prof. dr. A. de Bruin

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E-mail:
a.de.bruin02 umcg.nl

Research

  1. 2020
  2. Sladky, V. C., Knapp, K., Soratroi, C., Heppke, J., Eichin, F., Rocamora-Reverte, L., ... Villunger, A. (2020). E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration. Developmental Cell, 52, 335-349. https://doi.org/10.1016/j.devcel.2019.12.016
  3. 2019
  4. Yuan, R., Liu, Q., Segeren, H. A., Yuniati, L., Guardavaccaro, D., Lebbink, R. J., ... De Bruin, A. (2019). Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression. EMBO Journal, 38(20), [101430]. https://doi.org/10.15252/embj.2018101430
  5. Gal, H., Lysenko, M., Stroganov, S., Vadai, E., Youssef, S. A., Tzadikevitch-Geffen, K., ... Krizhanovsky, V. (2019). Molecular pathways of senescence regulate placental structure and function. EMBO Journal, 38(18), [100849]. https://doi.org/10.15252/embj.2018100849
  6. Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., ... van Deursen, J. M. (2019). Cyclin E Drives Hepatocellular Carcinoma. Gastroenterology, 157(1), 2-3.
  7. 2018
  8. Yuan, R., Vos, H. R., van Es, R. M., Chen, J., Burgering, B. M. T., Westendorp, B., & de Bruin, A. (2018). Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest. EMBO Journal, 37(5), [97877]. https://doi.org/10.15252/embj.201797877
  9. Matondo, R. B., Moreno, E., Toussaint, M. J. M., Tooten, P. C. J., van Essen, S. C., van Liere, E. A., ... de Bruin, A. (2018). Atypical E2f functions are critical for pancreas polyploidization. PLoS ONE, 13(1), [0190899]. https://doi.org/10.1371/journal.pone.0190899
  10. Weijts, B. G. M. W., Westendorp, B., Hien, B. T., Martinez-Lopez, L. M., Zijp, M., Thurlings, I., ... de Bruin, A. (2018). Atypical E2Fs inhibit tumor angiogenesis. ONCOGENE, 37(2), 271-276. https://doi.org/10.1038/onc.2017.336
  11. 2017
  12. Segura-Bayona, S., Knobel, P. A., Gonzalez-Buron, H., Youssef, S. A., Pena-Blanco, A., Coyaud, E., ... Stracker, T. H. (2017). Differential requirements for Tousled-like kinases 1 and 2 in mammalian development. Cell death and differentiation, 24(11), 1872-1885. https://doi.org/10.1038/cdd.2017.108
  13. de Groot, J. S., van Diest, P. J., van Amersfoort, M., Vlug, E. J., Pan, X., ter Hoeve, N. D., ... Derksen, P. W. B. (2017). Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice. Oncotarget, 8(37), 60750-60763. https://doi.org/10.18632/oncotarget.18490
  14. Mohs, A., Kuttkat, N., Reissing, J., Zimmermann, H. W., Sonntag, R., Proudfoot, A., ... Trautwein, C. (2017). Functional role of CCL5/RANTES for HCC progression during chronic liver disease. Journal of Hepatology, 66(4), 743-753. https://doi.org/10.1016/j.jhep.2016.12.011
  15. Kent, L. N., Bae, S., Tsai, S-Y., Tang, X., Srivastava, A., Koivisto, C., ... Leone, G. (2017). Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. CLIN Journal, 127(3), 830-842. https://doi.org/10.1172/JCI87583
  16. Thurlings, I., Lopez-Martinez, M. J., Westendorp, B., Zijp, M., Kuiper, R., Tooten, PCJ., ... de Bruin, A. (2017). Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer. ONCOGENE, 36(6), 829-839. https://doi.org/10.1038/onc.2016.251
  17. Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., ... Campisi, J. (2017). Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer discovery, 7(2), 165-176. https://doi.org/10.1158/2159-8290.CD-16-0241
  18. Pedone, E., Olteanu, V-A., Marucci, L., Isabel Munoz-Martin, M., Youssef, S. A., de Bruin, A., & Pia Cosma, M. (2017). Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration. Cell reports, 18(1), 107-121. https://doi.org/10.1016/j.celrep.2016.12.008
  19. De Cian, M-C., Pauper, E., Bandiera, R., Vidal, V. P. I., Sacco, S., Gregoire, E. P., ... Chaboissier, M-C. (2017). Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary. ONCOGENE, 36, 208-218. https://doi.org/10.1038/onc.2016.191
  20. 2016
  21. Vermeij, W. P., Dolle, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., ... Hoeijmakers, J. H. J. (2016). Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature, 537(7620), 427-431. https://doi.org/10.1038/nature19329
  22. Matondo, R. B., Toussaint, M. J. M., Govaert, K. M., van Vuuren, L. D., Nantasanti, S., Nijkamp, M. W., ... de Bruin, A. (2016). Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19(+)- liver cells deficient for p53 and Rb. Oncotarget, 7(34), 54662-54675. https://doi.org/10.18632/oncotarget.9952
  23. Kent, L. N., Rakijas, J. B., Pandit, S. K., Westendorp, B., Chen, H-Z., Huntington, J. T., ... Leone, G. (2016). E2f8 mediates tumor suppression in postnatal liver development. CLIN Journal, 126(8), 2955-2969. https://doi.org/10.1172/JCI85506
  24. Sudria-Lopez, E., Koppers, M., de Wit, M., van der Meer, C., Westeneng, H-J., Zundel, C. A. C., ... Pasterkamp, R. J. (2016). Full ablation of C9orf72 in mice causes immune system-related pathology and neoplastic events but no motor neuron defects. Acta Neuropathologica, 132(1), 145-147. https://doi.org/10.1007/s00401-016-1581-x
  25. Catrysse, L., Ghahremani, M. F., Vereecke, L., Youssef, S. A., Mc Guire, C., Sze, M., ... van Loo, G. (2016). A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death. Cell death & disease, 7, [2250]. https://doi.org/10.1038/cddis.2016.154
  26. de Bruin, A., Cornelissen, P. W. A., Kirchmaier, B. C., Mokry, M., Iich, E., Nirmala, E., ... Bakker, W. J. (2016). Genome-wide analysis reveals NRP1 as a direct HIF1 alpha-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic Acids Research, 44(8), 3549-3566. https://doi.org/10.1093/nar/gkv1471
  27. Terre, B., Piergiovanni, G., Segura-Bayona, S., Gil-Gomez, G., Youssef, S. A., Attolini, C. S-O., ... Stracker, T. H. (2016). GEMC1 is a critical regulator of multiciliated cell differentiation. The EMBO Journal, 35(9), 942-960. https://doi.org/10.15252/embj.201592821
  28. Boekhout, M., Yuan, R., Wondergem, A. P., Segeren, H. A., van Liere, E. A., Awol, N., ... Westendorp, B. (2016). Feedback regulation between atypical E2Fs and APC/C-Cdh1 coordinates cell cycle progression. Embo Reports, 17(3), 414-427. https://doi.org/10.15252/embr.201540984
  29. 2015
  30. Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., ... Schotanus, B. A. (2015). Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports, 5(5), 895-907. https://doi.org/10.1016/j.stemcr.2015.09.002
  31. 2014
  32. Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., ... Campisi, J. (2014). An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell, 31(6), 722-733. https://doi.org/10.1016/j.devcel.2014.11.012

ID: 20654684