Prof. dr. W. Zinth, Ludwig-Maximilians-Universität, München: DNA-damage by ultraviolet light – New insight by femtosecond infrared spectroscopy
|19 April 2012||FWN-Building 5111.0080, Nijenborgh 4, 9747 AG, Groningen|
|Speaker:||Prof. dr. Wolfgang Zinth|
DNA-damage by ultraviolet light – New insight by femtosecond infrared spectroscopy
|Start:||16.00 (Doors open and coffee available at 15.30)|
Ultraviolet radiation induces a number of different photo damages in DNA. Among them the CPD (cyclobutane-pyrimidine-dimer) photolesion of neighbouring thymines is most frequent while the Dewar valence isomer is very serious. With time-resolved infrared spectroscopy we address the dynamics of the formation of the two photolesions. We show that these reactions occur on the timescale of picoseconds via excited singlet states. The understanding of reaction dynamics gives new insight into the molecular parameters controlling lesion formation and shows how nature preserves the integrity of DNA on the molecular level.
|Last modified:||12 September 2014 11.21 a.m.|