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Lecture Harm-Anton Klok


14 July 2011 FWN-Building 5113.0202, Nijenborgh 4, 9747 AG, Groningen
Speaker: Prof. Dr. Harm-Anton Klok
Affiliation: Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Title: Combating diseases with peptide-synthetic polymer conjugates
Date: Thu Jul 14, 2011
Start: 13.30
Location: FWN-Building 5113.0202
Host: A. Herrmann
Telephone: +31 50 363 6318


Peptides and proteins often combine unique self-assembly properties with very specific biological activity. From a therapeutic point of view, peptides and proteins are of interest, not only because of the possibilities to act as inhibitors or antagonists of biological processes (i.e. to act as therapeutics), but also because they provide opportunities e.g. for targeted delivery or to guide intracellular trafficking. Judiciously combining biologically active peptides or proteins provides opportunities to overcome problems related to the limited stability and plasma half life of peptides and proteins, to enhance the efficacy of polymer-drug conjugates and the augment the activity of peptide based therapeutics. This presentation will consist of three parts which will successively discuss: (i) non-covalent polymer – drug conjugates in which the peptide-based linker not only acts to bind and release cargo but also is involved in directing intracellular trafficking; (ii) polymer-modified HIV fusion inhibitors that show increased stabilities as compared to the unmodified peptides while maintaining activity and (iii) multivalent HIV entry inhibitors based on side-chain peptide – polymer conjugates which allow to augment the activity of the peptide. In all three cases, precision polymer synthesis is essential in the successful design of the final conjugates. Amongst others, the examples will highlight the importance of controlling molecular weight, the site of polymer – peptide conjugation as well as polymer architecture on the final properties and activity of the peptide – synthetic polymer conjugates.

Last modified:22 October 2012 2.30 p.m.