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OnderzoekVan Swinderen Institute

Physics: Dr. T. Schlatholter, KVI - Atomic Physics, Univ. of Groningen, the Netherlands: Molecular mechanisms underlying particle therapy


22 October 2009 FWN-Building 5111.0080, Nijenborgh 4, 9747 AG, Groningen
Speaker: Physics: Dr. Thomas Schlatholter
Affiliation: KVI - Atomic Physics, Univ. of Groningen, the Netherlands
Title: Molecular mechanisms underlying particle therapy
Date: 22-10-2009
Start: 16.00
Location: FWN-Building 5111.0080


Fast ions exhibit a unique dose-distribution when interacting with human tissue. At a well- defined depth, ions are slowed down to MeV energies and cell killing is most effective due to maximum linear energy transfer and radiobiological effectiveness. Such volume sensitivity renders ion-therapy a superior tool for a number of localized tumors, in some cases decreasing the yearly risk of radiation induced development of lethal secondary tumors by one order of magnitude!
Molecular mechanisms underlying biological radiation action still remain unclear. Particularly the exceptional cell killing efficiency of heavy ions and protons is largely unexplored on the molecular level.  In this talk I will briefly introduce various aspects of bio-molecular radiation action. Emphasis will then be laid on ion induced fragmentation dynamics of the smallest building blocks of life such as DNA building blocks and amino acids. The results for instance indicate that the particularly fatal clustered DNA strand breaks are easily induced by proton or heavy ion impact. Finally, the current trend towards investigation of complex nanosolvated biomolecules will be discussed.
Last modified:12 September 2014 11.21 a.m.