Publication

White matter architecture in major depression with anxious distress symptoms

Heij, G. J., Penninx, B. W. H. J., van Velzen, L. S., van Tol, M-J., van der Wee, N. J. A., Veltman, D. J. & Aghajani, M., 30-Aug-2019, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 94, 13 p., 109664.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Heij, G. J., Penninx, B. W. H. J., van Velzen, L. S., van Tol, M-J., van der Wee, N. J. A., Veltman, D. J., & Aghajani, M. (2019). White matter architecture in major depression with anxious distress symptoms. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 94, [109664]. https://doi.org/10.1016/j.pnpbp.2019.109664

Author

Heij, Gijs J ; Penninx, Brenda W H J ; van Velzen, Laura S ; van Tol, Marie-José ; van der Wee, Nic J A ; Veltman, Dick J ; Aghajani, Moji. / White matter architecture in major depression with anxious distress symptoms. In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2019 ; Vol. 94.

Harvard

Heij, GJ, Penninx, BWHJ, van Velzen, LS, van Tol, M-J, van der Wee, NJA, Veltman, DJ & Aghajani, M 2019, 'White matter architecture in major depression with anxious distress symptoms' Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 94, 109664. https://doi.org/10.1016/j.pnpbp.2019.109664

Standard

White matter architecture in major depression with anxious distress symptoms. / Heij, Gijs J; Penninx, Brenda W H J; van Velzen, Laura S; van Tol, Marie-José; van der Wee, Nic J A; Veltman, Dick J; Aghajani, Moji.

In: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol. 94, 109664, 30.08.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Heij GJ, Penninx BWHJ, van Velzen LS, van Tol M-J, van der Wee NJA, Veltman DJ et al. White matter architecture in major depression with anxious distress symptoms. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2019 Aug 30;94. 109664. https://doi.org/10.1016/j.pnpbp.2019.109664


BibTeX

@article{6ff09a5f479f4ace8762fb937a66b431,
title = "White matter architecture in major depression with anxious distress symptoms",
abstract = "Background: Comorbid anxious distress is common in Major Depressive Disorder (MDD), and associated with significantly worse clinical course and treatment response. While DSM-5 recently introduced the Anxious Distress (AD) specifier as a potentially useful symptom-based subtyping scheme for MDD, its neurobiological underpinnings remain unclear. The current study hence uniquely probed whether MDD with co-occurring AD (MDD/AD+) relates to distinct perturbations in frontolimbic white matter (WM) pathways tentatively theorized in MDD/AD+ pathophysiology.Methods: Tract-based spatial statistics (TBSS) was therefore used to analyze diffusion tensor imaging data on WM microstructure, in MDD/AD+ patients (N = 20) relative to MDD patients without AD (MDD/AD-; N = 29) and healthy controls (HC; N = 39). Using TBSS, we probed fractional anisotropy and axial/radial/mean diffusivity as proxies for WM integrity. Categorical (between-groups) and dimensional (within-patients) analyses subsequently assessed how Anxious Distress in MDD impacts frontolimbic WM connectivity. Receiver-Operating Characteristics additionally assessed classification capabilities of between-groups WM effects.Results: Compared to MDD/AD- and HC participants, MDD/AD+ patients exhibited diminished integrity within the anterior thalamic radiation (ATR). Higher AD specifier scores within MDD patients additionally related to diminished integrity of the uncinate fasciculus and cingulum pathways. These effects were not confounded by key clinical (e.g., comorbid anxiety disorder) and sociodemographic (e.g., age/sex) factors, with altered ATR integrity moreover successfully classifying MDD/AD+ patients from MDD/AD- and HC participants (90{\%} sensitivity vertical bar 73{\%} specificity vertical bar 77{\%} accuracy).Conclusions: These findings collectively link MDD/AD+ to distinct WM anomalies in frontolimbic tracts important to adaptive emotional functioning, and may as such provide relevant, yet preliminary, clues on MDD/AD+ pathophysiology.",
keywords = "ANTERIOR THALAMIC RADIATION, MEDIAL FOREBRAIN-BUNDLE, FUNCTIONAL CONNECTIVITY, UNCINATE FASCICULUS, MICROSTRUCTURE ALTERATIONS, FRACTIONAL ANISOTROPY, SPATIAL STATISTICS, DIFFUSION, DISORDER, ANXIETY",
author = "Heij, {Gijs J} and Penninx, {Brenda W H J} and {van Velzen}, {Laura S} and {van Tol}, Marie-Jos{\'e} and {van der Wee}, {Nic J A} and Veltman, {Dick J} and Moji Aghajani",
note = "Copyright {\circledC} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = "8",
day = "30",
doi = "10.1016/j.pnpbp.2019.109664",
language = "English",
volume = "94",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
issn = "1878-4216",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - White matter architecture in major depression with anxious distress symptoms

AU - Heij, Gijs J

AU - Penninx, Brenda W H J

AU - van Velzen, Laura S

AU - van Tol, Marie-José

AU - van der Wee, Nic J A

AU - Veltman, Dick J

AU - Aghajani, Moji

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/8/30

Y1 - 2019/8/30

N2 - Background: Comorbid anxious distress is common in Major Depressive Disorder (MDD), and associated with significantly worse clinical course and treatment response. While DSM-5 recently introduced the Anxious Distress (AD) specifier as a potentially useful symptom-based subtyping scheme for MDD, its neurobiological underpinnings remain unclear. The current study hence uniquely probed whether MDD with co-occurring AD (MDD/AD+) relates to distinct perturbations in frontolimbic white matter (WM) pathways tentatively theorized in MDD/AD+ pathophysiology.Methods: Tract-based spatial statistics (TBSS) was therefore used to analyze diffusion tensor imaging data on WM microstructure, in MDD/AD+ patients (N = 20) relative to MDD patients without AD (MDD/AD-; N = 29) and healthy controls (HC; N = 39). Using TBSS, we probed fractional anisotropy and axial/radial/mean diffusivity as proxies for WM integrity. Categorical (between-groups) and dimensional (within-patients) analyses subsequently assessed how Anxious Distress in MDD impacts frontolimbic WM connectivity. Receiver-Operating Characteristics additionally assessed classification capabilities of between-groups WM effects.Results: Compared to MDD/AD- and HC participants, MDD/AD+ patients exhibited diminished integrity within the anterior thalamic radiation (ATR). Higher AD specifier scores within MDD patients additionally related to diminished integrity of the uncinate fasciculus and cingulum pathways. These effects were not confounded by key clinical (e.g., comorbid anxiety disorder) and sociodemographic (e.g., age/sex) factors, with altered ATR integrity moreover successfully classifying MDD/AD+ patients from MDD/AD- and HC participants (90% sensitivity vertical bar 73% specificity vertical bar 77% accuracy).Conclusions: These findings collectively link MDD/AD+ to distinct WM anomalies in frontolimbic tracts important to adaptive emotional functioning, and may as such provide relevant, yet preliminary, clues on MDD/AD+ pathophysiology.

AB - Background: Comorbid anxious distress is common in Major Depressive Disorder (MDD), and associated with significantly worse clinical course and treatment response. While DSM-5 recently introduced the Anxious Distress (AD) specifier as a potentially useful symptom-based subtyping scheme for MDD, its neurobiological underpinnings remain unclear. The current study hence uniquely probed whether MDD with co-occurring AD (MDD/AD+) relates to distinct perturbations in frontolimbic white matter (WM) pathways tentatively theorized in MDD/AD+ pathophysiology.Methods: Tract-based spatial statistics (TBSS) was therefore used to analyze diffusion tensor imaging data on WM microstructure, in MDD/AD+ patients (N = 20) relative to MDD patients without AD (MDD/AD-; N = 29) and healthy controls (HC; N = 39). Using TBSS, we probed fractional anisotropy and axial/radial/mean diffusivity as proxies for WM integrity. Categorical (between-groups) and dimensional (within-patients) analyses subsequently assessed how Anxious Distress in MDD impacts frontolimbic WM connectivity. Receiver-Operating Characteristics additionally assessed classification capabilities of between-groups WM effects.Results: Compared to MDD/AD- and HC participants, MDD/AD+ patients exhibited diminished integrity within the anterior thalamic radiation (ATR). Higher AD specifier scores within MDD patients additionally related to diminished integrity of the uncinate fasciculus and cingulum pathways. These effects were not confounded by key clinical (e.g., comorbid anxiety disorder) and sociodemographic (e.g., age/sex) factors, with altered ATR integrity moreover successfully classifying MDD/AD+ patients from MDD/AD- and HC participants (90% sensitivity vertical bar 73% specificity vertical bar 77% accuracy).Conclusions: These findings collectively link MDD/AD+ to distinct WM anomalies in frontolimbic tracts important to adaptive emotional functioning, and may as such provide relevant, yet preliminary, clues on MDD/AD+ pathophysiology.

KW - ANTERIOR THALAMIC RADIATION

KW - MEDIAL FOREBRAIN-BUNDLE

KW - FUNCTIONAL CONNECTIVITY

KW - UNCINATE FASCICULUS

KW - MICROSTRUCTURE ALTERATIONS

KW - FRACTIONAL ANISOTROPY

KW - SPATIAL STATISTICS

KW - DIFFUSION

KW - DISORDER

KW - ANXIETY

U2 - 10.1016/j.pnpbp.2019.109664

DO - 10.1016/j.pnpbp.2019.109664

M3 - Article

VL - 94

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

SN - 1878-4216

M1 - 109664

ER -

ID: 90742523