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Lecture Aleksei Aksimentiev

Roster

WhenWhere
11 July 2012 FWN-Building 5111.0080, Nijenborgh 4, 9747 AG, Groningen
Speaker: Prof. Dr. Aleksei Aksimentiev
Affiliation: University of Illinois, Urbana-Champaign, USA
Title: Molecular mechanics of nucleid acids: DNA condensation, replication and nanopore sequencing
Date: Wed Jul 11, 2012
Start: 16.00 h
Location: FWN-Building 5111.0080
Host: S.J. Marrink
Telephone: +31 50 363 4323

Abstract

After water and oxygen, DNA is, very likely, the most famous molecule of life known to men. This is not surprising, as we all know that an eye-catching, double-helical molecule of DNA carries instructions to manufacture and

assemble all the components of a living organism. The wealth of information encoded in DNA often overshadows its unusual physical properties, for example, the possibility of effective attraction between same-charge DNA molecules. Furthermore, the methods used to determine the informational content of DNA

—its nucleotide sequence—until now relied on biological processes.

In this talk, I will describe our recent efforts to characterize the physical properties of DNA through atomistic simulations and demonstrate how these properties can be exploited in a physics-based technology for sequencing DNA.

 

Last modified:22 October 2012 2.30 p.m.