prof. dr. ir. E.A.A. (Ellen) Nollen

Professor

prof. dr. ir. E.A.A. (Ellen) Nollen
E-mail:
e.a.a.nollen umcg.nl

Research

Postal address:
Netherlands
  1. 2020
  2. 2019
  3. Laine, R. F., Sinnige, T., Ma, K. Y., Haack, A. J., Poudel, C., Gaida, P., Curry, N., Perni, M., Nollen, E. A. A., Dobson, C. M., Vendruscolo, M., Schierle, G. S. K., & Kaminski, C. F. (2019). Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of alpha-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. ACS chemical biology, 14(7), 1628-1636. https://doi.org/10.1021/acschembio.9b00354
  4. Janssens, G. E., Lin, X-X., Millan-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., Stroustrup, N., Nollen, E. A. A., & Riedel, C. G. (2019). Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell reports, 27(2), 467-480.e6. https://doi.org/10.1016/j.celrep.2019.03.044
  5. 2018
  6. Javer, A., Currie, M., Lee, C. W., Hokanson, J., Li, K., Martineau, C. N., Yemini, E., Grundy, L. J., Li, C., Ch'ng, Q., Schafer, W. R., Nollen, E. A. A., Kerr, R., & Brown, A. E. X. (2018). An open-source platform for analyzing and sharing worm-behavior data. Nature Methods, 15(9), 645-646. https://doi.org/10.1038/s41592-018-0112-1
  7. Perni, M., Challa, P. K., Kirkegaard, J. B., Limbocker, R., Koopman, M., Hardenberg, M. C., Sormanni, P., Mueller, T., Saar, K. L., Roode, L. W. Y., Habchi, J., Vecchi, G., Fernando, N., Casford, S., Nollen, E. A. A., Vendruscolo, M., Dobson, C. M., & Knowles, T. P. J. (2018). Massively parallel C elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of Neuroscience Methods, 306, 57-67. https://doi.org/10.1016/j.jneumeth.2018.02.005
  8. Perni, M., Flagmeier, P., Limbocker, R., Cascella, R., Aprile, F. A., Galvagnion, C., Heller, G. T., Meisl, G., Chen, S. W., Kumita, J. R., Challa, P. K., Kirkegaard, J. B., Cohen, S. I. A., Mannini, B., Barbut, D., Nollen, E. A. A., Cecchi, C., Cremades, N., Knowles, T. P. J., ... Dobson, C. M. (2018). Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology, 13(8), 2308-2319. https://doi.org/10.1021/acschembio.8b00466
  9. Sinnige, T., Laine, R. F., Ma, K. Y., Haack, A. J., Gaida, P., Curry, N., Perni, M., Nollen, E. A. A., Dobson, C. M., Vendruscolo, M., Schierle, G. S. K., & Kaminski, C. F. (2018). Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans. Biophysical Journal, 114(3), 350A.
  10. 2017
  11. Yoshimura, Y., Holmberg, M. A., Kukic, P., Andersen, C. B., Mata-Cabana, A., Falsone, S. F., Vendruscolo, M., Nollen, E. A. A., & Mulder, F. A. A. (2017). MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions. The Journal of Biological Chemistry, 292(20), 8269-8278. https://doi.org/10.1074/jbc.M116.764886
  12. Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limboker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., ... Dobson, C. M. (2017). Correction for Perni et al., A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017). Proceedings of the National Academy of Science of the United States of America, 114(12), E2543-E2543. https://doi.org/10.1073/pnas.1701964114
  13. Sin, O., de Jong, T., Mata-Cabana, A., Kudron, M., Zaini, M. A., Aprile, F. A., Seinstra, R. I., Stroo, E., Prins, R. W., Martineau, C. N., Wang, H. H., Hogewerf, W., Steinhof, A., Wanker, E. E., Vendruscolo, M., Calkhoven, C. F., Reinke, V., Guryev, V., & Nollen, E. A. A. (2017). Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell, 65(6), 1096-1108. https://doi.org/10.1016/j.molcel.2017.02.022
  14. Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limboker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., ... Dobson, C. M. (2017). A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America, 114(6), E1009-E1017. https://doi.org/10.1073/pnas.1610586114
  15. Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., Lubbe, S. J., Drouet, V., Lesage, S., Majounie, E., Gibbs, J. R., Nalls, M. A., Ryten, M., Botia, J. A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., ... International Parkinson’s Disease Genetics Consortium (IPGDC) (2017). Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology, 18(22). https://doi.org/10.1186/s13059-017-1147-9
  16. 2016
  17. Koopman, M., Michels, H., Dancy, B. M., Kamble, R., Mouchiroud, L., Auwerx, J., Nollen, E. A. A., & Houtkooper, R. H. (2016). A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans. Nature protocols, 11(10), 1798-1816. https://doi.org/10.1038/nprot.2016.106
  18. Visscher, M., De Henau, S., Wildschut, M. H. E., van Es, R. J. J., Dhondt, I., Michels, H., Kemmeren, P., Nollen, E. A., Braeckman, B. P., Burgering, B. M. T., Vos, H. R., & Dansen, T. B. (2016). Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease. Cell reports, 16(11), 3041-3051. https://doi.org/10.1016/j.celrep.2016.08.025
  19. Habchi, J., Arosio, P., Perni, M., Costa, A. R., Yagi-Utsumi, M., Joshi, P., Chia, S., Cohen, S. I. A., Müller, M. B. D., Linse, S., Nollen, E. A. A., Dobson, C. M., Knowles, T. P. J., & Vendruscolo, M. (2016). An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science Advances, 2(2), [e1501244]. https://doi.org/10.1126/sciadv.1501244
  20. 2015
  21. 2014
  22. 2013
  23. Holmberg, M., & Nollen, E. A. A. (2013). Analyzing modifiers of protein aggregation in C. elegans by native agarose gel electrophoresis. In D. M. Hatters, & A. J. Hannan (Eds.), Tandem Repeats in Genes, Proteins, and Disease (Vol. 1017, pp. 193-199). (Methods in Molecular Biology; Vol. 1017). Humana Press. https://doi.org/10.1007/978-1-62703-438-8_14
  24. 2012
  25. van der Goot, A. T., Zhu, W., Vazquez-Manrique, R. P., Seinstra, R. I., Dettmer, K., Michels, H., Farina, F., Krijnen, J., Melki, R., Buijsman, R. C., Silva, M. R., Thijssen, K. L., Kema, I. P., Neri, C., Oefner, P. J., & Nollen, E. A. A. (2012). Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. https://doi.org/10.1073/pnas.1203083109
  26. Falsone, S. F., Meyer, N. H., Schrank, E., Leitinger, G., Pham, C. L. L., Fodero-Tavoletti, M. T., Holmberg, M., Dulle, M., Scicluna, B., Gesslbauer, B., Rueckert, H-M., Wagner, G. E., Merle, D. A., Nollen, E. A., Kungl, A. J., Hill, A. F., Cappai, R., & Zangger, K. (2012). SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly. Cell reports, 2(2), 358-371. https://doi.org/10.1016/j.celrep.2012.06.012
  27. 2011
  28. Schierle, G. S. K., Bertoncini, C. W., Chan, F. T. S., van der Goot, A. T., Schwedler, S., Skepper, J., Schlachter, S., van Ham, T., Esposito, A., Kumita, J. R., Nollen, E. A. A., Dobson, C. M., & Kaminski, C. F. (2011). A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo. Chemphyschem, 12(3), 673-680. https://doi.org/10.1002/cphc.201000996
  29. 2010
  30. van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., Du, D., Thijssen, K. L., Wiersma, M., Burggraaff, R., van Bergeijk, P., van Rheenen, J., van Veluw, G. J., Hofstra, R. M. W., Rubinsztein, D. C., & Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity. Cell, 142(4), 601-612. https://doi.org/10.1016/j.cell.2010.07.020
  31. van Ham, T. J., Esposito, A., Kumita, J. R., Hsu, S-T. D., Schierle, G. S. K., Kaminsk, C. F., Dobson, C. M., Nollen, E. A. A., & Bertoncini, C. W. (2010). Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of alpha-Synuclein Aggregation. Journal of Molecular Biology, 395(3), 627-642. https://doi.org/10.1016/j.jmb.2009.10.066
  32. 2009
  33. Roodveldt, C., Bertoncini, C. W., Andersson, A., van der Goot, A. T., Hsu, S-T., Fernandez-Montesinos, R., de Jong, J., van Ham, T. J., Nollen, E. A., Pozo, D., Christodoulou, J., & Dobson, C. M. (2009). Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO Journal, 28(23), 3758-3770. https://doi.org/10.1038/emboj.2009.298
  34. 2008
  35. 2004
  36. 2002
  37. Kim, S., Nollen, E. A. A., Kitagawa, K., Bindokas, V. P., & Morimoto, R. I. (2002). Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4(10), 826-831. https://doi.org/10.1038/ncb863
  38. 2001
  39. 2000
  40. 1999
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