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Lecture A. Herrmann


15 maart 2007 FWN-Building 5118.-152, Nijenborgh 4, 9747 AG, Groningen
Speaker:Dr. A. Herrmann
Affiliation:Max-Planck-Institute for Polymer Research, Mainz, Germany
Title:DNA block copolymers: synthesis, morphologies and interactions with living systems
Date:Thu Mar 15, 2007
Location:FWN-Building 5118.-152
Host:G. ten Brinke and A.J. Schouten
Telephone:+31 50 363 4509, 4513


Different synthetic strategies for the generation of linear, single stranded (ss) and double stranded (ds) DNA block copolymers will be presented. Ss nucleocopolymers are prepared by a grafting onto approach in solution or on the solid phase. Ds DNA block copolymers with large nucleic acid segments are synthesized applying the polymerase chain reaction. The morphologies which are adopted by amphiphilic DNA block copolymers will be discussed. Special attention will be paid to engineering the structural properties of micelles by hybridization. In the context of applications regarding DNA block copolymers, programmable, sequence specific organic reactions in spherical micelles will be presented. In a second example, triblock architectures containing a central fluorene unit and two attached oligonucleotides are used for the detection of single nucleotide polymorphisms (SNPs) by fluorescence. _______________________ (1) Safak M. Alemdaroglu F. Li Y. Ergen E. Herrmann A. Adv. Mater. 2007, accepted. (2) Ding K. Alemdaroglu, F. E. Boersch, M. Berger, R. Herrmann, A. Angew. Chem. Int. Ed. 2007, 46, 1172-1175. (3) Alemdaroglu, F. E. Ding, K. Berger, R. Herrmann, A. Angew. Chem. Int. Ed. 2006, 45, 4206-4210. (4) Ergen, E. Weber, M. Jacob, J. Herrmann, A. Muellen, K. Eur. J. 2006, 12, 3707-3713.
Laatst gewijzigd:22 oktober 2012 14:31