prof. dr. ir. E.A.A. (Ellen) Nollen
Professor

Telephone:
E-mail:
e.a.a.nollen umcg.nl
Research
Research units:
Postal address:
Netherlands
1 - 50 out of 54Page size: 50
- 2020
- Koopman, M., Peter, Q., Seinstra, R. I., Perni, M., Vendruscolo, M., Dobson, C. M., Knowles, T. P. J., & Nollen, E. A. A. (2020). Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform. Nature protocols, 15(6), 2071-2106. https://doi.org/10.1038/s41596-020-0321-9
- 2019
- Koopman, M., Hetz, C., & Nollen, E. A. A. (2019). Saved by the Matrix: UPR Independent Survival under ER Stress. Cell, 179(6), 1246-1248. https://doi.org/10.1016/j.cell.2019.11.012
- Sorgdrager, F. J. H., Naude, P. J. W., Kema, I. P., Nollen, E. A., & De Deyn, P. P. (2019). Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target. Frontiers in Immunology, 10, [2565]. https://doi.org/10.3389/fimmu.2019.02565
- Sorgdrager, F. J. H., Vermeiren, Y., Van Faassen, H. J. R., Van Der Ley, C. P., Nollen, E. A. A., Kema, I. P., & De Deyn, P. P. (2019). Age- and Disease-Specific Changes of the Kynurenine Pathway in Parkinson's and Alzheimer's Disease. Journal of Neurochemistry, 151(5), 656-668. https://doi.org/10.1111/jnc.14843
- Laine, R. F., Sinnige, T., Ma, K. Y., Haack, A. J., Poudel, C., Gaida, P., Curry, N., Perni, M., Nollen, E. A. A., Dobson, C. M., Vendruscolo, M., Schierle, G. S. K., & Kaminski, C. F. (2019). Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of alpha-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. ACS chemical biology, 14(7), 1628-1636. https://doi.org/10.1021/acschembio.9b00354
- Platten, M., Nollen, E. A. A., Röhrig, U. F., Fallarino, F., & Opitz, C. A. (2019). Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nature Reviews Drug Discovery, 18(8), 379-401. https://doi.org/10.1038/s41573-019-0016-5
- Janssens, G. E., Lin, X-X., Millan-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., Stroustrup, N., Nollen, E. A. A., & Riedel, C. G. (2019). Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell reports, 27(2), 467-480.e6. https://doi.org/10.1016/j.celrep.2019.03.044
- Koopman, M., Seinstra, R. I., & Nollen, E. A. A. (2019). C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques. In T. Bartels (Ed.), Alpha-Synuclein (pp. 93-112). (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-9124-2_9
- 2018
- Perni, M., Casford, S., Aprile, F. A., Nollen, E. A., Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2018). Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform. Journal of visualized experiments : JoVE, (141), [58643]. https://doi.org/10.3791/58643
- Mata-Cabana, A., Sin, O., Seinstra, R. I., & Nollen, E. A. A. (2018). Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans. JMIR research protocols, 8(20), [3053]. https://doi.org/10.21769/BioProtoc.3053
- Sin, O., Mata-Cabana, A., Seinstra, R. I., & Nollen, E. A. A. (2018). Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Lysates. JMIR research protocols, 8(19), [3042]. https://doi.org/10.21769/BioProtoc.3042
- Javer, A., Currie, M., Lee, C. W., Hokanson, J., Li, K., Martineau, C. N., Yemini, E., Grundy, L. J., Li, C., Ch'ng, Q., Schafer, W. R., Nollen, E. A. A., Kerr, R., & Brown, A. E. X. (2018). An open-source platform for analyzing and sharing worm-behavior data. Nature Methods, 15(9), 645-646. https://doi.org/10.1038/s41592-018-0112-1
- Perni, M., Challa, P. K., Kirkegaard, J. B., Limbocker, R., Koopman, M., Hardenberg, M. C., Sormanni, P., Mueller, T., Saar, K. L., Roode, L. W. Y., Habchi, J., Vecchi, G., Fernando, N., Casford, S., Nollen, E. A. A., Vendruscolo, M., Dobson, C. M., & Knowles, T. P. J. (2018). Massively parallel C elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of Neuroscience Methods, 306, 57-67. https://doi.org/10.1016/j.jneumeth.2018.02.005
- Perni, M., Flagmeier, P., Limbocker, R., Cascella, R., Aprile, F. A., Galvagnion, C., Heller, G. T., Meisl, G., Chen, S. W., Kumita, J. R., Challa, P. K., Kirkegaard, J. B., Cohen, S. I. A., Mannini, B., Barbut, D., Nollen, E. A. A., Cecchi, C., Cremades, N., Knowles, T. P. J., ... Dobson, C. M. (2018). Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology, 13(8), 2308-2319. https://doi.org/10.1021/acschembio.8b00466
- Sinnige, T., Laine, R. F., Ma, K. Y., Haack, A. J., Gaida, P., Curry, N., Perni, M., Nollen, E. A. A., Dobson, C. M., Vendruscolo, M., Schierle, G. S. K., & Kaminski, C. F. (2018). Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans. Biophysical Journal, 114(3), 350A.
- 2017
- Yoshimura, Y., Holmberg, M. A., Kukic, P., Andersen, C. B., Mata-Cabana, A., Falsone, S. F., Vendruscolo, M., Nollen, E. A. A., & Mulder, F. A. A. (2017). MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions. The Journal of Biological Chemistry, 292(20), 8269-8278. https://doi.org/10.1074/jbc.M116.764886
- Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limboker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., ... Dobson, C. M. (2017). Correction for Perni et al., A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017). Proceedings of the National Academy of Science of the United States of America, 114(12), E2543-E2543. https://doi.org/10.1073/pnas.1701964114
- Sin, O., de Jong, T., Mata-Cabana, A., Kudron, M., Zaini, M. A., Aprile, F. A., Seinstra, R. I., Stroo, E., Prins, R. W., Martineau, C. N., Wang, H. H., Hogewerf, W., Steinhof, A., Wanker, E. E., Vendruscolo, M., Calkhoven, C. F., Reinke, V., Guryev, V., & Nollen, E. A. A. (2017). Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell, 65(6), 1096-1108. https://doi.org/10.1016/j.molcel.2017.02.022
- Stroo, E., Koopman, M., Nollen, E. A. A., & Mata-Cabana, A. (2017). Cellular Regulation of Amyloid Formation in Aging and Disease. Frontiers in Neuroscience, 11, [64]. https://doi.org/10.3389/fnins.2017.00064
- Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limboker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., ... Dobson, C. M. (2017). A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America, 114(6), E1009-E1017. https://doi.org/10.1073/pnas.1610586114
- Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., Lubbe, S. J., Drouet, V., Lesage, S., Majounie, E., Gibbs, J. R., Nalls, M. A., Ryten, M., Botia, J. A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., ... International Parkinson’s Disease Genetics Consortium (IPGDC) (2017). Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology, 18(22). https://doi.org/10.1186/s13059-017-1147-9
- 2016
- Michels, H., Seinstra, R. I., Uitdehaag, J. C. M., Koopman, M., van Faassen, M., Martineau, C. N., Kema, I. P., Buijsman, R., & Nollen, E. A. A. (2016). Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase. Scientific Reports, 6, [39199]. https://doi.org/10.1038/srep39199
- Koopman, M., Michels, H., Dancy, B. M., Kamble, R., Mouchiroud, L., Auwerx, J., Nollen, E. A. A., & Houtkooper, R. H. (2016). A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans. Nature protocols, 11(10), 1798-1816. https://doi.org/10.1038/nprot.2016.106
- Visscher, M., De Henau, S., Wildschut, M. H. E., van Es, R. J. J., Dhondt, I., Michels, H., Kemmeren, P., Nollen, E. A., Braeckman, B. P., Burgering, B. M. T., Vos, H. R., & Dansen, T. B. (2016). Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease. Cell reports, 16(11), 3041-3051. https://doi.org/10.1016/j.celrep.2016.08.025
- Habchi, J., Arosio, P., Perni, M., Costa, A. R., Yagi-Utsumi, M., Joshi, P., Chia, S., Cohen, S. I. A., Müller, M. B. D., Linse, S., Nollen, E. A. A., Dobson, C. M., Knowles, T. P. J., & Vendruscolo, M. (2016). An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science Advances, 2(2), [e1501244]. https://doi.org/10.1126/sciadv.1501244
- 2015
- Alvarenga Fernandes Sin, O., & Nollen, E. A. A. (2015). Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes. Cellular and molecular life sciences, 72(21), 4027-4047. https://doi.org/10.1007/s00018-015-1985-0
- Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., Schaap, O., Nollen, E. A., Podgorsek, A., Kosec, G., Petkovic, H., Hayflick, S., Tiranti, V., Reijngoud, D-J., Grzeschik, N. A., & Sibon, O. C. M. (2015). Extracellular 4 '-phosphopantetheine is a source for intracellular coenzyme A synthesis. Nature Chemical Biology, 11(10), 784-792.e3. https://doi.org/10.1038/NCHEMBIO.1906
- 2014
- Alvarenga Fernandes Sin, O., Michels, H., & Nollen, E. A. A. (2014). Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases. Biochimica et biophysica acta-Molecular basis of disease, 1842(10), 1951-1959. https://doi.org/10.1016/j.bbadis.2014.01.015
- 2013
- van der Goot, A. T., & Nollen, E. A. A. (2013). Tryptophan metabolism: entering the field of aging and age-related pathologies. TRENDS IN MOLECULAR MEDICINE, 19(6), 336-344. https://doi.org/10.1016/j.molmed.2013.02.007
- Holmberg, M., & Nollen, E. A. A. (2013). Analyzing modifiers of protein aggregation in C. elegans by native agarose gel electrophoresis. In D. M. Hatters, & A. J. Hannan (Eds.), Tandem Repeats in Genes, Proteins, and Disease (Vol. 1017, pp. 193-199). (Methods in Molecular Biology; Vol. 1017). Humana Press. https://doi.org/10.1007/978-1-62703-438-8_14
- 2012
- van der Goot, A. T., Zhu, W., Vazquez-Manrique, R. P., Seinstra, R. I., Dettmer, K., Michels, H., Farina, F., Krijnen, J., Melki, R., Buijsman, R. C., Silva, M. R., Thijssen, K. L., Kema, I. P., Neri, C., Oefner, P. J., & Nollen, E. A. A. (2012). Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. https://doi.org/10.1073/pnas.1203083109
- Falsone, S. F., Meyer, N. H., Schrank, E., Leitinger, G., Pham, C. L. L., Fodero-Tavoletti, M. T., Holmberg, M., Dulle, M., Scicluna, B., Gesslbauer, B., Rueckert, H-M., Wagner, G. E., Merle, D. A., Nollen, E. A., Kungl, A. J., Hill, A. F., Cappai, R., & Zangger, K. (2012). SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly. Cell reports, 2(2), 358-371. https://doi.org/10.1016/j.celrep.2012.06.012
- 2011
- Siudeja, K., Srinivasan, B., Xu, L., Rana, A., de Jong, J., Nollen, E. A. A., Jackowski, S., Sanford, L., Hayflick, S., & Sibon, O. C. M. (2011). Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration. EMBO Molecular Medicine, 3(12), 755-766. https://doi.org/10.1002/emmm.201100180
- Schierle, G. S. K., Bertoncini, C. W., Chan, F. T. S., van der Goot, A. T., Schwedler, S., Skepper, J., Schlachter, S., van Ham, T., Esposito, A., Kumita, J. R., Nollen, E. A. A., Dobson, C. M., & Kaminski, C. F. (2011). A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo. Chemphyschem, 12(3), 673-680. https://doi.org/10.1002/cphc.201000996
- Teuling, E., Bourgonje, A., Veenje, S., Thijssen, K., de Boer, J., van der Velde, J., Swertz, M., & Nollen, E. (2011). Modifiers of mutant huntingtin aggregation: Functional conservation of C. elegans-modifiers of polyglutamine aggregation. PLoS Currents, 3(RRN1255). https://doi.org/10.1371/currents.RRN1255
- 2010
- van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., Du, D., Thijssen, K. L., Wiersma, M., Burggraaff, R., van Bergeijk, P., van Rheenen, J., van Veluw, G. J., Hofstra, R. M. W., Rubinsztein, D. C., & Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity. Cell, 142(4), 601-612. https://doi.org/10.1016/j.cell.2010.07.020
- van Ham, T. J., Esposito, A., Kumita, J. R., Hsu, S-T. D., Schierle, G. S. K., Kaminsk, C. F., Dobson, C. M., Nollen, E. A. A., & Bertoncini, C. W. (2010). Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of alpha-Synuclein Aggregation. Journal of Molecular Biology, 395(3), 627-642. https://doi.org/10.1016/j.jmb.2009.10.066
- 2009
- Roodveldt, C., Bertoncini, C. W., Andersson, A., van der Goot, A. T., Hsu, S-T., Fernandez-Montesinos, R., de Jong, J., van Ham, T. J., Nollen, E. A., Pozo, D., Christodoulou, J., & Dobson, C. M. (2009). Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO Journal, 28(23), 3758-3770. https://doi.org/10.1038/emboj.2009.298
- van Ham, T. J., Breitling, R., Swertz, M. A., & Nollen, E. A. A. (2009). Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Molecular Medicine, 1(8-9), 360-370. https://doi.org/10.1002/emmm.200900051
- 2008
- van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W., Plasterk, R. H. A., & Nollen, E. A. A. (2008). C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS genetics, 4(3), [1000027]. https://doi.org/10.1371/journal.pgen.1000027
- 2004
- van Haaften, G., Vastenhouw, N. L., Nollen, E. A. A., Plasterk, R. H. A., & Tijsterman, M. (2004). Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proceedings of the National Academy of Sciences of the United States of America, 101(35), 12992-12996. https://doi.org/10.1073/pnas.0403131101
- Nollen, E. A. A., Garcia, S. M., van Haaften, G., Kim, S., Chavez, A., Morimoto, R. I., & Plasterk, R. H. A. (2004). Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6403-6408. https://doi.org/10.1073/pnas.0307697101
- 2002
- Nollen, E. A. A., & Morimoto, R. I. (2002). Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. Journal of Cell Science, 115(14), 2809-2816. http://jcs.biologists.org/content/115/14/2809.long
- Kim, S., Nollen, E. A. A., Kitagawa, K., Bindokas, V. P., & Morimoto, R. I. (2002). Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4(10), 826-831. https://doi.org/10.1038/ncb863
- 2001
- Nollen, E. A., Salomons, F. A., Brunsting, J. F., van der Want, J. J. L., Sibon, O. C. M., & Kampinga, H. H. (2001). Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection. Proceedings of the National Academy of Sciences of the United States of America, 98(21), 12038-12043. https://doi.org/10.1073/pnas.201112398
- Nollen, E. A., Kabakov, A. E., Brunsting, J. F., Kanon, B., Höhfeld, J., & Kampinga, H. H. (2001). Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1. The Journal of Biological Chemistry, 276(7), 4677-4682. https://doi.org/10.1074/jbc.M009745200
- 2000
- 1999
- Nollen, EAA., Brunsting, JF., Roelofsen, H., Weber, LA., & Kampinga, HH. (1999). In vivo chaperone activity of heat shock protein 70 and thermotolerance. Molecular and Cellular Biology, 19(3), 2069-2079. https://doi.org/10.1128/MCB.19.3.2069
ID: 121250