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MSC Colloquium Helmut Ringsdorf


01 December 2005 FWN-Building 5111.0080, Nijenborgh 4, 9747 AG, Groningen
Helmut Ringsdorf
Helmut Ringsdorf
Speaker: Prof. Helmut Ringsdorf
Affiliation: Institute of Organic Chemistry, University of Mainz, Germany
Title: Polymer science and cell biology: tissue and cell specific polymer antitumor agents from lab to clinic
Date: Thu Dec 1, 2005
Start: 16.00 (Doors open and coffee available at 15.30)
Location: FWN-Building 5111.0080


In Europe and USA approximately one in three people get some form of cancer; of these patients one in four die of their disease. How can we cope with it? Nowadays, many primary tumors - early recognized - are treatable and can even be cured. So, where is the problem? The problems are the metastases: Most cancer death are based on metastases-induced secondary tumors. Starting from singled out tumor cells, vascularization is needed to support these tumor nodules with oxygene, nutrition etc. (angiogenesis). Developing its growing vascularization system hastily, the tumor makes mistakes leading to hyperpermeable arteries and veins by the formation of irregularities and even holes. These defects open new opportunities for tissue and cell selective localization of macromolecular drug delivery systems, which can not enter normal arteries and veins. Polymer antitumor agents and polymeric angiogenesis inhibitors are not only in clinical Phase I- and Phase II-studies, but several polymer therapeutics are already in clinical use.
Last modified:22 October 2012 2.30 p.m.