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Vroege omschakeling van intraveneuze naar orale antibiotica even effectief als standaard intraveneuze therapie bij ernstige, buiten het ziekenhuis opgelopen pneumonie

Oosterheert, J. J., Bonten, M. J. M., Schneider, M. M. E., Buskens, E., Lammers, J. W. J., Hustinx, W. N. M., Kramer, M. H. H., Prins, J. M. & Slee, P. T., 2008, In : Nederlands Tijdschrift voor Geneeskunde. 152, p. 269-274 6 p.

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  • J.J. Oosterheert
  • M.J.M. Bonten
  • M.M.E. Schneider
  • E. Buskens
  • J.W.J. Lammers
  • W.N.M. Hustinx
  • M.H.H. Kramer
  • J.M. Prins
  • Ph Th Slee
OBJECTIVE: To compare an early switch from intravenous to oral antibiotics with the standard intravenous therapy in patients admitted to hospital with severe community acquired pneumonia. DESIGN: Multicentre randomised prospective trial with follow-up at 28 days. METHOD: Patients with severe pneumonia who were admitted to hospital were randomised for 7 days intravenous antibiotic therapy (control group) or for an early switch to oral antibiotic therapy after 3 days of intravenous antibiotic therapy (intervention group). An intention-to-treat analysis was performed. The primary outcome measure was clinical cure. The length of hospital stay was a secondary outcome measure. RESULTS: Out of the 302 patients included in the trial, data was analysed from 265 patients. The mortality rate in the intervention group did not differ significantly from that of the control group (mean difference: 2%; 95% CI: -3-8). After 28 days, 83% of the patients in the intervention group and 85% in the control group were clinically cured (mean difference: 2%; 95% CI: -7-10). The length of hospital stay was 1.9 days shorter in the intervention group (95% CI: 0.6-3.2 days). CONCLUSION: An early switch from intravenous to oral antibiotics in patients admitted to hospital for severe community acquired pneumonia is safe and reduces the length of hospital stay by approximately 2 days.
Original languageEnglish
Pages (from-to)269-274
Number of pages6
JournalNederlands Tijdschrift voor Geneeskunde
Volume152
Publication statusPublished - 2008

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