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Lecture A. Tokmakoff


20 January 2005 FWN-Building 5118.-152, Nijenborgh 4, 9747 AG, Groningen
Speaker: Prof.dr. A. Tokmakoff
Affiliation: Massachusetts Institute of Technology, Cambridge, MA, USA
Title: Two-dimensional infrared spectroscopy of protein conformation and unfolding
Date: Thu Jan 20, 2005
Start: 11.00
Location: FWN-Building 5118.-152
Host: J. Knoester
Telephone: +31 50 363 4369


Two-dimensional infrared spectroscopy is a tool for probing transient molecular structure in solution through a characterization of vibrational couplings. I will discuss the application of this method to the study of protein conformation through 2D IR spectroscopy of amide I vibrations. Vibrational couplings lead to delocalized states that are sensitive to secondary structure, but also influenced by disorder. 2D IR spectroscopy helps to characterize these variables and can thereby reveal information on mesoscopic structure in protein, and how it changes on thermal denaturing. Studies of transient thermal unfolding on nanosecond to millisecond time scales will also be presented.


This lecture is part of the MSC mini-symposium New developments in two-dimensional infrared spectroscopy. Please pre-register with Margriet Derix if you wish to attend one or more of its three lectures.

Last modified:22 October 2012 2.30 p.m.