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Koopman, M., Hetz, C., & Nollen, E. A. A. (2019). Saved by the Matrix: UPR Independent Survival under ER Stress. Cell, 179(6), 1246-1248. https://doi.org/10.1016/j.cell.2019.11.012

Sorgdrager, F. J. H., Naude, P. J. W., Kema, I. P., Nollen, E. A., & De Deyn, P. P. (2019). Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target. Frontiers in Immunology, 10, [2565]. https://doi.org/10.3389/fimmu.2019.02565

Sorgdrager, F. J. H., Vermeiren, Y., Van Faassen, H. J. R., Van Der Ley, C. P., Nollen, E. A. A., Kema, I. P., & De Deyn, P. P. (2019). Age- and Disease-Specific Changes of the Kynurenine Pathway in Parkinson's and Alzheimer's Disease. Journal of Neurochemistry, 151(5), 656-668. https://doi.org/10.1111/jnc.14843

Laine, R. F., Sinnige, T., Ma, K. Y., Haack, A. J., Poudel, C., Gaida, P., Curry, N., Perni, M., Nollen, E. A. A., Dobson, C. M., Vendruscolo, M., Schierle, G. S. K., & Kaminski, C. F. (2019). Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of alpha-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. ACS chemical biology, 14(7), 1628-1636. https://doi.org/10.1021/acschembio.9b00354

Platten, M., Nollen, E. A. A., Röhrig, U. F., Fallarino, F., & Opitz, C. A. (2019). Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nature Reviews Drug Discovery, 18(8), 379-401. https://doi.org/10.1038/s41573-019-0016-5

Janssens, G. E., Lin, X-X., Millan-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., Stroustrup, N., Nollen, E. A. A., & Riedel, C. G. (2019). Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell reports, 27(2), 467-480.e6. https://doi.org/10.1016/j.celrep.2019.03.044

Perni, M., Casford, S., Aprile, F. A., Nollen, E. A., Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2018). Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform. Journal of visualized experiments : JoVE, (141), [58643]. https://doi.org/10.3791/58643

Mata-Cabana, A., Sin, O., Seinstra, R. I., & Nollen, E. A. A. (2018). Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans. JMIR research protocols, 8(20), [3053]. https://doi.org/10.21769/BioProtoc.3053

Sin, O., Mata-Cabana, A., Seinstra, R. I., & Nollen, E. A. A. (2018). Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Lysates. JMIR research protocols, 8(19), [3042]. https://doi.org/10.21769/BioProtoc.3042

Javer, A., Currie, M., Lee, C. W., Hokanson, J., Li, K., Martineau, C. N., Yemini, E., Grundy, L. J., Li, C., Ch'ng, Q., Schafer, W. R., Nollen, E. A. A., Kerr, R., & Brown, A. E. X. (2018). An open-source platform for analyzing and sharing worm-behavior data. Nature Methods, 15(9), 645-646. https://doi.org/10.1038/s41592-018-0112-1

Perni, M., Challa, P. K., Kirkegaard, J. B., Limbocker, R., Koopman, M., Hardenberg, M. C., Sormanni, P., Mueller, T., Saar, K. L., Roode, L. W. Y., Habchi, J., Vecchi, G., Fernando, N., Casford, S., Nollen, E. A. A., Vendruscolo, M., Dobson, C. M., & Knowles, T. P. J. (2018). Massively parallel C elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of Neuroscience Methods, 306, 57-67. https://doi.org/10.1016/j.jneumeth.2018.02.005

Perni, M., Flagmeier, P., Limbocker, R., Cascella, R., Aprile, F. A., Galvagnion, C., Heller, G. T., Meisl, G., Chen, S. W., Kumita, J. R., Challa, P. K., Kirkegaard, J. B., Cohen, S. I. A., Mannini, B., Barbut, D., Nollen, E. A. A., Cecchi, C., Cremades, N., Knowles, T. P. J., ... Dobson, C. M. (2018). Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology, 13(8), 2308-2319. https://doi.org/10.1021/acschembio.8b00466

Sinnige, T., Laine, R. F., Ma, K. Y., Haack, A. J., Gaida, P., Curry, N., Perni, M., Nollen, E. A. A., Dobson, C. M., Vendruscolo, M., Schierle, G. S. K., & Kaminski, C. F. (2018). Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans. Biophysical Journal, 114(3), 350A.

Yoshimura, Y., Holmberg, M. A., Kukic, P., Andersen, C. B., Mata-Cabana, A., Falsone, S. F., Vendruscolo, M., Nollen, E. A. A., & Mulder, F. A. A. (2017). MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions. The Journal of Biological Chemistry, 292(20), 8269-8278. https://doi.org/10.1074/jbc.M116.764886

Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limboker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., ... Dobson, C. M. (2017). Correction for Perni et al., A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017). Proceedings of the National Academy of Science of the United States of America, 114(12), E2543-E2543. https://doi.org/10.1073/pnas.1701964114

Sin, O., de Jong, T., Mata-Cabana, A., Kudron, M., Zaini, M. A., Aprile, F. A., Seinstra, R. I., Stroo, E., Prins, R. W., Martineau, C. N., Wang, H. H., Hogewerf, W., Steinhof, A., Wanker, E. E., Vendruscolo, M., Calkhoven, C. F., Reinke, V., Guryev, V., & Nollen, E. A. A. (2017). Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell, 65(6), 1096-1108. https://doi.org/10.1016/j.molcel.2017.02.022

Stroo, E., Koopman, M., Nollen, E. A. A., & Mata-Cabana, A. (2017). Cellular Regulation of Amyloid Formation in Aging and Disease. Frontiers in Neuroscience, 11, [64]. https://doi.org/10.3389/fnins.2017.00064

Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limboker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., ... Dobson, C. M. (2017). A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America, 114(6), E1009-E1017. https://doi.org/10.1073/pnas.1610586114

Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., Lubbe, S. J., Drouet, V., Lesage, S., Majounie, E., Gibbs, J. R., Nalls, M. A., Ryten, M., Botia, J. A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., ... International Parkinson’s Disease Genetics Consortium (IPGDC) (2017). Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology, 18(22). https://doi.org/10.1186/s13059-017-1147-9

Michels, H., Seinstra, R. I., Uitdehaag, J. C. M., Koopman, M., van Faassen, M., Martineau, C. N., Kema, I. P., Buijsman, R., & Nollen, E. A. A. (2016). Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase. Scientific Reports, 6, [39199]. https://doi.org/10.1038/srep39199

Koopman, M., Michels, H., Dancy, B. M., Kamble, R., Mouchiroud, L., Auwerx, J., Nollen, E. A. A., & Houtkooper, R. H. (2016). A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans. Nature protocols, 11(10), 1798-1816. https://doi.org/10.1038/nprot.2016.106

Visscher, M., De Henau, S., Wildschut, M. H. E., van Es, R. J. J., Dhondt, I., Michels, H., Kemmeren, P., Nollen, E. A., Braeckman, B. P., Burgering, B. M. T., Vos, H. R., & Dansen, T. B. (2016). Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease. Cell reports, 16(11), 3041-3051. https://doi.org/10.1016/j.celrep.2016.08.025

Habchi, J., Arosio, P., Perni, M., Costa, A. R., Yagi-Utsumi, M., Joshi, P., Chia, S., Cohen, S. I. A., Müller, M. B. D., Linse, S., Nollen, E. A. A., Dobson, C. M., Knowles, T. P. J., & Vendruscolo, M. (2016). An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science Advances, 2(2), [e1501244]. https://doi.org/10.1126/sciadv.1501244

Alvarenga Fernandes Sin, O., & Nollen, E. A. A. (2015). Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes. Cellular and molecular life sciences, 72(21), 4027-4047. https://doi.org/10.1007/s00018-015-1985-0

Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., Schaap, O., Nollen, E. A., Podgorsek, A., Kosec, G., Petkovic, H., Hayflick, S., Tiranti, V., Reijngoud, D-J., Grzeschik, N. A., & Sibon, O. C. M. (2015). Extracellular 4 '-phosphopantetheine is a source for intracellular coenzyme A synthesis. Nature Chemical Biology, 11(10), 784-792.e3. https://doi.org/10.1038/NCHEMBIO.1906

Alvarenga Fernandes Sin, O., Michels, H., & Nollen, E. A. A. (2014). Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases. Biochimica et biophysica acta-Molecular basis of disease, 1842(10), 1951-1959. https://doi.org/10.1016/j.bbadis.2014.01.015

van der Goot, A. T., & Nollen, E. A. A. (2013). Tryptophan metabolism: entering the field of aging and age-related pathologies. TRENDS IN MOLECULAR MEDICINE, 19(6), 336-344. https://doi.org/10.1016/j.molmed.2013.02.007

van der Goot, A. T., Zhu, W., Vazquez-Manrique, R. P., Seinstra, R. I., Dettmer, K., Michels, H., Farina, F., Krijnen, J., Melki, R., Buijsman, R. C., Silva, M. R., Thijssen, K. L., Kema, I. P., Neri, C., Oefner, P. J., & Nollen, E. A. A. (2012). Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. https://doi.org/10.1073/pnas.1203083109

Falsone, S. F., Meyer, N. H., Schrank, E., Leitinger, G., Pham, C. L. L., Fodero-Tavoletti, M. T., Holmberg, M., Dulle, M., Scicluna, B., Gesslbauer, B., Rueckert, H-M., Wagner, G. E., Merle, D. A., Nollen, E. A., Kungl, A. J., Hill, A. F., Cappai, R., & Zangger, K. (2012). SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly. Cell reports, 2(2), 358-371. https://doi.org/10.1016/j.celrep.2012.06.012

Siudeja, K., Srinivasan, B., Xu, L., Rana, A., de Jong, J., Nollen, E. A. A., Jackowski, S., Sanford, L., Hayflick, S., & Sibon, O. C. M. (2011). Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration. EMBO Molecular Medicine, 3(12), 755-766. https://doi.org/10.1002/emmm.201100180

Schierle, G. S. K., Bertoncini, C. W., Chan, F. T. S., van der Goot, A. T., Schwedler, S., Skepper, J., Schlachter, S., van Ham, T., Esposito, A., Kumita, J. R., Nollen, E. A. A., Dobson, C. M., & Kaminski, C. F. (2011). A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo. Chemphyschem, 12(3), 673-680. https://doi.org/10.1002/cphc.201000996

Teuling, E., Bourgonje, A., Veenje, S., Thijssen, K., de Boer, J., van der Velde, J., Swertz, M., & Nollen, E. (2011). Modifiers of mutant huntingtin aggregation: Functional conservation of C. elegans-modifiers of polyglutamine aggregation. PLoS Currents, 3(RRN1255). https://doi.org/10.1371/currents.RRN1255

van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., Du, D., Thijssen, K. L., Wiersma, M., Burggraaff, R., van Bergeijk, P., van Rheenen, J., van Veluw, G. J., Hofstra, R. M. W., Rubinsztein, D. C., & Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity. Cell, 142(4), 601-612. https://doi.org/10.1016/j.cell.2010.07.020

van Ham, T. J., Esposito, A., Kumita, J. R., Hsu, S-T. D., Schierle, G. S. K., Kaminsk, C. F., Dobson, C. M., Nollen, E. A. A., & Bertoncini, C. W. (2010). Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of alpha-Synuclein Aggregation. Journal of Molecular Biology, 395(3), 627-642. https://doi.org/10.1016/j.jmb.2009.10.066

Roodveldt, C., Bertoncini, C. W., Andersson, A., van der Goot, A. T., Hsu, S-T., Fernandez-Montesinos, R., de Jong, J., van Ham, T. J., Nollen, E. A., Pozo, D., Christodoulou, J., & Dobson, C. M. (2009). Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO Journal, 28(23), 3758-3770. https://doi.org/10.1038/emboj.2009.298

van Ham, T. J., Breitling, R., Swertz, M. A., & Nollen, E. A. A. (2009). Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Molecular Medicine, 1(8-9), 360-370. https://doi.org/10.1002/emmm.200900051

van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W., Plasterk, R. H. A., & Nollen, E. A. A. (2008). C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS genetics, 4(3), [1000027]. https://doi.org/10.1371/journal.pgen.1000027

van Haaften, G., Vastenhouw, N. L., Nollen, E. A. A., Plasterk, R. H. A., & Tijsterman, M. (2004). Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proceedings of the National Academy of Sciences of the United States of America, 101(35), 12992-12996. https://doi.org/10.1073/pnas.0403131101

Nollen, E. A. A., Garcia, S. M., van Haaften, G., Kim, S., Chavez, A., Morimoto, R. I., & Plasterk, R. H. A. (2004). Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6403-6408. https://doi.org/10.1073/pnas.0307697101

Nollen, E. A. A., & Morimoto, R. I. (2002). Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. Journal of Cell Science, 115(14), 2809-2816. http://jcs.biologists.org/content/115/14/2809.long

Kim, S., Nollen, E. A. A., Kitagawa, K., Bindokas, V. P., & Morimoto, R. I. (2002). Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4(10), 826-831. https://doi.org/10.1038/ncb863

Nollen, E. A., Salomons, F. A., Brunsting, J. F., van der Want, J. J. L., Sibon, O. C. M., & Kampinga, H. H. (2001). Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection. Proceedings of the National Academy of Sciences of the United States of America, 98(21), 12038-12043. https://doi.org/10.1073/pnas.201112398

Nollen, E. A., Kabakov, A. E., Brunsting, J. F., Kanon, B., Höhfeld, J., & Kampinga, H. H. (2001). Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1. The Journal of Biological Chemistry, 276(7), 4677-4682. https://doi.org/10.1074/jbc.M009745200

Nollen, EAA., Brunsting, JF., Kampinga, HH., & Morimoto, RI. (2000). Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Molecular and Cellular Biology, 20(3), 1083-1088. https://doi.org/10.1128/MCB.20.3.1083-1088.2000

Nollen, EAA., Brunsting, JF., Roelofsen, H., Weber, LA., & Kampinga, HH. (1999). In vivo chaperone activity of heat shock protein 70 and thermotolerance. Molecular and Cellular Biology, 19(3), 2069-2079. https://doi.org/10.1128/MCB.19.3.2069