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Lecture Chris Binns

Roster

WhenWhere
14 January 2011 FWN-Building 5118.-152, Nijenborgh 4, 9747 AG, Groningen
Speaker: Dr. Chris Binns
Affiliation: Department of Physics and Astronomy, University of Leicester, Leicester LE1 7RH, UK
Title: Gas-Phase Preparation of Nanoparticle Suspensions in Liquids for Medical Applications
Date: Fri Jan 14, 2011
Start: 11.00
Location: FWN-Building 5118.-152
Host: G. Palasantzas
Telephone: +31 50 363 4794

Abstract

Nanoparticles are increasingly important in clinical and research applications and combined with biological targeting that enables them to label specific cells they form a powerful toolkit for cell labeling, diagnosis and therapy. Gas-phase synthesis affords the opportunity to ‘design’ almost any type of nanoparticle including core-shell and alloy structures with a tight size selection. The technical problem that has prevented gas-phase nanoparticles from being used in medicine has been how to manufacture liquid suspensions from the ultra-high vacuum environment required for clean nanoparticle production. We present a solution to this problem and have demonstrated it by producing liquid suspensions of nanoparticles. We have extended the method to manufacture liquid suspensions of Fe@Au core-shell nanoparticles. These are expected to produce an order of magnitude more heat per gram of material in response to a given AC magnetic field than the oxides and a similar improvement in the MRI relaxivity. Their Au shell renders them biocompatible and easy to conjugate to targeting moieties such as antibodies or peptides so they will make ideal theranostic nanovectors for hyperthermia treatment.

Last modified:22 October 2012 2.30 p.m.