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Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation

Liu, Q., Chiu, A., Wang, L-H., An, D., Zhong, M., Smink, A. M., de Haan, B. J., de Vos, P., Keane, K., Vegge, A., Chen, E. Y., Song, W., Liu, W. F., Flanders, J., Rescan, C., Grunnet, L. G., Wang, X. & Ma, M., 20-Nov-2019, In : Nature Communications. 10, 1, 14 p., 5262.

Research output: Contribution to journalArticleAcademicpeer-review

Foreign body reaction (FBR) to implanted biomaterials and medical devices is common and can compromise the function of implants or cause complications. For example, in cell encapsulation, cellular overgrowth (CO) and fibrosis around the cellular constructs can reduce the mass transfer of oxygen, nutrients and metabolic wastes, undermining cell function and leading to transplant failure. Therefore, materials that mitigate FBR or CO will have broad applications in biomedicine. Here we report a group of zwitterionic, sulfobetaine (SB) and carboxybetaine (CB) modifications of alginates that reproducibly mitigate the CO of implanted alginate microcapsules in mice, dogs and pigs. Using the modified alginates (SB-alginates), we also demonstrate improved outcome of islet encapsulation in a chemically-induced diabetic mouse model. These zwitterion-modified alginates may contribute to the development of cell encapsulation therapies for type 1 diabetes and other hormone-deficient diseases.

Original languageEnglish
Article number5262
Number of pages14
JournalNature Communications
Volume10
Issue number1
Publication statusPublished - 20-Nov-2019

    Keywords

  • FOREIGN-BODY RESPONSE, BETA-CELLS, POLY(SULFOBETAINE METHACRYLATE), PROTEIN ADSORPTION, PIG ISLETS, SURFACE, BIOCOMPATIBILITY, HYDROGELS, POLYMER, TRANSPLANTATION

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