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prof. dr. ir. E.A.A. (Ellen) Nollen

Professor

prof. dr. ir. E.A.A. (Ellen) Nollen
E-mail:
e.a.a.nollen umcg.nl

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Postal address:
Netherlands
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  1. 2020
  2. Koopman, M., Peter, Q., Seinstra, R. I., Perni, M., Vendruscolo, M., Dobson, C. M., ... Nollen, E. A. A. (2020). Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform. Nature protocols. https://doi.org/10.1038/s41596-020-0321-9
  3. 2019
  4. Koopman, M., Hetz, C., & Nollen, E. A. A. (2019). Saved by the Matrix: UPR Independent Survival under ER Stress. Cell, 179(6), 1246-1248. https://doi.org/10.1016/j.cell.2019.11.012
  5. Sorgdrager, F. J. H., Naude, P. J. W., Kema, I. P., Nollen, E. A., & De Deyn, P. P. (2019). Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target. Frontiers in Immunology, 10, [2565]. https://doi.org/10.3389/fimmu.2019.02565
  6. Sorgdrager, F. J. H., Vermeiren, Y., Van Faassen, H. J. R., Van Der Ley, C. P., Nollen, E. A. A., Kema, I. P., & De Deyn, P. P. (2019). Age- and Disease-Specific Changes of the Kynurenine Pathway in Parkinson's and Alzheimer's Disease. Journal of Neurochemistry, 151(5), 656-668. https://doi.org/10.1111/jnc.14843
  7. Laine, R. F., Sinnige, T., Ma, K. Y., Haack, A. J., Poudel, C., Gaida, P., ... Kaminski, C. F. (2019). Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of alpha-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. ACS chemical biology, 14(7), 1628-1636. https://doi.org/10.1021/acschembio.9b00354
  8. Platten, M., Nollen, E. A. A., Röhrig, U. F., Fallarino, F., & Opitz, C. A. (2019). Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nature Reviews Drug Discovery, 18(8), 379-401. https://doi.org/10.1038/s41573-019-0016-5
  9. Janssens, G. E., Lin, X-X., Millan-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., ... Riedel, C. G. (2019). Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell reports, 27(2), 467-480.e6. https://doi.org/10.1016/j.celrep.2019.03.044
  10. Koopman, M., Seinstra, R. I., & Nollen, E. A. A. (2019). C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques. In T. Bartels (Ed.), Alpha-Synuclein (pp. 93-112). (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-9124-2_9
  11. 2018
  12. Perni, M., Casford, S., Aprile, F. A., Nollen, E. A., Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2018). Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform. Journal of visualized experiments : JoVE, (141), [58643]. https://doi.org/10.3791/58643
  13. Mata-Cabana, A., Sin, O., Seinstra, R. I., & Nollen, E. A. A. (2018). Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans. JMIR research protocols, 8(20), [3053]. https://doi.org/10.21769/BioProtoc.3053
  14. Sin, O., Mata-Cabana, A., Seinstra, R. I., & Nollen, E. A. A. (2018). Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Lysates. JMIR research protocols, 8(19), [3042]. https://doi.org/10.21769/BioProtoc.3042
  15. Javer, A., Currie, M., Lee, C. W., Hokanson, J., Li, K., Martineau, C. N., ... Brown, A. E. X. (2018). An open-source platform for analyzing and sharing worm-behavior data. Nature Methods, 15(9), 645-646. https://doi.org/10.1038/s41592-018-0112-1
  16. Perni, M., Challa, P. K., Kirkegaard, J. B., Limbocker, R., Koopman, M., Hardenberg, M. C., ... Knowles, T. P. J. (2018). Massively parallel C elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of Neuroscience Methods, 306, 57-67. https://doi.org/10.1016/j.jneumeth.2018.02.005
  17. Perni, M., Flagmeier, P., Limbocker, R., Cascella, R., Aprile, F. A., Galvagnion, C., ... Dobson, C. M. (2018). Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology, 13(8), 2308-2319. https://doi.org/10.1021/acschembio.8b00466
  18. Sinnige, T., Laine, R. F., Ma, K. Y., Haack, A. J., Gaida, P., Curry, N., ... Kaminski, C. F. (2018). Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans. Biophysical Journal, 114(3), 350A.
  19. 2017
  20. Nollen, E. A. A., & Michels, H. (2017). Cysteine dioxygenase inhibitors for prolonging the lifespan of a subject. (Patent No. EP3251664).
  21. Yoshimura, Y., Holmberg, M. A., Kukic, P., Andersen, C. B., Mata-Cabana, A., Falsone, S. F., ... Mulder, F. A. A. (2017). MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions. The Journal of Biological Chemistry, 292(20), 8269-8278. https://doi.org/10.1074/jbc.M116.764886
  22. Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., ... Dobson, C. M. (2017). Correction for Perni et al., A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017). Proceedings of the National Academy of Science of the United States of America, 114(12), E2543-E2543. https://doi.org/10.1073/pnas.1701964114
  23. Sin, O., de Jong, T., Mata-Cabana, A., Kudron, M., Zaini, M. A., Aprile, F. A., ... Nollen, E. A. A. (2017). Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell, 65(6), 1096-1108. https://doi.org/10.1016/j.molcel.2017.02.022
  24. Stroo, E., Koopman, M., Nollen, E. A. A., & Mata-Cabana, A. (2017). Cellular Regulation of Amyloid Formation in Aging and Disease. Frontiers in Neuroscience, 11, [64]. https://doi.org/10.3389/fnins.2017.00064
  25. Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., ... Dobson, C. M. (2017). A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America, 114(6), E1009-E1017. https://doi.org/10.1073/pnas.1610586114
  26. Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., ... International Parkinson’s Disease Genetics Consortium (IPGDC) (2017). Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology, 18(22). https://doi.org/10.1186/s13059-017-1147-9
  27. 2016
  28. Michels, H., Seinstra, R. I., Uitdehaag, J. C. M., Koopman, M., van Faassen, M., Martineau, C. N., ... Nollen, E. A. A. (2016). Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase. Scientific Reports, 6, [39199]. https://doi.org/10.1038/srep39199
  29. Koopman, M., Michels, H., Dancy, B. M., Kamble, R., Mouchiroud, L., Auwerx, J., ... Houtkooper, R. H. (2016). A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans. Nature protocols, 11(10), 1798-1816. https://doi.org/10.1038/nprot.2016.106
  30. Visscher, M., De Henau, S., Wildschut, M. H. E., van Es, R. J. J., Dhondt, I., Michels, H., ... Dansen, T. B. (2016). Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease. Cell reports, 16(11), 3041-3051. https://doi.org/10.1016/j.celrep.2016.08.025
  31. Habchi, J., Arosio, P., Perni, M., Costa, A. R., Yagi-Utsumi, M., Joshi, P., ... Vendruscolo, M. (2016). An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science Advances, 2(2), [e1501244]. https://doi.org/10.1126/sciadv.1501244
  32. 2015
  33. Alvarenga Fernandes Sin, O., & Nollen, E. A. A. (2015). Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes. Cellular and molecular life sciences, 72(21), 4027-4047. https://doi.org/10.1007/s00018-015-1985-0
  34. Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., ... Sibon, O. C. M. (2015). Extracellular 4 '-phosphopantetheine is a source for intracellular coenzyme A synthesis. Nature Chemical Biology, 11(10), 784-792.e3. https://doi.org/10.1038/NCHEMBIO.1906
  35. 2014
  36. Alvarenga Fernandes Sin, O., Michels, H., & Nollen, E. A. A. (2014). Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases. Biochimica et biophysica acta-Molecular basis of disease, 1842(10), 1951-1959. https://doi.org/10.1016/j.bbadis.2014.01.015
  37. 2013
  38. van der Goot, A. T., & Nollen, E. A. A. (2013). Tryptophan metabolism: entering the field of aging and age-related pathologies. TRENDS IN MOLECULAR MEDICINE, 19(6), 336-344. https://doi.org/10.1016/j.molmed.2013.02.007
  39. Holmberg, M., & Nollen, E. A. A. (2013). Analyzing modifiers of protein aggregation in C. elegans by native agarose gel electrophoresis. In D. M. Hatters, & A. J. Hannan (Eds.), Tandem Repeats in Genes, Proteins, and Disease (Vol. 1017, pp. 193-199). (Methods in Molecular Biology; Vol. 1017). Humana Press. https://doi.org/10.1007/978-1-62703-438-8_14
  40. 2012
  41. van der Goot, A. T., Zhu, W., Vazquez-Manrique, R. P., Seinstra, R. I., Dettmer, K., Michels, H., ... Nollen, E. A. A. (2012). Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. https://doi.org/10.1073/pnas.1203083109
  42. Falsone, S. F., Meyer, N. H., Schrank, E., Leitinger, G., Pham, C. L. L., Fodero-Tavoletti, M. T., ... Zangger, K. (2012). SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly. Cell reports, 2(2), 358-371. https://doi.org/10.1016/j.celrep.2012.06.012
  43. 2011
  44. Siudeja, K., Srinivasan, B., Xu, L., Rana, A., de Jong, J., Nollen, E. A. A., ... Sibon, O. C. M. (2011). Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration. EMBO Molecular Medicine, 3(12), 755-766. https://doi.org/10.1002/emmm.201100180
  45. Schierle, G. S. K., Bertoncini, C. W., Chan, F. T. S., van der Goot, A. T., Schwedler, S., Skepper, J., ... Kaminski, C. F. (2011). A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo. Chemphyschem, 12(3), 673-680. https://doi.org/10.1002/cphc.201000996
  46. Teuling, E., Bourgonje, A., Veenje, S., Thijssen, K., de Boer, J., van der Velde, J., ... Nollen, E. (2011). Modifiers of mutant huntingtin aggregation: Functional conservation of C. elegans-modifiers of polyglutamine aggregation. PLoS Currents, 3(RRN1255). https://doi.org/10.1371/currents.RRN1255
  47. 2010
  48. van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., ... Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity. Cell, 142(4), 601-612. https://doi.org/10.1016/j.cell.2010.07.020
  49. van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., ... Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. Cell, 142(4), 601-12. https://doi.org/10.1016/j.cell.2010.07.020
  50. van Ham, T. J., Esposito, A., Kumita, J. R., Hsu, S-T. D., Schierle, G. S. K., Kaminsk, C. F., ... Bertoncini, C. W. (2010). Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of alpha-Synuclein Aggregation. Journal of Molecular Biology, 395(3), 627-642. https://doi.org/10.1016/j.jmb.2009.10.066
  51. 2009
  52. Roodveldt, C., Bertoncini, C. W., Andersson, A., van der Goot, A. T., Hsu, S-T., Fernandez-Montesinos, R., ... Dobson, C. M. (2009). Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO Journal, 28(23), 3758-3770. https://doi.org/10.1038/emboj.2009.298
  53. van Ham, T. J., Breitling, R., Swertz, M. A., & Nollen, E. A. A. (2009). Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Molecular Medicine, 1(8-9), 360-370. https://doi.org/10.1002/emmm.200900051
  54. 2008
  55. van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W., Plasterk, R. H. A., & Nollen, E. A. A. (2008). C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS genetics, 4(3), [1000027]. https://doi.org/10.1371/journal.pgen.1000027
  56. 2004
  57. van Haaften, G., Vastenhouw, N. L., Nollen, E. A. A., Plasterk, R. H. A., & Tijsterman, M. (2004). Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proceedings of the National Academy of Sciences of the United States of America, 101(35), 12992-12996. https://doi.org/10.1073/pnas.0403131101
  58. Nollen, E. A. A., Garcia, S. M., van Haaften, G., Kim, S., Chavez, A., Morimoto, R. I., & Plasterk, R. H. A. (2004). Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6403-6408. https://doi.org/10.1073/pnas.0307697101
  59. 2002
  60. Nollen, E. A. A., & Morimoto, R. I. (2002). Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. Journal of Cell Science, 115(14), 2809-2816.
  61. Kim, S., Nollen, E. A. A., Kitagawa, K., Bindokas, V. P., & Morimoto, R. I. (2002). Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4(10), 826-831. https://doi.org/10.1038/ncb863
  62. 2001
  63. Nollen, E. A., Salomons, F. A., Brunsting, J. F., van der Want, J. J. L., Sibon, O. C. M., & Kampinga, H. H. (2001). Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection. Proceedings of the National Academy of Sciences of the United States of America, 98(21), 12038-12043. https://doi.org/10.1073/pnas.201112398
  64. Nollen, E. A., Kabakov, A. E., Brunsting, J. F., Kanon, B., Höhfeld, J., & Kampinga, H. H. (2001). Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1. The Journal of Biological Chemistry, 276(7), 4677-4682. https://doi.org/10.1074/jbc.M009745200
  65. 2000
  66. Nollen, EAA., Brunsting, JF., Kampinga, HH., & Morimoto, RI. (2000). Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Molecular and Cellular Biology, 20(3), 1083-1088. https://doi.org/10.1128/MCB.20.3.1083-1088.2000
  67. Nollen, E. A. (2000). HSP70 chaperone functions in stressed cells. s.n.
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