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Lecture Aleksei Aksimentiev


11 July 2012 FWN-Building 5111.0080, Nijenborgh 4, 9747 AG, Groningen
Speaker: Prof. Dr. Aleksei Aksimentiev
Affiliation: University of Illinois, Urbana-Champaign, USA
Title: Molecular mechanics of nucleid acids: DNA condensation, replication and nanopore sequencing
Date: Wed Jul 11, 2012
Start: 16.00 h
Location: FWN-Building 5111.0080
Host: S.J. Marrink
Telephone: +31 50 363 4323


After water and oxygen, DNA is, very likely, the most famous molecule of life known to men. This is not surprising, as we all know that an eye-catching, double-helical molecule of DNA carries instructions to manufacture and

assemble all the components of a living organism. The wealth of information encoded in DNA often overshadows its unusual physical properties, for example, the possibility of effective attraction between same-charge DNA molecules. Furthermore, the methods used to determine the informational content of DNA

—its nucleotide sequence—until now relied on biological processes.

In this talk, I will describe our recent efforts to characterize the physical properties of DNA through atomistic simulations and demonstrate how these properties can be exploited in a physics-based technology for sequencing DNA.


Last modified:22 October 2012 2.30 p.m.