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Lecture Brigitte Voit and Piet Bron


10 januari 2007 FWN-Building 5118.-152, Nijenborgh 4, 9747 AG, Groningen
Speaker: Prof. Brigitte Voit1 and Ir. Piet Bron2
Affiliation: 1Leibniz Institute of Polymer Research and Max-Bergmann Center for Biomaterials
2Cordis Europa NV
Title: Dual lecture: 1. Biocompatible and bioactive coationgs for medical devices and tissue engineering; 2. Catheters, treatment procedure and high level catheter requirements
Date: Wed Jan 10, 2007
Start: 10.30
Location: FWN-Building 5118.-152
Host: T. Loontjens
Telephone: +31 50 3634510


Lecture 1: Biocompatible and bioactive coatings for medical devices and tissue engineering

For many biomedical applications of polymeric materials, e. for stents, catheter, implants, membranes, cell cultures or even syringes, a biocompatible surface is required which prevents infection or blood clotting, reduces protein adsorption or increases just hydrophilicity. Additional bioactivity is needed, when the field of tissue engineering is addressed. Several hydrophilic, amphiphilic and thermoresponsive polymers have been developed in our group which can be attached to polymeric and metal substrates by using macroinitiators, grafting onto processes or plasma and electron beam activation. Stable polyacrylic acid hydrogel formed from a thin macroinitiator layer could be used to reduce the friction of polymeric catheters and to allow a better sliding into the blood vessels without damaging tissue. A similar approach could be used to fix hydrogel layers on stents which are able to carry anticlotting drugs being released after the fixation of the stent within the blood vessel. Copolymers of NiPAAm with poly(oligo)ethyleneoxide macromonomers allowed the preparation of thermoresponsive materials which could be immobilized on surfaces by a plasma induced process. Cell growth on these modified substrates could be stimulated and by changing the temperature, a smooth and cell friendly release of the cells into the cell culture medium was possible. These materials are further combined with biocompatible and bioactive oligosaccharide units.

Lecture 2: Catheters, treatment procedure and high level catheter requirements

First, a very short introduction of Johnson and Johnson and Cordis will be given to be able to put the catheter and medical products in perspective. Than an explanation of the treatment procedure will be given. This will be done by presenting some slides, demonstrating products and the procedure will be illustrated by showing a short movie. After the procedure has been explained, the configuration of a catheter will be explained and high level requirements for catheters, related to the procedure will be discussed. Finally, it will be discussed of what kind of work is being done by engineers to develop new products and it will be explained what is needed to bring these products to the market.

Laatst gewijzigd:22 oktober 2012 14:31