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Lecture Wybren Jan Buma


21 September 2012 FWN-Building 5115.0017, Nijenborgh 4, 9747 AG, Groningen
Speaker: Prof. Dr. Wybren Jan Buma
Affiliation: UvA, Van 't Hoff Institute for Molecular Sciences
Title: The difference between left and right
Date: Fri Sep 21, 2012
Start: 15.00
Location: FWN-Building 5115.0017
Host: Thomas La Cour Jansen
Telephone: +31 50 363 4957


proven to be powerful means to unravel the stereochemistry and conformational heterogeneity of chiral molecules. Their practical applicability, however, is often impeded by small signal intensities. Strategies that would enhance VOA signals and thereby improve the ability of accurately differentiating between optical isomers by means of their vibrational signatures could therefore be of substantial importance.

 Here, we present a novel approach to amplify VCD signals based on the controlled modulation of the energies of the electronically excited-state manifold. In a first example, we employ electrochemical modulation and show that VCD enhancements by one order of magnitude can be achieved. In a second approach, we adapt the excited-state manifold by using an auxiliary to provide electronically excited states with the appropriate properties. In this case we find that amplification factors of more than two orders of magnitude can be obtained, bringing vibrational differential absorption on an equal footing with electronic differential absorption. Finally, we will discuss an all-optical amplification approach based on preparing molecules in electronically excited states.

Last modified:22 October 2012 2.31 p.m.