Publication

Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice

de Haas, R., Struikmans, R., van der Plasse, G., van Kerkhof, L., Brakkee, J. H., Kas, M. J. H. & Westenberg, H. G. M., 30-Jul-2012, In : Journal of Neuroscience Methods. 209, 1, p. 113-9 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

de Haas, R., Struikmans, R., van der Plasse, G., van Kerkhof, L., Brakkee, J. H., Kas, M. J. H., & Westenberg, H. G. M. (2012). Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice. Journal of Neuroscience Methods, 209(1), 113-9. https://doi.org/10.1016/j.jneumeth.2012.05.028

Author

de Haas, Ria ; Struikmans, Rolf ; van der Plasse, Geoffrey ; van Kerkhof, Linda ; Brakkee, Jan H ; Kas, Martien J H ; Westenberg, Herman G M. / Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice. In: Journal of Neuroscience Methods. 2012 ; Vol. 209, No. 1. pp. 113-9.

Harvard

de Haas, R, Struikmans, R, van der Plasse, G, van Kerkhof, L, Brakkee, JH, Kas, MJH & Westenberg, HGM 2012, 'Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice', Journal of Neuroscience Methods, vol. 209, no. 1, pp. 113-9. https://doi.org/10.1016/j.jneumeth.2012.05.028

Standard

Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice. / de Haas, Ria; Struikmans, Rolf; van der Plasse, Geoffrey; van Kerkhof, Linda; Brakkee, Jan H; Kas, Martien J H; Westenberg, Herman G M.

In: Journal of Neuroscience Methods, Vol. 209, No. 1, 30.07.2012, p. 113-9.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

de Haas R, Struikmans R, van der Plasse G, van Kerkhof L, Brakkee JH, Kas MJH et al. Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice. Journal of Neuroscience Methods. 2012 Jul 30;209(1):113-9. https://doi.org/10.1016/j.jneumeth.2012.05.028


BibTeX

@article{fbaa8836adcb45d4acbd5a6870ea630d,
title = "Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice",
abstract = "Although deep brain stimulation (DBS) has been proven to be an effective treatment for several neuropsychiatric disorders, such as Parkinson's disease, the underlying working mechanisms are still largely unknown. Behavioral animal models are essential in examining the working mechanisms of DBS and especially mouse models are necessary to investigate the genetic component underlying specific behaviors related to psychiatric diseases. Unfortunately, currently available stimulation devices are unsuitable to test behavior in freely-moving mice. As such, no DBS studies in behaving mice have been reported thus far. In order to overcome this limitation we have developed a new light-weight wireless implantable micro stimulator device for mice that delivers biphasic pulse patterns to two individual electrode pairs, mimicking partly the clinical situation. This paper describes in detail the bench-top validation and in vivo implementation of this device. The results in this study indicate that the wireless implantable stimulator in mice reliably delivers continuous bilateral stimulation, importantly, does not restrict the animals mobility and hygiene (grooming behavior). In vivo testing furthermore showed that stimulation of the mice ventral striatum yields similar results as previously shown by others in rats where conventional deep brain stimulation techniques were used. This newly designed device can now be used in the highly needed DBS behavioral studies in mice, to further investigate the underlying mechanisms of DBS in behavioral animal models for psychiatric disorders.",
keywords = "Animals, Deep Brain Stimulation, Disease Models, Animal, Electric Stimulation, Electrodes, Implanted, Male, Mice, Mice, Inbred C57BL, Microelectrodes, Movement, Parkinson Disease, Wireless Technology",
author = "{de Haas}, Ria and Rolf Struikmans and {van der Plasse}, Geoffrey and {van Kerkhof}, Linda and Brakkee, {Jan H} and Kas, {Martien J H} and Westenberg, {Herman G M}",
note = "Copyright {\circledC} 2012 Elsevier B.V. All rights reserved.",
year = "2012",
month = "7",
day = "30",
doi = "10.1016/j.jneumeth.2012.05.028",
language = "English",
volume = "209",
pages = "113--9",
journal = "Journal of Neuroscience Methods",
issn = "0165-0270",
publisher = "ELSEVIER SCIENCE BV",
number = "1",

}

RIS

TY - JOUR

T1 - Wireless implantable micro-stimulation device for high frequency bilateral deep brain stimulation in freely moving mice

AU - de Haas, Ria

AU - Struikmans, Rolf

AU - van der Plasse, Geoffrey

AU - van Kerkhof, Linda

AU - Brakkee, Jan H

AU - Kas, Martien J H

AU - Westenberg, Herman G M

N1 - Copyright © 2012 Elsevier B.V. All rights reserved.

PY - 2012/7/30

Y1 - 2012/7/30

N2 - Although deep brain stimulation (DBS) has been proven to be an effective treatment for several neuropsychiatric disorders, such as Parkinson's disease, the underlying working mechanisms are still largely unknown. Behavioral animal models are essential in examining the working mechanisms of DBS and especially mouse models are necessary to investigate the genetic component underlying specific behaviors related to psychiatric diseases. Unfortunately, currently available stimulation devices are unsuitable to test behavior in freely-moving mice. As such, no DBS studies in behaving mice have been reported thus far. In order to overcome this limitation we have developed a new light-weight wireless implantable micro stimulator device for mice that delivers biphasic pulse patterns to two individual electrode pairs, mimicking partly the clinical situation. This paper describes in detail the bench-top validation and in vivo implementation of this device. The results in this study indicate that the wireless implantable stimulator in mice reliably delivers continuous bilateral stimulation, importantly, does not restrict the animals mobility and hygiene (grooming behavior). In vivo testing furthermore showed that stimulation of the mice ventral striatum yields similar results as previously shown by others in rats where conventional deep brain stimulation techniques were used. This newly designed device can now be used in the highly needed DBS behavioral studies in mice, to further investigate the underlying mechanisms of DBS in behavioral animal models for psychiatric disorders.

AB - Although deep brain stimulation (DBS) has been proven to be an effective treatment for several neuropsychiatric disorders, such as Parkinson's disease, the underlying working mechanisms are still largely unknown. Behavioral animal models are essential in examining the working mechanisms of DBS and especially mouse models are necessary to investigate the genetic component underlying specific behaviors related to psychiatric diseases. Unfortunately, currently available stimulation devices are unsuitable to test behavior in freely-moving mice. As such, no DBS studies in behaving mice have been reported thus far. In order to overcome this limitation we have developed a new light-weight wireless implantable micro stimulator device for mice that delivers biphasic pulse patterns to two individual electrode pairs, mimicking partly the clinical situation. This paper describes in detail the bench-top validation and in vivo implementation of this device. The results in this study indicate that the wireless implantable stimulator in mice reliably delivers continuous bilateral stimulation, importantly, does not restrict the animals mobility and hygiene (grooming behavior). In vivo testing furthermore showed that stimulation of the mice ventral striatum yields similar results as previously shown by others in rats where conventional deep brain stimulation techniques were used. This newly designed device can now be used in the highly needed DBS behavioral studies in mice, to further investigate the underlying mechanisms of DBS in behavioral animal models for psychiatric disorders.

KW - Animals

KW - Deep Brain Stimulation

KW - Disease Models, Animal

KW - Electric Stimulation

KW - Electrodes, Implanted

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Microelectrodes

KW - Movement

KW - Parkinson Disease

KW - Wireless Technology

U2 - 10.1016/j.jneumeth.2012.05.028

DO - 10.1016/j.jneumeth.2012.05.028

M3 - Article

VL - 209

SP - 113

EP - 119

JO - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

SN - 0165-0270

IS - 1

ER -

ID: 32493008