Publication

YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex

Kostic, M., Paridaen, J. T. M. L., Long, K. R., Kalebic, N., Langen, B., Gruebling, N., Wimberger, P., Kawasaki, H., Namba, T. & Huttner, W. B., 23-Apr-2019, In : Cell reports. 27, 4, p. 1103-1118.e6 22 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Kostic, M., Paridaen, J. T. M. L., Long, K. R., Kalebic, N., Langen, B., Gruebling, N., ... Huttner, W. B. (2019). YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex. Cell reports, 27(4), 1103-1118.e6. https://doi.org/10.1016/j.celrep.2019.03.091

Author

Kostic, Milos ; Paridaen, Judith T. M. L. ; Long, Katherine R. ; Kalebic, Nereo ; Langen, Barbara ; Gruebling, Nannette ; Wimberger, Pauline ; Kawasaki, Hiroshi ; Namba, Takashi ; Huttner, Wieland B. / YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex. In: Cell reports. 2019 ; Vol. 27, No. 4. pp. 1103-1118.e6.

Harvard

Kostic, M, Paridaen, JTML, Long, KR, Kalebic, N, Langen, B, Gruebling, N, Wimberger, P, Kawasaki, H, Namba, T & Huttner, WB 2019, 'YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex' Cell reports, vol. 27, no. 4, pp. 1103-1118.e6. https://doi.org/10.1016/j.celrep.2019.03.091

Standard

YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex. / Kostic, Milos; Paridaen, Judith T. M. L.; Long, Katherine R.; Kalebic, Nereo; Langen, Barbara; Gruebling, Nannette; Wimberger, Pauline; Kawasaki, Hiroshi; Namba, Takashi; Huttner, Wieland B.

In: Cell reports, Vol. 27, No. 4, 23.04.2019, p. 1103-1118.e6.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Kostic M, Paridaen JTML, Long KR, Kalebic N, Langen B, Gruebling N et al. YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex. Cell reports. 2019 Apr 23;27(4):1103-1118.e6. https://doi.org/10.1016/j.celrep.2019.03.091


BibTeX

@article{ae165348a0774eb4882b8763f5dad3af,
title = "YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex",
abstract = "Neocortex expansion during mammalian evolution has been linked to an increase in proliferation of basal progenitors in the subventricular zone. Here, we explored a potential role of YAP, the major down-stream effector of the Hippo pathway, in proliferation of basal progenitors. YAP expression and activity are high in ferret and human basal progenitors, which exhibit high proliferative capacity, but low in mouse basal progenitors, which lack such capacity. Conditional expression of a constitutively active YAP in mouse basal progenitors resulted in increased proliferation of basal progenitor and promoted production of upper-layer neurons. Pharmacological and genetic interference with YAP function in ferret and human developing neocortex resulted in decreased abundance of cycling basal progenitors. Together, our data indicate that YAP is necessary and sufficient to promote the proliferation of basal progenitors and suggest that increases in YAP levels and presumably activity contributed to the evolutionary expansion of the neocortex.",
keywords = "OUTER SUBVENTRICULAR ZONE, RADIAL GLIA, EXTRACELLULAR-MATRIX, GENE-EXPRESSION, HIPPO PATHWAY, NEURONS ARISE, SELF-RENEWAL, CELL CONTACT, SIZE-CONTROL, ORGAN SIZE",
author = "Milos Kostic and Paridaen, {Judith T. M. L.} and Long, {Katherine R.} and Nereo Kalebic and Barbara Langen and Nannette Gruebling and Pauline Wimberger and Hiroshi Kawasaki and Takashi Namba and Huttner, {Wieland B.}",
year = "2019",
month = "4",
day = "23",
doi = "10.1016/j.celrep.2019.03.091",
language = "English",
volume = "27",
pages = "1103--1118.e6",
journal = "Cell reports",
issn = "2211-1247",
publisher = "CELL PRESS",
number = "4",

}

RIS

TY - JOUR

T1 - YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex

AU - Kostic, Milos

AU - Paridaen, Judith T. M. L.

AU - Long, Katherine R.

AU - Kalebic, Nereo

AU - Langen, Barbara

AU - Gruebling, Nannette

AU - Wimberger, Pauline

AU - Kawasaki, Hiroshi

AU - Namba, Takashi

AU - Huttner, Wieland B.

PY - 2019/4/23

Y1 - 2019/4/23

N2 - Neocortex expansion during mammalian evolution has been linked to an increase in proliferation of basal progenitors in the subventricular zone. Here, we explored a potential role of YAP, the major down-stream effector of the Hippo pathway, in proliferation of basal progenitors. YAP expression and activity are high in ferret and human basal progenitors, which exhibit high proliferative capacity, but low in mouse basal progenitors, which lack such capacity. Conditional expression of a constitutively active YAP in mouse basal progenitors resulted in increased proliferation of basal progenitor and promoted production of upper-layer neurons. Pharmacological and genetic interference with YAP function in ferret and human developing neocortex resulted in decreased abundance of cycling basal progenitors. Together, our data indicate that YAP is necessary and sufficient to promote the proliferation of basal progenitors and suggest that increases in YAP levels and presumably activity contributed to the evolutionary expansion of the neocortex.

AB - Neocortex expansion during mammalian evolution has been linked to an increase in proliferation of basal progenitors in the subventricular zone. Here, we explored a potential role of YAP, the major down-stream effector of the Hippo pathway, in proliferation of basal progenitors. YAP expression and activity are high in ferret and human basal progenitors, which exhibit high proliferative capacity, but low in mouse basal progenitors, which lack such capacity. Conditional expression of a constitutively active YAP in mouse basal progenitors resulted in increased proliferation of basal progenitor and promoted production of upper-layer neurons. Pharmacological and genetic interference with YAP function in ferret and human developing neocortex resulted in decreased abundance of cycling basal progenitors. Together, our data indicate that YAP is necessary and sufficient to promote the proliferation of basal progenitors and suggest that increases in YAP levels and presumably activity contributed to the evolutionary expansion of the neocortex.

KW - OUTER SUBVENTRICULAR ZONE

KW - RADIAL GLIA

KW - EXTRACELLULAR-MATRIX

KW - GENE-EXPRESSION

KW - HIPPO PATHWAY

KW - NEURONS ARISE

KW - SELF-RENEWAL

KW - CELL CONTACT

KW - SIZE-CONTROL

KW - ORGAN SIZE

U2 - 10.1016/j.celrep.2019.03.091

DO - 10.1016/j.celrep.2019.03.091

M3 - Article

VL - 27

SP - 1103-1118.e6

JO - Cell reports

JF - Cell reports

SN - 2211-1247

IS - 4

ER -

ID: 93018325