prof. dr. A. (Arjan) Kortholt

associate professor

prof. dr. A. (Arjan) Kortholt
Telephone:
E-mail:
a.kortholt rug.nl

Research

Research units:

Postal address:
Nijenborgh7
Gebouw 5172, ruimte 0536
9747 AG
Groningen
Netherlands
Phone: +31 50 363 4206Fax: +31 50 363 2368
  1. 2020
  2. Leemans, M., Galicia, C., Deyaert, E., Daems, E., Krause, L., Paesmans, J., ... Versées, W. (2020). Allosteric modulation of the GTPase activity of a bacterial LRRK2 homologue by conformation-specific Nanobodies. Biochemical Journal, 477(7), 1203-1218. https://doi.org/10.1042/BCJ20190843
  3. 2019
  4. Deyaert, E., Leemans, M., Singh, R. K., Gallardo, R., Steyaert, J., Kortholt, A., ... Versées, W. (2019). Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein. Biochemical Journal, 476(1), 51-66. https://doi.org/10.1042/BCJ20180803
  5. 2018
  6. 2017
  7. Deyaert, E., Wauters, L., Guaitoli, G., Konijnenberg, A., Leemans, M., Terheyden, S., ... Versées, W. (2017). A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover. Nature Communications, 8(1), 1-12. [1008]. https://doi.org/10.1038/s41467-017-01103-4
  8. 2016
  9. Skoge, M., Wong, E., Hamza, B., Bae, A., Martel, J., Kataria, R., ... Irimia, D. (2016). A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells. PLoS ONE, 11(6), [e0154491]. https://doi.org/10.1371/journal.pone.0154491
  10. Khanna, A., Lotfi, P., Chavan, A. J., Montaño, N. M., Bolourani, P., Weeks, G., ... Charest, P. G. (2016). The small GTPases Ras and Rap1 bind to and control TORC2 activity. Scientific Reports, 6, 1-9. [25823]. https://doi.org/10.1038/srep25823
  11. 2015
  12. Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A., & Kortholt, A. (2015). Structural Characterization of LRRK2 Inhibitors. Journal of Medicinal Chemistry, 58(9), 3751−3756. https://doi.org/10.1021/jm5018779
  13. Wu, J., Pipathsouk, A., Keizer-Gunnink, A., Fusetti, F., Alkema, W., Liu, S., ... Weiner, O. D. (2015). Homer3 regulates the establishment of neutrophil polarity. Molecular Biology of the Cell, 26(9), 1629-1639. https://doi.org/10.1091/mbc.E14-07-1197
  14. Terheyden, S., Ho, F. Y., Gilsbach, B. K., Wittinghofer, A., & Kortholt, A. (2015). Revisiting the Roco G-protein cycle. Biochemical Journal, 465(1), 139-147. https://doi.org/10.1042/BJ20141095
  15. 2014
  16. 2013
  17. 2012
  18. 2011
  19. 2010
  20. 2009
  21. 2008
  22. 2007
  23. 2006
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