D. Chen

PhD student

Faculty of Science and Engineering

Telephone:

E-mail:

d.chen rug.nl

ORCID Research Portal

Publications

Modulating CRISPR/Cas9 genome-editing activity by small molecules

Chen, S. , Chen, D. , Liu, B. & Haisma, H. J. , Apr-2022 , In: Drug Discovery Today. 27 , 4 , p. 951-966 16 p.

Research output: Contribution to journal › Review article › Academic › peer-review

Thieno[2,3- d]pyrimidine-2,4(1 H,3 H)-dione Derivative Inhibits d -Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells

Xiao, Z. , Osipyan, A. , Song, S. , Chen, D. , Schut, R. A. , van Merkerk, R. , van der Wouden, P. E. , Cool, R. H. , Quax, W. J. , Melgert, B. N. , Poelarends, G. J. & Dekker, F. J. , 10-Feb-2022 , In: Journal of Medicinal Chemistry. 3 , p. 2059-2077

Research output: Contribution to journal › Article › Academic › peer-review

4-Iodopyrimidine labeling reveals nuclear translocation and nuclease activity for both MIF and MIF2

Xiao, Z. , Chen, D. , Mulder, F. , Song, S. , van der Wouden, P. E. , Cool, R. H. , Melgert, B. N. , Poelarends, G. J. & Dekker, F. J. , 3-Jan-2022 , In: Chemistry. 28 , 1 , e202103030.

Research output: Contribution to journal › Article › Academic › peer-review

Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

Osipyan, A. , Chen, D. & Dekker, F. J. , Jul-2021 , In: Drug Discovery Today. 26 , 7 , p. 1728-1734

Research output: Contribution to journal › Review article › Academic › peer-review

Experimental approaches toward histone acetyltransferase modulators as therapeutics

Chen, D. , Wapenaar, H. & Dekker, F. J. , 1-Jan-2021 , Medical Epigenetics. Tollefsbol, T. (ed.). 2nd ed. Elsevier , p. 665-692 28 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway

Cao, F. , Xiao, Z. , Chen, S. , Zhao, C. , Chen, D. , Haisma, H. J. & Dekker, F. J. , Dec-2021 , In: Bioorganic Chemistry. 117 , 8 p. , 105396.

Research output: Contribution to journal › Article › Academic › peer-review

Identification of a Bromodomain-like region in 15-Lipoxygenase-1 explains its Nuclear Localization

Chen, D. , Xiao, Z. , Guo, H. , Gogishvili, D. , Setroikromo, R. , van der Wouden, P. E. & Dekker, F. J. , 27-Sep-2021 , In: Angewandte Chemie (International ed. in English). 60 , 40 , p. 21875-21883 21875 p.

Research output: Contribution to journal › Article › Academic › peer-review

Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti-Proliferative Activity in Lung Cancer Cells

Xiao, Z. , Song, S. , Chen, D. , van Merkerk, R. , van der Wouden, P. , Cool, R. , Quax, W. , Poelarends, G. , Melgert, B. & Dekker, F. J. , 2-Aug-2021 , In: Angewandte Chemie (International ed. in English). 60 , 32 , p. 17514-17521 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

A bispecific inhibitor of the EGFR/ADAM17 axis decreases cell proliferation and migration of EGFR-dependent cancer cells

Soto-Gamez, A. , Chen, D. , Nabuurs, A. G. E. , Quax, W. J. , Demaria, M. & Boersma, Y. L. , Feb-2020 , In: Cancers. 12 , 2 , 14 p. , 411.

Research output: Contribution to journal › Article › Academic › peer-review

A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL

Zhang, B. , Chen, D. , Liu, B. , Dekker, F. J. & Quax, W. J. , May-2020 , In: Biochemical Pharmacology. 175 , 10 p. , 113914.

Research output: Contribution to journal › Article › Academic › peer-review

All (17) publications

View full research profile