Publication

WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

Genome Netherlands Consortium, Nersisyan, L. & Nikoghosyan, M., 10-Dec-2019, In : Scientific Reports. 9, 9 p., 18758.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Genome Netherlands Consortium, Nersisyan, L., & Nikoghosyan, M. (2019). WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. Scientific Reports, 9, [18758]. https://doi.org/10.1038/s41598-019-55109-7

Author

Genome Netherlands Consortium ; Nersisyan, Lilit ; Nikoghosyan, Maria. / WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. In: Scientific Reports. 2019 ; Vol. 9.

Harvard

Genome Netherlands Consortium, Nersisyan, L & Nikoghosyan, M 2019, 'WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene', Scientific Reports, vol. 9, 18758. https://doi.org/10.1038/s41598-019-55109-7

Standard

WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. / Genome Netherlands Consortium; Nersisyan, Lilit; Nikoghosyan, Maria.

In: Scientific Reports, Vol. 9, 18758, 10.12.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Genome Netherlands Consortium, Nersisyan L, Nikoghosyan M. WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. Scientific Reports. 2019 Dec 10;9. 18758. https://doi.org/10.1038/s41598-019-55109-7


BibTeX

@article{b6e6c3d9f2f642979962a2a9151ceba1,
title = "WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene",
abstract = "Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative contribution to TL variability is still understudied. We have used whole genome sequencing data of 250 family trios from the Genome of the Netherlands project to perform computational measurement of TL and a series of regression and genome-wide association analyses to reveal TL inheritance patterns and associated genetic factors. Our results confirm that TL is a largely heritable trait, primarily with mother's, and, to a lesser extent, with father's TL having the strongest influence on the offspring. In this cohort, mother's, but not father's age at conception was positively linked to offspring TL. Age-related TL attrition of 40 bp/year had relatively small influence on TL variability. Finally, we have identified TL-associated variations in ribonuclease reductase catalytic subunit M1 (RRM1 gene), which is known to regulate telomere maintenance in yeast. We also highlight the importance of multivariate approach and the limitations of existing tools for the analysis of TL as a polygenic heritable quantitative trait.",
keywords = "PATERNAL AGE, LUNG-CANCER, ASSOCIATION, METAANALYSIS, PROTEINS, SUBUNIT, HUMANS, CELLS, SIZE",
author = "{Genome Netherlands Consortium} and Lilit Nersisyan and Maria Nikoghosyan and Francioli, {Laurent C.} and Androniki Menelaou and Pulit, {Sara L.} and Elbers, {Clara C.} and Kloosterman, {Wigard P.} and {van Setten}, Jessica and Nijman, {Isaac J.} and Ivo Renkens and {de Bakker}, {Paul I. W.} and {van Dijk}, Freerk and Neerincx, {Pieter B. T.} and Patrick Deelen and Alexandros Kanterakis and Martijn Dijkstra and Heorhiy Byelas and {van der Velde}, {K. Joeri} and Mathieu Platteel and Swertz, {Morris A.} and Cisca Wijmenga and Palamara, {Pier Francesco} and Itsik Pe'er and Kai Ye and Eric-Wubbo Lameijer and Moed, {Matthijs H.} and Marian Beekman and {de Craen}, {Anton J. M.} and Suchiman, {H. Eka D.} and Slagboom, {P. Eline} and Victor Guryev and Abdel Abdellaoui and Hottenga, {Jouke Jan} and Mathijs Kattenberg and Gonneke Willemsen and Boomsma, {Dorret I.} and {van Leeuwen}, {Elisabeth M.} and Karssen, {Lennart C.} and Najaf Amin and Fernando Rivadeneira and Aaron Isaacs and Albert Hofman and Uitterlinden, {Andre G.} and {van Duijn}, {Cornelia M.} and {van Oven}, Mannis and Manfred Kayser and Martijn Vermaat and Laros, {Jeroen F. J.} and {van Enckevort}, David and Veldink, {Jan H.}",
year = "2019",
month = dec,
day = "10",
doi = "10.1038/s41598-019-55109-7",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

AU - Genome Netherlands Consortium

AU - Nersisyan, Lilit

AU - Nikoghosyan, Maria

AU - Francioli, Laurent C.

AU - Menelaou, Androniki

AU - Pulit, Sara L.

AU - Elbers, Clara C.

AU - Kloosterman, Wigard P.

AU - van Setten, Jessica

AU - Nijman, Isaac J.

AU - Renkens, Ivo

AU - de Bakker, Paul I. W.

AU - van Dijk, Freerk

AU - Neerincx, Pieter B. T.

AU - Deelen, Patrick

AU - Kanterakis, Alexandros

AU - Dijkstra, Martijn

AU - Byelas, Heorhiy

AU - van der Velde, K. Joeri

AU - Platteel, Mathieu

AU - Swertz, Morris A.

AU - Wijmenga, Cisca

AU - Palamara, Pier Francesco

AU - Pe'er, Itsik

AU - Ye, Kai

AU - Lameijer, Eric-Wubbo

AU - Moed, Matthijs H.

AU - Beekman, Marian

AU - de Craen, Anton J. M.

AU - Suchiman, H. Eka D.

AU - Slagboom, P. Eline

AU - Guryev, Victor

AU - Abdellaoui, Abdel

AU - Hottenga, Jouke Jan

AU - Kattenberg, Mathijs

AU - Willemsen, Gonneke

AU - Boomsma, Dorret I.

AU - van Leeuwen, Elisabeth M.

AU - Karssen, Lennart C.

AU - Amin, Najaf

AU - Rivadeneira, Fernando

AU - Isaacs, Aaron

AU - Hofman, Albert

AU - Uitterlinden, Andre G.

AU - van Duijn, Cornelia M.

AU - van Oven, Mannis

AU - Kayser, Manfred

AU - Vermaat, Martijn

AU - Laros, Jeroen F. J.

AU - van Enckevort, David

AU - Veldink, Jan H.

PY - 2019/12/10

Y1 - 2019/12/10

N2 - Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative contribution to TL variability is still understudied. We have used whole genome sequencing data of 250 family trios from the Genome of the Netherlands project to perform computational measurement of TL and a series of regression and genome-wide association analyses to reveal TL inheritance patterns and associated genetic factors. Our results confirm that TL is a largely heritable trait, primarily with mother's, and, to a lesser extent, with father's TL having the strongest influence on the offspring. In this cohort, mother's, but not father's age at conception was positively linked to offspring TL. Age-related TL attrition of 40 bp/year had relatively small influence on TL variability. Finally, we have identified TL-associated variations in ribonuclease reductase catalytic subunit M1 (RRM1 gene), which is known to regulate telomere maintenance in yeast. We also highlight the importance of multivariate approach and the limitations of existing tools for the analysis of TL as a polygenic heritable quantitative trait.

AB - Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative contribution to TL variability is still understudied. We have used whole genome sequencing data of 250 family trios from the Genome of the Netherlands project to perform computational measurement of TL and a series of regression and genome-wide association analyses to reveal TL inheritance patterns and associated genetic factors. Our results confirm that TL is a largely heritable trait, primarily with mother's, and, to a lesser extent, with father's TL having the strongest influence on the offspring. In this cohort, mother's, but not father's age at conception was positively linked to offspring TL. Age-related TL attrition of 40 bp/year had relatively small influence on TL variability. Finally, we have identified TL-associated variations in ribonuclease reductase catalytic subunit M1 (RRM1 gene), which is known to regulate telomere maintenance in yeast. We also highlight the importance of multivariate approach and the limitations of existing tools for the analysis of TL as a polygenic heritable quantitative trait.

KW - PATERNAL AGE

KW - LUNG-CANCER

KW - ASSOCIATION

KW - METAANALYSIS

KW - PROTEINS

KW - SUBUNIT

KW - HUMANS

KW - CELLS

KW - SIZE

U2 - 10.1038/s41598-019-55109-7

DO - 10.1038/s41598-019-55109-7

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 18758

ER -

ID: 111701818