Publication

Vitamin D status indicators in indigenous populations in East Africa

Luxwolda, M. F., Kuipers, R. S., Kema, I. P., van der Veer, E., Dijck-Brouwer, D. A. J. & Muskiet, F. A. J., Apr-2013, In : European journal of nutrition. 52, 3, p. 1115-1125 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sufficient vitamin D status may be defined as the evolutionary established circulating 25-hydroxyvitamin D [25(OH)D] matching our Paleolithic genome.

We studied serum 25(OH)D [defined as 25(OH)D-2 + 25(OH)D-3] and its determinants in 5 East African ethnical groups across the life cycle: Maasai (MA) and Hadzabe (HA) with traditional life styles and low fish intakes, and people from Same (SA; intermediate fish), Sengerema (SE; high fish), and Ukerewe (UK; high fish). Samples derived from non-pregnant adults (MA, HA, SE), pregnant women (MA, SA, SE), mother-infant couples at delivery (UK), infants at delivery and their lactating mothers at 3 days (MA, SA, SE), and lactating mothers at 3 months postpartum (SA, SE). Erythrocyte docosahexaenoic acid (RBC-DHA) was determined as a proxy for fish intake.

The mean +/- A SD 25(OH)D of non-pregnant adults and cord serum were 106.8 +/- A 28.4 and 79.9 +/- A 26.4 nmol/L, respectively. Pregnancy, delivery, ethnicity (which we used as a proxy for sunlight exposure), RBC-DHA, and age were the determinants of 25(OH)D. 25(OH)D increased slightly with age. RBC-DHA was positively related to 25(OH)D, notably 25(OH)D-2. Pregnant MA (147.7 vs. 118.3) and SE (141.9 vs. 89.0) had higher 25(OH)D than non-pregnant counterparts (MA, SE). Infant 25(OH)D at delivery in Ukerewe was about 65 % of maternal 25(OH)D.

Our ancient 25(OH)D amounted to about 115 nmol/L and sunlight exposure, rather than fish intake, was the principal determinant. The fetoplacental unit was exposed to high 25(OH)D, possibly by maternal vitamin D mobilization from adipose tissue, reduced insulin sensitivity, trapping by vitamin D-binding protein, diminished deactivation, or some combination.

Original languageEnglish
Pages (from-to)1115-1125
Number of pages11
JournalEuropean journal of nutrition
Volume52
Issue number3
Publication statusPublished - Apr-2013

    Keywords

  • 25-Hydroxyvitamin D, Evolution, East Africa, Sunlight exposure, Fish intake, Pregnancy, TANDEM MASS-SPECTROMETRY, D DEFICIENCY, D SUPPLEMENTATION, D METABOLISM, PREGNANCY, HEALTH, RISK, DIET, TERRESTRIAL, LACTATION

ID: 5836544