A.M. Sabogal Guaqueta, MSc

Telephone:

E-mail:

a.m.sabogal.guaqueta rug.nl

Research interests

My research interest focuses on the research of molecular mechanisms underlying cerebrovascular diseases, aging processes, and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. I investigated the role of statins and various natural products, including linalool, as potential neuroprotective agents in neurodegenerative diseases. Lately, my focus has shifted towards delving into mitochondrial metabolism and its link to inflammation in the context of neurodegenerative diseases, particularly the generation and characterization of human microglia derived from induced pluripotent stem cells of Parkinson's disease patients. I am greatly interested in expanding my research in understanding neuroinflammation as a key factor in neurodegenerative diseases.

Publications

Mitochondrial transplantation rescues neuronal cells from ferroptosis

Chen, T., Majerníková, N., Marmolejo-Garza, A., Trombetta-Lima, M., Sabogal-Guáqueta, A. M., Zhang, Y., Ten Kate, R., Zuidema, M., Mulder, P. P. M. F. A., den Dunnen, W., Gosens, R., Verpoorte, E., Culmsee, C., Eisel, U. L. M. & Dolga, A. M., 1-Nov-2023, In: Free Radical Biology and Medicine. 208, p. 62-72 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction

Sabogal-Guáqueta, A. M., Marmolejo-Garza, A., Trombetta-Lima, M., Oun, A., Hunneman, J., Chen, T., Koistinaho, J., Lehtonen, S., Kortholt, A., Wolters, J. C., Bakker, B. M., Eggen, B. J. L., Boddeke, E. & Dolga, A., 13-Oct-2023, In: Nature Communications. 14, 1, 24 p., 6454.

Research output: Contribution to journal › Article › Academic › peer-review

The importance of microglia in metabolic changes in the brain: A world to explore

Sabogal Guaqueta, A., 2023.

Research output: Contribution to conference › Poster › Academic

Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

Goldsteen, P., Sabogal Guaqueta, A., Mulder, P., Bos, I. S. T., Eggens, M., van der Koog, L., Soeiro, J. T., Halayko, A. J., Mathwig, K., Kistemaker, L., Verpoorte, E., Dolga, A. & Gosens, R., 28-Oct-2022, In: Frontiers in Pharmacology. 13, 16 p., 991072.

Research output: Contribution to journal › Article › Academic › peer-review

Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity

Musheshe, N., Oun, A., Sabogal-Guáqueta, A. M., Trombetta-Lima, M., Mitchel, S. C., Adzemovic, A., Speek, O., Morra, F., van der Veen, C. H. J. T., Lezoualc'h, F., Cheng, X., Schmidt, M. & Dolga, A. M., 4-Feb-2022, In: Antioxidants (Basel, Switzerland). 11, 2, 20 p., 314.

Research output: Contribution to journal › Article › Academic › peer-review

The multifaceted role of LRRK2 in Parkinson's disease: From human iPSC to organoids

Oun, A., Sabogal-Guaqueta, A. M., Galuh, S., Alexander, A., Kortholt, A. & Dolga, A. M., 15-Oct-2022, In: Neurobiology of Disease. 173, 14 p., 105837.

Research output: Contribution to journal › Review article › peer-review

Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models

Trombetta-Lima, M., Sabogal-Guáqueta, A. M. & Dolga, A. M., Mar-2021, In: Cell calcium. 94, 14 p., 102362.

Research output: Contribution to journal › Article › Academic › peer-review

Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms

Sabogal-Guáqueta, A. M., Marmolejo-Garza, A., de Pádua, V. P., Eggen, B., Boddeke, E. & Dolga, A. M., Jul-2020, In: Progress in Neurobiology. 190, 17 p., 101805.

Research output: Contribution to journal › Review article › peer-review

Unraveling molecular signaling in neurodegenerative diseases: focus on a protective mechanism mediated by linalool

Sabogal Guaqueta, A., 2020, [Groningen]: University of Groningen. 258 p.

Research output: Thesis › Thesis fully internal (DIV)

Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity

Sabogal-Guáqueta, A. M., Hobbie, F., Keerthi, A., Oun, A., Kortholt, A., Boddeke, E. & Dolga, A., Oct-2019, In: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 118, 12 p., 109295.

Research output: Contribution to journal › Article › Academic › peer-review

All (10) publications

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