A.S.S. Dömling, Prof Dr
ALEXANDER DÖMLING
Curriculum Vitae (short form)
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Contact Information
University of Groningen Department for Drug Design A. Deusinglaan 1 9713 AV Groningen, Netherlands phone:+31 (0)50 363 7943 e-mail: a.s.s.domling rug.nl
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EDUCATION and TRAINING
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Dates |
Name and Location of Institution |
Degree and Year |
Major Subject |
A. Undergraduate
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10/1987 – 02/1992 |
Technical University of Munich, Munich, Germany |
Diploma, 1992 |
Chemistry |
B. Graduate
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02/1992– 03/1994 |
Technical University of Munich, Munich, Germany |
PhD, 1994 |
Multicomponent Reaction Chemistry; Thesis Advisor: Ivar Ugi |
C. Postgraduate
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01/1995 – 05/1996 |
The Scripps Research Institute, La Jolla, CA, USA |
Postdoc |
Combinatorial Chemistry; Advisor: Barry Sharpless (Nobel Laureate) |
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2003 |
Technical University Munich |
Habilitation |
Natural Product Synthesis, Combinatorial Chemistry |
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ACADEMIC APPOINTMENTS and POSITIONS
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Years |
Name and Location of Institution |
Rank/Title |
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January 2003 – 2006 |
Department of Chemistry, Technical University Munich, Germany |
Privat Dozent, Faculty Member |
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September 2006 – 2012 |
Department of Pharmaceutical Sciences Associate Professor, University of Pittsburgh |
Associate Professor, Primary Appointment, School of Pharmacy, Pittsburgh, PA, USA |
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January 2007 – present |
Department of Chemistry, University of Pittsburgh, School of Chemistry Pittsburgh, PA, USA
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Secondary Appointment, Associate Professor |
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May 2007 – present |
University of Pittsburgh - Carnegie Melon University Pittsburgh, PA, USA
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Molecular Biophysical & Structural Biology (MBSB) teaching faculty |
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October 2007 – present |
University of Pittsburgh - Carnegie Melon University Pittsburgh, PA, USA
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Secondary Appointment, Computational Biology Teaching Faculty |
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since June 2008 |
University of Pittsburgh, Cancer Center |
Member |
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Mai 2011 - October |
University of Pittsburgh, USA |
Tenured Professor |
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Since October 2010 |
University of Pittsburgh, USA |
Adjunct Professor |
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Since October 2011 |
University of Groningen, Netherlands |
Tenured Professor, Chair of Drug Design |
EXTRA ACADEMIC APPOINTMENTS and POSITIONS
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Years |
Name and Location of Institution |
Rank/Title |
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1996 – 2003 |
MORPOHOCHEM AG, Munich, Basel, Princeton |
Founder, Vice President Chemistry |
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1996 – 2003 |
MORPOHOCHEM AG |
Board of Directors |
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2000 - current |
Synthatex Corp., Israel |
Board of Directors |
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2004 – 2006 |
R&D Biopharmaceuticals, Munich |
Founder, Board of Directors |
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2011 |
Carmolex Inc (USA) |
Founder, Board of Directors |
MEMBERSHIPS in PROFESSIONAL and SCIENTIFIC SOCIETIES
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Organization
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Year |
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ACS (American Chemical Society)
ACS Division of Medicinal Chemistry
ACS Division of Fluorine Chemistry
German Chemical Society
Max Bergmann Kreis
AACR (American Association for Cancer Research) Chemistry in Cancer Research Working Group (CICR)
AACP (American Association of Colleges of Pharmacy) |
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Since 2007
Since 2007
Since 2008
Since 1995
Since 1995
Since 2007
Since 2007 |
HONORS
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Title of Award
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1BYear |
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Humboldt Fellowship (Feodor Lynen Research Fellowship for Postdoctoral Researchers)
Friedrich-Weygand Award of the Max Bergmann Society
Publication “Multicomponent reactions with isocyanides” found by ISI to be the one of most cited reviews in the area of multicomponent reaction chemsitry.
Guest Professor, Institute for Plant Biochemistry, Halle, Germany
Guest Professor, Technical University of Vienna, Austria
Publication "Recent developments in isocyanide based multicomponent reactions in applied chemistry" found by ISI to be the most cited review of 2006 published in Chemical Reviews.
Publication "Recent developments in isocyanide based multicomponent reactions in applied chemistry" found to be the second most read review of 2006 published in Chemical Reviews.
Science 2007, Poster Award, winner of the faculty category
Moissan Stipend 2008, (American Chemical Society, Fluorine Division)
‘ERUDITE Scholar in Residence’ at University of Calicut, India
Senior Vice Chancellor Research Seminar, University of Pittsburgh
PITT Innovation Award
International Professor Teaching Program of Wuhan University (“111 plan”)
Honorary Diploma (University of Kharkov, Ukraine)
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1993 – 1994
1996
2000
2006
2007
2007
2007
2007
2008
2011
2011
2011, 2012
2012
2012
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Smoluchuwski visiting professor (Jagiellonian University, Krakow, Poland) |
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2013 |
PUBLICATIONS
Examples of recently published papers, reviews, books and patents representing the areas of work of the PI
- Czarna, B. Beck, S. Srivastava, G.M. Popowicz, S. Wolf, T Holak, A. DömlingRobust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists Angewandte Chemie, 2010, 49, 5342-5356. (HOT PAPER: Hot Papers are chosen by the Editors for their importance in a rapidly evolving field of high current interest.)
- H. Cao, H, Liu, A. DömlingEfficient MCR Synthesis of the Schistosomiasis Drug PraziquantelChemistry-A European Journal, 2010, 16, 12296-98.
- K. Wang, A. DömlingOne-Pot Synthesis of 2-Amino-indole-3-carboxamides, Journal Combinatorial Chemistry2010, 13, 140-146.
- W. Wang, S. Ollio, E. Herdtweck, A. Dömling Polycyclic Compounds by Ugi-Pictet-Spengler SequenceJournal Organic Chemistry2011, 76, 637-44.
- J.-C. Rwigema, B. Beck, W. Wang, A. Dömling, M.W. Epperly, D. Shields, J. Goff, D. Franicola, T. Dixon, M.-C. Frantz, P. Wipf, Y. Tyurina, V.E. Kagan, H. Wang, J.S. Greenberger Two Strategies for the Development of Mitochondrion-Targeted Small Molecule Radiation Damage Mitigators.International Journal of Radiation Oncology, Biology, Physics 2011, 80, 860-868.
- Koes, D.; Khoury, K.; Huang, Y.; Wang, W.; Bista, M.; Popowicz, G.M.; Wolf, S.; Holak, T.A.; Dömling, A.; Camacho, C.J. Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonistsPLoS One2012, 7(3): e32839. doi:10.1371/journal.pone.0032839.
- K. Khoury, M.K. Sinha, T. Nagashima, E. Herdtweck, A. DömlingEfficient Assembly of Iminodicarboxamides by a “Truly” Four-Component ReactionAngew. Chem. Intl. ed. Engl.2012, DOI: 10.1002/anie.201205366
- Dömling, Tad Holak Programmed Death-1: Therapeutic Success after >100 Years of Cancer ImmunotherapyAngew. Chem,2013 in press.
- Dömling HURecent Progress In Isocyanide Based Multicomponent Reaction ChemistryUH Chemical Review, 2006, 106, 17. (Belongs to the most highly cited papers in Chemical Review: cited more than 1029 times)
- Dömling, W. Wang, K. Wang Chemistry & Biology Of Multicomponent Reactions Chem. Rev. 2012, 112, 3083–3135.
- Editor of the book “Protein protein interactions in drug discovery” of the book series "Methods and Principles in Medicinal Chemistry", Vol 56, (Wiley) series edited by Raimund Mannhold, University of Düsseldorf, Gerd Folkers, ETH Zurich, and Hugo Kubinyi. 2013 ISBN 978-3-527-33107-9.
- Tubulysin Conjugates, A. Dömling, L. Weber; US2005249740.
- Novel Compounds For Stimulation Of Nerve Growth, For The Inhibition Of Scar Tissue Formation And/Or Reduction Of Secondary Damage. C. Leppert, A. Dömling; AU2003255331.
- Utilization of inhibitors of rho-kinases for stimulating nerve growth, inhibiting scar tissue formation and/or reducing a secondary lesion. MONNIER PHILIPPE P (DE); STAHL BERND (DE); MULLER BERNHARD K (DE); DöMLING ALEXANDER (DE); SCHIEBLER WERNER (DE), WO03037308; EP1448176
- Dömling, Alexander; Beck, Barbara; Mueller, Bernhard; Stahl, Bernd; Leppert, Christian. Preparation of N-allyl-N-(1-allyl-carbamoylpentyl)isonicotinamide and related compounds for the stimulation of nerve growth and inhibition of scar tissue formation. Ger. Offen. (2004), 7 pp. CODEN: GWXXBX DE 10234786
- Doemling, Alexander; Camacho Ives, Carlos Jaime. Nexavar for use in organ transplantation. Ger. Offen. (2009), 5pp. DE 102008031035
SHORT COURSES ON MCR CHEMISTRY
HRSMC Autumn School, Synthesis towards Bioactive Compounds, 15.-19.10.2001, Arnhem, The Netherlands.
ABBOTT Pharmaceuticals, 10th April 2007.
University of Pittsburgh, 1 March – 30 April 2007
Technical University Vienna, Austria, 18 June – 29 June 2007.
University of Bologna, Italy, June 2007
Nerviano Medical Sciences, Milano, Italy, June 2007
University Lund, Sweden, December 2007
Oragnon, Oss, TheNetherlands, December 2007
Astra Zeneca, Lund, Sweden December 2007
The Galilee Society (Haifa University), Nazareth, Israel December 2007
Advances in Synthetic Chemistry Symposium, Frankfurt, Germany 10 April 2008
Ecole Nationale Superieure des Techniques Avancées, Paris, 09/12/2008
Schering Plough, Kenilworth, NJ, 23 January 2009
Schering Plough, Cambridge, Boston 26 February 2009
Cape Town University, South Africa, April 2009
University of Patras, Greece, October 2009
University of Thessaloniki, Greece, October 2009
MedChem Europe 04/07/2010
Biogen Idec, Boston/SanDiego, October 2010
University of Calicut, India, 2011
Wuhan University, China, 2012
Bayer Pharma Research Center, Wuppertal, 2013
Invited Speaker to >hundred of seminars (most recent)
- Invited lecture: Bayer Research Center Wuppertal
- Invited lecture: The Dutch Computational Chemistry Symposium, The Trippenhuis, Amsterdam 05.07.2013
- Invited lecture: "The Dr Paul Janssen Invited Lecture Series" Janssen Pharmaceuticals, Beerse-campus
- Invited Lecture: 11. Tagung über Iminiumsalze IMSAT-2013, Gosslar 22-15.09.2013.
- Invited lecture: University of Wrazlow, Poland, 2-6.12.2013
- Invited lecture: “MedChem 2013 Constrained Peptides and Macrocycles – New Opportunities for Drug Discovery” Janssen Pharmaceuticals, Beerse-campus 22.11.2013
FUNDING
The PI’s laboratory is funded by numerous grants from US, Europe from public and private organization.
| Laatst gewijzigd: | 08 november 2014 16:46 |