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Lecture Alexander Popkov


12 augustus 2009 FWN-Building 5114.0004, Nijenborgh 4, 9747 AG, Groningen
Speaker: Dr. Alexander Popkov
Affiliation: Department of Nuclear Medicine and Molecular Imaging,  UMCG and University of South Bohema, Czech Republic
Title: Molecular modeling in positron emission tomography
Date: Wed Aug 12, 2009
Start: 14.00
Location: FWN-Building 5114.0004
Host: M. Filatov
Telephone: +31 50 363 4377


Positron emission tomography (PET) utilises positron emitting radiopharmaceuticals in the study of metabolic and physiological processes. Production of the positron emitting radionuclide by a cyclotron followed by its incorporation into a molecule of a physiologically active compound using the appropriate radiochemical techniques is the starting point for any PET study.After the injection of the labelled tracer, the space- and time-resolved image of positron annihilations is detected externally using rings of coincidence detectors placed around the subject (a PET scanner). PET investigations using 2-[18F]fluoro-2-deoxy-D-glucose (FDG) become available in a large number of hospitals worldwide. Specific tracers are being developed mostly for oncological, neurological and cardiological applications and for drug design.

DFT modelling of conformational behaviour of FDG and its interactions with water molecules attracted little attention. [i] , [ii] A Web of Science search with the keywords "positron emission tomography" and "molecular modelling" returned one result. [iii] Replacement of "molecular modelling" for "DFT" led to five meaningful publications. Placing of "MP2" instead of "DFT" again led to just one result.ii In this talk I wish to highlight perspectives of molecular modelling for the development of PET analogues of large aromatic amino acids for oncological and neurological applications. [iv]

[i] Zhou JM, Zhou JH, Zhang HB, Dong XC, Chen MB, Carbohydrate Research 2006, 341, 2224-2232

[ii] Hoffmann M, Rychlewski J, JACS 2001, 123, 2308-2316

[iii] Tuttle CTT, Seabrook SA, Wise LE, Katsifis A, Knott RB, Yates BF, Australian Journal of Chemistry 2004, 57, 87-96.

[iv] Popkov A, Blahutova A, Kanova M, Journal of Labelled Compounds and Radiopharmaceuticals 2007, 50, 528-529.

Laatst gewijzigd:22 oktober 2012 14:30