Miniture Symposium Photochemistry and Photobiology
|09 March 2011||FWN-Building 5114.0004, Nijenborgh 4, 9747 AG, Groningen|
- Prof. Bernd Epe (Institute of Pharmacay and Biochemistry, University of Mainz, Germany;
- Dr. Danaboyina Ramaiah (Chem. Sciences and Technology Div., Nat. Institute for Interdisciplinary Science and Technology, Trivandrum, India;- Kathrin Butzbach, Institute of Pharmacy and Biochemistry, University of Mainz, Germany.
- Cytotoxicity and DNA damage induced by photosensitization;
- Development of Sensitizers for Photodynamic Therapy;- Carriersystems for Photodynamic Therapy.
|Date:||Wed Mar 9, 2011|
|Start:||14.45 - 16.00|
|Telephone:||+31 50 363 6318|
The generation of DNA damage by endogenous photosensitizers in mammalian cells is of considerable interest since it contributes to the well-established carcinogenic risk associated with solar radiation, in particular in the UVA and visible range of the spectrum. On the other hand, the cytotoxic and genotoxic effects of photosensitizers can be exploited in the so-called Photodynamic Therapy (PDT), for example in order to kill selectively tumor cells in an organism. The photophysical and pharmacological characteristics of the photosensitizers to be applied in PDT have to fulfil many requirements. An important goal for future development is the combination of the photosensitizers with macromolecular delivery systems, which allow an accumulation of the photosensitizers in the target cells (tumor cells) prior to the irradiation with light.
|Last modified:||22 October 2012 2.30 p.m.|