Zootechnical Issues in Small Animal Imaging

Sijbesma, J., Doorduin, J. & van Waarde, A., 2017, Quality in Nuclear Medicine. Glaudemans, A., Medema, J., van Zanten, A. K., Dierckx, R. & Ahaus, C. T. B. (eds.). Springer, p. 295-319 25 p. 18

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

This chapter is focused on animal handling during rodent imaging. Particularly
in studies of peripheral organs, the nutritional status of an animal may affect
the imaging results. Anesthetics can also have a strong impact on scan data,
for example, in drug research or studies of the brain. Physiological parameters
like body temperature, heart rate, ventilation frequency, and oxygenation of the
blood should always be carefully monitored and be kept close to their normal
values or be standardized as much as possible when data from different animals
are compared. Most PET and SPECT studies have employed the intravenous
route for tracer administration. Several other routes are possible although these
are probably not as widely applicable. For many studies, the combination of
functional (PET, SPECT, fMRI) and anatomic (CT, US, MRI) imaging offers
significant advantages, particularly if functional and anatomic data can be
acquired simultaneously.
Original languageEnglish
Title of host publicationQuality in Nuclear Medicine
EditorsAndor Glaudemans, Jitze Medema, Annie K van Zanten, Rudi Dierckx, Cees T B Ahaus
Number of pages25
ISBN (Electronic)978-3-319-33531-5
Publication statusPublished - 2017


  • Positron Emission Tomography (PET), Small animal imaging, Multimodal Imaging, Anesthesia, Nutritional status, Body temperature, Heart rate, Ventilation rate, BLOOD OXYGENATION, Single photon emission computed tomography, animal health, animal welfare

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