Publication

What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning?

Knegtering, H., van der Moolen, AEGM., Castelein, S., Kluiter, H. & van den Bosch, RJ., Apr-2003, In : Psychoneuroendocrinology. 28, p. 109-123 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Knegtering, H., van der Moolen, AEGM., Castelein, S., Kluiter, H., & van den Bosch, RJ. (2003). What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning? Psychoneuroendocrinology, 28, 109-123. https://doi.org/10.1016/S0306-4530(02)00130-0

Author

Knegtering, H ; van der Moolen, AEGM ; Castelein, S ; Kluiter, H ; van den Bosch, RJ. / What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning?. In: Psychoneuroendocrinology. 2003 ; Vol. 28. pp. 109-123.

Harvard

Knegtering, H, van der Moolen, AEGM, Castelein, S, Kluiter, H & van den Bosch, RJ 2003, 'What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning?', Psychoneuroendocrinology, vol. 28, pp. 109-123. https://doi.org/10.1016/S0306-4530(02)00130-0

Standard

What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning? / Knegtering, H; van der Moolen, AEGM; Castelein, S; Kluiter, H; van den Bosch, RJ.

In: Psychoneuroendocrinology, Vol. 28, 04.2003, p. 109-123.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Knegtering H, van der Moolen AEGM, Castelein S, Kluiter H, van den Bosch RJ. What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning? Psychoneuroendocrinology. 2003 Apr;28:109-123. https://doi.org/10.1016/S0306-4530(02)00130-0


BibTeX

@article{26f3ffe338eb45adabce284741050c84,
title = "What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning?",
abstract = "The literature is reviewed and preliminary results of new studies are presented showing that treatment with classical antipsychotics, as well as risperidone, induces sexual dysfunctions in 30-60% of the patients. These antipsychotics also frequently induce amenorrhoea and galactorrhoea.Although comparative studies are rare, it is likely that prolactin-sparing antipsychotics, as recently shown in a randomized trial of olanzapine versus risperidone, induce less sexual side effects.From these studies, it becomes apparent that prolactin elevation induced by classical antipsychotics and risperidone is probably a factor in inducing sexual dysfunctions, amenorrhoea and galactorrhoea. The role of other factors inducing sexual dysfunctions like sedation, alpha-blockade, testosterone, dopamine, and serotonin is discussed. Finally, it is concluded that sexual and hormonal effects of antipsychotics, although clearly important, are often neglected in research as in clinical practice. Lowering the dosage or switching to a prolactin-sparing antipsychotic often reduces sexual side effects, amenorrhoea, and galactorrhoea. (C) 2003 Elsevier Science Ltd. All rights reserved.",
keywords = "antipsychotics, prolactin, schizophrenia, sexual dysfunctions, amenorrhoea, galactorrhoea, MALE-SCHIZOPHRENIC PATIENTS, D-2 RECEPTOR OCCUPANCY, PROLACTIN LEVELS, CLASSICAL ANTIPSYCHOTICS, ATYPICAL ANTIPSYCHOTICS, PSYCHIATRIC-PATIENTS, PSYCHOTROPIC-DRUGS, NEUROLEPTIC DRUGS, ADVERSE EVENTS, RISPERIDONE",
author = "H Knegtering and {van der Moolen}, AEGM and S Castelein and H Kluiter and {van den Bosch}, RJ",
year = "2003",
month = apr,
doi = "10.1016/S0306-4530(02)00130-0",
language = "English",
volume = "28",
pages = "109--123",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning?

AU - Knegtering, H

AU - van der Moolen, AEGM

AU - Castelein, S

AU - Kluiter, H

AU - van den Bosch, RJ

PY - 2003/4

Y1 - 2003/4

N2 - The literature is reviewed and preliminary results of new studies are presented showing that treatment with classical antipsychotics, as well as risperidone, induces sexual dysfunctions in 30-60% of the patients. These antipsychotics also frequently induce amenorrhoea and galactorrhoea.Although comparative studies are rare, it is likely that prolactin-sparing antipsychotics, as recently shown in a randomized trial of olanzapine versus risperidone, induce less sexual side effects.From these studies, it becomes apparent that prolactin elevation induced by classical antipsychotics and risperidone is probably a factor in inducing sexual dysfunctions, amenorrhoea and galactorrhoea. The role of other factors inducing sexual dysfunctions like sedation, alpha-blockade, testosterone, dopamine, and serotonin is discussed. Finally, it is concluded that sexual and hormonal effects of antipsychotics, although clearly important, are often neglected in research as in clinical practice. Lowering the dosage or switching to a prolactin-sparing antipsychotic often reduces sexual side effects, amenorrhoea, and galactorrhoea. (C) 2003 Elsevier Science Ltd. All rights reserved.

AB - The literature is reviewed and preliminary results of new studies are presented showing that treatment with classical antipsychotics, as well as risperidone, induces sexual dysfunctions in 30-60% of the patients. These antipsychotics also frequently induce amenorrhoea and galactorrhoea.Although comparative studies are rare, it is likely that prolactin-sparing antipsychotics, as recently shown in a randomized trial of olanzapine versus risperidone, induce less sexual side effects.From these studies, it becomes apparent that prolactin elevation induced by classical antipsychotics and risperidone is probably a factor in inducing sexual dysfunctions, amenorrhoea and galactorrhoea. The role of other factors inducing sexual dysfunctions like sedation, alpha-blockade, testosterone, dopamine, and serotonin is discussed. Finally, it is concluded that sexual and hormonal effects of antipsychotics, although clearly important, are often neglected in research as in clinical practice. Lowering the dosage or switching to a prolactin-sparing antipsychotic often reduces sexual side effects, amenorrhoea, and galactorrhoea. (C) 2003 Elsevier Science Ltd. All rights reserved.

KW - antipsychotics

KW - prolactin

KW - schizophrenia

KW - sexual dysfunctions

KW - amenorrhoea

KW - galactorrhoea

KW - MALE-SCHIZOPHRENIC PATIENTS

KW - D-2 RECEPTOR OCCUPANCY

KW - PROLACTIN LEVELS

KW - CLASSICAL ANTIPSYCHOTICS

KW - ATYPICAL ANTIPSYCHOTICS

KW - PSYCHIATRIC-PATIENTS

KW - PSYCHOTROPIC-DRUGS

KW - NEUROLEPTIC DRUGS

KW - ADVERSE EVENTS

KW - RISPERIDONE

U2 - 10.1016/S0306-4530(02)00130-0

DO - 10.1016/S0306-4530(02)00130-0

M3 - Article

VL - 28

SP - 109

EP - 123

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -

ID: 4095331