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OnderzoekVan Swinderen Institute

Prof. dr. W. Zinth, Ludwig-Maximilians-Universität, München: DNA-damage by ultraviolet light – New insight by femtosecond infrared spectroscopy

Roster

WhenWhere
19 April 2012 FWN-Building 5111.0080, Nijenborgh 4, 9747 AG, Groningen
Speaker: Prof. dr. Wolfgang Zinth
Affiliation: Ludwig-Maximilians-Universität, München
Title:

DNA-damage by ultraviolet light – New insight by femtosecond infrared spectroscopy

Date: 19-04-2012
Start: 16.00 (Doors open and coffee available at 15.30)
Location: FWN-Building 5111.0080
Host: Thorben Cordes

Abstract

Ultraviolet radiation induces a number of different photo damages in DNA. Among them the CPD (cyclobutane-pyrimidine-dimer) photolesion of neighbouring thymines is most frequent while the Dewar valence isomer is very serious. With time-resolved infrared spectroscopy we address the dynamics of the formation of the two photolesions. We show that these reactions occur on the timescale of picoseconds via excited singlet states. The understanding of reaction dynamics gives new insight into the molecular parameters controlling lesion formation and shows how nature preserves the integrity of DNA on the molecular level.

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Last modified:12 September 2014 11.21 a.m.