Auwerx, J., ... Houtkooper, R. H. (2016). A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans. Nature protocols, 11(10), 1798-1816. https://doi.org/10.1038/nprot.2016.106
  12. Visscher, M., De Henau, S., Wildschut, M. H. E., van Es, R. J. J., Dhondt, I., Michels, H., ... Dansen, T. B. (2016). Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease. Cell reports, 16(11), 3041-3051. https://doi.org/10.1016/j.celrep.2016.08.025
  13. 2015
  14. 2014
  15. 2013
  16. Holmberg, M., & Nollen, E. A. A. (2013). Analyzing modifiers of protein aggregation in C. elegans by native agarose gel electrophoresis. In D. M. Hatters, & A. J. Hannan (Eds.), Tandem Repeats in Genes, Proteins, and Disease (Vol. 1017, pp. 193-199). (Methods in Molecular Biology; Vol. 1017). Humana Press. https://doi.org/10.1007/978-1-62703-438-8_14
  17. 2012
  18. Falsone, S. F., Meyer, N. H., Schrank, E., Leitinger, G., Pham, C. L. L., Fodero-Tavoletti, M. T., ... Zangger, K. (2012). SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly. Cell reports, 2(2), 358-371. https://doi.org/10.1016/j.celrep.2012.06.012
  19. 2011
  20. Schierle, G. S. K., Bertoncini, C. W., Chan, F. T. S., van der Goot, A. T., Schwedler, S., Skepper, J., ... Kaminski, C. F. (2011). A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo. Chemphyschem, 12(3), 673-680. https://doi.org/10.1002/cphc.201000996
  21. 2010
  22. van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., ... Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity. Cell, 142(4), 601-612. https://doi.org/10.1016/j.cell.2010.07.020
  23. van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., ... Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. Cell, 142(4), 601-12. https://doi.org/10.1016/j.cell.2010.07.020
  24. van Ham, T. J., Esposito, A., Kumita, J. R., Hsu, S-T. D., Schierle, G. S. K., Kaminsk, C. F., ... Bertoncini, C. W. (2010). Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of alpha-Synuclein Aggregation. Journal of Molecular Biology, 395(3), 627-642. https://doi.org/10.1016/j.jmb.2009.10.066
  25. 2009
  26. Roodveldt, C., Bertoncini, C. W., Andersson, A., van der Goot, A. T., Hsu, S-T., Fernandez-Montesinos, R., ... Dobson, C. M. (2009). Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO Journal, 28(23), 3758-3770. https://doi.org/10.1038/emboj.2009.298
  27. 2008
  28. 2004
  29. 2002
  30. Kim, S., Nollen, E. A. A., Kitagawa, K., Bindokas, V. P., & Morimoto, R. I. (2002). Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4(10), 826-831. https://doi.org/10.1038/ncb863
  31. 2001
  32. 2000
  33. 1999
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